lysine has been researched along with Lung Neoplasms in 100 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (8.00) | 18.7374 |
1990's | 3 (3.00) | 18.2507 |
2000's | 18 (18.00) | 29.6817 |
2010's | 40 (40.00) | 24.3611 |
2020's | 31 (31.00) | 2.80 |
Authors | Studies |
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Alhebshi, H; Bezecny, P; Bittar, MN; Creamer, DPM; Demonacos, C; Hall, C; Krstic-Demonacos, M; Muller, PAJ; Mutti, L; Patnaik, L; Safari, N; Taylor, R; Tian, K | 1 |
Diao, H; Hao, N; Koropatnick, J; Liu, Q; Maleki Vareki, S; Min, J; Min, W; Raphael, J; Sang, Y; Wang, Z; Xiong, J; Xu, D; Zhang, Y; Zheng, X | 1 |
Calhoun, S; Duan, L; Maki, CG; Perez, RE | 1 |
Agredo, A; Bains, M; Clingerman, J; Gates, K; Kasinski, AL; Lanman, NA; Li, C; Pal, AS; Sohal, IS; Son, J | 1 |
Choi, BJ; Han, SB; Kang, JS; Kwon, JH; Lee, CW; Lee, H; Lee, MY; Park, KH; Yang, JW; Yoon, YD | 1 |
Arnold, HU; Friesen, TJ; Garrison, SM; Hiatt, JB; Houghton, AM; Liao, SY; MacPherson, D; Martins, R; Norton, JP; Rienhoff, HY; Sandborg, H; Srivastava, S; Sutherland, KD; Wu, F | 1 |
Dai, J; Fan, J; Gu, Y; Hu, Z; Jin, G; Ma, H; Qin, N; Shen, H; Sun, Q; Zhang, C; Zhang, E; Zhang, X; Zhu, M | 1 |
Cao, L; Cui, J; Guo, W; Ma, L; Miao, Y; Qiu, S; Tian, X; Wang, Y; Xia, J; Zhang, C; Zhang, X | 1 |
Lou, K; Xu, X; Xu, Y; Zhang, Y; Zheng, B | 1 |
Guo, Y; Li, B; Li, J; Li, N; Lu, M; Wen, S; Yang, J; Yang, L; Zhan, X; Zheng, S | 1 |
He, Z; Liu, Y; Zhan, Z; Zhang, J; Zhong, D | 1 |
Chen, J; Chen, L; Diao, X; He, Q; Wu, Y; Xue, H; Zhong, D | 1 |
Abdel-Wahab, YHA; Attoub, S; Casciaro, B; Conlon, JM; Hunter, L; Mechkarska, M | 1 |
Arafet, K; Galvani, F; Lodola, A; Martí, S; Moliner, V; Mor, M; Scalvini, L | 1 |
Cao, L; Wang, M; Xu, K | 1 |
Akcora, C; Fang, B; Grimes, M; Haura, EB; Koomen, J; Lin, Y; Ross, KE; Zhang, G | 1 |
Liu, B; Wen, X; Zhao, X | 1 |
Cai, Q; Chen, Y; He, B; Liu, F; Peng, W; Peng, X; Shi, S; Tao, Y; Tu, G; Wang, X; Xiao, D; Yang, R; Yin, W; Zhang, Y; Zhao, Z | 1 |
Chen, JY; Ding, K; Gao, L; Lu, X; Ngan, SC; Sze, SK; Tang, G; Wang, W; Wang, X; Yao, SQ; Yuan, P | 1 |
Ding, Y; Du, L; He, P; Liu, H; Ren, Y; Xu, Y; Yang, H; Zi, X | 1 |
Chen, W; Chen, YH; Ruan, Q; Sun, H; Tang, A; Wan, X; Wang, J; Yan, D; Yang, X; Zamani, A; Zhang, H | 1 |
Kim, CH; Kim, H; Kim, HR; Kim, SY; Lee, TG | 1 |
Han, Q; Han, YC; Liang, Y; Liu, SL; Luo, Y; Wang, EH; Wei, L; Yan, T; Yang, Y; Zhang, MY | 1 |
Cho, SY; Jadvar, H; Kim, CK; Potvin, K; Winquist, E; Zukotynski, KA | 1 |
Hu, J; Li, M; Li, X; Li, Y; Ling, T; Mu, X; Pan, J; Shen, J; Su, Z; Wang, C; Wen, H; Wen, J; You, Q; Zhang, C; Zhang, X; Zhao, T | 1 |
Bosgana, P; Bravou, V; Dimitrakopoulos, FI; Kalophonos, C; Kourea, E; Logotheti, S; Nikou, S; Sampsonas, F; Tzelepi, V; Zolota, V | 1 |
Hong, J; Hong, SE; Jang, SK; Jin, HO; Lee, DH; Park, IC | 1 |
Ding, L; Fan, C; Kong, S; Li, Y; Shi, X; Wang, C; Wang, F; Wang, K; Wu, Q; Xu, W | 1 |
Bourgoin-Voillard, S; Boyault, C; Cascante, M; Cortés, R; Cunin, V; Martín-Bernabé, A; Michelland, S; Poignant, J; Rachidi, W; Seve, M; Tarragó-Celada, J | 1 |
Chen, H; Cheng, C; Gui, X; Hong, H; Huang, HY; Ji, H; Kuang, M; Meng, F; Pan, Y; Peng, Y; Shao, Z; Shen, X; Sun, Y; Tao, X; Tu, S; Yao, X; Yuan, C; Zhang, Y; Zheng, Q | 1 |
Chingin, K; Feng, S; Huang, K; Li, Y; Lu, H; Wei, Y; Zhang, H | 1 |
Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW | 1 |
Ahn, SG; Bae, E; Ha, J; Jeong, J; Jung, SM; Kim, JH; Kim, M; Kim, SJ; Lee, J; Lee, JH; Lee, S; Lee, YS; Ooshima, A; Park, J; Park, JS; Park, SH; Seo, D; Shin, D; van Loo, G; Yang, KM | 1 |
Chen, Y; Yang, C | 1 |
Shao, B; Tian, L; Yan, Y; Zhou, W; Zhu, B | 1 |
Chung, KC; Yoo, L; Yoon, AR; Yun, CO | 1 |
Chen, J; Chen, L; Fang, H; Fang, L; Ge, X; Han, D; Jiao, C; Jin, J; Jin, X; Li, C; Li, Y; Liao, G; Liao, L; Liu, M; Liu, Z; Peng, X; Qin, HL; Teng, H; Wang, P; Wang, X; Wang, Y; Wei, Q; Weng, L; Yang, Y; Zhang, S; Zhao, B; Zhou, D; Zhou, J | 1 |
Ahmad, S; Khan, H; Khan, MS | 1 |
Geng, B; Li, M; Li, X; Mu, X; Pan, J; Shen, J; Shi, H; Wang, C; Wen, H; Xu, C; Xu, Y; You, Q; Zhang, C; Zhao, T | 1 |
Cai, Z; Chen, TY; Gao, Y; Han, F; Hou, Z; Hsu, CC; Hu, J; Jin, G; Lan, J; Lee, MG; Li, H; Lin, HK; Long, J; Sun, L; Wang, G; Wang, YH; Xu, C; Yang, SC; Zhang, W | 1 |
Chen, J; Chen, L; Deng, A; Kang, J; Leng, Y; Li, Y; Si, X; Wang, G; Wang, Q; Wei, T; Zhu, S | 1 |
Huo, DF; Lu, LN; Qiu, MF; Wu, HB; Xin, X; Zhou, Y | 1 |
Gerber, SA; Rigas, JR; Schweppe, DK | 1 |
Chen, X; Endo, D; Hayashi, T; Koji, T; Matsumoto, K; Nagayasu, T; Nanashima, A; Song, N; Wu, Z; Ying, M | 1 |
Chang, CK; Chen, CL; Chen, SH; Chou, YA; Dong, JJ; Hsiao, M; Huang, MS; Jan, YH; Lai, TC; Liang, PH; Lin, YF; Liu, HG; Teng, KH; Tian, WT; Yang, CJ | 1 |
Chen, X; Huang, HH; Jin, W; Lin, Q; Lin, ZF; Liu, FB; Ruan, Z; Wang, JY; Xu, HB | 1 |
Berry, A; Donn, R; Farrow, SN; Hanley, N; Jangani, M; Matthews, L; Poolman, TM; Ray, DW; Whetton, AD; Williamson, AJ; Yang, N | 1 |
Barbash, O; Butte, AJ; Dhanak, D; Garcia, BA; Gozani, O; Huddleston, M; Jansen, PW; Khatri, P; Kruger, RG; Liu, S; Mazur, PK; Reynoird, N; Sage, J; Tummino, PJ; Van Aller, GS; Vermeulen, M; Wilkinson, AW | 1 |
Chen, Z; Li, Z; Lu, S; Niu, X; Shen, S; Tang, N; Xu, L; Xu, Y; Ye, X | 1 |
Chen, P; Chen, S; Cheng, S; Fan, L; Finley, D; Gao, H; Gu, Y; Hu, R; Ji, H; Komatsu, M; Li, L; Liu, X; Liu, Z; Peng, H; Ruan, K; Sun, Y; Wang, H; White, E; Xu, X; Yang, J; Yang, M; Zhou, J | 1 |
Arellano, ML; Boggon, TJ; Brat, DJ; Chen, GZ; Chen, J; Chen, PR; DeBerardinis, RJ; Elf, S; Fan, J; Gu, TL; He, C; Hitosugi, T; Ji, Q; Jiang, L; Jin, L; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lee, BH; Li, Y; Lin, R; Lonial, S; Mao, H; Seo, JH; Shan, C; Sudderth, J; Tucker, M; Wang, D; Wu, S; Xie, J; Ye, K; Zhang, L; Zhou, L | 1 |
Ma, YH; Ni, F; Peng, HY; Yang, RX | 1 |
Colón-Bolea, P; Crespo, P | 1 |
Hamamoto, R; Jenuwein, T; Nakakido, M; Nakamura, Y; Piao, L; Sone, K; Ueda, K | 1 |
Liu, Q; Liu, Y; Lu, X; Luo, F; Qin, Y; Shi, L; Wang, B; Xiang, Q; Xu, W; Xu, Y | 1 |
Alam, K; Ali, A; Habib, S; Khan, F; Mir, AR | 1 |
Chen, JS; Hsu, LC; Lai, TY; Lee, CY; Ou-Yang, P; Tsai, CY; Tsai, MK; Wu, SW | 1 |
Cai, J; Cai, R; Cao, Y; Chen, FL; Cheng, J; Mu, J; Wang, T; Zuo, Y | 1 |
Chung, DH; Ha, GH; Jeon, YK; Kim, CK; Koh, J | 1 |
Chen, D; Costa, M; Fang, L; Jin, C; Kluz, T; Sun, H; Zhang, X | 1 |
Hsia, TC; Mong, MC; Yin, MC | 1 |
Biancucci, M; Gius, D; Jiang, H; Kang, HJ; O'Callaghan, C; Park, SH; Principe, DR; Raparia, K; Satchell, KF; Song, HY; Vassilopoulos, A; Yan, Y | 1 |
Botuyan, MV; Bruns, CJ; Cui, G; Klein, BJ; Kutateladze, TG; Lin, K; Lu, Y; Mer, G; Shi, X; Wang, X; Yuan, C; Zhao, Y | 1 |
Igarashi, Y; Miyanaga, S; Onaka, H; Saiki, I; Sakurai, H | 1 |
Arita, A; Costa, M; Li, Q; Sun, H; Zhou, X | 1 |
Beezhold, K; Castranova, V; Chang, Q; Chen, F; Lu, Y; Rojanasakul, Y; Shi, X; Zhang, Y; Zhao, H | 1 |
Becker, K; Hanel, W; Li, D; Marchenko, ND; Moll, UM; Reich, N | 1 |
Choi, JH; Jung, BK; Kim, B; Kim, HM; Kim, JH; Kim, KW; Kim, SH; Lee, MN; Lee, MR; Lee, SN; Lee, ST; Oh, GT; Park, JG; Park, JH; Ryeom, S; Seo, JH; Yim, SH; Yoo, JY | 1 |
Kaetzel, DM; McCorkle, JR; Novak, M; Yang, M; Zhang, Q | 1 |
Arita, A; Chen, H; Costa, M; Kluz, T; Sun, H; Zavadil, J; Zhou, X | 1 |
Jaiswal, AK; Niture, SK | 1 |
Chinnasamy, N; Hong, JA; Liu, F; Marquez, VE; Morgan, RA; Rao, M; Schrump, DS; Xi, S; Zhang, M; Zhang, Y | 1 |
Brambilla, E; Eymin, B; Gazzeri, S; Nissou, D; Van Den Broeck, A | 1 |
Beverly, LJ; Erdjument-Bromage, H; Lockwood, WW; Shah, PP; Varmus, H | 1 |
DOUTRE, JC; QUINTON, A | 1 |
Bouterfa, H; Bushnell, D; Carlisle, T; Connolly, M; Kahn, D; Karwal, M; Madsen, M; Menda, Y; Miller, S; O'Dorisio, S; O'Dorisio, T; Ponto, J; Squires, S; Walkner, W | 1 |
Bussolati, O; Dall'Asta, V; Gazzola, GC; Rotoli, BM; Sala, R | 1 |
Horio, Y; Osada, H; Sugito, N; Takahashi, T; Tatematsu, Y | 1 |
Chen, H; Costa, M; Ke, Q; Kluz, T; Yan, Y | 1 |
Degani, H; Eshhar, Z; Kalchenko, V; Makovitzki, A; Papo, N; Seger, D; Shai, Y | 1 |
Guo, L; Ma, Y; Qi, R; Vogel, U; Wang, H; Yin, J | 1 |
Campo, I; Inghilleri, S; Luisetti, M; Morbini, P; Villa, C; Zorzetto, M | 1 |
Chen, H; Costa, M; Davidson, TL; Shinkai, Y; Yan, Y | 1 |
Ivanov, V; Kalinovsky, T; Niedzwiecki, A; Rath, M; Waheed Roomi, M | 1 |
Brun, J; Chiu, RK; Godschalk, RW; Gray, DA; Knaapen, AM; Lambin, P; Langie, SA; Ramaekers, CH; Theys, J; van Schooten, FJ; Wouters, BG | 1 |
DeMarchi, M; Ghio, P; Giachino, DF; Gregori, D; Mandrile, G; Novello, S; Regazzoni, S; Scagliotti, GV; Selvaggi, G | 1 |
Jiang, QJ; Liu, SY; Xiao, XS; Yuan, Z; Zhong, GR | 1 |
Chiappetta, G; De Gisi, S; De Marco, C; De Rosa, N; Fabiani, F; Franco, R; Malanga, D; Malara, N; Pirozzi, G; Rocco, G; Savino, R; Scrima, M; Tirino, V; Viglietto, G | 1 |
Jeong, EG; Kim, MS; Lee, SH; Yoo, NJ | 1 |
Ahmed, S; Boumber, Y; Charo, C; Cheng, AS; Furukawa, K; Gold, DL; Huang, TH; Issa, JP; Kondo, Y; Kwabi-Addo, B; Sekido, Y; Shen, L; Urano, T; Yamochi, T | 1 |
Hahn, FF; Kelly, G; Stegelmeier, BL | 1 |
Cole, SP; Falck, J; Jensen, PB; Mirski, SE; Sehested, M; Wessel, I | 1 |
Holmes, EH | 1 |
Chlebowski, RT; Heber, D; Tayek, JA | 1 |
Gabrielli, F; Tsugita, A | 1 |
Amatruda, TT; Upton, GV | 1 |
Phillips, ME | 1 |
Murase, T; Saito, T; Yoshida, S | 1 |
Bürgi, W; Schärer, HU | 1 |
Bojan, O; Mustea, I; Preda, N | 1 |
1 review(s) available for lysine and Lung Neoplasms
Article | Year |
---|---|
Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway.
Topics: Adenocarcinoma; Antineoplastic Agents; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Methylation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pancreatic Neoplasms; Protein Binding; Protein Kinase Inhibitors; Protein Phosphatase 2; Proto-Oncogene Proteins p21(ras); Signal Transduction | 2014 |
3 trial(s) available for lysine and Lung Neoplasms
Article | Year |
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Effects of intravenous amino acid administration with Y-90 DOTA-Phe1-Tyr3-Octreotide (SMT487[OctreoTher) treatment.
Topics: Adult; Aged; Amino Acids; Arginine; Carcinoid Tumor; Female; Humans; Infusions, Intravenous; Kidney; Lung Neoplasms; Lysine; Male; Meningioma; Middle Aged; Octreotide; Pancreatic Neoplasms; Radiopharmaceuticals; Yttrium Radioisotopes | 2004 |
Prospective assessment of XPD Lys751Gln and XRCC1 Arg399Gln single nucleotide polymorphisms in lung cancer.
Topics: Adult; Aged; Amino Acid Substitution; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; DNA-Binding Proteins; Female; Glutamine; Humans; Lung Neoplasms; Lysine; Male; Middle Aged; Platinum Compounds; Polymorphism, Single Nucleotide; Prognosis; Prospective Studies; Survival; Treatment Outcome; X-ray Repair Cross Complementing Protein 1; Xeroderma Pigmentosum Group D Protein | 2007 |
Effect of hydrazine sulphate on whole-body protein breakdown measured by 14C-lysine metabolism in lung cancer patients.
Topics: Adult; Aged; Cachexia; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hydrazines; Lung Neoplasms; Lysine; Male; Middle Aged; Prospective Studies; Proteins; Random Allocation; Serum Albumin; Sex Factors | 1987 |
96 other study(ies) available for lysine and Lung Neoplasms
Article | Year |
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Evaluation of the Role of p53 Tumour Suppressor Posttranslational Modifications and TTC5 Cofactor in Lung Cancer.
Topics: A549 Cells; Acetylation; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lysine; Male; Neoplasm Grading; Prognosis; Protein Processing, Post-Translational; Sex Characteristics; Sirtuin 1; Survival Analysis; Transcription Factors; Tumor Suppressor Protein p53 | 2021 |
TdIF1-LSD1 Axis Regulates Epithelial-Mesenchymal Transition and Metastasis via Histone Demethylation of E-Cadherin Promoter in Lung Cancer.
Topics: Animals; Cadherins; Carcinogenesis; Cell Line, Tumor; Cell Movement; Demethylation; DNA-Binding Proteins; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histone Demethylases; Histones; Lung Neoplasms; Lysine; Methylation; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Protein Binding; Transcription Factors | 2021 |
Inhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF15.
Topics: Antigens, CD; Cadherins; Carcinoma, Non-Small-Cell Lung; Cisplatin; Histone Demethylases; Humans; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Lysine; Paclitaxel | 2022 |
Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; RNA, Long Noncoding; Up-Regulation | 2022 |
Targeted Induction of Endogenous VDUP1 by Small Activating RNA Inhibits the Growth of Lung Cancer Cells.
Topics: Carrier Proteins; Histones; Humans; Lung Neoplasms; Lysine; RNA, Double-Stranded | 2022 |
Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing.
Topics: Animals; Cell Death; Enzyme Inhibitors; Etoposide; Histone Demethylases; Humans; Immune Checkpoint Inhibitors; Lung Neoplasms; Lysine; Mice; Platinum; Small Cell Lung Carcinoma; Tumor Microenvironment | 2022 |
A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer.
Topics: Apoptosis; Arginine; Carcinoma, Non-Small-Cell Lung; Caspase 8; Caspases; Genome-Wide Association Study; Humans; Ligands; Lung Neoplasms; Lysine; Sincalide; TNF-Related Apoptosis-Inducing Ligand | 2022 |
ISGylation of EMD promotes its interaction with PDHA to inhibit aerobic oxidation in lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; beta Catenin; Glucose; Humans; Lung Neoplasms; Lysine; Membrane Proteins; Nuclear Proteins; Pyruvate Dehydrogenase (Lipoamide); Serine | 2022 |
Methylation patterns of Lys9 and Lys27 on histone H3 correlate with patient outcome and tumor progression in lung cancer.
Topics: Adenocarcinoma of Lung; DNA Methylation; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Prognosis; Retrospective Studies | 2022 |
Ubiquitination-mediated molecular pathway alterations in human lung squamous cell carcinomas identified by quantitative ubiquitinomics.
Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Humans; Lung; Lung Neoplasms; Lysine; Phosphatidylinositol 3-Kinases; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Ubiquitin; Ubiquitination | 2022 |
SMYD3 regulates the abnormal proliferation of non-small-cell lung cancer cells via the H3K4me3/ANO1 axis.
Topics: Anoctamin-1; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chromatin; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung Neoplasms; Lysine; Neoplasm Proteins; RNA, Messenger | 2022 |
Covalent Binding Mechanism of Furmonertinib and Osimertinib With Human Serum Albumin.
Topics: Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Lysine; Serum Albumin; Serum Albumin, Human | 2023 |
Antimicrobial, cytotoxic, and insulin-releasing activities of the amphibian host-defense peptide ocellatin-3N and its L-lysine-substituted analogs.
Topics: Amphibian Proteins; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antimicrobial Cationic Peptides; Antineoplastic Agents; Anura; Carcinoma, Non-Small-Cell Lung; Diabetes Mellitus, Type 2; Endothelial Cells; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Insulin; Lung Neoplasms; Lysine; Mice; Skin | 2023 |
Mechanistic Modeling of Lys745 Sulfonylation in EGFR C797S Reveals Chemical Determinants for Inhibitor Activity and Discriminates Reversible from Irreversible Agents.
Topics: Drug Resistance, Neoplasm; ErbB Receptors; Humans; Lung Neoplasms; Lysine; Mutation; Protein Kinase Inhibitors | 2023 |
[Research Progress of Role and Mechanism of SETD7 in Tumor Occurrence
and Progression].
Topics: Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung Neoplasms; Lysine | 2023 |
Network models of protein phosphorylation, acetylation, and ubiquitination connect metabolic and cell signaling pathways in lung cancer.
Topics: Acetylation; Humans; Lung Neoplasms; Lysine; Phosphorylation; Protein Processing, Post-Translational; Signal Transduction; Ubiquitination | 2023 |
Wee1 epigenetically modulates H2B mono-ubiquitination at K120 lysine and DNA double-strand break repair through phosphorylation of H2BY37-dependent manner in small-cell lung cancer.
Topics: Cell Cycle Proteins; Cell Line, Tumor; DNA; DNA Breaks, Double-Stranded; DNA Repair; Histones; Humans; Lung Neoplasms; Lysine; Phosphorylation; Protein-Tyrosine Kinases; Small Cell Lung Carcinoma; Ubiquitin-Protein Ligases | 2023 |
The NLRP11 Protein Bridges the Histone Lysine Acetyltransferase KAT7 to Acetylate Vimentin in the Early Stage of Lung Adenocarcinoma.
Topics: Adenocarcinoma of Lung; Histone Acetyltransferases; Histones; Humans; Lung Neoplasms; Lysine; Vimentin | 2023 |
Cell-active, irreversible covalent inhibitors that selectively target the catalytic lysine of EGFR by using fluorosulfate-based SuFEx chemistry.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Erlotinib Hydrochloride; Humans; Lung Neoplasms; Lysine; Mammals; Protein Kinase Inhibitors | 2023 |
Inhibition of LSD1 induces ferroptosis through the ATF4-xCT pathway and shows enhanced anti-tumor effects with ferroptosis inducers in NSCLC.
Topics: Activating Transcription Factor 4; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Ferroptosis; Histone Demethylases; Histones; Humans; Lung Neoplasms; Lysine | 2023 |
TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis.
Topics: Acetylcysteine; Adoptive Transfer; Animals; Carcinogenesis; Cell Polarity; Cell Transformation, Neoplastic; Female; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myeloid Cells; Myeloid-Derived Suppressor Cells; Reactive Oxygen Species; Signal Transduction; Transfection | 2020 |
Radiation Induces Autophagy
Topics: Adaptor Proteins, Signal Transducing; Autophagy; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Epigenesis, Genetic; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Microtubule-Associated Proteins; RNA, Small Interfering | 2020 |
Lamin B2 promotes the malignant phenotype of non-small cell lung cancer cells by upregulating dimethylation of histone 3 lysine 9.
Topics: Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Histones; Humans; Lamin Type B; Lung Neoplasms; Lysine; Up-Regulation | 2020 |
Prostate Cancer Lymphangitic Pulmonary Carcinomatosis: Appearance on 18F-FDG PET/CT and 18F-DCFPyL PET/CT.
Topics: Disease Progression; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Lysine; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Prednisone; Prostatic Neoplasms; Urea | 2020 |
Lysine-222 succinylation reduces lysosomal degradation of lactate dehydrogenase a and is increased in gastric cancer.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carnitine O-Palmitoyltransferase; Cell Proliferation; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; L-Lactate Dehydrogenase; Lung Neoplasms; Lysine; Lysosomes; Male; Melanoma; Mice; Mice, Nude; Middle Aged; Prognosis; Protein Processing, Post-Translational; Proteolysis; Sequestosome-1 Protein; Stomach Neoplasms; Succinic Acid; Survival Rate; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
H3K4 Methylation Status and Lysine Specific Methyltransferase KMT2C Expression Correlate with Prognosis in Lung Adenocarcinoma.
Topics: Adenocarcinoma of Lung; DNA-Binding Proteins; Female; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Methyltransferases; Prognosis | 2021 |
Lysine is required for growth factor-induced mTORC1 activation.
Topics: A549 Cells; AMP-Activated Protein Kinases; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Culture Media, Serum-Free; Gene Knockdown Techniques; Humans; Insulin; Insulin-Like Growth Factor I; Lung Neoplasms; Lysine; Mechanistic Target of Rapamycin Complex 1; Protein Serine-Threonine Kinases; RNA, Small Interfering | 2020 |
Global analysis of lysine acetylome reveals the potential role of CCL18 in non-small cell lung cancer.
Topics: A549 Cells; Acetylation; Carcinoma, Non-Small-Cell Lung; Chemokines, CC; Humans; Lung Neoplasms; Lysine; Protein Processing, Post-Translational | 2021 |
Quantitative Proteomic Approach Reveals Altered Metabolic Pathways in Response to the Inhibition of Lysine Deacetylases in A549 Cells under Normoxia and Hypoxia.
Topics: A549 Cells; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Lung Neoplasms; Lysine; Machine Learning; Metabolic Networks and Pathways; Oxidative Phosphorylation; Oxygen; Proteome; Proteomics; Proto-Oncogene Proteins p21(ras); Reactive Oxygen Species | 2021 |
A systematic dissection of the epigenomic heterogeneity of lung adenocarcinoma reveals two different subclasses with distinct prognosis and core regulatory networks.
Topics: Acetylation; Adenocarcinoma of Lung; Enhancer Elements, Genetic; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genes, Tumor Suppressor; Histones; Humans; Lung Neoplasms; Lysine; Oncogenes; Prognosis; Transcription, Genetic; Transcriptome; Treatment Outcome | 2021 |
Direct quantitative profiling of amino acids in tissues for the assessment of lung cancer.
Topics: Alanine; Amino Acids; Humans; Isoleucine; Leucine; Lung Neoplasms; Lysine | 2021 |
A Specific Mixture of Nutrients Suppresses Ovarian Cancer A-2780 Tumor Incidence, Growth, and Metastasis to Lungs.
Topics: Animals; Antioxidants; Ascorbic Acid; Cell Line, Tumor; Cell Proliferation; Dietary Supplements; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Lysine; Matrix Metalloproteinase 9; Mice; Mice, Nude; Micronutrients; Neoplasm Metastasis; Ovarian Neoplasms; Plant Extracts; Proline; Quercetin; Tea; Xenograft Model Antitumor Assays | 2017 |
A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.
Topics: Animals; Breast Neoplasms; Cell Movement; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; HEK293 Cells; Humans; Lung Neoplasms; Lysine; MCF-7 Cells; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; Neoplastic Stem Cells; Phosphorylation; Protein Stability; RNA Interference; Signal Transduction; Snail Family Transcription Factors; Time Factors; Transfection; Transforming Growth Factor beta1; Tumor Necrosis Factor alpha-Induced Protein 3; Tumor Necrosis Factor-alpha; Ubiquitination | 2017 |
miR‑197‑3p‑induced downregulation of lysine 63 deubiquitinase promotes cell proliferation and inhibits cell apoptosis in lung adenocarcinoma cell lines.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antagomirs; Apoptosis; Base Sequence; Binding Sites; Cell Line; Cell Line, Tumor; Cell Proliferation; Deubiquitinating Enzyme CYLD; Epithelial Cells; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Luciferases; Lung; Lung Neoplasms; Lysine; MicroRNAs; Oligoribonucleotides; Signal Transduction | 2018 |
Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.
Topics: Aged; Asian People; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Down-Regulation; Ethnicity; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Lysine; Male; Middle Aged; NAD; Neoplasm Metastasis; Prognosis; RNA, Messenger; Sirtuins; Survival Analysis | 2018 |
Covalent ISG15 conjugation to CHIP promotes its ubiquitin E3 ligase activity and inhibits lung cancer cell growth in response to type I interferon.
Topics: A549 Cells; Animals; Cell Proliferation; Cytokines; HEK293 Cells; Humans; Interferon Type I; Interferon-alpha; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Lysine; Male; Mice, Nude; Necrosis; Proteolysis; Proto-Oncogene Proteins c-myc; Transcription Factors; Tripartite Motif Proteins; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Ubiquitination; Ubiquitins | 2018 |
SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis.
Topics: A549 Cells; Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Colorectal Neoplasms; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; Methylation; Mice, Inbred C57BL; Mice, Knockout; Phosphoproteins; Prognosis; Protein Binding; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Signal Transduction; Transcription Factors; Tumor Burden; YAP-Signaling Proteins | 2018 |
The in vivo and in vitro approaches for establishing a link between advanced glycation end products and lung cancer.
Topics: A549 Cells; Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Humans; Lung Neoplasms; Lysine; Male; Mice; Protein Carbonylation; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor for Advanced Glycation End Products | 2018 |
CPT1A-mediated succinylation of S100A10 increases human gastric cancer invasion.
Topics: Animals; Annexin A2; Carnitine O-Palmitoyltransferase; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lysine; Male; Melanoma, Experimental; Mice, Inbred C57BL; Protein Processing, Post-Translational; S100 Proteins; Sirtuins; Stomach Neoplasms; Succinates | 2019 |
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis.
Topics: A549 Cells; Animals; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Female; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; Methylation; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Nude; NIH 3T3 Cells; Protein Methyltransferases; Proto-Oncogene Proteins c-akt; Transplantation, Heterologous; Ubiquitination | 2019 |
Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression.
Topics: Adult; Aged; Aged, 80 and over; Animals; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Cyclin E; E2F1 Transcription Factor; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lysine; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Transplantation; Oligonucleotide Array Sequence Analysis; Oncogene Proteins; p300-CBP Transcription Factors | 2013 |
[Preparation, characterization and Calu-3 cellular uptake of three kinds of poly(b-benzyl-L-amino)block-poly(ethylene glycol) nanoparticles].
Topics: Adenocarcinoma; Administration, Intranasal; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Cell Line, Tumor; Cell Survival; Curcumin; Drug Carriers; Ethylene Glycol; Humans; Lung Neoplasms; Lysine; Nanoparticles; Particle Size; Polyethylene Glycols; Polyglutamic Acid | 2013 |
Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors.
Topics: Amino Acid Motifs; Arginine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Isotope Labeling; Lung Neoplasms; Lysine; Mutation; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Proteome; Proteomics; Signal Transduction | 2013 |
High expression of trimethylated histone H3 at lysine 27 predicts better prognosis in non-small cell lung cancer.
Topics: Adenocarcinoma; Aged; Biomarkers, Tumor; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Female; Histones; Humans; Immunoenzyme Techniques; Lung; Lung Neoplasms; Lysine; Male; Neoplasm Staging; Polycomb Repressive Complex 2; Prognosis; Survival Rate | 2013 |
Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies.
Topics: Alkylation; Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 7; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Activation; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Lysine; MCF-7 Cells; Mice; Mice, Inbred NOD; Mice, SCID; Protein Interaction Maps; Signal Transduction; X-Linked Inhibitor of Apoptosis Protein; Xenograft Model Antitumor Assays | 2013 |
SIRT5 desuccinylates and activates SOD1 to eliminate ROS.
Topics: Amino Acid Sequence; Biocatalysis; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Humans; Lung Neoplasms; Lysine; Molecular Sequence Data; Mutation; Protein Binding; Reactive Oxygen Species; Sirtuins; Succinates; Superoxide Dismutase; Superoxide Dismutase-1 | 2013 |
The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer.
Topics: B-Lymphocytes; Bronchi; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Chromatin Assembly and Disassembly; Epithelium; Gene Expression Regulation, Neoplastic; Glucocorticoids; Histones; Humans; Inflammation; Interferon-gamma; Lung Neoplasms; Lysine; Methylation; Methyltransferases; Protein Binding; Protein Kinases; Protein Structure, Tertiary; Receptors, Glucocorticoid; RNA, Messenger; Signal Transduction; Transcriptional Activation; Tumor Necrosis Factor-alpha; Ubiquitination | 2014 |
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Methylation; Mice; Mitogen-Activated Protein Kinases; Oncogene Protein p21(ras); Pancreatic Neoplasms; Protein Phosphatase 2; Proto-Oncogene Proteins A-raf; Signal Transduction | 2014 |
The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Histones; Humans; Lung Neoplasms; Lysine; Male; Methylation; Middle Aged; NF-E2-Related Factor 2; Polycomb Repressive Complex 2; Survival Analysis | 2014 |
Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression.
Topics: Adaptor Proteins, Signal Transducing; Animals; Autophagy; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; DNA Damage; Eye Proteins; Heat-Shock Proteins; HEK293 Cells; Humans; Lung Neoplasms; Lysine; Macrophages; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Microtubule-Associated Proteins; Oxidative Stress; Protein Binding; RNA Interference; Sequestosome-1 Protein; Signal Transduction; Time Factors; Transcription Factor TFIIIA; Transfection; Tumor Burden; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Ubiquitination | 2014 |
Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.
Topics: Acetyl-CoA C-Acetyltransferase; Acetylation; Animals; Cell Line, Tumor; Dihydrolipoyllysine-Residue Acetyltransferase; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Leukemia; Lung Neoplasms; Lysine; Mice; NADP; Neoplasms, Experimental; Phosphogluconate Dehydrogenase; Protein Binding; Protein Multimerization | 2014 |
Preparation of lysine-coated magnetic Fe2O3 nanoparticles and influence on viability of A549 lung cancer cells.
Topics: Apoptosis; Cell Proliferation; Contrast Media; Ferric Compounds; Humans; Lung Neoplasms; Lysine; Magnetic Resonance Imaging; Magnetite Nanoparticles; Microscopy, Electron, Transmission; Tumor Cells, Cultured | 2014 |
Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair.
Topics: Animals; Cell Separation; Chlorocebus aethiops; Chromatin; COS Cells; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Fibroblasts; Flow Cytometry; Gamma Rays; Gene Expression Regulation; Genes, Dominant; HeLa Cells; Histones; Humans; Immunohistochemistry; Lung Neoplasms; Lysine; Methylation; Mice; Mutation; Phosphorylation; RNA, Small Interfering; Tissue Array Analysis | 2014 |
Epigenetic silencing of microRNA-218 via EZH2-mediated H3K27 trimethylation is involved in malignant transformation of HBE cells induced by cigarette smoke extract.
Topics: Bronchi; Cell Line; Cell Transformation, Neoplastic; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; Lysine; Methylation; MicroRNAs; Mitogen-Activated Protein Kinase 7; Smoking | 2016 |
Structural changes in histone H2A by methylglyoxal generate highly immunogenic amorphous aggregates with implications in auto-immune response in cancer.
Topics: Adolescent; Adult; Animals; Antibodies, Neoplasm; Autoantibodies; Case-Control Studies; Epitopes; Female; Gastrointestinal Neoplasms; Histones; Humans; Lung Neoplasms; Lysine; Male; Middle Aged; Prostatic Neoplasms; Pyruvaldehyde; Rabbits | 2016 |
The influence of a caveolin-1 mutant on the function of P-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B; Carcinoma, Non-Small-Cell Lung; Caveolin 1; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; Lysine; Mutation; Protein Multimerization; Protein Processing, Post-Translational; Protein Transport | 2016 |
A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity.
Topics: A549 Cells; Acetylation; Carcinogenesis; Cell Proliferation; Genes, Tumor Suppressor; Histone Deacetylases; Humans; Lung Neoplasms; Lysine; Proto-Oncogene Proteins c-myc; Sirtuins; Sumoylation | 2016 |
Pellino-1 confers chemoresistance in lung cancer cells by upregulating cIAP2 through Lys63-mediated polyubiquitination.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; Cell Line; Cell Line, Tumor; Cell Survival; Cisplatin; Drug Resistance, Neoplasm; HCT116 Cells; HEK293 Cells; Humans; Lung Neoplasms; Lysine; Nuclear Proteins; Paclitaxel; Polyubiquitin; RNA Interference; Ubiquitin-Protein Ligases; Ubiquitination; Up-Regulation | 2016 |
Hexavalent Chromium (Cr(VI)) Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1.
Topics: Acetylation; Basic Helix-Loop-Helix Transcription Factors; Carcinogens, Environmental; Cell Line; Cell Transformation, Neoplastic; Chromium; Epigenesis, Genetic; Histones; Humans; Lung; Lung Neoplasms; Lysine; Neoplasm Proteins; Up-Regulation | 2016 |
Advanced Glycation End-Products Enhance Lung Cancer Cell Invasion and Migration.
Topics: Arginine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Fibronectins; Glycation End Products, Advanced; Humans; Intercellular Adhesion Molecule-1; Interleukin-6; Lung Neoplasms; Lysine; Matrix Metalloproteinase 2; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2016 |
SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.
Topics: Acetylation; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Gene Deletion; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; HCT116 Cells; HEK293 Cells; Humans; Lung Neoplasms; Lysine; Male; Mice; Mice, Knockout; Mice, Nude; Mutation; NIH 3T3 Cells; Pancreatic Neoplasms; Phenotype; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Signal Transduction; Sirtuin 2; Time Factors; Tumor Burden | 2016 |
PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
Topics: Acetylation; Amino Acid Sequence; Antigens, Neoplasm; Aspartic Acid; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Glutamic Acid; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Models, Biological; Models, Molecular; Mutation; Protein Binding; Protein Domains; Transcription Factors; Tumor Suppressor Protein p53 | 2016 |
Synthesis and evaluation of myxochelin analogues as antimetastatic agents.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Catechols; Cell Line, Tumor; Lung Neoplasms; Lysine; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Neoplasm Metastasis; Stereoisomerism; Structure-Activity Relationship | 2009 |
Effects of nickel, chromate, and arsenite on histone 3 lysine methylation.
Topics: Arsenites; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromates; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Nickel; Potassium Compounds; Protein Processing, Post-Translational; Sodium Compounds; Time Factors | 2009 |
Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3.
Topics: Amino Acid Sequence; Chromatin Immunoprecipitation; Dioxygenases; F-Box Proteins; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Lysine; Methylation; Molecular Sequence Data; Nuclear Proteins; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; Protein Interaction Domains and Motifs; RNA Polymerase I; RNA, Ribosomal; RNA, Small Interfering; Sequence Alignment | 2009 |
Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-alpha3 binding.
Topics: Active Transport, Cell Nucleus; Adenocarcinoma; alpha Karyopherins; Cell Division; Cell Nucleus; Colonic Neoplasms; Cytoplasm; HCT116 Cells; Humans; Lung Neoplasms; Lysine; Protein Binding; Proto-Oncogene Proteins c-mdm2; Stress, Physiological; Tumor Suppressor Protein p53; Ubiquitination | 2010 |
Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis.
Topics: Acetylation; Acetyltransferases; Animals; Blotting, Western; Cell Line, Tumor; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Immunoprecipitation; Intestinal Polyps; Lung Neoplasms; Lysine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Mice, Transgenic; Microcirculation; Mutation; N-Terminal Acetyltransferase A; N-Terminal Acetyltransferase E; Neovascularization, Pathologic; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation; Vascular Endothelial Growth Factor A | 2010 |
Metastasis suppressor function of NM23-H1 requires its 3'-5' exonuclease activity.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Exonucleases; Female; Glutamic Acid; Histidine; Histidine Kinase; Humans; Lung Neoplasms; Lysine; Melanoma, Experimental; Mice; Mice, Nude; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; NM23 Nucleoside Diphosphate Kinases; Protein Conformation; Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Heterologous | 2011 |
Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase.
Topics: Biomarkers; Blotting, Western; Bronchi; Cells, Cultured; Chromatin Immunoprecipitation; DNA Methylation; Epithelial Cells; Gene Expression Profiling; Heme Oxygenase-1; Histones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Lysine; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Retinoblastoma Protein; Retinoblastoma-Binding Protein 2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering | 2010 |
INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carrier Proteins; Cell Line, Tumor; Cell Survival; Cullin Proteins; Cytoskeletal Proteins; DNA Fragmentation; Etoposide; Gamma Rays; Humans; Hydroquinones; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Lung Neoplasms; Lysine; Mice; Phosphorylation; Phosphoserine; Protein Binding; Protein Processing, Post-Translational; Protein Stability; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Ubiquitination; Ultraviolet Rays; Up-Regulation | 2011 |
Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer.
Topics: Antigens, Neoplasm; Cell Line, Tumor; Chromatin; DNA Methylation; Enzyme Inhibitors; Gene Expression Profiling; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunotherapy, Adoptive; Lung Neoplasms; Lysine; Melanoma-Specific Antigens; Membrane Proteins; Methylation; Neoplasm Proteins | 2011 |
Activation of a Tip60/E2F1/ERCC1 network in human lung adenocarcinoma cells exposed to cisplatin.
Topics: Acetylation; Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Line, Tumor; Cisplatin; DNA Damage; DNA Repair; DNA-Binding Proteins; E1A-Associated p300 Protein; E2F1 Transcription Factor; Endonucleases; Histone Acetyltransferases; Humans; Lung Neoplasms; Lysine; Lysine Acetyltransferase 5; p300-CBP Transcription Factors; Protein Interaction Domains and Motifs; Up-Regulation | 2012 |
Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Apoptosis; Autophagy-Related Proteins; Carrier Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytoplasm; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lysine; Mice; Models, Biological; Protein Binding; Protein Stability; Protein Transport; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Subcellular Fractions; Survival Analysis; Ubiquitination; Ubiquitins | 2012 |
[TRIAL OF AN ANABOLIC AND HEMATOPOIETIC PREPARATION IN A PNEUMO-PHTHISIOLOGY DEPARTMENT].
Topics: Appetite; Body Weight; Cobalt; Copper; Corrinoids; Drug Synergism; Drug Therapy; Geriatrics; Hematopoiesis; Humans; Iron; Liver Extracts; Lung Neoplasms; Lysine; Manganese; Tissue Extracts; Tuberculosis; Tuberculosis, Pulmonary; Vitamin B 12; Vitamin B Complex | 1964 |
The transport of cationic amino acids in human airway cells: expression of system y+L activity and transepithelial delivery of NOS inhibitors.
Topics: Adenocarcinoma; Amino Acid Transport System y+L; Amino Acids; Animals; Arginine; Biological Transport; Cations; Cell Line; Cell Line, Tumor; Cell Membrane Permeability; Culture Media, Conditioned; Epithelial Cells; Gene Expression; Humans; Lung Neoplasms; Lysine; Macrophages; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; omega-N-Methylarginine; Respiratory System; Reverse Transcriptase Polymerase Chain Reaction | 2005 |
Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines.
Topics: Acetylation; Androstadienes; Azacitidine; Chromatin; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Lysine; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Wortmannin | 2005 |
Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing.
Topics: Animals; Azacitidine; Blotting, Western; Carcinoma; Cell Line; Cell Line, Tumor; Cell Survival; Chromatin Immunoprecipitation; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epigenesis, Genetic; Fibroblasts; Gene Silencing; Histones; Humans; Kinetics; Lung Neoplasms; Lysine; Methyltransferases; Mice; Nickel; Trace Elements; Transgenes | 2006 |
Inhibition of tumor growth and elimination of multiple metastases in human prostate and breast xenografts by systemic inoculation of a host defense-like lytic peptide.
Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Female; Humans; Leucine; Lung Neoplasms; Lysine; Male; Membrane Potentials; Mice; Mice, SCID; Neoplasm Metastasis; Peptides; Phosphatidylserines; Prostate-Specific Antigen; Prostatic Neoplasms; Xenograft Model Antitumor Assays | 2006 |
Polymorphism of the DNA repair gene ERCC2 Lys751Gln and risk of lung cancer in a northeastern Chinese population.
Topics: Adult; Base Sequence; China; DNA Primers; DNA Repair; Female; Glycine; Humans; Lung Neoplasms; Lysine; Male; Middle Aged; Polymorphism, Genetic; Risk Factors; Xeroderma Pigmentosum Group D Protein | 2006 |
The receptor for advanced glycation end products and its ligands: a new inflammatory pathway in lung disease?
Topics: Airway Obstruction; Granuloma, Respiratory Tract; Humans; Immunohistochemistry; Ligands; Lung; Lung Diseases; Lung Diseases, Interstitial; Lung Neoplasms; Lysine; Nerve Growth Factors; Pneumonia; Receptor for Advanced Glycation End Products; Receptors, Immunologic; S100 Calcium Binding Protein beta Subunit; S100 Proteins; S100A12 Protein; Smoking | 2006 |
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells.
Topics: Acetylation; Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Hypoxia; Cell Line, Tumor; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Mice; MutL Protein Homolog 1; Nuclear Proteins; Promoter Regions, Genetic; Protein Methyltransferases; Protein Processing, Post-Translational; Tetrahydrofolate Dehydrogenase; Transfection | 2006 |
In vivo and in vitro antitumor effect of a unique nutrient mixture on lung cancer cell line A-549.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Camellia sinensis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Collagen; Dietary Supplements; Dose-Response Relationship, Drug; Drug Combinations; Drug Screening Assays, Antitumor; Humans; Laminin; Lung Neoplasms; Lysine; Mice; Mice, Nude; Plant Extracts; Proline; Proteoglycans | 2006 |
Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity.
Topics: Benzo(a)pyrene; Cell Line, Tumor; DNA Damage; DNA Mutational Analysis; DNA Repair; Dose-Response Relationship, Drug; Green Fluorescent Proteins; HeLa Cells; Humans; Lung; Lung Neoplasms; Lysine; Mutagens; Polyubiquitin; Ultraviolet Rays | 2007 |
[Folate-poly-L-lysine-Gd-DTPA as MR contrast agent for tumor imaging via folate receptor-targeted delivery].
Topics: Animals; Carrier Proteins; Contrast Media; Drug Delivery Systems; Folate Receptors, GPI-Anchored; Folic Acid; Gadolinium DTPA; Humans; Lung Neoplasms; Lysine; Magnetic Resonance Imaging; Mice; Mice, Nude; Neoplasms, Experimental; Receptors, Cell Surface; Reproducibility of Results; Sensitivity and Specificity; Transplantation, Heterologous | 2007 |
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung.
Topics: Aged; Amino Acid Substitution; Base Sequence; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA Mutational Analysis; Enzyme Activation; Glutamic Acid; Humans; Lung Neoplasms; Lysine; Male; Molecular Sequence Data; Mutation; Protein Transport; Proto-Oncogene Proteins c-akt | 2008 |
Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias.
Topics: Acute Disease; Adenocarcinoma; Adult; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; DNA Mutational Analysis; Female; Glutamic Acid; Humans; Leukemia; Liver Neoplasms; Lung Neoplasms; Lysine; Male; Middle Aged; Mutation; Neoplasms; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Proteins c-akt; Stomach Neoplasms | 2008 |
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation.
Topics: Acetylation; Alkaline Phosphatase; Biomarkers, Tumor; Breast Neoplasms; Cells, Cultured; Chromatin Immunoprecipitation; Colony-Forming Units Assay; CpG Islands; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Female; Gene Silencing; Histones; Humans; Lung Neoplasms; Lysine; Male; Microarray Analysis; Microfilament Proteins; Phosphatidylinositol 3-Kinases; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Prostate; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors | 2008 |
p53 alterations in plutonium-induced F344 rat lung tumors.
Topics: Adenocarcinoma; Aerosols; Amino Acid Sequence; Animals; Blotting, Southern; Carcinoma, Adenosquamous; Carcinoma, Squamous Cell; DNA Primers; DNA, Neoplasm; Exons; Female; Genes, p53; Glutamine; Immunohistochemistry; Lung Neoplasms; Lysine; Molecular Sequence Data; Mutagenesis; Neoplasms, Radiation-Induced; Plutonium; Point Mutation; Polymerase Chain Reaction; Rats; Rats, Inbred F344; Tumor Suppressor Protein p53 | 1995 |
Loss of amino acids 1490Lys-Ser-Lys1492 in the COOH-terminal region of topoisomerase IIalpha in human small cell lung cancer cells selected for resistance to etoposide results in an extranuclear enzyme localization.
Topics: Amino Acid Sequence; Amino Acid Substitution; Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Carcinoma, Small Cell; Cell Nucleus; Consensus Sequence; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Humans; Isoenzymes; Lung Neoplasms; Lysine; Molecular Sequence Data; Molecular Weight; Multidrug Resistance-Associated Proteins; Peptide Fragments; Point Mutation; Polymerase Chain Reaction; RNA, Messenger; Sequence Deletion; Serine; Tumor Cells, Cultured | 1997 |
Presence of an essential lysine residue in a GDP-fucose protected site of the alpha 1----3fucosyltransferase from human small cell lung carcinoma NCl-H69 cells.
Topics: Binding Sites; Binding, Competitive; Borohydrides; Carcinoma, Small Cell; Enzyme Activation; Fucosyltransferases; Guanosine Diphosphate Fucose; Humans; Lung Neoplasms; Lysine; Oxidation-Reduction; Pyridoxal Phosphate; Tumor Cells, Cultured | 1992 |
H1(0) histones of normal and cancer human cells. Amino acid composition of H1 purified by polyacrylamide gel electrophoresis.
Topics: Amino Acids; Arginine; Carcinoma, Hepatocellular; Cell Line; Histones; Humans; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Lysine; Neoplasms | 1986 |
Evidence for the presence of tumor peptides with corticotropin-releasing-factor-like activity in the ectopic ACTH syndrome.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenocorticotropic Hormone; Amino Acids; Animals; Biological Assay; Carcinoma, Bronchogenic; Corticotropin-Releasing Hormone; Dexamethasone; Electrophoresis; Feedback; Hormones, Ectopic; Humans; Lung Neoplasms; Lysine; Metyrapone; Neoplasm Metastasis; Neoplasm Proteins; Pancreatic Neoplasms; Peptides; Rats; Vasopressins | 1971 |
Tumor antigens. 3. Immunological studies of tissue and tumor antigens and serum protein production by transplantable murine tumors.
Topics: Absorption; Adenocarcinoma; Animals; Antigens; Autoradiography; Blood Proteins; Carbon Isotopes; Culture Techniques; Granulosa Cell Tumor; Immune Sera; Immunodiffusion; Immunoelectrophoresis; Isoleucine; Lung Neoplasms; Lysine; Melanoma; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Rabbits; Stomach Neoplasms; Teratoma | 1970 |
[Radioimmunoassay of arginine vasopressin].
Topics: Animals; Antibodies, Anti-Idiotypic; Arginine; Carcinoma, Bronchogenic; Humans; Lung Neoplasms; Lysine; Rabbits; Radioimmunoassay; Vasopressins | 1971 |
Occurrence of L-lysine dehydrogenase (LyDH) in human serum in normal and some pathological states.
Topics: Adolescent; Adult; Amino Acid Oxidoreductases; Breast Neoplasms; Female; Heart Diseases; Heart Failure; Humans; Kidney Neoplasms; Leukemia, Lymphoid; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Lysine; Male; Middle Aged; Multiple Myeloma; Myocardial Infarction; Neoplasms; Prostatic Neoplasms; Urogenital Neoplasms | 1967 |
[Modification of some free amino acids in the serum of cancer patients under the influence of glucose on tumoral metabolism].
Topics: Alanine; Amino Acids; Breast Neoplasms; Chromatography, Paper; Dietary Carbohydrates; Dietary Proteins; Female; Gastrointestinal Neoplasms; Glucose; Glycolysis; Leucine; Lung Neoplasms; Lysine; Neoplasm Metastasis; Perfusion; Stimulation, Chemical; Uterine Neoplasms; Valine | 1969 |