Page last updated: 2024-08-17

lysine and Leukemia

lysine has been researched along with Leukemia in 60 studies

Research

Studies (60)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (23.33)	18.7374
1990's	3 (5.00)	18.2507
2000's	9 (15.00)	29.6817
2010's	18 (30.00)	24.3611
2020's	16 (26.67)	2.80

Authors

Authors	Studies
Costa, MN; Silva, RN	1
Arango, S; Hromas, R; Hu, W; Hua, N; Jia, Y; Khan, S; Konopleva, M; Liu, X; Lv, D; Nayak, D; Olsen, SK; Pal, P; Pei, J; Thummuri, D; Weintraub, ST; Yang, Q; Yuan, Y; Zhang, P; Zhang, Q; Zhang, W; Zhang, X; Zheng, G; Zhou, D; Zhou, S	1
Geil, CN; Lee, TH; Li, D; McGinty, RK; Smith, CB; Spangler, CJ; Wang, GG; Yadav, SP	1
Ge, S; Yi, Y	1
Chen, QX; Fan, XD; Jiang, JG; Liu, CJ; Zhu, W	1
Chen, Y; Huang, N; Lei, M; Li, G; Li, Y; Liu, Z; Mencius, J; Peng, C; Quan, S; Shi, P; Tian, C; Wang, X; Wu, P; Xu, W; Xu, Y; Ye, X; Zhang, Y; Zhao, L; Zheng, Y	1
Davie, JR; Fatemiyan, N; Lakowski, TM; Sattarifard, H; Sharma, P	1
Baweja, L; Wereszczynski, J	1
Cui, B; Hou, X; Liu, N; Qiu, A; Zhuang, S	1
Alekbaeva, GD; Bondarenko, EA; Chakraborty, D; Chetal, K; Dillingham, ME; Duttweiler, RR; Duy, C; Ferman, BI; Gozani, O; Gray, ZH; Honer, MA; Ji, F; Jin, J; Kaniskan, HÜ; Lee, H; Miranda, C; Murphy, SE; Myers, C; Sadreyev, RI; Santoro, JN; Skorski, T; Sun, R; Tang, R; Toma, MM; Wang, Z; Whetstine, JR	1
Ouyang, ZS; Shen, J; Yang, L; Yang, MH; Zeng, MJ; Zeng, ZH; Zhao, MY	1
Bartkuhn, M; Borggrefe, T; Close, V; Ferrante, F; Giaimo, BD; Just, S; Klöble, P; Kracht, M; Meier-Soelch, J; Mertens, D; Nist, A; Oswald, F; Stiewe, T; Zimmermann, T	1
Alshiraihi, I; Brown, MA; Dekker, JD; Edwards, MA; Geng, H; Tucker, HO	1
Chen, GD; Cheng, JK; Ho, YC; Hsieh, MC; Lai, CY; Lin, TB; Ng, SC; Peng, HY; Wang, HH; Yang, PS	1
Altaf, M; Banday, S; Farooq, Z; Ganai, SA	1
An, S; Chen, X; Long, X; Qi, Y; Qin, Y; Shen, Y; Wu, H; Xing, Z; Yang, X; Zhang, S; Zhang, Y; Zhang, Z; Zhao, B	1
Yokoyama, A	1
Bardwell, VJ; Gearhart, MD; Gregory, G; Johnstone, RW; Kats, LM; Kelly, MJ; Li, J; Rogers, AJ; So, J; Vervoort, SJ; Zethoven, M	1
Armache, JP; Armache, KJ; Chen, R; De Ioannes, P; Nudler, E; Valencia-Sánchez, MI; Vasilyev, N; Wang, M	1
Arellano, ML; Boggon, TJ; Brat, DJ; Chen, GZ; Chen, J; Chen, PR; DeBerardinis, RJ; Elf, S; Fan, J; Gu, TL; He, C; Hitosugi, T; Ji, Q; Jiang, L; Jin, L; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lee, BH; Li, Y; Lin, R; Lonial, S; Mao, H; Seo, JH; Shan, C; Sudderth, J; Tucker, M; Wang, D; Wu, S; Xie, J; Ye, K; Zhang, L; Zhou, L	1
Bohlander, SK; Chopra, M	1
Balzano, AL; Castellano, S; Feoli, A; La Pietra, V; Mai, A; Marinelli, L; Milite, C; Novellino, E; Sasaki, K; Sbardella, G; Tosco, A	1
Cleary, ML; Duque-Afonso, J; Goode, DL; Iwasaki, M; Kuo, HP; Schneidawind, D; Wei, MC; Weng, Z; Wong, SH; Zhu, L	1
Chen, F; Dong, S; Feng, Z; Liu, W; Mo, Q; Redell, M; Song, Y; Wei, L; Wu, F; Yao, Y; Zhou, C	1
Buechele, C; Cleary, ML; Duque-Afonso, J; Gozani, O; Hansen, L; Huang, M; Ikenouye, L; Klein, BJ; Kutateladze, TG; Li, Q; Majeti, R; Martin, GM; Onishi, M; Schneidawind, D; Shen, J; Wong, SH; Zhu, F; Zhu, L	1
Balbach, ST; Orkin, SH	1
Ballabio, E; Blackledge, NP; Geng, H; Godfrey, L; Heidenreich, O; Kerry, J; Klose, RJ; Konopleva, M; Ma, H; Milne, TA; O'Byrne, S; Ponthan, F; Repapi, E; Roberts, I; Roy, A; Tapia, M	1
Cosgrove, MS; Dharmarajan, V; Patel, A; Vought, VE	1
Cosgrove, MS; Patel, A	1
Morishita, K; Nishikata, I; Shimahara, A; Yamakawa, N	1
Brown, EJ; Cheng, EH; Hsieh, JJ; Kumar, R; Liu, H; Pandita, TK; Takeda, S; Westergard, TD	1
Shu, HB; Wu, M	1
Chijiwa, T; Fujimoto, R; Hamaguchi, K; Kamikado, N; Murakami, T; Nakamura, H; Oda-Ueda, N; Ohno, M	1
Bhanap, B; Niedzwiecki, A; Rath, M; Roomi, MW; Roomi, NW	1
Ma, XD; Zhao, T	1
ANTONI, F; ARKY, I; HIDVEGI, EJ; VARTERESZ, V	1
BUTLER, JA; LAURENCE, DJ	1
Bae, YS; Han, KH; Jun, DY; Kim, YH; Lee, YS; Rue, SW; Taub, D	1
Yang, XJ	1
Kozasa, T; Kreutz, B; Nakamura, S; Suzuki, N; Tanabe, S	1
Bauer, RA; Pores-Fernando, AT; Wurth, GA; Zweifach, A	1
Brown, EJ; Chen, YX; Hess, JL; Hua, X; Keeshan, K; Pear, WS; Silva, A; Tubbs, AT; Wang, H; Yan, J	1
Balabanov, S; Bokemeyer, C; Brassat, U; Brümmendorf, TH; Copland, M; Gontarewicz, A; Hartmann, U; Hauber, I; Hauber, J; Holyoake, TL; Kammer, W; Kanz, L; Nordheim, A; Priemer, M; Schwarz, G; Wilhelm, T; Ziegler, P	1
Jeong, EG; Kim, MS; Lee, SH; Yoo, NJ	1
Baert, JL; de Launoit, Y; Degerny, C; Wohlkonig, A	1
Antoni, F; Hidvégi, EJ; Holland, J; Horváth, IP; Institoris, L; Lónai, P	1
Humphries, GM; Lovejoy, JP	1
Briedis, DM; Reiken, SR	1
Abbruzzese, A; Budillon, A; Caraglia, M; Tagliaferri, P	1
Kass, L	1
Iavorkovskiĭ, LI; Poddubnaia, EV	1
Labie, D; Pagnier, J	1
Gabius, HJ; Zeng, FY	1
Carlino, JA; Niu, EM; Sherman, MR; Stevens, YW; Tuazon, FB	1
Frank, M; Green, I; Herberman, R; Shevach, EM; Stobo, J	1
Al-Sarraf, M; Belamaric, J; Cejka, J; Kithier, K; Peterson, WD; Poulik, MD; Vaitkevicius, VK	1
Liu, LP; Ortwerth, BJ	1
Carlson, JV; Ortwerth, BJ; Yonuschot, GR	1
Stacher, A; Stöckl, W; Weiser, M; Zacherl, MK	1
Kolosova, NN; Zozuliakova, SV	1

Reviews

13 review(s) available for lysine and Leukemia

Article	Year
Cytotoxic activity of l-lysine alpha-oxidase against leukemia cells. Seminars in cancer biology, 2022, Volume: 86, Issue:Pt 3 Topics: Amino Acid Oxidoreductases; Amino Acids; Antineoplastic Agents; Asparaginase; Humans; Leukemia; Lysine	2022
Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias. Journal of hematology & oncology, 2022, 03-24, Volume: 15, Issue:1 Topics: Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Methyltransferases; Myeloid-Lymphoid Leukemia Protein	2022
Potential anticancer activities of securinine and its molecular targets. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 106 Topics: Alkaloids; Azepines; Cell Line, Tumor; Heterocyclic Compounds, Bridged-Ring; Humans; Janus Kinases; Lactones; Leukemia; Lysine; Male; Phosphatidylinositols; Piperidines; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Tyrosine	2022
[Research Advances in Lysine-specific Demethylase 6A and Its Application in Treating Leukemia]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2019, Aug-30, Volume: 41, Issue:4 Topics: Epigenesis, Genetic; Histone Demethylases; Histones; Humans; Leukemia; Lysine; Nuclear Proteins	2019
Therapeutic strategies against hDOT1L as a potential drug target in MLL-rearranged leukemias. Clinical epigenetics, 2020, 05-25, Volume: 12, Issue:1 Topics: Chromatin; DNA Repair; Drug Delivery Systems; Epigenesis, Genetic; Gene Silencing; Heterografts; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Myeloid-Lymphoid Leukemia Protein; Protein Methyltransferases	2020
The important roles of protein SUMOylation in the occurrence and development of leukemia and clinical implications. Journal of cellular physiology, 2021, Volume: 236, Issue:5 Topics: Humans; Leukemia; Lysine; Promyelocytic Leukemia Protein; Protein Processing, Post-Translational; Small Ubiquitin-Related Modifier Proteins; Ubiquitin-Conjugating Enzymes	2021
Leukemogenesis via aberrant self-renewal by the MLL/AEP-mediated transcriptional activation system. Cancer science, 2021, Volume: 112, Issue:10 Topics: Acetylation; Cell Differentiation; Cell Self Renewal; Cellular Senescence; CpG Islands; DNA-Binding Proteins; E1A-Associated p300 Protein; Gene Rearrangement; Hematopoiesis; Hematopoietic Stem Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Multipotent Stem Cells; Mutation; Myeloid-Lymphoid Leukemia Protein; Positive Transcriptional Elongation Factor B; Proto-Oncogene Proteins; RNA Polymerase II; Transcriptional Activation; Transcriptional Elongation Factors	2021
Disturbing the histone code in leukemia: translocations and mutations affecting histone methyl transferases. Cancer genetics, 2015, Volume: 208, Issue:5 Topics: Cell Transformation, Neoplastic; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Methyltransferases; Myeloid-Lymphoid Leukemia Protein; Polycomb Repressive Complex 2; Translocation, Genetic	2015
Mixed lineage leukemia: a structure-function perspective of the MLL1 protein. The FEBS journal, 2010, Volume: 277, Issue:8 Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Forecasting; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Ligands; Lysine; Methylation; Models, Biological; Models, Molecular; Molecular Sequence Data; Myeloid-Lymphoid Leukemia Protein; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship	2010
MLL1/WDR5 complex in leukemogenesis and epigenetic regulation. Chinese journal of cancer, 2011, Volume: 30, Issue:4 Topics: Animals; DNA Methylation; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Leukemia; Lysine; Multiprotein Complexes; Myeloid-Lymphoid Leukemia Protein; Transcriptional Activation	2011
[Epigenetic regulation of histone H3 lysine 9 methylation in leukemia]. Zhongguo shi yan xue ye xue za zhi, 2012, Volume: 20, Issue:1 Topics: Animals; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Leukemia; Lysine; Methylation	2012
The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic acids research, 2004, Volume: 32, Issue:3 Topics: Acetylation; Acetyltransferases; Humans; Leukemia; Lysine; Neoplasms; Protein Structure, Tertiary; Proteins; Substrate Specificity	2004
"Defective" receptors in steroid-resistant conditions may be proteolytic artifacts. Advances in experimental medicine and biology, 1986, Volume: 196 Topics: Animals; Breast; Breast Neoplasms; Centrifugation, Density Gradient; Cytosol; Drug Resistance; Endometrium; Endopeptidases; Female; Humans; Kidney; Leukemia; Leupeptins; Liver; Lysine; Macromolecular Substances; Male; Molybdenum; Osmolar Concentration; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone; Substrate Specificity; Ultracentrifugation; Uterine Neoplasms	1986

Other Studies

47 other study(ies) available for lysine and Leukemia

Article	Year
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nature communications, 2021, 11-25, Volume: 12, Issue:1 Topics: Antineoplastic Agents; bcl-X Protein; Cell Line; Cell Survival; Humans; Leukemia; Lysine; Models, Molecular; Proteasome Endopeptidase Complex; Protein Binding; Protein Conformation; Proteolysis; Proto-Oncogene Proteins c-bcl-2; Small Molecule Libraries; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitination; Von Hippel-Lindau Tumor Suppressor Protein	2021
DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding. Cell reports, 2022, 02-15, Volume: 38, Issue:7 Topics: Cell Line, Tumor; Cell Proliferation; Gene Rearrangement; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Male; Methylation; Models, Molecular; Myeloid-Lymphoid Leukemia Protein; Nucleosomes; Protein Binding; Ubiquitin; Ubiquitination	2022
Structural basis for product specificities of MLL family methyltransferases. Molecular cell, 2022, 10-20, Volume: 82, Issue:20 Topics: Fluorine; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Methyltransferases; Myeloid-Lymphoid Leukemia Protein; Phenylalanine; Tyrosine	2022
Bioinformatic Analyses of Broad H3K79me2 Domains in Different Leukemia Cell Line Data Sets. Cells, 2022, 09-10, Volume: 11, Issue:18 Topics: Cell Line; Chromatin; Computational Biology; Histone-Lysine N-Methyltransferase; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Leukemia; Lysine; Oxidoreductases, N-Demethylating; RNA, Long Noncoding	2022
Conformational and Thermodynamic Differences Underlying Wild-Type and Mutant Eleven-Nineteen-Leukemia YEATS Domain Specificity for Epigenetic Marks. Journal of chemical information and modeling, 2023, 02-27, Volume: 63, Issue:4 Topics: Acetylation; Epigenesis, Genetic; Histones; Humans; Leukemia; Lysine; Nucleosomes; Peptides; Protein Processing, Post-Translational	2023
Pharmacological inhibition of the mixed lineage leukemia 1-menin interaction aggravates acute kidney injury induced by folic acid and ischemia-reperfusion in mice. American journal of physiology. Renal physiology, 2023, 11-01, Volume: 325, Issue:5 Topics: Acute Kidney Injury; Animals; Creatinine; ErbB Receptors; Folic Acid; Histones; Ischemia; Leukemia; Lysine; Methyltransferases; Mice; Myeloid-Lymphoid Leukemia Protein; Reperfusion; Reperfusion Injury; Transcription Factors	2023
Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement. Cell, 2023, 10-12, Volume: 186, Issue:21 Topics: Adult; Animals; Doxorubicin; Epigenesis, Genetic; Gene Rearrangement; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Infant; Jumonji Domain-Containing Histone Demethylases; Leukemia; Lysine; Mice; Myeloid-Lymphoid Leukemia Protein; Translocation, Genetic	2023
HDAC3 functions as a positive regulator in Notch signal transduction. Nucleic acids research, 2020, 04-17, Volume: 48, Issue:7 Topics: Animals; Cell Line; Cell Line, Tumor; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Leukemia; Lysine; Mice; Mutation; Peptides, Cyclic; Protein Stability; Receptor, Notch1; Signal Transduction	2020
The lysine methyltransferase SMYD2 is required for normal lymphocyte development and survival of hematopoietic leukemias. Genes and immunity, 2020, Volume: 21, Issue:2 Topics: Animals; Cell Line, Tumor; Hematopoietic Stem Cell Transplantation; Histone-Lysine N-Methyltransferase; Humans; Leukemia; Lymphocytes; Lysine; Male; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Proto-Oncogene Mas	2020
Inhibiting MLL1-WDR5 interaction ameliorates neuropathic allodynia by attenuating histone H3 lysine 4 trimethylation-dependent spinal mGluR5 transcription. Pain, 2020, 09-01, Volume: 161, Issue:9 Topics: Histone-Lysine N-Methyltransferase; Histones; Humans; Hyperalgesia; Intracellular Signaling Peptides and Proteins; Leukemia; Lysine; Myeloid-Lymphoid Leukemia Protein; Receptor, Metabotropic Glutamate 5; Spinal Nerves	2020
Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis. Nature communications, 2019, 03-22, Volume: 10, Issue:1 Topics: Animals; Carcinogenesis; Cell Differentiation; Cell Proliferation; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; Histones; Homeodomain Proteins; Leukemia; Lysine; Mice, Inbred C57BL; Mutation; Myeloid Cells; Polycomb Repressive Complex 1; Proto-Oncogene Proteins p21(ras); Repressor Proteins; Transcription Factors; Transcription, Genetic; Ubiquitination	2019
Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination. Molecular cell, 2019, 06-06, Volume: 74, Issue:5 Topics: Binding Sites; Cryoelectron Microscopy; Genome, Human; Genomic Instability; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Nuclear Proteins; Nucleosomes; Protein Binding; Protein Conformation; Saccharomyces cerevisiae Proteins; Transcription, Genetic; Ubiquitination	2019
Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Molecular cell, 2014, Aug-21, Volume: 55, Issue:4 Topics: Acetyl-CoA C-Acetyltransferase; Acetylation; Animals; Cell Line, Tumor; Dihydrolipoyllysine-Residue Acetyltransferase; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Leukemia; Lung Neoplasms; Lysine; Mice; NADP; Neoplasms, Experimental; Phosphogluconate Dehydrogenase; Protein Binding; Protein Multimerization	2014
A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach. Journal of medicinal chemistry, 2015, Mar-26, Volume: 58, Issue:6 Topics: Acetylation; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Histones; Humans; Leukemia; Lysine; Models, Molecular; p300-CBP Transcription Factors	2015
The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential. Cancer cell, 2015, Aug-10, Volume: 28, Issue:2 Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Leukemic; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Interleukin Receptor Common gamma Subunit; Jumonji Domain-Containing Histone Demethylases; Leukemia; Lysine; Methylation; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Myeloid-Lymphoid Leukemia Protein; Neoplastic Stem Cells; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transplantation, Heterologous	2015
Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia. Journal of hematology & oncology, 2016, Mar-12, Volume: 9 Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Child; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Leukemic; Gene Rearrangement; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; MCF-7 Cells; Methylation; Methyltransferases; Mice, Inbred NOD; Mice, SCID; Molecular Structure; Monoamine Oxidase Inhibitors; Myeloid-Lymphoid Leukemia Protein; Reverse Transcriptase Polymerase Chain Reaction; U937 Cells; Xenograft Model Antitumor Assays	2016
ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. Cancer discovery, 2016, Volume: 6, Issue:7 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; Disease Models, Animal; DNA-Binding Proteins; F-Box Proteins; Female; Gene Expression Regulation, Leukemic; Heterografts; High-Throughput Nucleotide Sequencing; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intercellular Signaling Peptides and Proteins; Jumonji Domain-Containing Histone Demethylases; Leukemia; Lysine; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Transcription Factors	2016
An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation. Cancer discovery, 2016, Volume: 6, Issue:7 Topics: DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Hematopoiesis; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Methylation; Myeloid-Lymphoid Leukemia Protein; Transcription Factors; Translocation, Genetic	2016
MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia. Cell reports, 2017, 01-10, Volume: 18, Issue:2 Topics: Binding Sites; Cell Line, Tumor; CpG Islands; DNA Methylation; Enhancer Elements, Genetic; Gene Expression Regulation, Leukemic; Genome, Human; Histone-Lysine N-Methyltransferase; Histones; Humans; Intercellular Signaling Peptides and Proteins; Leukemia; Lysine; Methyltransferases; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Prognosis; Protein Binding; Proto-Oncogene Proteins	2017
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. The Journal of biological chemistry, 2009, Sep-04, Volume: 284, Issue:36 Topics: DNA-Binding Proteins; Gene Rearrangement; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Leukemia; Lysine; Methylation; Multiprotein Complexes; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Retinol-Binding Proteins, Cellular; Transcription Factors	2009
Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2. The Journal of biological chemistry, 2010, May-28, Volume: 285, Issue:22 Topics: Amino Acid Motifs; Animals; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; DNA-Binding Proteins; GATA2 Transcription Factor; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Lysine; MDS1 and EVI1 Complex Locus Protein; Protein Structure, Tertiary; Proto-Oncogenes; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Zinc Fingers	2010
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint. Nature, 2010, Sep-16, Volume: 467, Issue:7313 Topics: Alleles; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Chromatin; DNA Damage; DNA Replication; Genes, Dominant; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Methylation; Mice; Myeloid Progenitor Cells; Myeloid-Lymphoid Leukemia Protein; Phosphorylation; Phosphoserine; Protein Binding; Protein Serine-Threonine Kinases; S Phase; S-Phase Kinase-Associated Proteins; Signal Transduction; Translocation, Genetic	2010
A [Lys⁴⁹]phospholipase A₂ from Protobothrops flavoviridis venom induces caspase-independent apoptotic cell death accompanied by rapid plasma-membrane rupture in human leukemia cells. Bioscience, biotechnology, and biochemistry, 2011, Volume: 75, Issue:5 Topics: Animals; Apoptosis; Biological Transport; Caspases; Cell Line, Tumor; Cell Membrane; Cell Nucleus; DNA Fragmentation; Humans; Isoenzymes; Leukemia; Lysine; Phosphatidylserines; Phospholipases A2; Time Factors; Trimeresurus; Viper Venoms	2011
In vivo and in vitro antitumor effects of nutrient mixture in murine leukemia cell line P-388. Experimental oncology, 2011, Volume: 33, Issue:2 Topics: Animals; Antioxidants; Apoptosis; Ascorbic Acid; Camellia sinensis; Cell Line, Tumor; Cell Proliferation; Collagen; Drug Combinations; Food; Laminin; Leukemia; Lysine; Mice; Mice, Nude; Neoplasm Invasiveness; Plant Extracts; Proline; Proteoglycans	2011
STUDIES ON THE HETEROGENEITY AND METABOLIC ACTIVITY OF HISTONES FROM RABBIT BONE MARROW CELLS. British journal of cancer, 1963, Volume: 17 Topics: Animals; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Chromatography; Histones; Leukemia; Lysine; Proteins; Rabbits; Research	1963
METABOLISM OF HISTONES IN MALIGNANT TISSUES AND LIVER OF THE RAT AND MOUSE. The Biochemical journal, 1965, Volume: 96 Topics: Amino Acids; Animals; Arginine; Carcinoma; Carcinoma, Krebs 2; Chemistry Techniques, Analytical; DNA; Glycine; Growth; Histones; Leukemia; Leukemia, Experimental; Liver; Lysine; Metabolism; Mice; Neoplasm Proteins; Proteins; Rats; Research	1965
Mechanism underlying cytotoxicity of thialysine, lysine analog, toward human acute leukemia Jurkat T cells. Biochemical pharmacology, 2003, Dec-15, Volume: 66, Issue:12 Topics: Apoptosis; bcl-X Protein; Caspases; Cell Cycle; Cell Survival; Cysteine; Cytochromes c; Enzyme Activation; Humans; Jurkat Cells; Leukemia; Lysine; Mitochondria; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured	2003
Critical role of lysine 204 in switch I region of Galpha13 for regulation of p115RhoGEF and leukemia-associated RhoGEF. Molecular pharmacology, 2004, Volume: 66, Issue:4 Topics: Alanine; Amino Acid Substitution; Animals; COS Cells; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; HeLa Cells; Humans; Leukemia; Lysine; Mutation; Rho Guanine Nucleotide Exchange Factors	2004
Exocytic responses of single leukaemic human cytotoxic T lymphocytes stimulated by agents that bypass the T cell receptor. The Journal of physiology, 2005, Sep-15, Volume: 567, Issue:Pt 3 Topics: Cell Degranulation; Cell Line, Tumor; Flow Cytometry; Granzymes; Humans; Leukemia; Lysine; Lysosomal-Associated Membrane Protein 1; Membrane Glycoproteins; Perforin; Pore Forming Cytotoxic Proteins; Receptors, Antigen, T-Cell; Serine Endopeptidases; Stimulation, Chemical; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate; Thapsigargin	2005
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proceedings of the National Academy of Sciences of the United States of America, 2006, Jan-24, Volume: 103, Issue:4 Topics: Animals; Blotting, Western; Cell Line, Transformed; Cell Proliferation; Chromatin Immunoprecipitation; DNA; DNA Methylation; DNA-Binding Proteins; Exons; Flow Cytometry; Gene Expression Regulation; Genotype; Hematopoiesis; Histones; Homeodomain Proteins; Homozygote; Leukemia; Lysine; Methylation; Mice; Mice, Knockout; Mice, Transgenic; Models, Genetic; Models, Statistical; Myeloid Cells; Proto-Oncogene Proteins; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Time Factors; Transgenes	2006
Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL-positive leukemias identified by a proteomics approach. Blood, 2007, Feb-15, Volume: 109, Issue:4 Topics: Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Proliferation; Down-Regulation; Drug Delivery Systems; Drug Synergism; Eukaryotic Translation Initiation Factor 5A; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Imatinib Mesylate; K562 Cells; Leukemia; Lysine; Peptide Initiation Factors; Piperazines; Protein Processing, Post-Translational; Proteomics; Pyrimidines; RNA-Binding Proteins	2007
Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias. British journal of cancer, 2008, May-06, Volume: 98, Issue:9 Topics: Acute Disease; Adenocarcinoma; Adult; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; DNA Mutational Analysis; Female; Glutamic Acid; Humans; Leukemia; Liver Neoplasms; Lung Neoplasms; Lysine; Male; Middle Aged; Mutation; Neoplasms; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Proteins c-akt; Stomach Neoplasms	2008
[Multiple post-translational modifications implied in the gene expression regulation: example of the sumoylation of Ets factors]. Bulletin et memoires de l'Academie royale de medecine de Belgique, 2007, Volume: 162, Issue:5-6 Topics: Acetylation; Animals; Disease Models, Animal; Gene Expression Regulation; Humans; Leukemia; Lysine; Mice; Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Protein c-ets-1; SUMO-1 Protein; Ubiquitin	2007
The effect of mannitol-myleran and two new dibromo-hexitols on the metabolic activities of nucleic acids and proteins. I. Biochemical pharmacology, 1967, Volume: 16, Issue:11 Topics: Alkanes; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Bromine; Busulfan; Carbohydrates; Carbon Isotopes; Cell-Free System; Culture Techniques; DNA; Formates; HeLa Cells; Leukemia; Lysine; Mannitol; Nucleic Acids; Protein Biosynthesis; Rabbits; Rats; Ribosomes; RNA	1967
Cholesterol-free phospholipid domains may be the membrane feature selected by N epsilon-dansyl-L-lysine and merocyanine 540. Biochemical and biophysical research communications, 1983, Mar-16, Volume: 111, Issue:2 Topics: Animals; Fluorescent Dyes; Humans; Leukemia; Lysine; Membrane Lipids; Mice; Mice, Inbred BALB C; Phospholipids; Pyrimidinones	1983
The use of an enzyme single fiber reactor in the study of leukemic cell proliferation: in vitro experiments and computer simulation. Leukemia research, 1993, Volume: 17, Issue:2 Topics: Amino Acid Oxidoreductases; Cell Division; Computer Simulation; Enzymes, Immobilized; Humans; In Vitro Techniques; Leukemia; Lysine; Models, Theoretical; Tumor Cells, Cultured; Ultrafiltration	1993
Post-translational modifications of eukaryotic initiation factor-5A (eIF-5A) as a new target for anti-cancer therapy. Advances in experimental medicine and biology, 1999, Volume: 472 Topics: Antineoplastic Agents; Cell Cycle; Cell Death; Chelating Agents; Cytarabine; Deferoxamine; Epidermal Growth Factor; ErbB Receptors; Eukaryotic Translation Initiation Factor 5A; Exotoxins; Humans; Interferon-gamma; Iron; Kinetics; Leukemia; Lysine; Oropharyngeal Neoplasms; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Transforming Growth Factor alpha; Tumor Cells, Cultured	1999
Histone abnormalities in adult acute leukemias. Blood, 1975, Volume: 45, Issue:4 Topics: Adult; Arginine; Electrophoresis, Disc; Esterases; Hematopoietic Stem Cells; Histones; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lysine; Monocytes	1975
[Change in the fractional composition of the histones of leukocytes in various forms of leukemia]. Problemy gematologii i perelivaniia krovi, 1975, Volume: 20, Issue:10 Topics: Granulocytes; Histones; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Lysine	1975
Abnormal hemoglobin synthesis in some leukemic patients. Biochimie, 1975, Volume: 57, Issue:1 Topics: Carbon Radioisotopes; Chromatography, Gel; Fetal Hemoglobin; Globins; Hemoglobins, Abnormal; Humans; Leucine; Leukemia; Lysine; Reticulocytes; Tritium	1975
Carbohydrate-binding specificity of calcyclin and its expression in human tissues and leukemic cells. Archives of biochemistry and biophysics, 1991, Aug-15, Volume: 289, Issue:1 Topics: Acetylglucosamine; alpha-Fetoproteins; Animals; Arginine; Biotin; Calcium; Calcium-Binding Proteins; Carbohydrate Metabolism; Carbohydrates; Cattle; Cell Cycle Proteins; Cell Nucleus; Cytoplasm; G(M1) Ganglioside; Glycoproteins; Humans; Lactose; Leukemia; Lysine; Mannose; Mucins; Myocardium; S100 Calcium Binding Protein A6; S100 Proteins; Submandibular Gland; Tumor Cells, Cultured	1991
B cell, T cell and monocyte origin of the guinea pig L2C leukemia, mouse lymphomas and human leukemias and lymphoblastic cell lines. Advances in experimental medicine and biology, 1973, Volume: 29, Issue:0 Topics: Animals; Antibodies; Antibody Formation; Antilymphocyte Serum; B-Lymphocytes; Binding Sites, Antibody; Carbon Radioisotopes; Cell Transformation, Neoplastic; Chromium Radioisotopes; Complement System Proteins; Cytotoxicity Tests, Immunologic; Epitopes; Fluorescent Antibody Technique; Guinea Pigs; Humans; Immune Adherence Reaction; Immunoglobulin Fab Fragments; Immunoglobulin Fragments; Leukemia; Leukemia, Experimental; Leukemia, Lymphoid; Lymphoma; Lysine; Mice; Monocytes; Rabbits; T-Lymphocytes	1973
Beta2-microglobulin: occurrence in fetal life and malignancy. Clinica chimica acta; international journal of clinical chemistry, 1974, May-17, Volume: 52, Issue:3 Topics: Aging; Carbon Radioisotopes; Female; Fetal Proteins; Fetus; Gestational Age; Humans; Immunodiffusion; Infant, Newborn; Infant, Premature; Isoleucine; Leukemia; Lysine; Maternal-Fetal Exchange; Neoplasms; Pregnancy; Serum Globulins; Umbilical Cord	1974
Correlation between a specific isoaccepting lysyl transfer ribonucleic acid and cell division in mammalian tissues. Biochemistry, 1973, Sep-25, Volume: 12, Issue:20 Topics: Aging; Animals; Bone Marrow; Brain; Carcinoma, Hepatocellular; Cattle; Cell Division; Cells, Cultured; Chromatography, Ion Exchange; Female; Fetus; Lens, Crystalline; Leukemia; Liver; Liver Neoplasms; Lysine; Mice; Neoplasms, Experimental; Organ Specificity; Pancreas; Pregnancy; Rats; RNA, Transfer; Species Specificity; Spectrophotometry, Ultraviolet; Spleen; Swine; Tritium	1973
Properties of tRNALys4 from various tissues. Biochemistry, 1973, Sep-25, Volume: 12, Issue:20 Topics: Acylation; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cats; Cell Division; Cells, Cultured; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Escherichia coli; Hydrogen-Ion Concentration; Leukemia; Liver; Liver Neoplasms; Lysine; Mice; Neoplasms, Experimental; Organ Specificity; Oxidation-Reduction; Rats; Ribosomes; RNA, Transfer; Species Specificity; Spectrophotometry, Ultraviolet; Spleen; Tritium	1973
[Behavior of free amino acids in the blood of leukemia patients following amino acid infusion]. Wiener medizinische Wochenschrift (1946), 1968, Nov-30, Volume: 118, Issue:48 Topics: Adult; Aged; Amino Acids; Arginine; Female; Glycine; Histidine; Humans; Infusions, Parenteral; Isoleucine; Leucine; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocyte Count; Lysine; Male; Methionine; Phenylalanine; Threonine; Tryptophan; Valine	1968
[Free serum amino acids in leukosis]. Voprosy onkologii, 1969, Volume: 15, Issue:8 Topics: Adult; Amino Acids; Central Nervous System Diseases; Histidine; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lysine; Middle Aged; Serine; Threonine	1969