lysine has been researched along with Glial Cell Tumors in 61 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (1.64) | 18.7374 |
1990's | 5 (8.20) | 18.2507 |
2000's | 7 (11.48) | 29.6817 |
2010's | 26 (42.62) | 24.3611 |
2020's | 22 (36.07) | 2.80 |
Authors | Studies |
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Ayyannan, SR; Mitra, R | 1 |
Gao, M; Ji, L; Li, M; Qiao, W; Song, Y; Su, P; Sun, L; Wang, X; Yang, X; Yi, B; Zhan, Y; Zhang, F; Zhang, R; Zhao, W | 1 |
Bedekovics, J; Kurdi, N; Mehes, G; Mokanszki, A | 1 |
Alejo, S; Brenner, AJ; Chen, Y; Clarke, K; Gilbert, AR; He, Y; Jayamohan, S; Johnson, JD; Lai, Z; Li, W; Lv, Y; Palacios, BE; Pratap, UP; Sareddy, GR; Suzuki, T; Tekmal, RR; Vadlamudi, RK; Venkata, PP; Viswanadhapalli, S; Weldon, K; Ye, Z; Zhao, W; Zheng, S; Zou, Y | 1 |
Aldape, K; Bhaduri, A; Chinnaiyan, AM; Cieslik, M; Englinger, B; Filbin, MG; Jiang, L; Joshi, PK; Nano, PR; Pfister, S; Pratt, D; Pun, M; Rao, A; Venneti, S | 1 |
Cai, J; Chen, C; Chen, J; Chen, Z; Fan, Z; Gu, J; Guo, C; Hu, J; Jiang, B; Leng, T; Li, Q; Liang, J; Liang, X; Lin, Y; Liu, X; Mai, J; Sai, K; Sun, S; Wang, J; Xu, J; Yan, G; Yang, W; Yin, W; Zhong, Y; Zhu, W | 1 |
Cong, H; Dong, C; Fan, B; Guo, X; Liu, Y; Sui, A | 1 |
Cao, X; Chinnaiyan, AM; Chung, C; Ding, Y; Hawes, D; Judkins, AR; Mota, M; Natarajan, SK; Parolia, A; Pun, M; Samajdar, S; Sweha, SR; Venneti, S; Xiao, L; Yang, F | 1 |
Fu, X; Li, J; Li, T; Shang, W; Wang, J; Wang, X; Zhang, L | 1 |
Andrade, J; Garcia, BA; Granat, J; Jin, Y; Lee, CH; LeRoy, G; Lund, P; Reinberg, D; Saldaña-Meyer, R; Stafford, JM; Ueberheide, B; Yu, JR | 1 |
Arzt, M; Filbin, MG; Gillespie, SM; Hovestadt, V; Kambhampati, M; Lennon, JJ; Monje, M; Nagaraja, S; Nazarian, J; Quezada, MA; Suva, ML; Woo, PJ | 1 |
Bailey, CP; Becher, OJ; Chandra, J; Collier, T; Figueroa, M; Gangadharan, A; Gopalakrishnan, V; Henry, V; Kennis, BA; Lee, DA; Monje, M; Nazarian, J; Romero, MM; Wang, L; Yadavilli, S; Yang, Y; Zaky, W | 1 |
Bao, S; Chen, L; Cui, J; Guo, S; Han, Q; He, K; Huang, H; Li, A; Li, D; Li, T; Li, Y; Man, J; Mi, L; Ran, H; Rich, JN; Wang, X; Wu, J; Xiao, D; Yan, X; Yu, Y; Zhan, X; Zhang, S; Zhang, X; Zhou, T | 1 |
Amer, N; El-Ayadi, M; El-Beltagy, M; El-Naggar, S; Hassan, Z; Khorshed, EN; Mosaab, A; Refaat, A; Soror, SH; Zaghloul, MS | 1 |
Bush, K; Carcaboso, AM; Cervantes, V; Chen, KY; Klein, RH; Knoepfler, PS; Lechpammer, M; Lewis, N; Naqvi, A | 1 |
Hashizume, R; Nicolaides, TP | 1 |
Allis, CD; Deshmukh, S; Garcia, BA; Jabado, N; Jain, SU; Juretic, N; Khazaei, S; Lewis, PW; Lu, C; Lundgren, SM; Marchione, DM; Wang, X; Weinberg, DN | 1 |
Alimova, I; Balakrishnan, I; Birks, DK; Carcaboso, AM; Dahl, N; Danis, E; Davidson, N; Donson, A; Foreman, N; Fosmire, S; Gilani, A; Green, A; Gupta, N; Hashizume, R; Hawkins, C; Hulleman, E; Jabado, N; Jones, K; Katagi, H; Lemma, R; Madhavan, K; Meel, MH; Metselaar, DS; Monje, M; Pierce, A; Sanford, B; Serkova, NJ; Sola, I; Steiner, J; Venkataraman, S; Vibhakar, R; Vijmasi, T; Wang, D | 1 |
Chen, L; Qiu, Q; Yang, J | 1 |
Bareke, E; Chen, H; Coradin, M; Garcia, BA; Harutyunyan, AS; Horth, C; Jabado, N; Krug, B; Lu, T; Majewski, J; Marchione, DM; Nikbakht, H; Russo, C | 1 |
A, D; Albrecht, S; Andrade, AF; Bajic, A; Bandopadhayay, P; Bassenden, AV; Berghuis, AM; Beroukhim, R; Blanchette, M; Bognar, L; Brandner, S; Chen, CCL; Coutelier, M; Dali, R; De Jay, N; Deshmukh, S; Dubois, F; Ekert, PG; Ellezam, B; Faury, D; Filbin, MG; Garcia, BA; Garzia, L; Gayden, T; Hadjadj, D; Hansford, JR; Harutyunyan, AS; Hauser, P; Hébert, S; Jabado, N; Jawhar, W; Jessa, S; Jones, DTW; Juretic, N; Karamchandani, J; Khuong-Quang, DA; Kleinman, CL; Klekner, A; Korshunov, A; Kramm, C; Krskova, L; Ligon, KL; Lisi, V; Mack, SC; Maestro, N; Marchione, DM; Mikael, LG; Pathania, M; Pfister, SM; Russo, C; Salomoni, P; Sturm, D; Sumerauer, D; Suzuki, H; Taylor, MD; Vanova, K; Vicha, A; Virga, J; Weil, AG; Woodward, E; Zamecnik, J; Zapotocky, M; Zeinieh, M; Ziegler, DS | 1 |
Agnihotri, S; Bridge, T; Hawkins, C; Huang, A; Kim, B; Li, C; Milos, S; Pajovic, S; Patel, P; Phillips, L; Rakopoulos, P; Ryall, S; Sheth, J; Siddaway, R; Srikanthan, D; Yu, M | 1 |
Alfazema, N; Bracken, AP; Bressan, RB; Brien, GL; Deevy, O; Doherty, AM; Fitzpatrick, DJ; Gannon, D; Grant, V; Healy, E; Lagan, E; Marqués-Torrejón, MA; Monger, C; Neikes, H; Pollard, SM | 1 |
Anderson, J; Cantilena, S; de Boer, J; Hargrave, D; Meier, S; Michod, D; Niklison Chirou, MV; Salomoni, P | 1 |
Cui, J; Han, J; Ou, J; Qin, Y; Wang, RF; Zhang, C; Zhang, J; Zhi, F | 1 |
Ferrigno, C; Holdhoff, M; Javadi, MS; Laterra, JJ; Menke, JR; Pomper, MG; Rowe, SP; Salas Fragomeni, RA; Solnes, LB; Szabo, Z | 1 |
Chen, Q; Guo, Q; He, X; Jiang, C; Jiang, X; Liu, L; Liu, Y; Lu, Y; Ruan, C; Sun, T; Wang, Q; Zhang, Y | 1 |
Haldar, D; Vadla, R | 1 |
Dai, B; Guan, F; Hu, Z; Huang, H; Mao, B; Su, H; Xiao, Z; Zhu, G | 1 |
Cai, J; Dinislam, M; Duan, C; Gao, F; Gao, W; Han, B; Jiang, C; Kang, C; Lin, L; Meng, X; Wang, R; Wu, P | 1 |
Cai, C; Daoud, EV; Foong, C; Hatanpaa, KJ; Martin, GR; Mickey, BE; Oberle, RJ; Pan, E; Raisanen, JM; Rajaram, V; White, CL | 1 |
Arnold, EP; Haile, S; Hulleman, E; Kadapakkam, M; Labanieh, L; Mackall, CL; Majzner, RG; Monje, M; Mount, CW; Rietberg, SP; Sundaresh, S; Vogel, H; Woo, PJ | 1 |
Budka, H; Leske, H; Niehusmann, P; Pahnke, J; Panagopoulos, I; Rushing, E | 1 |
Bannykh, S; Bastian, BC; Bollen, AW; Cham, E; Cooney, T; Danielpour, M; Fan, X; Grenert, JP; Hu, J; Johnston, J; Jones, DTW; Kool, M; Korshunov, A; Li, R; McDermott, M; Oberheim Bush, NA; Onodera, C; Pekmezci, M; Perry, A; Pfister, SM; Sill, M; Solomon, DA; Sun, PP; Van Ziffle, J; Villanueva-Meyer, JE | 1 |
Anderson, B; Bruzek, A; Carcaboso, AM; Garcia, T; Garton, H; Hashizume, R; Heth, J; Koschmann, C; McMurray, KQ; Miklja, Z; Mody, R; Mullan, B; Muraszko, K; Robertson, PL; Savelieff, MG; Siada, R; Singer, BH; Stallard, S; Venneti, S; Wierzbicki, K | 1 |
Gorin, MA; Pienta, KJ; Pomper, MG; Rowe, SP; Salas Fragomeni, RA | 1 |
Barret, E; Castel, D; Debily, MA; Grill, J; Jones, C; Jones, DTW; Kergrohen, T; Kramm, CM; Merlevede, J; Pfister, SM; Philippe, C; Puget, S; Sainte-Rose, C; Sill, M; Varlet, P | 1 |
Bayin, NS; Chapman, JR; Descostes, N; Karajannis, MA; Lee, CH; Leroy, G; Modrek, AS; Oksuz, O; Placantonakis, DG; Reinberg, D; Saldaña-Meyer, R; Snuderl, M; Stafford, JM; Suarez, F; Ueberheide, B; Voigt, P; Yu, JR | 1 |
Sang, B; Wang, F; Wei, Y; Xu, Z; Yang, D | 1 |
Byun, HS; Choi, SW; Hong, JH; Huang, SM; Hur, GM; Jeon, J; Kim, JM; Kim, SH; Lee, JH; Lee, Y; Li, Y; Liu, ZG; Lu, T; Park, J; Park, KA; Ro, H; Shen, HM; Sohn, KC; Stark, GR; Zhang, T | 1 |
Allis, CD; Lewis, PW | 1 |
Feng, D; Hu, Q; Li, H; Ma, H; Su, Y; Tao, H; Wang, X; Zhang, C | 1 |
Butterfield, LH; Connelly, AK; Dibridge, SA; Hamilton, RL; Jakacki, RI; Okada, H; Panigrahy, A; Pollack, IF; Potter, DM; Whiteside, TL | 1 |
Eissenberg, JC; Florens, L; Gao, X; Herz, HM; Jackson, J; Morgan, M; Rickels, R; Shilatifard, A; Swanson, SK; Washburn, MP | 1 |
Daniels, D; Han, J; Huang, H; Zhang, R; Zhang, Z | 1 |
Gao, JL; Hu, G; Lin, YJ; Liu, J; Tian, YX; Wei, J; Zhang, K; Zhen, YZ | 1 |
Cui, J; Ou, J; Xia, X; Yang, Z; Zhang, J; Zhi, F | 1 |
Karst, A; Lehnus, M; Pehar, M; Puglielli, L | 1 |
Barth, RF; Ciesielski, MJ; Fenstermaker, RA; Kazim, AL | 1 |
Bulte, JW; Gilad, AA; McMahon, MT; Raman, V; Skoglund, CM; van Laarhoven, HW; van Zijl, PC; Walczak, P; Winnard, PT | 1 |
Badn, W; Darabi, A; Esbjörnsson, M; Fellert, MA; Hegardt, P; Janelidze, S; Salford, LG; Siesjö, P; Smith, KE; Visse, E | 1 |
Badn, W; Darabi, A; Salford, LG; Siesjö, P; Smith, KE; Visse, E | 1 |
Ivanov, V; Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW | 1 |
Busek, P; Krepela, E; Sedo, A; Stremeňová, J | 1 |
Beckman, EJ; Petoud, S; Pollack, IF; Sivak, WN; Zamboni, WC; Zhang, J | 1 |
Autry, SA; Boggan, JE; Higgins, RJ; Leach, MW; Lee, SJ; Smith, KM | 1 |
Felsenstein, KM; Ingalls, KM; Ripellino, JA; Robakis, NK; Roberts, SB | 1 |
Debinski, W; Gibo, DM; Kealiher, A; Obiri, NI; Puri, RK | 1 |
Berens, ME; Djawaheri, J; Giese, A; Hagel, C; Kim, EL; Westphal, M; Zapf, S | 1 |
Autry, S; Boggan, JE; Higgins, RJ; Leach, MW; Lee, SJ; Smith, KM | 1 |
Hannuniemi, R; Oja, OS; Oja, SS; Pajari-Backas, M | 1 |
3 review(s) available for lysine and Glial Cell Tumors
Article | Year |
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Role of Lysine-specific Demethylase 1 and Its Small Molecule Inhibitors in Glioblastoma Multiforme Therapy.
Topics: Flavins; Glioblastoma; Glioma; Histone Demethylases; Histones; Humans; Lysine; Neoplasm Recurrence, Local | 2022 |
Histone H3 K27 alterations in central nervous system tumours: Challenges and alternative diagnostic approaches.
Topics: Central Nervous System Neoplasms; Child; Glioma; Histones; Humans; Lysine; Methionine | 2022 |
Histone Lysine-to-Methionine Mutation as Anticancer Drug Target.
Topics: Antineoplastic Agents; Chondroblastoma; Glioma; Histones; Humans; Lysine; Methionine; Mutation | 2021 |
1 trial(s) available for lysine and Glial Cell Tumors
Article | Year |
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Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and n
Topics: Adolescent; Antigens, Neoplasm; Brain Neoplasms; Brain Stem Neoplasms; Cancer Vaccines; Carboxymethylcellulose Sodium; Child; Child, Preschool; Disease-Free Survival; Drug Carriers; Enzyme-Linked Immunospot Assay; Epitopes; Female; Glioma; Humans; Immunohistochemistry; Immunotherapy, Active; Infant; Inhibitor of Apoptosis Proteins; Injections, Subcutaneous; Interferon Inducers; Interleukin-13 Receptor alpha1 Subunit; Kaplan-Meier Estimate; Lysine; Magnetic Resonance Imaging; Male; Poly I-C; Receptor, EphA2; Receptors, Interleukin-13; Survivin; Young Adult | 2014 |
57 other study(ies) available for lysine and Glial Cell Tumors
Article | Year |
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Dual role of pseudogene TMEM198B in promoting lipid metabolism and immune escape of glioma cells.
Topics: ATP Citrate (pro-S)-Lyase; DNA-Binding Proteins; Fatty Acid Elongases; Fatty Acids; Glioma; Histones; Humans; Lipid Metabolism; Lipids; Lysine; Pseudogenes; RNA-Binding Proteins; Transcription Factors; Tumor Microenvironment | 2022 |
Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; DNA; DNA Breaks, Double-Stranded; DNA Repair; Drug Resistance, Neoplasm; Glioblastoma; Glioma; Histone Demethylases; Lysine; Mice; Tandem Mass Spectrometry; Temozolomide; Xenograft Model Antitumor Assays | 2023 |
Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways.
Topics: Brain Neoplasms; Ependymoma; Fluorocarbons; Glioma; Histones; Humans; Lysine; Mutation; Rhombencephalon | 2023 |
Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell.
Topics: Acetylation; Glioblastoma; Glioma; Histone Deacetylase Inhibitors; Histones; Humans; Lysine | 2023 |
Dimethylation of histone H3 lysine 36 (H3K36me2) as a potential biomarker for glioma diagnosis, grading, and prognosis.
Topics: Biomarkers; Brain Neoplasms; DNA Methylation; Glioma; Histones; Humans; Isocitrate Dehydrogenase; Lysine; Middle Aged; Mutation; Neoplasm Grading; Prognosis | 2023 |
Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas.
Topics: Adenosine Triphosphatases; Brain Neoplasms; Child; Chromatin; Diffuse Intrinsic Pontine Glioma; DNA Helicases; Glioma; Histones; Humans; Lysine; Mutation; Nuclear Proteins; Transcription Factors | 2023 |
Mechanism of NURP1 in temozolomide resistance in hypoxia-treated glioma cells via the KDM3A/TFEB axis.
Topics: Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Disease Models, Animal; Glioma; Humans; Hypoxia; Jumonji Domain-Containing Histone Demethylases; Lysine; Nuclear Proteins; Temozolomide | 2023 |
Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma.
Topics: Child; Enzyme Activation; Gene Silencing; Glioma; Histones; Humans; Lysine; Methylation; Polycomb Repressive Complex 2; Protein Subunits | 2019 |
Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State.
Topics: Brain; Brain Neoplasms; Cellular Reprogramming; Diffuse Intrinsic Pontine Glioma; Enhancer Elements, Genetic; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Lysine; Mutation; Pons; Signal Transduction; Transcriptome | 2019 |
Pharmacologic inhibition of lysine-specific demethylase 1 as a therapeutic and immune-sensitization strategy in pediatric high-grade glioma.
Topics: Animals; Brain Stem Neoplasms; Child; Glioma; Histones; Humans; Lysine; Mice; Mutation | 2020 |
Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex-mediated STAT1 downregulation.
Topics: Acetylation; Aged; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Disease Progression; DNA-Binding Proteins; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Interferons; Lysine; Male; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Middle Aged; Neoplastic Stem Cells; Promoter Regions, Genetic; STAT1 Transcription Factor; Up-Regulation | 2020 |
Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas.
Topics: Brain; Brain Neoplasms; Child; Child, Preschool; Clinical Decision-Making; Disease-Free Survival; DNA Mutational Analysis; Egypt; Female; Follow-Up Studies; Genetic Testing; Glioma; Histones; Humans; Kaplan-Meier Estimate; Lysine; Male; Medical Oncology; Mutation; Neoplasm Grading; Practice Guidelines as Topic; Prognosis; Risk Assessment | 2020 |
Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Cell Proliferation; Child; Female; Gene Editing; Gene Expression Regulation, Neoplastic; Glioma; Glycine; Histones; Humans; Lysine; Male; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Receptors, Notch; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
LSD1 inhibition in pHGG: the key to unleashing immunotherapy?
Topics: Child; Glioma; Histone Demethylases; Humans; Immunotherapy; Lysine | 2020 |
Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.
Topics: Chromatin; Gene Expression; Gene Expression Regulation; Glioma; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Mesenchymal Stem Cells; Methylation; Mutation; Neoplastic Processes; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Protein Processing, Post-Translational | 2020 |
Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG.
Topics: Aging; Astrocytoma; Brain Stem Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Child; Child, Preschool; Chromatin; Diffuse Intrinsic Pontine Glioma; Epigenomics; Female; Glioma; Histones; Humans; Lysine; Male; Mutation; Neoplasm Recurrence, Local; Polycomb Repressive Complex 1 | 2020 |
H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation.
Topics: Cell Line, Tumor; Chromatin; DNA Methylation; Epigenomics; Gene Expression; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Lysine; Methionine; Methylation; Mutation; Polycomb Repressive Complex 2; Protein Processing, Post-Translational | 2020 |
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.
Topics: Animals; Astrocytes; Brain Neoplasms; Carcinogenesis; Cell Lineage; Cellular Reprogramming; Chromatin; Embryo, Mammalian; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioma; Histones; Interneurons; Lysine; Mice, Inbred C57BL; Models, Biological; Mutation; Neoplasm Grading; Neural Stem Cells; Oligodendroglia; Promoter Regions, Genetic; Prosencephalon; Receptor, Platelet-Derived Growth Factor alpha; Transcription, Genetic; Transcriptome | 2020 |
Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer.
Topics: Animals; Brain Neoplasms; Disease Models, Animal; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Lysine; Methylation; Mice, Knockout; Proto-Oncogene Proteins c-myc; ras Proteins; Tumor Suppressor Protein p53 | 2020 |
Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.
Topics: Animals; Brain Neoplasms; Cell Differentiation; Cell Line; Enhancer Elements, Genetic; Enhancer of Zeste Homolog 2 Protein; Epigenome; Gene Expression Regulation, Developmental; Glioma; Histones; Humans; Lysine; Male; Mice, Inbred Strains; Mutation; Neural Stem Cells; Oncogenes; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Rhombencephalon | 2021 |
Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation.
Topics: Alcoholism; Auranofin; Cell Line, Tumor; Cell Proliferation; Child; Disulfiram; Down-Regulation; Drug Repositioning; Drug Synergism; Gene Expression Regulation, Neoplastic; Glioma; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Myeloid-Lymphoid Leukemia Protein; Neoplasm Grading; Protein Processing, Post-Translational; Proteolysis; Transcription, Genetic | 2021 |
TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination.
Topics: Animals; Apoptosis; Biocatalysis; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Progression; Down-Regulation; Gene Expression Regulation, Neoplastic; Glioma; Humans; Lysine; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Protein Stability; Repressor Proteins; RNA, Messenger; Signal Transduction; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases; Ubiquitination | 2017 |
Prostate-Specific Membrane Antigen-Targeted Imaging With [18F]DCFPyL in High-Grade Gliomas.
Topics: Antigens, Surface; Brain Neoplasms; Glioma; Glutamate Carboxypeptidase II; Humans; Lysine; Magnetic Resonance Imaging; Male; Neoplasm Grading; Positron-Emission Tomography; Urea | 2017 |
Substance P Mediated DGLs Complexing with DACHPt for Targeting Therapy of Glioma.
Topics: Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Drug Delivery Systems; Glioma; Humans; Lysine; Substance P | 2017 |
Mammalian target of rapamycin complex 2 (mTORC2) controls glycolytic gene expression by regulating Histone H3 Lysine 56 acetylation.
Topics: Acetylation; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glioma; Glycolysis; HeLa Cells; Histones; Humans; Lysine; Mechanistic Target of Rapamycin Complex 2; Models, Biological; Promoter Regions, Genetic; Signal Transduction; Sirtuins | 2018 |
Histone demethylase KDM5A inhibits glioma cells migration and invasion by down regulating ZEB1.
Topics: Biocatalysis; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioma; Histones; Humans; Lysine; Methylation; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Retinoblastoma-Binding Protein 2; Zinc Finger E-box-Binding Homeobox 1 | 2018 |
Loss of ATRX suppresses ATM dependent DNA damage repair by modulating H3K9me3 to enhance temozolomide sensitivity in glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Brain Neoplasms; Cell Line, Tumor; Cell Survival; DNA Damage; DNA Repair; Female; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Glioma; Histones; Humans; Lysine; Methylation; Mice, Nude; Temozolomide; X-linked Nuclear Protein; Xenograft Model Antitumor Assays | 2018 |
Adult Brainstem Gliomas With H3K27M Mutation: Radiology, Pathology, and Prognosis.
Topics: Adult; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain Stem Neoplasms; Female; Follow-Up Studies; Glioma; Histones; Humans; Ki-67 Antigen; Lysine; Magnetic Resonance Imaging; Male; Methionine; Middle Aged; Mutation; Neurofilament Proteins; Retrospective Studies | 2018 |
Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M
Topics: Animals; Brain Neoplasms; Gangliosides; Glioma; Histones; Humans; Immunotherapy, Adoptive; Lysine; Methylation; Mice; Receptors, Antigen, T-Cell; Xenograft Model Antitumor Assays | 2018 |
K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution.
Topics: Brain Neoplasms; DNA Mutational Analysis; Glioma; Glycine; Histones; Humans; Lysine; Mutation | 2018 |
Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile.
Topics: Adult; Child; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Glioma; Humans; Lateral Ventricles; Lysine; Magnetic Resonance Imaging; Male; Mutation; Neoplasms, Neuroepithelial; Receptor, Platelet-Derived Growth Factor alpha; Septum Pellucidum; Tumor Suppressor Proteins; Young Adult | 2018 |
CSF H3F3A K27M circulating tumor DNA copy number quantifies tumor growth and in vitro treatment response.
Topics: Adolescent; Brain Neoplasms; Cell Proliferation; Child; Circulating Tumor DNA; DNA Copy Number Variations; Female; Glioma; Histones; Humans; In Vitro Techniques; Lysine; Magnetic Resonance Imaging; Male; Methionine; Mutation | 2018 |
Uptake of Prostate-Specific Membrane Antigen-Targeted 18F-DCFPyL in Cerebral Radionecrosis: Implications for Diagnostic Imaging of High-Grade Gliomas.
Topics: Aged; Antigens, Surface; Biological Transport; Brain; Glioma; Glutamate Carboxypeptidase II; Humans; Lysine; Male; Necrosis; Neoplasm Grading; Positron-Emission Tomography; Urea | 2018 |
Transcriptomic and epigenetic profiling of 'diffuse midline gliomas, H3 K27M-mutant' discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location.
Topics: Adolescent; Brain; Brain Neoplasms; Child; Child, Preschool; DNA Methylation; Epigenomics; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Lysine; Male; Methionine; Mutation; Principal Component Analysis; Transcriptome; Tumor Cells, Cultured | 2018 |
Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma.
Topics: Animals; Brain Stem Neoplasms; Cells, Cultured; Child; Chromatin; Disease Models, Animal; Embryonic Stem Cells; Glioma; Histones; Humans; Lysine; Mice; Polycomb Repressive Complex 2 | 2018 |
Activation of KRas-ERK1/2 signaling drives the initiation and progression of glioma by suppressing the acetylation of histone H4 at lysine 16.
Topics: Acetylation; Apoptosis; Cell Movement; Cell Proliferation; Glioma; Histones; Humans; Lysine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Signal Transduction; Tumor Cells, Cultured | 2019 |
PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Brain Neoplasms; DNA-Binding Proteins; Glioma; HEK293 Cells; HeLa Cells; Humans; Immunohistochemistry; Lysine; Methylation; Models, Biological; Phosphorylation; Protein Binding; Protein Phosphatase 2; Signal Transduction; Transcription Factor RelA; Transcription Factors; Tumor Necrosis Factor-alpha | 2013 |
Poisoning the "histone code" in pediatric gliomagenesis.
Topics: Brain Neoplasms; Child; Exome; Glioma; Histone Code; Histones; Humans; Lysine; Models, Biological; Mutation; Polycomb Repressive Complex 2 | 2013 |
Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.
Topics: AC133 Antigen; Antigens, CD; Azepines; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioma; Glycoproteins; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplastic Stem Cells; Peptides; Promoter Regions, Genetic; Quinazolines; Signal Transduction; SOXB1 Transcription Factors; Transfection | 2014 |
Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling.
Topics: Amino Acid Substitution; Animals; Chromatin; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Gene Silencing; Glioma; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methionine; Methylation; Mutation; Signal Transduction | 2014 |
Detecting the H3F3A mutant allele found in high-grade pediatric glioma by real-time PCR.
Topics: Animals; Brain Neoplasms; Child; DNA Mutational Analysis; Gene Library; Glioma; Histones; Humans; Lysine; Male; Methionine; Mice; Mutation; Real-Time Polymerase Chain Reaction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
Antitumor activity of rhein lysinate against human glioma U87 cells in vitro and in vivo.
Topics: Animals; Anthraquinones; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; Cell Line, Tumor; Cell Proliferation; Cyclin D; Gene Expression Regulation, Neoplastic; Glioma; Humans; Lysine; Membrane Proteins; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2016 |
The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt.
Topics: Apoptosis; Bcl-2-Like Protein 11; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Progression; F-Box Proteins; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioma; Humans; Lysine; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; Ubiquitination; Up-Regulation | 2017 |
Proteomic assessment shows that many endoplasmic reticulum (ER)-resident proteins are targeted by N(epsilon)-lysine acetylation in the lumen of the organelle and predicts broad biological impact.
Topics: Acetyl Coenzyme A; Acetylation; Brain Neoplasms; Calreticulin; Cell Line, Tumor; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Glioma; Heat-Shock Proteins; Humans; Lysine; Membrane Proteins; Plasmids; Protein Folding; Protein Processing, Post-Translational; Proteomics | 2012 |
Cellular antitumor immune response to a branched lysine multiple antigenic peptide containing epitopes of a common tumor-specific antigen in a rat glioma model.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Brain Neoplasms; Cancer Vaccines; Epitopes; ErbB Receptors; Glioma; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunity, Cellular; Immunotherapy; Interleukin-4; Lysine; Male; Models, Animal; Peptide Fragments; Rats; Rats, Inbred F344; Spleen; Survival Rate; T-Lymphocytes; T-Lymphocytes, Cytotoxic; Th2 Cells; Vaccination | 2005 |
Artificial reporter gene providing MRI contrast based on proton exchange.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Contrast Media; Genes, Reporter; Glioma; Image Enhancement; Lysine; Magnetic Resonance Imaging; Mice; Protons; Recombinant Proteins | 2007 |
Inhibition of inducible nitric oxide synthase enhances anti-tumour immune responses in rats immunized with IFN-gamma-secreting glioma cells.
Topics: Animals; B-Lymphocytes; Brain Neoplasms; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Enzyme Inhibitors; Flow Cytometry; Glioma; Immunotherapy; Interferon-gamma; Lysine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Rats; Rats, Inbred F344 | 2007 |
Postimmunization with IFN-gamma-secreting glioma cells combined with the inducible nitric oxide synthase inhibitor mercaptoethylguanidine prolongs survival of rats with intracerebral tumors.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Enzyme Inhibitors; Glioma; Guanidines; Immunization; Immunotherapy, Adoptive; Interferon-gamma; Lymph Nodes; Lysine; Nitric Oxide Synthase Type II; Rats; Rats, Inbred F344; Spleen; Survival; T-Lymphocytes | 2007 |
Inhibition of glioma cell line A-172 MMP activity and cell invasion in vitro by a nutrient mixture.
Topics: Acetylcysteine; Amino Acids; Antineoplastic Agents; Arginine; Ascorbic Acid; Camellia sinensis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Collagen; Drug Combinations; Glioma; Humans; Laminin; Lysine; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Neoplasm Invasiveness; Plant Extracts; Proline; Proteoglycans | 2007 |
Modulation of substance P signaling by dipeptidyl peptidase-IV enzymatic activity in human glioma cell lines.
Topics: Brain Neoplasms; Calcium Signaling; Chemokine CXCL12; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glioma; Humans; Lysine; Mifepristone; Oligopeptides; Pyrrolidines; Serine Proteinase Inhibitors; Substance P; Transfection; U937 Cells | 2008 |
LDI-glycerol polyurethane implants exhibit controlled release of DB-67 and anti-tumor activity in vitro against malignant gliomas.
Topics: Camptothecin; Cell Death; Cell Line, Tumor; Delayed-Action Preparations; Drug Screening Assays, Antitumor; Glioma; Glycerol; Humans; Isocyanates; Lysine; Microscopy, Electron, Scanning; Organosilicon Compounds; Polyurethanes; Prostheses and Implants; Solutions; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Tablets | 2008 |
In vitro photodynamic effects of lysyl chlorin p6: cell survival, localization and ultrastructural changes.
Topics: Animals; Cell Survival; Cytoplasm; Dihematoporphyrin Ether; Dose-Response Relationship, Radiation; Glioma; Intracellular Membranes; Lasers; Light; Lysine; Microscopy, Electron; Microscopy, Fluorescence; Mitochondria; Photosensitizing Agents; Porphyrins; Rats; Tumor Cells, Cultured | 1993 |
Non-amyloidogenic cleavage of the beta-amyloid precursor protein by an integral membrane metalloendopeptidase.
Topics: Alkaline Phosphatase; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Cell Line; Cell Membrane; Detergents; Enzyme Stability; Glioma; Humans; Kinetics; Lysine; Metalloendopeptidases; Models, Biological; Protease Inhibitors; Protein Processing, Post-Translational; Substrate Specificity; Transfection; Tumor Cells, Cultured | 1994 |
Novel anti-brain tumor cytotoxins specific for cancer cells.
Topics: Antineoplastic Agents; Brain Neoplasms; Carrier Proteins; Cell Division; Cytotoxins; Exotoxins; Glioma; Glutamic Acid; Humans; Interleukin-13; Interleukin-13 Receptor alpha1 Subunit; Lysine; Mutation; Plasmids; Pseudomonas aeruginosa; Receptors, Cell Surface; Receptors, Interleukin; Receptors, Interleukin-13; Recombinant Fusion Proteins; Tumor Cells, Cultured | 1998 |
Thromboxane synthase regulates the migratory phenotype of human glioma cells.
Topics: Arachidonic Acids; Aspirin; Astrocytes; Benzofurans; Brain Neoplasms; Cell Adhesion; Cell Movement; Enzyme Induction; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; GTP-Binding Proteins; Humans; Imidazoles; Indomethacin; Lysine; Models, Biological; Neoplasm Proteins; Neoplastic Stem Cells; Oligodendroglia; Pentanoic Acids; Phenotype; Pyridines; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Thromboxane B2; Thromboxane-A Synthase; Tumor Cells, Cultured | 1999 |
Effectiveness of a lysyl chlorin p6/chlorin p6 mixture in photodynamic therapy of the subcutaneous 9L glioma in the rat.
Topics: Animals; Drug Screening Assays, Antitumor; Glioma; Lysine; Male; Necrosis; Neoplasm Transplantation; Photochemotherapy; Porphyrins; Rats; Rats, Inbred F344; Skin; Skin Neoplasms | 1992 |
Transport of leucine, lysine, glycine and aspartate in neuroblastoma C1300 and glioma C6 cells.
Topics: Animals; Aspartic Acid; Cell Line, Transformed; Glioma; Glycine; Humans; Leucine; Lysine; Neuroblastoma | 1987 |