lysine and Genome Instability

Topics: Animals; Carcinogenesis; Chromatin; Genomic Instability; Histones; Humans; Lysine; Mammals; Methylation; Neoplasms

Topics: Acetylation; Animals; Chromatin; Chromatin Assembly and Disassembly; DNA Repair; DNA Replication; Genomic Instability; Histones; Humans; Lysine; Protein Processing, Post-Translational; Transcription, Genetic

Topics: Animals; Cell Cycle; Chromatin; DNA Damage; DNA Replication; Epigenesis, Genetic; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Tumor Suppressor p53-Binding Protein 1

Topics: Arabidopsis; Arabidopsis Proteins; DNA Breaks, Double-Stranded; DNA Polymerase theta; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; DNA, Plant; Genome, Plant; Genomic Instability; Histones; Lysine; Methylation; Methyltransferases; Mutation; Protein Interaction Domains and Motifs

Topics: Breast Neoplasms; Cisplatin; DNA; Female; Genomic Instability; Humans; Lysine; Proteasome Endopeptidase Complex; Recombination, Genetic; RecQ Helicases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins

Topics: Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; Co-Repressor Proteins; DNA-Binding Proteins; Genomic Instability; Histones; Humans; Lysine; MCF-7 Cells; Mitosis; Phosphoproteins; RNA Interference

Topics: Acetylation; Animals; Binding Sites; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Escherichia coli; Genomic Instability; Histone Acetyltransferases; Histones; Humans; Lysine; Methanosarcina barkeri; Mice; Nucleosomes; Protein Binding; Protein Processing, Post-Translational; Sirtuins; Xenopus laevis

Topics: Catalytic Domain; Cell Cycle Proteins; DNA; DNA Polymerase II; DNA Replication; Genomic Instability; Lysine; Multiprotein Complexes; Mutation; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Small Ubiquitin-Related Modifier Proteins; Sumoylation; Telomere

Topics: Animals; Cellular Microenvironment; DNA; DNA Damage; Epithelium; Extracellular Matrix; Genome; Genomic Instability; Histones; Humans; Lysine; Methylation; Stem Cells; Stress, Mechanical

Topics: Animals; Binding Sites; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Female; Fibroblasts; Genomic Instability; Humans; Lysine; Mice; Neuroblastoma; NF-kappa B p50 Subunit; Protein Domains; Protein Processing, Post-Translational; Serine; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Ubiquitination

Topics: Chromatin Immunoprecipitation Sequencing; Chromosomes, Plant; DNA Transposable Elements; Evolution, Molecular; Genome, Plant; Genomic Instability; Histones; Lysine; Polyploidy; Recombination, Genetic; Triticum

Topics: Amino Acid Substitution; Arginine; Ataxia Telangiectasia Mutated Proteins; Cell Line; Cyclin-Dependent Kinases; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA Replication; Endodeoxyribonucleases; Genes, Reporter; Genomic Instability; Humans; Lysine; Poly-ADP-Ribose Binding Proteins; Proliferating Cell Nuclear Antigen; Protein Inhibitors of Activated STAT; Protein Interaction Mapping; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Recombinational DNA Repair; RNA Interference; RNA, Small Interfering; Sumoylation

Topics: Acetylation; Arabidopsis; Arabidopsis Proteins; Gene Silencing; Genome, Plant; Genomic Instability; Heterochromatin; Histone Acetyltransferases; Histones; Lysine; Methylation; Methyltransferases; Mutation; Plants, Genetically Modified; Transcription Factors

Topics: Binding Sites; Bone Neoplasms; Cell Line, Tumor; Deubiquitinating Enzymes; DNA Damage; Genomic Instability; HEK293 Cells; Humans; Lysine; Osteosarcoma; Polyubiquitin; Protein Binding; Protein Interaction Domains and Motifs; Retinal Pigment Epithelium; Substrate Specificity; Ubiquitination

Topics: Binding Sites; Cell Nucleus; Cell Survival; Deubiquitinating Enzymes; DNA Damage; Genomic Instability; HEK293 Cells; HeLa Cells; Humans; Jurkat Cells; Lysine; Polyubiquitin; Protein Binding; Protein Conformation; Protein Interaction Domains and Motifs; Structure-Activity Relationship; Substrate Specificity; Ubiquitination

Topics: Animals; Carcinogenesis; Carcinoma, Renal Cell; Cell Line, Tumor; Chromosomes, Human, Pair 3; Fibroblasts; Gene Knockdown Techniques; Genomic Instability; Haploinsufficiency; Histone-Lysine N-Methyltransferase; Histones; Humans; Kidney Neoplasms; Kidney Tubules, Proximal; Lysine; Methylation; Mice; Micronuclei, Chromosome-Defective; Microtubules

Topics: A549 Cells; Acetylation; Cell Line, Tumor; Cell Survival; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA Damage; Genomic Instability; HCT116 Cells; HEK293 Cells; HeLa Cells; Histones; Humans; Lysine; Mutation; Nucleosomes; p300-CBP Transcription Factors

Topics: Adaptor Proteins, Signal Transducing; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Chromatin; DNA Damage; DNA Methylation; DNA Repair; Genomic Instability; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Neoplasms; Nuclear Proteins; Trans-Activators; Tumor Cells, Cultured

Topics: Binding Sites; Cryoelectron Microscopy; Genome, Human; Genomic Instability; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Nuclear Proteins; Nucleosomes; Protein Binding; Protein Conformation; Saccharomyces cerevisiae Proteins; Transcription, Genetic; Ubiquitination

Topics: Ascomycota; Chromosomes, Fungal; Gene Deletion; Genomic Instability; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Repetitive Sequences, Nucleic Acid; Transcriptional Activation

Topics: Arabidopsis; Arabidopsis Proteins; Chromatin Assembly and Disassembly; Chromatin Assembly Factor-1; Comet Assay; DNA Damage; Fluorescent Antibody Technique; Genomic Instability; Histones; Indoleacetic Acids; Lysine; Methylation; Methyltransferases; Microscopy, Confocal; Plant Roots

Topics: B-Lymphocytes; Cell Cycle Proteins; Cell Death; Cell Survival; Checkpoint Kinase 1; Chromatin; DNA Damage; DNA Replication; Down-Regulation; Gene Expression Regulation; Genomic Instability; HEK293 Cells; Humans; Lysine; Mitosis; Proteasome Endopeptidase Complex; Protein Kinases; Proteins; Spindle Apparatus; Tumor Suppressor Proteins; Ubiquitin; Ubiquitination; Ultraviolet Rays

Topics: Amino Acid Substitution; Animals; Asia; Cell Line; Chickens; Europe; Genomic Instability; Glutamic Acid; Humans; Influenza A Virus, H5N1 Subtype; Influenza in Birds; Lysine; Mutagenesis, Site-Directed; Mutant Proteins; Mutation, Missense; Reverse Genetics; RNA-Dependent RNA Polymerase; Viral Proteins; Virus Replication

Topics: BRCA1 Protein; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Repair; DNA Replication; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation; Genomic Instability; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Phosphorylation; Protein Processing, Post-Translational; Radiation, Ionizing; Signal Transduction; Tumor Suppressor p53-Binding Protein 1; Ubiquitin-Protein Ligases; Ubiquitination

Topics: Cell Cycle; Cell Line; Cytoplasm; Gene Expression; Gene Silencing; Genome, Human; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Mitosis; Protein Transport; RNA Interference; RNA, Small Interfering; Ubiquitin-Protein Ligases

Topics: Chromatin; DNA Breaks, Double-Stranded; DNA Repair; Genomic Instability; Histones; Homologous Recombination; Lysine; Methylation; Models, Biological

Topics: Animals; Cell Cycle Proteins; Cell Nucleus; Chromatin; Chromosomes, Mammalian; Cytoskeletal Proteins; DNA Breaks, Double-Stranded; DNA Repair; Embryo, Mammalian; Endopeptidases; Endosomal Sorting Complexes Required for Transport; Fibroblasts; Genomic Instability; HEK293 Cells; Histones; Homologous Recombination; Humans; Inhibitor of Apoptosis Proteins; Lysine; Mice; Multiprotein Complexes; Nerve Tissue Proteins; Polyubiquitin; Protein Transport; Ubiquitin Thiolesterase; Ubiquitination

Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; BRCA1 Protein; Carrier Proteins; Cell Cycle Proteins; Cell Line, Tumor; Chromatin Assembly Factor-1; DNA Damage; DNA Replication; DNA-Binding Proteins; Endodeoxyribonucleases; Gene Expression; Genomic Instability; Humans; Hydroxyurea; Lysine; Molecular Sequence Data; Nuclear Proteins; Nucleic Acid Synthesis Inhibitors; Osteoblasts; Protein Interaction Mapping; Recombinant Fusion Proteins; Signal Transduction; Small Ubiquitin-Related Modifier Proteins; Sumoylation; Trans-Activators; Transcription Factors

Topics: Adaptor Proteins, Signal Transducing; Animals; Binding Sites; Carrier Proteins; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Co-Repressor Proteins; DNA Helicases; DNA Methylation; Embryonic Development; Genome; Genomic Instability; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methyltransferases; Mice; Mice, Knockout; Molecular Chaperones; Mouse Embryonic Stem Cells; Nuclear Proteins; Protein Binding; Repressor Proteins; Tandem Repeat Sequences; Telomere; Transcription, Genetic; X-linked Nuclear Protein

Topics: Animals; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line; DNA Damage; DNA Replication; DNA Replication Timing; Drosophila melanogaster; Drosophila Proteins; Genome, Insect; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Protein Serine-Threonine Kinases; Replication Origin; S Phase

Topics: Animals; CHO Cells; Cricetulus; DNA; DNA Damage; DNA-Activated Protein Kinase; Dose-Response Relationship, Radiation; Endodeoxyribonucleases; Escherichia coli Proteins; Genomic Instability; Lysine; Nuclear Proteins; Radiation Dosage; Radiation Tolerance; Structure-Activity Relationship

Topics: Chromatin; DNA Repair; DNA Replication; DNA-Binding Proteins; Genomic Instability; Histones; Homologous Recombination; Humans; Lysine; Methylation; Models, Molecular; Molecular Chaperones; NF-kappa B; Nuclear Proteins; Protein Binding; Protein Structure, Tertiary

Topics: Biocatalysis; Cell Line; Cell Survival; Chromatin; DNA Damage; DNA Repair; Genomic Instability; Histones; Humans; Lysine; Poly(ADP-ribose) Polymerases; Sirtuins; Succinates

Topics: Acetylation; Cell Line, Tumor; DNA Damage; Genomic Instability; HeLa Cells; Humans; Lysine; Protein Processing, Post-Translational; Stress, Physiological; Succinic Acid; Ultraviolet Rays

Topics: Cell Line, Tumor; Chromatin Assembly and Disassembly; Cytokinesis; Cytoskeleton; Genomic Instability; Histone Code; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Microtubules; Mitosis; Protein Processing, Post-Translational; Tubulin

Topics: Chromatin; Cytoskeleton; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Tubulin

Topics: Acetylation; Acetyltransferases; Chromatids; Chromosomes, Fungal; DNA Damage; DNA Polymerase III; Genomic Instability; Genotype; Humans; Lysine; Models, Molecular; Mutation; Nuclear Proteins; Phenotype; Proliferating Cell Nuclear Antigen; Protein Conformation; Protein Processing, Post-Translational; Recombinational DNA Repair; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship

Topics: Acetylation; Acetyltransferases; Amino Acid Sequence; Cell Cycle Proteins; Cell Line; Cell Proliferation; Cell Survival; Chondroitin Sulfate Proteoglycans; Chromosomal Proteins, Non-Histone; Genomic Instability; Humans; Lysine; Molecular Sequence Data; Nuclear Proteins; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sister Chromatid Exchange; Substrate Specificity

Topics: Amino Acid Motifs; Cell Cycle Proteins; Chromatin; DNA Damage; DNA, Fungal; Genome, Fungal; Genomic Instability; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Protein Binding; Protein Methyltransferases; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins

Topics: Acetylation; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Nucleus; Cells, Cultured; Chromatin; DNA Breaks, Double-Stranded; DNA Damage; DNA-Binding Proteins; Enzyme Inhibitors; Genomic Instability; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; HMGN1 Protein; Lysine; Mice; Mice, Knockout; Phosphorylation; Protein Serine-Threonine Kinases; Radiation, Ionizing; Tumor Suppressor Proteins

Topics: Acetylation; Cell Cycle Proteins; Cell Line, Tumor; DNA Damage; Genomic Instability; HeLa Cells; Histones; Humans; Lysine; Molecular Chaperones; S Phase; Sirtuin 1; Sirtuins

Topics: Alleles; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Chromatin; DNA Damage; DNA Replication; Genes, Dominant; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Methylation; Mice; Myeloid Progenitor Cells; Myeloid-Lymphoid Leukemia Protein; Phosphorylation; Phosphoserine; Protein Binding; Protein Serine-Threonine Kinases; S Phase; S-Phase Kinase-Associated Proteins; Signal Transduction; Translocation, Genetic

Topics: Blotting, Western; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; Chromosomal Proteins, Non-Histone; Chromosome Deletion; Chromosomes, Human, Pair 20; DNA Damage; DNA Replication; Genomic Instability; HEK293 Cells; Histones; Humans; Immunoprecipitation; K562 Cells; Lysine; Methylation; Myeloproliferative Disorders; Neoplasm Proteins; Protein Binding; Repressor Proteins; Retinoblastoma Protein; RNA Interference; Tumor Suppressor Proteins

Topics: Acetyl Coenzyme A; Acetylation; Cell Cycle Proteins; Chromatin Assembly and Disassembly; Crystallography, X-Ray; Gene Expression; Genomic Instability; Histone Acetyltransferases; Histones; Humans; Lysine; Models, Molecular; Molecular Chaperones; Mutagenesis, Site-Directed; Protein Binding; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity

Topics: Analysis of Variance; Animals; Base Sequence; Blotting, Western; Chromatin Immunoprecipitation; Cocaine; Cocaine-Related Disorders; DNA Primers; Gene Regulatory Networks; Genomic Instability; Heterochromatin; Histones; Immunohistochemistry; Long Interspersed Nucleotide Elements; Lysine; Methylation; Mice; Models, Statistical; Molecular Sequence Data; Nucleus Accumbens; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Reward; Sequence Analysis, DNA

Topics: Amino Acid Sequence; Animals; Caloric Restriction; Chromatin Assembly and Disassembly; Enzyme Stability; Genomic Instability; Half-Life; HEK293 Cells; HeLa Cells; Heterochromatin; Humans; Lysine; Male; Methyltransferases; Mice; Molecular Sequence Data; Mutation; NIH 3T3 Cells; Oxidative Stress; Polyubiquitin; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Repressor Proteins; RNA Interference; Sirtuin 1; Time Factors; Transfection; Ubiquitination

Topics: Animals; DNA-(Apurinic or Apyrimidinic Site) Lyase; Gene Knockout Techniques; Genomic Instability; HeLa Cells; Humans; Lysine; Mice; Ubiquitin-Protein Ligases; Ubiquitination

Topics: Acetylation; Animals; Binding Sites; Crystallography, X-Ray; DNA Damage; Gene Silencing; Genomic Instability; Histones; Lysine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Chaperones; Mutation; Pliability; Protein Binding; Protein Multimerization; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship; Substrate Specificity; Xenopus laevis

Topics: Adenosine Triphosphatases; Base Sequence; DNA Damage; DNA Helicases; DNA Replication; DNA-Binding Proteins; DNA, Fungal; Genes, Fungal; Genomic Instability; Lysine; Mutation; Proliferating Cell Nuclear Antigen; Recombination, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Small Ubiquitin-Related Modifier Proteins; Ubiquitin-Conjugating Enzymes

Topics: Acetylation; Amino Acid Sequence; Binding Sites; Cell Cycle; Cell Cycle Proteins; Chromatin; DNA Damage; DNA Replication; Genome, Fungal; Genomic Instability; Histone Deacetylases; Histones; Lysine; Molecular Chaperones; Molecular Sequence Data; Mutation; Niacinamide; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sirtuins

Topics: Acetylation; Cell Cycle Proteins; Chromosomes, Fungal; DNA Breaks, Double-Stranded; DNA Damage; Genome, Fungal; Genomic Instability; Histone Acetyltransferases; Histones; Lysine; Molecular Chaperones; Mutation; Recombinant Proteins; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity

Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; Down-Regulation; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; RNA, Small Interfering; S Phase; Tumor Suppressor Proteins

Topics: Acetylation; Cell Cycle Proteins; Cell Nucleus; DNA Damage; DNA Repair; Enzyme Stability; Genome, Fungal; Genomic Instability; Histone Acetyltransferases; Histones; Lysine; Molecular Chaperones; Oligonucleotide Array Sequence Analysis; Protein Binding; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity