lysine has been researched along with Extravascular Hemolysis in 116 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (24.14) | 18.7374 |
| 1990's | 14 (12.07) | 18.2507 |
| 2000's | 26 (22.41) | 29.6817 |
| 2010's | 43 (37.07) | 24.3611 |
| 2020's | 5 (4.31) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, H; Chen, W; Fu, G; He, T; Hu, Y; Li, C; Li, H; Li, L; Luo, G; Qu, R; Tang, X; Wang, W; Xia, X; Zhang, J | 1 |
| Rybak, ME; Sternberg, MR; Zitomer, NC | 1 |
| He, T; Hu, Y; Li, H; Pu, Q; Wu, W; Xia, X; Zhang, J; Zhang, Q | 1 |
| Bauer, M; Jaśkiewicz, M; Kamysz, W; Neubauer, D; Olejniczak-Kęder, A; Sikora, K; Sikorska, E | 1 |
| Arichthota, S; Bhunia, A; Dutta, A; Haldar, D; Mohid, SA; Patel, KD; Sarojini, V | 1 |
| Domalaon, R; Gorityala, BK; Goswami, S; Idowu, T; Lyu, Y; Schweizer, F; Shan, A; Yang, X; Zhanel, GG | 1 |
| Jia, F; Kong, Z; Peng, J; Wang, J; Wang, K; Wang, R; Yan, W; Zhao, P | 1 |
| Benincasa, M; Gajski, G; Goić-Barišić, I; Ilić, N; Juretić, D; Krce, L; Maravić, A; Rončević, T; Sonavane, Y; Tonkić, M; Tossi, A; Vukičević, D; Zoranić, L | 1 |
| Cai, J; Cao, Y; Hu, J; Nimmagadda, A; Niu, Y; Wang, M; Wu, Y; Ye, XS | 1 |
| Kimura, R; Koeda, S; Miyagawa, A; Mizuno, T; Shibata, M; Yamamura, H | 1 |
| Kim, DH; Kim, YW; Lee, BJ; Luong, HX | 1 |
| Li, C; Yang, N; Zhang, QS; Zhang, W | 1 |
| Akbarzadeh, A; Ashjaran, M; Babazadeh, M; Davaran, S; Salehi, R | 1 |
| Adak, A; Ghosh, S; Gupta, V | 1 |
| Bhonde, RR; Pandey, PK; Rohde, M; Seong, CN; Shouche, YS; Spröer, C; Verma, P | 1 |
| de Lapuente, J; del Carmen Morán, M; Mitjans, M; Nogueira, DR; Pérez, L; Pilar Vinardell, M; Ramos, D | 1 |
| Amekoudi, EY; Noto Kadou Kaza, B; Sabi, KA | 1 |
| Ikeda, A; Ishiyama, Y; Kato, T; Ochiai, A; Saitoh, E; Takahashi, N; Takayanagi, T; Tanaka, T; Taniguchi, M | 1 |
| Chen, S; Li, W; Liu, L; Wang, G; Wang, L; Wang, Z; Yang, Q | 1 |
| Chen, X; Li, M; Lin, J; Liu, H; Lv, S; Song, W; Tang, Z; Zhang, D | 1 |
| Chen, R; Watkins, KA | 1 |
| Cabrera, MP; Dias, NB; Gomes, PC; Leite, NB; Neto, JR; Palma, MS; Souza, BM; Stabeli, RG | 1 |
| Abel, BA; Brown, TD; Choudhary, V; Elasri, MO; Exley, SE; Heinhorst, S; Koul, V; McCormick, CL; Morgan, SE; Paslay, LC; Sahukhal, GS | 1 |
| Bai, X; Chen, Y; Jin, L; Lai, R; Liu, W; Lu, Q; Luan, N; Rong, M; Yan, X; Yao, H; Zhang, Z | 1 |
| Gao, J; Joo, Y; Zerfas, BL | 1 |
| Dennison, SR; Harris, F; Morton, LH; Phoenix, DA | 1 |
| Hyun, S; Kim, S; Lee, Y; Yu, J | 1 |
| Damborg, P; Franzyk, H; Hansen, PR; Molchanova, N; Nielsen, HM | 1 |
| Danino, D; Mor, A; Rotem, S; Sarig, H; Ziserman, L | 1 |
| Feix, JB; Sato, H | 1 |
| Hodges, RS; Jelokhani-Niaraki, M; Kondejewski, LH; Wheaton, LC | 1 |
| Cho, SJ; Gopal, R; Ha, KJ; Hahm, KS; Kim, SW; Nah, JW; Park, SC; Park, Y; Song, PI | 1 |
| Clark, RJ; Colgrave, ML; Craik, DJ; Huang, YH; Kotze, AC | 1 |
| de Souza, BM; Dos Santos Cabrera, MP; Neto, JR; Palma, MS | 1 |
| Collyer, CA; Ghadikolaee, NB; Hunter, N; Lee, M; Li, N; Nadkarni, MA; Nguyen, KA; Yun, P | 1 |
| Hahm, KS; Kang, SW; Kim, Y; Nan, YH; Park, IS; Shin, SY; Wang, P; Yang, ST | 1 |
| Andreu, D; Cabrales-Rico, A; de la Torre, BG; Díaz, D; Fernández-Reyes, M; Jiménez-Barbero, J; Rivas, L; Vallès-Miret, M | 1 |
| Kim, HJ; Lee, SH; Nan, YH; Shin, SY | 1 |
| Biemond, BJ; Brandjes, DP; Fijnvandraat, K; Nur, E; Otten, HM; Schalkwijk, CG; Schnog, JJ | 1 |
| Fumoto, S; Higuchi, N; Kitahara, T; Kodama, Y; Kurosaki, T; Nakagawa, H; Nakamura, T; Nishida, K; Sasaki, H; Yamamoto, K | 1 |
| Colomer, A; Infante, MR; Manresa, MA; Mitjans, M; Pérez, L; Pinazo, A; Vinardell, MP | 1 |
| Infante, MR; Mitjans, M; Nogueira, DR; Vinardell, MP | 1 |
| Gopal, R; Hahm, KS; Kim, YJ; Park, Y; Seo, CH | 1 |
| Conlon, JM; Hewage, CM; O'Flynn, D; Subasinghage, AP | 1 |
| de Boer, L; Nguyen, LT; Vogel, HJ; Zaat, SA | 1 |
| Mitjans, M; Morán, MC; Nogueira, DR; Pérez, L; Vinardell, MP | 1 |
| Arnauld, T; Fattal, E; Lefoulon, F; Ménard, N; Moine, L; Péan, JM; Poirier, C; Tsapis, N | 1 |
| Fujinuma, K; Harada, T; Kimura, M; Shindo, M; Takanashi, K; Tamaki, M; Uchida, Y | 1 |
| Colomer, A; García, MT; Infante, MR; Martínez, V; Mitjans, M; Pérez, L; Pinazo, A; Vinardell, MP | 1 |
| Abdolhosseini, M; Gorr, SU; Hirt, H; Nandula, SR; Song, J | 1 |
| Busquets, MA; Mitjans, M; Nogueira, DR; Pérez, L; Vinardell, MP | 1 |
| Gopal, R; Park, Y; Seo, CH; Song, PI | 1 |
| Hahm, KS; Kim, JI; Kim, YC; Lee, CW; Shin, SY; Yang, ST | 1 |
| Epand, RF; Epand, RM; Lehrer, RI; Lelièvre, D; Maget-Dana, R; Wang, W; Waring, A | 1 |
| Papo, N; Shai, Y | 1 |
| FUDENBERG, H; TAYLOR, FB | 1 |
| Hahm, KS; Lee, DG; Park, Y | 1 |
| Alkhalil, A; Cohn, JV; Desai, SA; Rajapandi, T; Wagner, MA | 1 |
| TYLER, DB | 1 |
| Baydoun, L; Daniels, R; Drust, A; Düvel, A; Goldhagen, T; Müller-Goymann, CC; Schwan, I; Zeidler, C | 1 |
| Infante, MR; Mitjans, M; Sanchez, L; Vinardell, MP | 1 |
| Hansen, PR; Ryge, TS | 2 |
| Bhadra, D; Bhadra, S; Jain, NK | 1 |
| Bryszewska, M; Janiszewska, J; Klajnert, B; Labieniec, M; Shcharbin, D; Urbanczyk-Lipkowska, Z | 1 |
| Infante, MR; Martínez, V; Mitjans, M; Sánchez, L; Vinardell, MP | 1 |
| Ginsburg, H; Krugliak, M; Mor, A; Radzishevsky, I | 1 |
| Clark, RJ; Colgrave, ML; Craik, DJ; Daly, NL; Göransson, U; Plan, MR | 1 |
| Bartosz, G; Robaszkiewicz, A; Soszyński, M | 1 |
| Bourdetsky, D; Carmeli, Y; Mor, A; Navon-Venezia, S; Radzishevsky, IS; Rotem, S | 1 |
| Larsen, PR; Wolff, J | 1 |
| Chelapurath, A; Essers, U; Häussinger, G; Pfennigs, H; Reul, H | 1 |
| Condrea, E; Fletcher, JE; Rapuano, BE; Rosenberg, P; Yang, CC | 1 |
| Takada, A; Takada, Y | 1 |
| Gray, MC; Guo, L; Hackett, M; Hewlett, EL; Hunt, DF; Sebo, P; Shabanowitz, J; Ullmann, A; Van Cuyk, S; Walker, CB | 1 |
| Hughes, C; Koronakis, V; Packman, LC; Stanley, P | 1 |
| Guo, L; Hackett, M; Hewlett, EL; Hunt, DF; Shabanowitz, J | 1 |
| Asami, I; Choorit, W; Kamio, Y; Kaneko, J; Muramoto, K; Sudo, K | 1 |
| Ando, S; Lee, S; Nishihama, M; Nishikawa, H; Sugihara, G; Takiguchi, H | 1 |
| Infante, MR; Macián, M; Seguer, J; Selve, C; Vinardell, MP | 1 |
| Kiyota, T; Lee, S; Sugihara, G | 1 |
| Chen, WC; Ho, CL; Hwang, LL; Lin, YL; Wang, KT; Yu, HM | 1 |
| Infante, MR; Macián, M; Seguer, J; Vinardell, MP; Vives, MA | 1 |
| Garcia, E; Infante, MR; Maugras, M; Selve, C; Vinardell, MP; Vives, MA | 1 |
| Hosoya, K; Iwata, S; Kobayashi, D; Miyamoto, M; Morimoto, Y; Natsume, H; Ohtake, K; Sugibayashi, K; Yamaguchi, M | 1 |
| Anderluh, G; Barlic, A; Macek, P; Menestrina, G; Potrich, C | 1 |
| Eom, SH; Kang, SW; Kim, JI; Lee, DG; Shin, SY; Song, WK | 1 |
| Basar, T; Bezousková, S; Hackett, M; Havlícek, V; Sebo, P | 1 |
| Alape-Girón, A; Basak, AK; Carr, FJ; Carter, G; Flores-Díaz, M; Holley, J; Keyte, M; Miller, J; Moss, DS; Naylor, CE; Thelestam, M; Titball, RW; Walker, N | 1 |
| Juránková, J; Votava, M | 1 |
| Ho, CL; Shih, YP; Wang, KT; Yu, HM | 1 |
| Baker, P; Behrends, C; Gewurz, H; McLeod, B | 1 |
| Cooper, NR | 1 |
| Kindred, B | 1 |
| Baker, PJ; Gewurz, H; Kies, MW; Lint, TF; Siegel, J | 1 |
| Baker, P; Behrends, C; Gewurz, H; Lint, TF; McLeod, B | 1 |
| Macek, P; Turk, T | 1 |
| Chandy, M; Nagaraj, R; Pillai, VN; Sitaram, N | 1 |
| Cheng, TS; Ko, WH; Swaminathan, R; Tam, SC | 1 |
| Fukuda, T; Fukumori, Y; Kaneko, I; Morimoto, Y; Takeuchi, Y; Yamaoka, Y | 1 |
| Shirahama, S; Sugawara, Y; Takada, A; Takada, Y | 1 |
| Benjamin, S; Condrea, E; Dhillon, DS; Heinrikson, RL; Maraganore, JM; Rosenberg, P | 1 |
| Eisen, HN; Ferguson, WS; Iannini, MJ; Reilly, EB; Verret, CR | 1 |
| Colten, HR | 1 |
| Aston, WP; Pang, AS | 1 |
| Loyter, A; Sabban, E | 1 |
| Scornik, JC | 1 |
| de Gaetano, G; Poggi, A; Reyers-Degli Innocenti, I | 1 |
| Freedman, ML; Friedberg, D; Mucha, J; Troll, W | 1 |
| Austen, KF; Fearon, DT; Ruddy, S | 1 |
| Ellner, PD; Wasilauskas, BL | 1 |
| Yamada, A; Yamada, H | 1 |
| Bliznakov, EG; Wilkins, DJ | 1 |
| Holmsen, H; Rozenberg, MC | 1 |
| Bargellesi, A; Conconi, F; Pontremoli, S | 1 |
| Honig, GR; Mason, RG; Rowan, BQ | 1 |
116 other study(ies) available for lysine and Extravascular Hemolysis
| Article | Year |
|---|---|
Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria
Topics: Animals; Antimicrobial Cationic Peptides; Bacterial Infections; Cell Survival; Drug Resistance, Multiple, Bacterial; Female; HEK293 Cells; Hemolysis; High-Throughput Screening Assays; Humans; In Vitro Techniques; Lysine; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests | 2022 |
Assessing the Impacts of Preanalytical Field Sampling Challenges on the Reliability of Serum Aflatoxin B1-Lysine Measurements by Use of LC-MS/MS.
Topics: Aflatoxin B1; Aflatoxins; Animals; Biomarkers; Bromcresol Green; Chromatography, Liquid; Hemolysis; Humans; Lysine; Rats; Reproducibility of Results; Serum Albumin; Tandem Mass Spectrometry | 2022 |
Novel Stapling by Lysine Tethering Provides Stable and Low Hemolytic Cationic Antimicrobial Peptides.
Topics: Amino Acid Sequence; Antimicrobial Cationic Peptides; Escherichia coli; HEK293 Cells; Hemolysis; Humans; Lysine; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests | 2020 |
Biological and Physico-Chemical Characteristics of Arginine-Rich Peptide Gemini Surfactants with Lysine and Cystine Spacers.
Topics: Amino Acid Motifs; Antimicrobial Cationic Peptides; Arginine; Biofilms; Candida; Cell Membrane; Cystine; Enterobacteriaceae; Fatty Acids; Hemolysis; Hydrophobic and Hydrophilic Interactions; Lipoproteins; Lysine; Micelles; Surface-Active Agents | 2021 |
Synthesis and antibacterial study of cell-penetrating peptide conjugated trifluoroacetyl and thioacetyl lysine modified peptides.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Biofilms; Cell Survival; Cell-Penetrating Peptides; Drug Design; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; Hemolysis; Humans; Lysine; Mice; Microbial Sensitivity Tests; Sirtuins; Staphylococcus aureus; Unilamellar Liposomes | 2021 |
Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline.
Topics: Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Hemolysis; Lysine; Microbial Sensitivity Tests; Minocycline; Models, Biological; Rifampin; Tobramycin | 2017 |
D-amino acid substitution enhances the stability of antimicrobial peptide polybia-CP.
Topics: Amino Acid Substitution; Animals; Antimicrobial Cationic Peptides; Hemolysis; Humans; Lysine; Microbial Sensitivity Tests; Peptide Hydrolases; Protein Stability; Wasps | 2017 |
Antibacterial Activity Affected by the Conformational Flexibility in Glycine-Lysine Based α-Helical Antimicrobial Peptides.
Topics: Algorithms; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Bacteria; Cell Membrane Permeability; Drug Design; Glycine; Hemolysis; In Vitro Techniques; Lysine; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Molecular Dynamics Simulation; Mutagenicity Tests; Structure-Activity Relationship | 2018 |
Rational Design of Dimeric Lysine N-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents.
Topics: Amides; Anti-Bacterial Agents; Biofilms; Cell Membrane Permeability; Drug Design; Drug Resistance, Multiple, Bacterial; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; Hemolysis; Humans; Lysine; Microbial Sensitivity Tests; Staphylococcus aureus | 2018 |
Development of New Antimicrobial Agents from Cationic PG-Surfactants Containing Oligo-Lys Peptides.
Topics: Administration, Intravenous; Animals; Anti-Infective Agents; Cations; Erythrocytes; Gram-Negative Bacteria; Gram-Positive Bacteria; Hemolysis; Lysine; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Oligopeptides; Rabbits; Surface-Active Agents | 2018 |
Effects of lysine-to-arginine substitution on antimicrobial activity of cationic stapled heptapeptides.
Topics: Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Arginine; Cells, Cultured; Drug Design; Gram-Negative Bacteria; Gram-Positive Bacteria; Hemolysis; Humans; Lysine; Microbial Sensitivity Tests; Structure-Activity Relationship | 2018 |
Fabrication of Organic Hec Nanocomposites Modified with Lysine as a Potential Adsorbent for Bilirubin Removal.
Topics: Adsorption; Animals; Bilirubin; Cell Line; Hemolysis; Hydrogen-Ion Concentration; Kinetics; Lysine; Mice; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanocomposites; Organic Chemicals; Osmolar Concentration; Silicates; Spectrometry, X-Ray Emission; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2019 |
Stimuli-responsive polyvinylpyrrolidone-NIPPAm-lysine graphene oxide nano-hybrid as an anticancer drug delivery on MCF7 cell line.
Topics: Acrylamides; bcl-2-Associated X Protein; Drug Carriers; Drug Liberation; Fluorouracil; Gene Expression Regulation, Neoplastic; Graphite; Hemolysis; Humans; Lysine; MCF-7 Cells; Models, Molecular; Molecular Conformation; Nanostructures; Oxides; Poly(ADP-ribose) Polymerases; Povidone; Proteolysis; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53 | 2019 |
Biocompatible Lipopeptide-Based Antibacterial Hydrogel.
Topics: Anti-Bacterial Agents; Cell Line; Cells, Cultured; Erythrocytes; Hemolysis; Humans; Hydrogels; Hydrophobic and Hydrophilic Interactions; Lipoproteins; Lysine; Oligopeptides; Protein Conformation, beta-Strand; Staphylococcus aureus | 2019 |
Bhargavaea indica sp. nov., a member of the phylum Firmicutes, isolated from Arabian Sea sediment.
Topics: Aerobiosis; Bacillales; Bacterial Typing Techniques; Base Composition; Cluster Analysis; DNA Gyrase; DNA, Bacterial; DNA, Ribosomal; Fatty Acids; Geologic Sediments; Hemolysin Proteins; Hemolysis; Hydrogen-Ion Concentration; India; Lysine; Molecular Sequence Data; Nucleic Acid Hybridization; Phospholipids; Phylogeny; Quinones; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Sodium Chloride; Spores, Bacterial; Temperature | 2013 |
Lysine-based surfactants in nanovesicle formulations: the role of cationic charge position and hydrophobicity in in vitro cytotoxicity and intracellular delivery.
Topics: 3T3 Cells; Analysis of Variance; Animals; Apoptosis; Cations; Cell Cycle; Cell Survival; DNA Damage; Drug Carriers; Erythrocytes; HeLa Cells; Hemolysis; Humans; Hydrophobic and Hydrophilic Interactions; Intracellular Space; Lysine; Mice; Nanostructures; Rats; Surface-Active Agents | 2014 |
[Profound anemia, hemoglobinuria ... where to stop in the etiological investigation?].
Topics: Acute Kidney Injury; Adolescent; Anemia, Hemolytic; Aspirin; Blackwater Fever; Erythrocyte Transfusion; Glucosephosphate Dehydrogenase Deficiency; Hemoglobinuria; Hemolysis; Humans; Hyperbilirubinemia; Lysine; Malaria; Male; Parasitemia; Quinine; Renal Dialysis; Togo | 2014 |
Effect of substituting arginine and lysine with alanine on antimicrobial activity and the mechanism of action of a cationic dodecapeptide (CL(14-25)), a partial sequence of cyanate lyase from rice.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Anti-Infective Agents; Arginine; Benzothiazoles; Carbocyanines; Carbon-Nitrogen Lyases; Cations; Hemolysis; Inhibitory Concentration 50; Lysine; Microbial Sensitivity Tests; Molecular Sequence Data; Oligopeptides; Oryza; Peptide Fragments; Porphyromonas gingivalis; Sheep; Time Factors; Unilamellar Liposomes | 2014 |
Investigation of nonfouling polypeptides of poly(glutamic acid) with lysine side chains synthesized by EDC·HCl/HOBt chemistry.
Topics: Adsorption; Biocompatible Materials; Biofouling; Cell Survival; Chemistry Techniques, Synthetic; Ethyldimethylaminopropyl Carbodiimide; Fibrinogen; Glutamic Acid; Hemolysis; Human Umbilical Vein Endothelial Cells; Humans; Hydrochloric Acid; Immunoglobulin G; Lysine; Peptides; Triazoles | 2014 |
Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Delayed-Action Preparations; Disulfides; Drug Delivery Systems; Hemolysis; Humans; Hydrogen-Ion Concentration; Lysine; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Micelles; Oxidation-Reduction; Paclitaxel; Pentetic Acid; Polyethylene Glycols; Polymers | 2014 |
pH-responsive, lysine-based hydrogels for the oral delivery of a wide size range of molecules.
Topics: Administration, Oral; Animals; Dextrans; Drug Liberation; Erythrocytes; Fluorescein; Fluorescein-5-isothiocyanate; Hemolysis; Hydrogels; Hydrogen-Ion Concentration; Lysine; Peptide Hydrolases; Phthalic Acids; Polylysine; Polymers; Sheep | 2015 |
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity.
Topics: Animals; Cell Degranulation; Erythrocytes; Hemolysis; Intercellular Signaling Peptides and Proteins; Lysine; Mast Cells; Membranes, Artificial; Peptides; Protein Structure, Secondary; Rats; Structure-Activity Relationship; Wasp Venoms | 2015 |
Antimicrobial Peptide Mimicking Primary Amine and Guanidine Containing Methacrylamide Copolymers Prepared by Raft Polymerization.
Topics: Acrylamides; Amines; Antimicrobial Cationic Peptides; Arginine; Cell Survival; Erythrocytes; Guanidines; Hemolysis; Humans; Lysine; MCF-7 Cells; Molecular Structure; Peptidomimetics; Polymerization; Polymers | 2015 |
A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis.
Topics: Animals; Antimicrobial Cationic Peptides; Arginine; Candida albicans; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Fungal; Female; HEK293 Cells; Hemolysis; Humans; Lysine; Mice; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Tryptophan; Vaginitis | 2016 |
Gramicidin A Mutants with Antibiotic Activity against Both Gram-Positive and Gram-Negative Bacteria.
Topics: Anti-Bacterial Agents; Cell Membrane Permeability; Gram-Negative Bacteria; Gram-Positive Bacteria; Gramicidin; Hemolysis; Lysine; Structure-Activity Relationship | 2016 |
Low pH Enhances the Action of Maximin H5 against Staphylococcus aureus and Helps Mediate Lysylated Phosphatidylglycerol-Induced Resistance.
Topics: Amphibian Proteins; Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Cell Membrane; Cells, Cultured; Drug Resistance, Microbial; Erythrocytes; Hemolysis; Hydrogen-Ion Concentration; Lysine; Phosphatidylglycerols; Sheep; Staphylococcal Infections; Staphylococcus aureus | 2016 |
Nonhemolytic Cell-Penetrating Peptides: Site Specific Introduction of Glutamine and Lysine Residues into the α-Helical Peptide Causes Deletion of Its Direct Membrane Disrupting Ability but Retention of Its Cell Penetrating Ability.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Cations; Cell Membrane; Cell Survival; Cell-Penetrating Peptides; Drug Delivery Systems; Female; Glutamine; Hemolysis; Humans; Hydrophobic and Hydrophilic Interactions; Lysine; Methotrexate; Mutation; Structure-Activity Relationship; Tumor Cells, Cultured | 2016 |
Lysine-Based α-Peptide/β-Peptoid Peptidomimetics: Influence of Hydrophobicity, Fluorination, and Distribution of Cationic Charge on Antimicrobial Activity and Cytotoxicity.
Topics: Animals; Anti-Infective Agents; Cations; Cell Survival; Drug Resistance, Multiple, Bacterial; Erythrocytes; Gram-Negative Bacteria; Gram-Positive Bacteria; Halogenation; Hemolysis; Hep G2 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Lysine; Mice; Microbial Sensitivity Tests; NIH 3T3 Cells; Peptides; Peptidomimetics; Peptoids; Structure-Activity Relationship | 2017 |
Impact of self-assembly properties on antibacterial activity of short acyl-lysine oligomers.
Topics: Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Calorimetry, Differential Scanning; Gram-Negative Bacteria; Gram-Positive Cocci; Hemolysis; Hydrophobic and Hydrophilic Interactions; Lysine; Microbial Sensitivity Tests; Oligopeptides; Structure-Activity Relationship; Surface Plasmon Resonance | 2008 |
Lysine-enriched cecropin-mellitin antimicrobial peptides with enhanced selectivity.
Topics: Animals; Anti-Infective Agents; Antimicrobial Cationic Peptides; Gram-Negative Bacteria; Hemolysis; Humans; Lysine; Macrophages; Mice; Microbial Sensitivity Tests; Species Specificity; Staphylococcus | 2008 |
Effect of ring size on conformation and biological activity of cyclic cationic antimicrobial peptides.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antimicrobial Cationic Peptides; Fungi; Gram-Negative Bacteria; Gram-Positive Bacteria; Gramicidin; Hemolysis; Humans; Hydrophobic and Hydrophilic Interactions; Leucine; Lysine; Microbial Sensitivity Tests; Models, Molecular; Molecular Conformation; Peptides, Cyclic; Stereoisomerism; Structure-Activity Relationship; Valine | 2009 |
Effect of Leucine and Lysine substitution on the antimicrobial activity and evaluation of the mechanism of the HPA3NT3 analog peptide.
Topics: Amino Acid Substitution; Antimicrobial Cationic Peptides; Candida albicans; Circular Dichroism; Computer Simulation; Fluoresceins; Gram-Negative Bacteria; Gram-Positive Bacteria; Hemolysis; Humans; Leucine; Liposomes; Lysine; Microbial Sensitivity Tests; Models, Molecular; Structure-Activity Relationship; Trichosporon | 2009 |
Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity.
Topics: Animals; Antinematodal Agents; Cyclotides; Cystine Knot Motifs; Erythrocytes; Gastrointestinal Tract; Haemonchiasis; Haemonchus; Hemolysis; Humans; Larva; Lysine; Mutagenesis, Site-Directed; Sheep; Trichostrongylosis; Trichostrongylus | 2010 |
Investigating the effect of different positioning of lysine residues along the peptide chain of mastoparans for their secondary structures and biological activities.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Bacteria; Cell Line; Cells, Cultured; Female; Hemolysin Proteins; Hemolysis; Intercellular Signaling Peptides and Proteins; Lysine; Mast Cells; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Peptides; Protein Structure, Secondary; Rats; Rats, Wistar; Structure-Activity Relationship; Wasp Venoms | 2011 |
Structure determination and analysis of a haemolytic gingipain adhesin domain from Porphyromonas gingivalis.
Topics: Adhesins, Bacterial; Amino Acid Sequence; Cells, Cultured; Crystallography, X-Ray; Cysteine Endopeptidases; Erythrocytes; Gingipain Cysteine Endopeptidases; Hemolysin Proteins; Hemolysis; Humans; Lysine; Molecular Sequence Data; Porphyromonas gingivalis; Protein Structure, Secondary; Protein Structure, Tertiary | 2010 |
Cell selectivity and anti-inflammatory activity of a Leu/Lys-rich alpha-helical model antimicrobial peptide and its diastereomeric peptides.
Topics: Amino Acid Sequence; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antimicrobial Cationic Peptides; Hemolysis; Humans; Leucine; Lysine; Mice; Microbial Sensitivity Tests; Molecular Sequence Data; Protein Structure, Secondary; Stereoisomerism | 2010 |
Lysine N(epsilon)-trimethylation, a tool for improving the selectivity of antimicrobial peptides.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Anti-Infective Agents; Antimicrobial Cationic Peptides; Gram-Negative Bacteria; Gram-Positive Bacteria; Hemolysis; Leishmania; Lysine; Methylation; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Structure-Activity Relationship; Trypanocidal Agents | 2010 |
Mammalian cell toxicity and candidacidal mechanism of Arg- or Lys-containing Trp-rich model antimicrobial peptides and their d-enantiomeric peptides.
Topics: Animals; Antifungal Agents; Antimicrobial Cationic Peptides; Arginine; Candida albicans; Hemolysis; Humans; Lysine; Mice; Microbial Sensitivity Tests; NIH 3T3 Cells; Stereoisomerism; Tryptophan | 2010 |
Plasma levels of advanced glycation end products are associated with haemolysis-related organ complications in sickle cell patients.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Arginine; Biomarkers; Female; Glycation End Products, Advanced; Hemolysis; Humans; Lysine; Male; Middle Aged; Oxidative Stress; Young Adult | 2010 |
Chondroitin sulfate capsule system for efficient and secure gene delivery.
Topics: Animals; Arginine; Cations; Cell Line, Tumor; Chondroitin Sulfates; Drug Delivery Systems; Erythrocytes; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Hemolysis; Liposomes; Lysine; Melanoma, Experimental; Mice; Phosphatidylethanolamines; Plasmids; Polyethylenes; Quaternary Ammonium Compounds; Transfection | 2010 |
Cationic surfactants derived from lysine: effects of their structure and charge type on antimicrobial and hemolytic activities.
Topics: Anti-Infective Agents; Cell Survival; Electric Conductivity; Erythrocytes; Gram-Negative Bacteria; Gram-Positive Bacteria; Hemolysis; Humans; Lysine; Magnetic Resonance Spectroscopy; Micelles; Microbial Sensitivity Tests; Spectrometry, Mass, Fast Atom Bombardment; Surface Properties; Surface-Active Agents | 2011 |
The role of counterions in the membrane-disruptive properties of pH-sensitive lysine-based surfactants.
Topics: Animals; Cell Membrane; Erythrocyte Count; Erythrocytes; Hemolysis; Humans; Hydrogen-Ion Concentration; Ions; Lysine; Materials Testing; Molecular Structure; Rats; Surface-Active Agents | 2011 |
Reversed sequence enhances antimicrobial activity of a synthetic peptide.
Topics: Amino Acid Sequence; Anti-Infective Agents; Antimicrobial Cationic Peptides; Bacteria; Circular Dichroism; Fluoresceins; Hemolysis; Humans; Lysine; Microbial Sensitivity Tests; Tryptophan | 2011 |
Conformational and membrane interaction studies of the antimicrobial peptide alyteserin-1c and its analogue [E4K]alyteserin-1c.
Topics: Anti-Infective Agents; Antimicrobial Cationic Peptides; Bacteria; Chlorides; Cyclic N-Oxides; Hemolysis; Humans; Lysine; Manganese Compounds; Membrane Lipids; Membranes, Artificial; Micelles; Microbial Sensitivity Tests; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Phospholipid Ethers; Phosphorylcholine; Protein Conformation; Sodium Dodecyl Sulfate; Solvents; Spin Labels; Structure-Activity Relationship; Trifluoroethanol; Valine; Water | 2011 |
Investigating the cationic side chains of the antimicrobial peptide tritrpticin: hydrogen bonding properties govern its membrane-disruptive activities.
Topics: Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Arginine; Bacillus subtilis; Cations; Erythrocytes; Escherichia coli; Guanidine; Hemolysis; Humans; Hydrogen Bonding; Lysine; Membranes; Methylation; Oligopeptides; Peptides; Spectrometry, Fluorescence; Staphylococcus aureus | 2011 |
Membrane-destabilizing activity of pH-responsive cationic lysine-based surfactants: role of charge position and alkyl chain length.
Topics: Animals; Cell Membrane; Cell Shape; Dose-Response Relationship, Drug; Erythrocytes; Hemolysis; Hydrogen-Ion Concentration; Kinetics; Lysine; Molecular Structure; Osmotic Fragility; Rats; Surface-Active Agents | 2012 |
Drug solubilization and in vitro toxicity evaluation of lipoamino acid surfactants.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Compounding; Hemolysis; Human Umbilical Vein Endothelial Cells; Humans; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Lipids; Lysine; Micelles; Models, Molecular; Molecular Structure; Nitrilotriacetic Acid; Polysorbates; Rats; Rats, Wistar; Solubility; Structure-Activity Relationship; Surface-Active Agents; Technology, Pharmaceutical | 2012 |
Fatty acyl-gramicidin S derivatives with both high antibiotic activity and low hemolytic activity.
Topics: Animals; Anti-Bacterial Agents; Blood Cells; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Design; Gram-Negative Bacteria; Gram-Positive Bacteria; Gramicidin; Hemolysis; Lysine; Microbial Sensitivity Tests; Models, Chemical; Sheep; Structure-Activity Relationship | 2012 |
pH-Sensitive surfactants from lysine: assessment of their cytotoxicity and environmental behavior.
Topics: 3T3 Cells; Animals; Aquatic Organisms; Chemical Phenomena; Cytotoxins; Daphnia; Drug Design; Environment; Erythrocytes; Fibroblasts; Hemolysis; Humans; Hydrogen-Ion Concentration; Lysine; Mice; Micelles; Structure-Activity Relationship; Surface-Active Agents | 2012 |
Lysine substitutions convert a bacterial-agglutinating peptide into a bactericidal peptide that retains anti-lipopolysaccharide activity and low hemolytic activity.
Topics: Agglutination; Amino Acid Substitution; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antimicrobial Cationic Peptides; Escherichia coli; Hemolysis; Lipopolysaccharides; Lysine; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Porphyromonas gingivalis; Pseudomonas aeruginosa; Streptococcus gordonii | 2012 |
Phospholipid bilayer-perturbing properties underlying lysis induced by pH-sensitive cationic lysine-based surfactants in biomembranes.
Topics: Animals; Cell Membrane; Erythrocytes; Fluorescent Dyes; Hemolysis; Humans; Hydrogen-Ion Concentration; Lipid Bilayers; Lysine; Membrane Fluidity; Phospholipids; Rats; Salts; Structure-Activity Relationship; Surface-Active Agents | 2012 |
Effect of repetitive lysine-tryptophan motifs on the bactericidal activity of antimicrobial peptides.
Topics: Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Bacteria; Erythrocytes; Hemolysin Proteins; Hemolysis; Humans; Lysine; Microbial Sensitivity Tests; Tryptophan | 2013 |
Selective cytotoxicity following Arg-to-Lys substitution in tritrpticin adopting a unique amphipathic turn structure.
Topics: Amino Acid Substitution; Anti-Bacterial Agents; Arginine; Circular Dichroism; Hemolysis; Liposomes; Lysine; Microbial Sensitivity Tests; Oligopeptides; Protein Conformation | 2003 |
Direct comparison of membrane interactions of model peptides composed of only Leu and Lys residues.
Topics: Anti-Infective Agents; Calorimetry, Differential Scanning; Circular Dichroism; Hemolysis; Humans; Leucine; Liposomes; Lysine; Membrane Fusion; Membranes, Artificial; Models, Biological; Oligopeptides; Peptides; Protein Structure, Secondary | 2003 |
New lytic peptides based on the D,L-amphipathic helix motif preferentially kill tumor cells compared to normal cells.
Topics: Anti-Infective Agents; Antimicrobial Cationic Peptides; Cell Death; Cell Membrane; Fluoresceins; Hemolysis; Humans; Leucine; Lysine; Male; Melanoma, Experimental; Membrane Lipids; Microscopy, Confocal; Mitomycin; Phosphatidylserines; Prostatic Neoplasms; Protein Conformation; Rhodamines; Skin; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Structure-Activity Relationship; Surface Plasmon Resonance; Tumor Cells, Cultured | 2003 |
INHIBITION OF THE C'-1 COMPONENT OF COMPLEMENT BY AMINO ACIDS.
Topics: Amino Acids; Aminocaproates; Aminocaproic Acid; Calcium Chloride; Complement System Proteins; Dialysis; Erythrocytes; Esterases; Hemolysis; Lysine; Pharmacology; Plasminogen; Renal Dialysis; Research | 1964 |
Antibiotic activity of Leu-Lys rich model peptides.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Agents; Bacteria; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Erythrocytes; Fungi; Hemolysis; Humans; Leucine; Lysine; Microbial Sensitivity Tests; Neoplasms; Peptide Fragments | 2003 |
Extracellular lysines on the plasmodial surface anion channel involved in Na+ exclusion.
Topics: Animals; Anions; Cell Membrane Permeability; Erythrocyte Membrane; Erythrocytes; Hemolysis; Humans; Hydrogen-Ion Concentration; Ion Channels; Kinetics; Lysine; Osmosis; Osmotic Pressure; Patch-Clamp Techniques; Plasmodium falciparum; Sodium; Succinimides | 2003 |
Naturally occurring inhibitors and lysins in various centrifugally prepared fractions of adult and fetal guinea pig tissue extracts.
Topics: Fetus; Guinea Pigs; Hemolysis; Lysine; Mucoproteins; Radioactivity; Tissue Extracts; Tissues | 1951 |
Comparison of different ibuprofen-amino acid compounds with respect to emulsifying and cytotoxic properties.
Topics: Adult; Animals; Arginine; Cornea; Drug Combinations; Drug Stability; Emulsifying Agents; Emulsions; Erythrocytes; Hemolysis; Humans; Ibuprofen; Lysine; Male; Surface Tension; Swine | 2004 |
Potential irritation of lysine derivative surfactants by hemolysis and HaCaT cell viability.
Topics: Betaine; Cell Line; Cell Survival; Cetrimonium; Cetrimonium Compounds; Colorimetry; Erythrocytes; Hemolysis; Humans; Inhibitory Concentration 50; Irritants; Lysine; Molecular Structure; Neutral Red; Sodium Dodecyl Sulfate; Surface-Active Agents; Tetrazolium Salts; Thiazoles | 2006 |
Novel lysine-peptoid hybrids with antibacterial properties.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Escherichia coli; Hemolysis; Humans; Lysine; Microbial Sensitivity Tests; Molecular Sequence Data; Peptoids; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staphylococcus aureus | 2005 |
PEGylated peptide dendrimeric carriers for the delivery of antimalarial drug chloroquine phosphate.
Topics: Animals; Antimalarials; Biological Availability; Chloroquine; Chondroitin Sulfates; Delayed-Action Preparations; Dendrimers; Drug Carriers; Drug Stability; Hemolysis; Lysine; Macrophages; Particle Size; Plasmodium falciparum; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Solubility | 2006 |
Biological properties of low molecular mass peptide dendrimers.
Topics: Animals; Anti-Infective Agents; Candida albicans; Cell Line; Cell Survival; Cricetinae; Dendrimers; DNA; Escherichia coli; Hemolysis; Humans; Inhibitory Concentration 50; Lysine; Microbial Sensitivity Tests; Molecular Weight; Oligopeptides; Protein Conformation; Staphylococcus aureus | 2006 |
Potent antibacterial lysine-peptoid hybrids identified from a positional scanning combinatorial library.
Topics: Anti-Bacterial Agents; Cyclohexanes; Erythrocytes; Escherichia coli; Hemolysis; Humans; Lysine; N-substituted Glycines; Oligopeptides; Peptide Library; Peptoids; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Staphylococcus aureus | 2006 |
Hemolysis and antihemolysis induced by amino acid-based surfactants.
Topics: Arginine; Dose-Response Relationship, Drug; Erythrocyte Membrane; Erythrocytes; Hemolysis; Humans; Lysine; Micelles; Osmolar Concentration; Surface-Active Agents | 2007 |
Antiplasmodial activity of lauryl-lysine oligomers.
Topics: Amino Acid Sequence; Animals; Antimalarials; Cell Line; Dogs; Hemolysis; Lysine; Molecular Sequence Data; Peptides; Plasmodium falciparum; Structure-Activity Relationship | 2007 |
The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.
Topics: Acetylation; Alkylation; Amino Acid Sequence; Amino Acids; Chromatography, High Pressure Liquid; Cyclotides; Disulfides; Hemolysis; Lysine; Macrocyclic Compounds; Mass Spectrometry; Molecular Sequence Data; Molecular Weight; Oldenlandia; Oxidation-Reduction; Peptide Mapping; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Tryptophan | 2007 |
Effect of N-chloroamino acids on the erythrocyte.
Topics: Alanine; Amino Acids; Aspartic Acid; Chloramines; Dose-Response Relationship, Drug; Drug Stability; Erythrocytes; Fluoresceins; Glutathione; Glutathione Disulfide; Hemolysis; Humans; Hypochlorous Acid; Lysine; Osmotic Fragility; Oxidants; Oxidation-Reduction; Oxidative Stress; Phenylalanine; Serine | 2008 |
Analogous oligo-acyl-lysines with distinct antibacterial mechanisms.
Topics: Animals; Antimicrobial Cationic Peptides; Cell Membrane; DNA, Bacterial; Escherichia coli; Escherichia coli Infections; Female; Hemolysis; Humans; In Vitro Techniques; Klebsiella pneumoniae; Lysine; Membrane Potentials; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Molecular Structure; Oligopeptides; Peritonitis; Salmonella typhimurium; Sepsis; Surface Plasmon Resonance | 2008 |
Inhibition of accumulative transport by a protein from cobra venom.
Topics: Amino Acids; Aminohippuric Acids; Animals; Antimetabolites; Biological Transport, Active; Erythrocytes; Hemolysis; Hexoses; Humans; In Vitro Techniques; Intestine, Small; Kidney; Kinetics; Leucine; Lysine; Phenylalanine; Proteins; Rats; Snakes; Sodium; Sodium Isotopes; Venoms | 1967 |
[Influence of platelet aggregation inhibitors on platelet damage at prosthetic heart valves in-vitro (author's transl)].
Topics: Aspirin; Blood Platelets; Dipyridamole; Heart Valve Prosthesis; Hemolysis; Humans; Lysine; Platelet Aggregation; Propionates; Sulfinpyrazone | 1981 |
Dissociation of enzymatic activity from lethality and pharmacological properties by carbamylation of lysines in Naja nigricollis and Naja naja atra snake venom phospholipases A2.
Topics: Animals; Chemical Phenomena; Chemistry; Elapid Venoms; Heart; Hemolysis; Lysine; Male; Mice; Muscles; Neurons; Phospholipases; Phospholipases A; Phospholipids; Rats; Snakes; Structure-Activity Relationship | 1981 |
The inhibition by lysine of the activation of the first component of complement, C1.
Topics: Complement Activation; Complement C1 Inactivator Proteins; Complement System Proteins; Dose-Response Relationship, Immunologic; Hemolysis; Humans; Immunoelectrophoresis, Two-Dimensional; Immunoglobulin G; Lysine | 1982 |
Hemolytic, but not cell-invasive activity, of adenylate cyclase toxin is selectively affected by differential fatty-acylation in Escherichia coli.
Topics: Acylation; Adenylate Cyclase Toxin; Amino Acid Sequence; Animals; Binding Sites; Bordetella pertussis; Chromatography, High Pressure Liquid; Cloning, Molecular; Erythrocytes; Escherichia coli; Hemolysis; Lysine; Mass Spectrometry; Molecular Sequence Data; Palmitic Acid; Palmitic Acids; Peptide Fragments; Protein Processing, Post-Translational; Recombinant Proteins; Sheep; Virulence Factors, Bordetella | 1995 |
Fatty acylation of two internal lysine residues required for the toxic activity of Escherichia coli hemolysin.
Topics: Acyl Carrier Protein; Acylation; Acyltransferases; Amino Acid Sequence; Animals; Bacterial Proteins; Bacterial Toxins; Escherichia coli; Escherichia coli Proteins; Hemolysin Proteins; Hemolysis; Horses; Lysine; Mass Spectrometry; Molecular Sequence Data; Protein Precursors; Sequence Alignment | 1994 |
Internal lysine palmitoylation in adenylate cyclase toxin from Bordetella pertussis.
Topics: Acylation; Adenylate Cyclase Toxin; Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Cyclic AMP; Hemolysis; Humans; Lysine; Mass Spectrometry; Molecular Sequence Data; Mutation; Palmitates; Peptide Fragments; Sheep; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1994 |
Substitution of lysine for arginine in the N-terminal 217th amino acid residue of the H gamma II of Staphylococcal gamma-hemolysin lowers the activity of the toxin.
Topics: Amino Acid Sequence; Arginine; Bacterial Proteins; Bacterial Toxins; Base Sequence; Chromatography; Erythrocytes; Hemolysin Proteins; Hemolysis; Humans; Leukocidins; Lysine; Molecular Sequence Data; Protein Engineering; Structure-Activity Relationship | 1995 |
Drastic reduction in antimicrobial activity by replacement of Orn residues with Lys in cyclized amphiphilic beta-structural model peptides.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Circular Dichroism; Complement Hemolytic Activity Assay; Gramicidin; Hemolysis; Humans; Liposomes; Lysine; Molecular Sequence Data; Ornithine; Protein Structure, Secondary; Structure-Activity Relationship | 1995 |
Preliminary studies of the toxic effects of non-ionic surfactants derived from lysine.
Topics: Allantois; Animal Testing Alternatives; Animals; Chick Embryo; Chorion; Fatty Acids; Hemolysis; Irritants; Lysine; Male; Polyethylene Glycols; Rats; Rats, Wistar; Surface-Active Agents; Toxicity Tests | 1996 |
Design and synthesis of amphiphilic alpha-helical model peptides with systematically varied hydrophobic-hydrophilic balance and their interaction with lipid- and bio-membranes.
Topics: Amino Acid Sequence; Bacteria; Cell Membrane; Chromatography, High Pressure Liquid; Circular Dichroism; Fungi; Hemolysis; Leucine; Lipid Metabolism; Liposomes; Lysine; Molecular Sequence Data; Nephelometry and Turbidimetry; Peptides; Permeability; Phosphatidylcholines; Protein Structure, Secondary; Spectrometry, Fluorescence; Structure-Activity Relationship; Surface-Active Agents; Tryptophan | 1996 |
Structural requirements for the edema-inducing and hemolytic activities of mastoparan B isolated from the hornet (Vespa basalis) venom.
Topics: Amino Acid Sequence; Animals; Circular Dichroism; Dose-Response Relationship, Drug; Edema; Erythrocytes; Guinea Pigs; Hemolysis; Intercellular Signaling Peptides and Proteins; Lysine; Peptides; Rats; Rats, Wistar; Structure-Activity Relationship; Tryptamines; Wasp Venoms | 1996 |
Hemolytic action of anionic surfactants of the diacyl lysine type.
Topics: Acylation; Animals; Anions; Erythrocytes; Hemolysis; L-Lactate Dehydrogenase; Lysine; Rats; Surface-Active Agents | 1997 |
Erythrocyte hemolysis and shape changes induced by new lysine-derivate surfactants.
Topics: Adult; Animals; Cell Size; Dose-Response Relationship, Drug; Erythrocytes; Hemolysis; Humans; Hypotonic Solutions; Lysine; Molecular Structure; Rats; Structure-Activity Relationship; Surface Tension; Surface-Active Agents | 1999 |
Screening of cationic compounds as an absorption enhancer for nasal drug delivery.
Topics: Absorption; Administration, Intranasal; Animals; Area Under Curve; Arginine; Cations; Cetylpyridinium; Chitin; Chitosan; Dextrans; Drug Synergism; Erythrocytes; Fluorescein-5-isothiocyanate; Hemolysis; Injections, Intravenous; L-Lactate Dehydrogenase; Lysine; Male; Nasal Mucosa; Peptides; Phospholipids; Proteins; Rabbits; Rats; Rats, Wistar; Surface-Active Agents | 1999 |
Lysine 77 is a key residue in aggregation of equinatoxin II, a pore-forming toxin from sea anemone Actinia equina.
Topics: Amino Acid Substitution; Animals; Binding Sites; Cnidarian Venoms; Cytotoxins; Erythrocyte Membrane; Erythrocytes; Escherichia coli; Hemolysis; Humans; In Vitro Techniques; Kinetics; Lysine; Mutagenesis, Site-Directed; Point Mutation; Recombinant Proteins; Sea Anemones; Spectroscopy, Fourier Transform Infrared | 2000 |
CRAMP analogues having potent antibiotic activity against bacterial, fungal, and tumor cells without hemolytic activity.
Topics: Amino Acid Sequence; Amino Acid Substitution; Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Antimicrobial Cationic Peptides; Antineoplastic Agents; Bacteria; Cathelicidins; Circular Dichroism; Dose-Response Relationship, Drug; Drug Design; Erythrocytes; Fungi; Hemolysis; Humans; Lysine; Micelles; Molecular Sequence Data; Peptides; Protein Structure, Secondary; Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Tumor Cells, Cultured | 2000 |
Acylation of lysine 983 is sufficient for toxin activity of Bordetella pertussis adenylate cyclase. Substitutions of alanine 140 modulate acylation site selectivity of the toxin acyltransferase CyaC.
Topics: Acylation; Acyltransferases; Adenylate Cyclase Toxin; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Bordetella pertussis; Electrophoresis, Gel, Two-Dimensional; Erythrocytes; Hemolysis; Histidine; Lysine; Mass Spectrometry; Molecular Sequence Data; Mutation; Palmitic Acid; Peptide Fragments; Protein Processing, Post-Translational; Sequence Alignment; Serine; Sheep; Substrate Specificity; Virulence Factors, Bordetella | 2001 |
Identification of residues in the carboxy-terminal domain of Clostridium perfringens alpha-toxin (phospholipase C) which are required for its biological activities.
Topics: Amino Acid Substitution; Aspartic Acid; Bacterial Toxins; Calcium-Binding Proteins; Clostridium perfringens; DNA, Bacterial; Egg Yolk; Glutamic Acid; Glycine; Hemolysis; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Phospholipids; Phosphorylcholine; Protein Conformation; Serine; Substrate Specificity; Type C Phospholipases | 2000 |
[Detection of Arcanobacterium haemolyticum in primoculture using the reverse CAMP test].
Topics: Acute Disease; Adolescent; Adult; Bacteriological Techniques; Corynebacterium; Female; Hemolysis; Humans; Lysine; Male; Pharyngitis; Pharynx; Phospholipase D; Staphylococcus aureus; Tonsillitis | 2001 |
Enhancing the hypotensive effect and diminishing the cytolytic activity of hornet mastoparan B by D-amino acid substitution.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Blood Pressure; Chromatography, High Pressure Liquid; Circular Dichroism; Dose-Response Relationship, Drug; Erythrocytes; Guinea Pigs; Hemolysis; Hypotension; Intercellular Signaling Peptides and Proteins; Lysine; Male; Peptides; Rats; Rats, Inbred SHR; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Time Factors; Wasp Venoms; Wasps | 2001 |
Studies of the inhibition of C56-initiated lysis (reactive lysis). IV. Antagonism of the inhibitory activity c567-INH by poly-L-lysine.
Topics: Alpha-Globulins; Animals; Blood; Cell Count; Cell Membrane; Complement C5; Complement C6; Complement C7; Complement Inactivator Proteins; Dose-Response Relationship, Drug; Erythrocytes; Guinea Pigs; Hemagglutination; Hemolysis; Humans; Lysine; Peptides; Sheep | 1975 |
Enzymatic activity of the second component of complement.
Topics: Complement C2; Complement C3; Complement System Proteins; Dipeptides; Esterases; Hemolysis; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Lysine; Oligopeptides; Structure-Activity Relationship | 1975 |
Antibody responses in nude mice injected with limiting numbers of congenic thymus cells.
Topics: Animals; Antibody Formation; Coliphages; Dinitrobenzenes; Dose-Response Relationship, Immunologic; Glutamates; Graft Survival; Hemagglutination Tests; Hemolysis; Lysine; Mice; Mice, Inbred BALB C; Mice, Nude; Skin Transplantation; T-Lymphocytes; Transplantation, Isogeneic; Tyrosine | 1977 |
Potentiation of C56-initiated lysis by leucocyte cationic proteins, myelin basic proteins and lysine-rich histones.
Topics: Animals; Blood Proteins; Cattle; Cell Membrane; Complement C5; Complement C6; Complement System Proteins; Guinea Pigs; Haplorhini; Hemolysis; Histones; Leukocytes; Lysine; Molecular Weight; Myelin Sheath; Nerve Tissue Proteins; Rabbits | 1976 |
Studies on the inhibition of C56-initiated lysis (reactive lysis). V. The roleof C567-INH in the regulation of complement-dependent haemolysis initiated by cobravenom factor.
Topics: Ammonium Sulfate; Animals; Chromatography, Gel; Complement C5; Complement C6; Complement C7; Complement Inactivator Proteins; Erythrocytes; Guinea Pigs; Hemolysis; Humans; Lysine; Molecular Weight; Sheep; Snake Venoms; Venoms | 1975 |
The role of lysine, histidine and carboxyl residues in biological activity of equinatoxin II, a pore forming polypeptide from the sea anemone Actinia equina L.
Topics: Animals; Cattle; Cnidarian Venoms; Diethyl Pyrocarbonate; Hemolysis; Histidine; Humans; Indicators and Reagents; Isoelectric Focusing; Lipoproteins; Lysine; Molecular Weight; Pyridoxal Phosphate; Sea Anemones; Spectrophotometry | 1992 |
Change of glutamic acid to lysine in a 13-residue antibacterial and hemolytic peptide results in enhanced antibacterial activity without increase in hemolytic activity.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Erythrocytes; Escherichia coli; Glutamates; Glutamic Acid; Hemolysis; Hydrogen-Ion Concentration; Kinetics; Lysine; Membrane Potentials; Molecular Sequence Data; Peptide Fragments; Peptides; Proteins; Rats; Seminal Vesicle Secretory Proteins; Structure-Activity Relationship | 1992 |
Effect of lysine on hemolysis-induced kidney damage.
Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Glomerular Filtration Rate; Glycine; Hemoglobins; Hemoglobinuria; Hemolysis; Lysine; Male; Rats; Rats, Inbred Strains; Time Factors | 1992 |
Stabilizing effects of some amino acids on membranes of rabbit erythrocytes perturbed by chlorpromazine.
Topics: Amino Acids; Animals; Aspartic Acid; Chlorpromazine; Erythrocyte Membrane; Glycine; Half-Life; Hemolysis; Hydrogen-Ion Concentration; Hypotonic Solutions; In Vitro Techniques; Lysine; Osmotic Fragility; Rabbits; Sodium Chloride; Spectrophotometry, Infrared; Time Factors | 1989 |
Inhibition by lysine and arginine of the conversion of C3 and B in the serum and a purified system.
Topics: Animals; Arginine; Circular Dichroism; Complement C3; Complement C3b; Complement Inactivator Proteins; Complement Pathway, Alternative; Hemolysis; Humans; Immunoelectrophoresis, Two-Dimensional; Lysine; Protein Conformation; Rabbits; Sulfhydryl Compounds | 1986 |
Comparison of enzymatic and pharmacological activities of lysine-49 and aspartate-49 phospholipases A2 from Agkistrodon piscivorus piscivorus snake venom.
Topics: Animals; Aspartic Acid; Blood Coagulation; Calcium; Crotalid Venoms; Heart; Hemolysis; Kinetics; Lysine; Mice; Neuromuscular Junction; Phospholipases; Phospholipases A; Phospholipases A2; Phospholipids; Rats | 1987 |
Serine esterase and hemolytic activity in human cloned cytotoxic T lymphocytes.
Topics: Cell Line; Centrifugation, Density Gradient; Clone Cells; Cloning, Molecular; Cytotoxicity, Immunologic; Electrophoresis, Polyacrylamide Gel; Esterases; Hemolysis; Humans; Hydrogen-Ion Concentration; Isoflurophate; Lysine; T-Lymphocytes, Cytotoxic | 1988 |
Biosynthesis of the fifth component of complement (C5) by human fetal tissues.
Topics: Carbon Radioisotopes; Complement System Proteins; Culture Techniques; Cycloheximide; Fetus; Gestational Age; Hemolysis; Humans; Immunodiffusion; Intestine, Small; Isoleucine; Leucine; Liver; Lysine; Valine | 1973 |
The role of the first component of the bovine complement system in the haemolytic activity of a bovine derived lytic intermediate.
Topics: Animals; Calcium; Cattle; Chromatography, Gel; Complement System Proteins; Edetic Acid; Erythrocytes; Esterases; Guinea Pigs; Hemolysis; Isoflurophate; Kinetics; Lysine; Magnesium; Mesylates; Methane; Osmolar Concentration; Sheep; Spectrophotometry; Time Factors; Tosyl Compounds; Tritium | 1974 |
Fusion of chicken erythrocytes by phospholipase C (Clostridium perfringens). The requirement for hemolytic and hydrolytic factors for fusion.
Topics: Animals; Bacteria; Cell Fusion; Chickens; Clostridium perfringens; Edetic Acid; Erythrocytes; Hemagglutination Tests; Hemolysis; Hydrogen-Ion Concentration; Immune Sera; Lysine; Manganese; Microscopy, Phase-Contrast; Peptides; Phospholipases; Structure-Activity Relationship; Time Factors; Toxins, Biological | 1974 |
Antibody-dependent cell-mediated cytotoxicity. II. Early interactions between effector and target cells.
Topics: Animals; Antibodies; Cell Membrane; Chickens; Chromium Radioisotopes; Cytotoxicity Tests, Immunologic; Dinitrophenols; Erythrocytes; Female; Hemagglutination Tests; Hemolysis; Immune Sera; Immunity, Cellular; Lymphocytes; Lysine; Mice; Mice, Inbred BALB C; Nitrophenols; Rabbits; Spleen | 1974 |
Platelet aggregation and haemolysis induced in rats by intravenous infusion of ADP - effect of potentially antithrombotic drugs.
Topics: Adenosine Diphosphate; Animals; Aspirin; Depression, Chemical; Female; Hemoglobins; Hemolysis; Infusions, Parenteral; Injections, Intravenous; Lysine; Microscopy, Phase-Contrast; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins E; Pyrimidines; Rats; Stimulation, Chemical; Time Factors | 1974 |
Tosyl lysine chloromethyl ketone inhibition of the initiation of hemoglobin synthesis.
Topics: Adenosine Triphosphate; Animals; Blood Proteins; Carbon Radioisotopes; Cycloheximide; Glutathione; Hemoglobin, Sickle; Hemolysis; In Vitro Techniques; Ketones; Leucine; Lysine; Oxidation-Reduction; Peptide Chain Initiation, Translational; Polyribosomes; Protein Biosynthesis; Rabbits; Reticulocytes; Ribosomes; RNA, Messenger; Time Factors; Tosyl Compounds; Trypsin Inhibitors | 1973 |
Properdin factor D: characterization of its active site and isolation of the precursor form.
Topics: Animals; Binding Sites; Chlorine; Complement System Proteins; Enzyme Activation; Enzyme Precursors; Esterases; Globulins; Hemolysis; Isoflurophate; Lysine; Snakes; Tosyl Compounds; Trypsin; Venoms | 1974 |
Presumptive identification of bacteria from blood cultures in four hours.
Topics: Bacteria; Bacteriological Techniques; Bile; Blood; Carboxy-Lyases; Catalase; Coagulase; Culture Media; Deoxyribonucleases; Fermentation; Galactosidases; Hemolysis; Humans; Indoles; Lactose; Lysine; Methods; Oxidoreductases; Phenylalanine; Phospholipases; Time Factors; Urease | 1971 |
Antibody formation against 2,4-dinitrophenyl-hapten at the cellular level. Hemolytic plaque-in-gel assay for lymphoid cells producing anti-2,4-dinitrophenyl-hapten antibody.
Topics: Animals; Antibody Formation; Benzene Derivatives; Complement System Proteins; Dinitrophenols; Erythrocytes; Haptens; Hemolysis; Immunodiffusion; Lymphocytes; Lysine; Mice; Serum Albumin, Bovine; Sheep; Spleen; Toluene | 1969 |
The influence of modifying the surface properties of sheep red cells upon hemolytic antibody production in mice.
Topics: Adsorption; Animals; Antibody Formation; Antigens; Carbon; Colloids; Electrophoresis; Erythrocyte Count; Erythrocytes; Gelatin; Hemolysis; Liver; Lysine; Mice; Mononuclear Phagocyte System; Organ Size; Pyrogens; Sheep; Spleen; Surface Properties | 1970 |
Adenine nucleotide metabolism of blood platelets. 3. Adenine phosphoribosyl transferase and nucleotide formation from exogenous adenine.
Topics: Adenine; Adenine Nucleotides; Adenosine Triphosphate; Blood Platelets; Carbon Isotopes; Glucosyltransferases; Hemolysis; Humans; Hydrogen-Ion Concentration; Kinetics; Lysine | 1968 |
Excess of alpha-globin synthesis in homozygous beta-thalassemia. Its cytoplasmic molecular forms.
Topics: Adult; Blood Proteins; Centrifugation, Density Gradient; Child; Child, Preschool; Chromatography, Ion Exchange; Cytoplasm; Erythrocytes; Globins; Heme; Hemoglobins; Hemolysis; Homozygote; Humans; Infant, Newborn; Infant, Premature; Leucine; Lysine; Peptides; Thalassemia; Tritium; Valine | 1968 |
Unequal synthesis of complementary globin chains of human fetal hemoglobin by the effect of L-O-methylthreonine.
Topics: Blood Proteins; Carbon Isotopes; Chromatography, Gel; Complement System Proteins; Depression, Chemical; Erythroblastosis, Fetal; Female; Fetal Hemoglobin; Globins; Heme; Hemolysis; Humans; In Vitro Techniques; Infant, Newborn; Isoleucine; Leucine; Lysine; Peptide Biosynthesis; Pregnancy; Solubility; Thalassemia; Threonine | 1969 |