lysine and Disease Models, Animal

Topics: Acetylation; Adaptive Immunity; Animals; Antineoplastic Agents; Carcinogenesis; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Embryonic Development; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Histone Acetyltransferases; Humans; Immunity, Innate; Lysine; Mice; Mice, Transgenic; Mutation; Neoplasms; p300-CBP Transcription Factors

Topics: Acylation; Animals; Disease Models, Animal; Histones; Humans; Lysine; Methylation; Mice; Polycomb-Group Proteins; Rubinstein-Taybi Syndrome

Topics: Acetylation; Animals; Disease Models, Animal; Embryonic Development; Histone Acetyltransferases; Histone Code; Histones; Humans; Lysine; Mice; Neurodevelopmental Disorders; Protein Processing, Post-Translational

Topics: Animals; Cardiomegaly; Disease Models, Animal; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Myocardium; Myocytes, Cardiac; NF-kappa B; Phosphorylation; Protein Processing, Post-Translational; Proteolysis; Proto-Oncogene Proteins c-akt; TNF Receptor-Associated Factor 6; Ubiquitin; Ubiquitin Thiolesterase; Ubiquitination

Topics: Absorption; Animals; Arginine; Biological Availability; Chromatography, Liquid; Cooking; Disease Models, Animal; Food; Glycation End Products, Advanced; Glycosylation; Humans; Lysine; Maillard Reaction; Mass Spectrometry; Molecular Weight; Odorants; Taste

Topics: Amino Acids, Basic; Animals; Arginine; Disease Models, Animal; Endoplasmic Reticulum Stress; Histological Techniques; Lysine; Mice; Molecular Structure; Ornithine; Oxidative Stress; Pancreas; Pancreatitis; Rats; Regeneration

Topics: Acetylation; Animals; Chromatin; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Dogs; Epigenesis, Genetic; Epigenomics; Histones; Humans; Inflammation; Kidney; Lysine; Methylation; Mice; Mice, Transgenic; MicroRNAs; Rats

Topics: Acetylation; Animals; Disease Models, Animal; Epigenesis, Genetic; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lysine; Rats

Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Asthma; Boronic Acids; Bortezomib; Clinical Trials as Topic; Cysteine Endopeptidases; Disease Models, Animal; Humans; Inflammation; Lysine; Models, Biological; Models, Chemical; Multienzyme Complexes; Multiple Sclerosis; Neoplasms; NF-kappa B; Peptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Psoriasis; Pyrazines; Reperfusion Injury

Topics: Animals; Biological Transport; Carnivora; Cycloleucine; Cystine; Cystinuria; Disease Models, Animal; Dogs; Female; History, 19th Century; History, 20th Century; Humans; Intestinal Mucosa; Kidney Cortex; Kidney Tubules; Lysine; Male; Microvilli; Models, Biological

Topics: 4-Aminobenzoic Acid; Animals; Aspergillosis; Aspergillus; Aspergillus fumigatus; Aspergillus nidulans; Disease Models, Animal; Humans; Lung Diseases, Fungal; Lysine; Mice; Molecular Biology; Mutation; Virulence

Topics: Amyloidosis; Animals; Capillary Permeability; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Endothelium, Vascular; Erythrocytes; Glycation End Products, Advanced; Humans; Ligands; Lung; Lysine; Membrane Proteins; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Serum Amyloid A Protein; Tumor Cells, Cultured

Topics: Alveolar Bone Loss; Animals; Diabetes Mellitus; Disease Models, Animal; Endothelium, Vascular; Glycation End Products, Advanced; Hyperglycemia; Immunoglobulins; Ligands; Lysine; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Periodontal Diseases; Periodontitis; Phagocytes; Receptor for Advanced Glycation End Products; Receptors, Immunologic

Topics: Animals; Arteriosclerosis; Chylomicrons; Diet, Atherogenic; Dietary Carbohydrates; Dietary Fats; Dietary Fiber; Dietary Proteins; Disease Models, Animal; Dogs; Haplorhini; Humans; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Lysine; Rabbits; Rats

Topics: Animals; Annexins; Benzazepines; Cornified Envelope Proline-Rich Proteins; Disease Models, Animal; Electrocoagulation; Female; Foot Injuries; Gene Expression Regulation; Gene Knock-In Techniques; Genes, fos; Genes, Reporter; Histone Code; Histones; Hyperalgesia; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuralgia; Neurons; Pain, Postoperative; Pyrimidines; RNA, Messenger; Spinal Cord; Tamoxifen

Topics: Animals; Arginine; Cell Line; Cell Nucleus; Chlorocebus aethiops; Chromatin; Disease Models, Animal; DNA, Viral; Humans; Lysine; Mice, Inbred BALB C; Models, Biological; Mutant Proteins; Mutation; Protein Binding; Protein Domains; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; RNA, Viral; Transcription, Genetic; Vero Cells; Viral Matrix Proteins; Viremia

Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain; Brain Diseases, Metabolic; Disease Models, Animal; Glutaryl-CoA Dehydrogenase; Humans; Lysine; Mice; Mice, Knockout; Quinolinic Acid; Seizures

Topics: Acetylation; Animals; Colitis, Ulcerative; Computational Biology; Dextran Sulfate; Disease Models, Animal; Heat-Shock Proteins; Humans; Lysine; Male; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Proteomics

Topics: Acetylation; Animals; Atrial Natriuretic Factor; Atrial Remodeling; Catechin; Constriction; Disease Models, Animal; Electrocardiography; Heart Failure; Histone Deacetylases; Histones; Lysine; Male; MEF2 Transcription Factors; Natriuretic Peptide, Brain; Survival Rate; Ventricular Remodeling

Topics: Animals; Chemical and Drug Induced Liver Injury; Cysteine; Dictamnus; Disease Models, Animal; Drugs, Chinese Herbal; Ethanol; Furans; Glutathione; Liver; Lysine; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Plant Extracts; Plants, Medicinal; Proteins

Topics: Animals; Antigens, Surface; Binding Sites; Cell Cycle Proteins; Disease Models, Animal; Disease Progression; Fluorescent Antibody Technique; Fluorescent Dyes; Gene Expression; Glutamate Carboxypeptidase II; Glutamates; Humans; Immunohistochemistry; Lysine; Male; Mice; Models, Molecular; Molecular Conformation; Molecular Imaging; Molecular Probes; Prostatic Neoplasms; Protein Binding; Receptors, Kainic Acid; Structure-Activity Relationship; Urea

Topics: Animals; Chronic Pain; Cisplatin; Disease Models, Animal; Histone Code; Histones; Lysine; Male; Mice; Mice, Inbred C57BL; Microglia; Neuralgia; Proteomics

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylation; Animals; Cytokines; Disease Models, Animal; HSP110 Heat-Shock Proteins; Lysine; Mice; Mice, Inbred C57BL; Neuroinflammatory Diseases; Parkinson Disease; Sirtuin 1

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Feedback, Physiological; Glucose; Histones; Lysine; Mice; Mice, Transgenic; Microglia

Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Humans; Isotopes; Lysine; Mammals; Mice; Mice, Transgenic; Prions; Proteomics

Topics: Animals; Disease Models, Animal; Epilepsy, Absence; Epilepsy, Generalized; Lysine; Proteomics; Rats; Seizures

Topics: Albumins; Animals; Carbon; Disease Models, Animal; Hypertension; Kidney; Lysine; Malonyl Coenzyme A; Rats

Topics: Aminopropionitrile; Angiotensin II; Angiotensinogen; Animals; Aortic Aneurysm, Thoracic; Aortic Rupture; Dilatation, Pathologic; Disease Models, Animal; Irbesartan; Losartan; Lysine; Male; Mice; Mice, Inbred C57BL; Protein-Lysine 6-Oxidase; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System

Topics: Adenosine Triphosphate; Animals; Autism Spectrum Disorder; Carboxylic Acids; Chromatography, Liquid; Citrates; Disease Models, Animal; Energy Metabolism; Fragile X Mental Retardation Protein; Fragile X Syndrome; Hippocampus; Intellectual Disability; Lactates; Lysine; Mice; Mice, Knockout; Proteomics; Tandem Mass Spectrometry

Topics: Animals; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Hypersensitivity; Lysine; Mice; Neuralgia; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Spinal Nerves

Topics: Acetyl Coenzyme A; Adjuvants, Immunologic; Animals; Autoimmune Diseases; Depression; Disease Models, Animal; Humans; Interleukin-6; Lysine; Male; Microbiota; Pelvic Pain; Prostate; Prostatitis; Rats; RNA, Ribosomal, 16S; Tumor Necrosis Factor-alpha

Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Brain; Disease Models, Animal; Lysine; Mice; Neurodegenerative Diseases; tau Proteins; Tauopathies

Topics: Acetylation; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cognition; Disease Models, Animal; Histones; Lysine; Mice; Mice, Transgenic; Neurodegenerative Diseases; Organelle Biogenesis; Protein Processing, Post-Translational

Topics: Animals; Colitis, Ulcerative; Dextrans; Disease Models, Animal; Histones; Lactate Dehydrogenase 5; Lysine; Mice; MicroRNAs; Occludin

Topics: Airway Remodeling; Animals; Asthma; Disease Models, Animal; Epithelial Cells; Humans; Lysine; Mice; Ovalbumin; Sirtuin 1; Transforming Growth Factor beta1

Topics: Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Disease Models, Animal; Glioma; Humans; Hypoxia; Jumonji Domain-Containing Histone Demethylases; Lysine; Nuclear Proteins; Temozolomide

Topics: Acetylation; Angiotensin-Converting Enzyme 2; Animals; Brain; Chromatography, Liquid; COVID-19; Disease Models, Animal; Humans; Lysine; Mice; Mice, Transgenic; Peptidyl-Dipeptidase A; SARS-CoV-2; Tandem Mass Spectrometry

Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Histone Methyltransferases; Histones; Humans; Janus Kinases; Lysine; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Tissue Inhibitor of Metalloproteinase-3

Topics: Animals; Disease Models, Animal; HEK293 Cells; Humans; Lysine; Mutation; Proteolysis; Rhodopsin; Ubiquitination

Topics: Acute Lung Injury; Animals; Cell Count; Cytokines; Disease Models, Animal; Glutathione; Lipid Peroxidation; Lipopolysaccharides; Lung; Lysine; Mice; Organ Size; Peroxidase; Sepsis; Superoxide Dismutase

Topics: Alphavirus Infections; Animals; Chikungunya virus; Disease Models, Animal; Kupffer Cells; Lysine; Mice; Mutation, Missense; O'nyong-nyong Virus; Receptors, Immunologic; Viral Envelope Proteins

Topics: Animals; Bone Marrow Transplantation; Cell Lineage; Disease Models, Animal; Doxycycline; Epigenesis, Genetic; Erythroid Cells; Female; Granulocytes; Histones; Leukemia, T-Cell; Lysine; Male; Methionine; Methylation; Mice; Mice, Transgenic; Mouse Embryonic Stem Cells; Mutation; Signal Transduction; Survival Analysis; T-Lymphocytes; Teratoma

Topics: Animals; Cytokines; Disease Models, Animal; Inflammation Mediators; Liver; Lysine; Male; Mice; Mice, Inbred C57BL; NF-kappa B; RAW 264.7 Cells; Reperfusion Injury; TNF Receptor-Associated Factor 6; Ubiquitin-Specific Proteases; Ubiquitination

Topics: Animals; Cell Polarity; Cerebral Hemorrhage; Disease Models, Animal; Down-Regulation; Inflammation; Lysine; Mice; Microglia; MicroRNAs; Neuroprotection; Neuroprotective Agents; PTEN Phosphohydrolase; Signal Transduction; Up-Regulation

Topics: Animals; Antioxidants; Biological Transport; Blood-Brain Barrier; Brain Injuries, Traumatic; Carbon; Cell Death; Cysteine; Disease Models, Animal; Free Radicals; Humans; Lipid Peroxidation; Lysine; Mice; Mice, Inbred C57BL; Morris Water Maze Test; Neurons; Oxidative Stress; Quantum Dots; Reactive Nitrogen Species; Reactive Oxygen Species; Superoxide Dismutase; Tissue Distribution

Topics: Albuminuria; Animals; Antibodies, Monoclonal; Capillary Leak Syndrome; Disease Models, Animal; Female; Fluorescent Dyes; Half-Life; Humans; Immunotoxins; Intravital Microscopy; Kidney Glomerulus; Kidney Tubules, Proximal; Lysine; Mesothelin; Mice; Microscopy, Fluorescence; Neoplasms; Recombinant Proteins; Renal Elimination; Serum Albumin; Staining and Labeling

Topics: 3-Hydroxybutyric Acid; Acyl Coenzyme A; Acylation; Animals; Cell Line, Tumor; Disease Models, Animal; Female; Hepatocytes; Histone Code; Histones; Humans; Ketone Bodies; Liver; Lysine; Male; Mice; Protein Processing, Post-Translational; Sex Factors; Starvation

Topics: Animals; Disease Models, Animal; Female; Graft Rejection; Kidney; Kidney Transplantation; Kynurenine; Lysine; Metabolomics; Mice; Mice, Inbred C57BL; Reperfusion Injury; Succinates

Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Antioxidants; Brain; Cinnamates; Depsides; Dietary Supplements; Disease Models, Animal; Infarction, Middle Cerebral Artery; Lysine; Male; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Rosmarinic Acid

Topics: Animals; Apoptosis; beta-Arrestin 1; Cytokines; Disease Models, Animal; Hepatocytes; Immunohistochemistry; Inflammation Mediators; Liver Diseases; Lysine; Male; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; Mice; Reperfusion Injury; TNF Receptor-Associated Factor 6; Ubiquitination

Topics: Animals; Animals, Genetically Modified; Anion Transport Proteins; Bicarbonates; Biological Transport; Corneal Dystrophies, Hereditary; Disease Models, Animal; Endothelium, Corneal; Gene Expression Regulation; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Ion Transport; Lysine; Mice; Mutation; Oocytes; Sodium; Symporters; Xenopus

Topics: Animals; Apoptosis; Atherosclerosis; Cells, Cultured; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipoproteins, LDL; Lysine; Male; Methylation; Mice, Knockout, ApoE; MicroRNAs; Phosphorylation; Plaque, Atherosclerotic; Signal Transduction; STAT3 Transcription Factor

Topics: Acetylation; Animals; Carnitine O-Acetyltransferase; Disease Models, Animal; Energy Metabolism; Heart Failure; Lysine; Male; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Heart; Mitochondrial Proteins; Myocytes, Cardiac; Oxidative Stress; Protein Processing, Post-Translational; Proteome; Proteomics; Sirtuin 3

Topics: Animals; Brain; Cell Death; Cells, Cultured; Disease Models, Animal; Humans; Huntingtin Protein; Huntington Disease; Lysine; Neurons; Proteasome Endopeptidase Complex; Protein Aggregation, Pathological; Rats; Rats, Transgenic; Ubiquitination

Topics: Animals; Cell Survival; Disease Models, Animal; Endocytosis; Hyaline Cartilage; Imaging, Three-Dimensional; Iron; Lysine; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Mesenchymal Stem Cells; Rats; Rats, Wistar; Regeneration; Staining and Labeling

Topics: Aldehyde Dehydrogenase; Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Female; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Pyridoxine

Topics: Adaptor Proteins, Signal Transducing; Animals; Cardiovirus Infections; Disease Models, Animal; Encephalomyocarditis virus; Female; HEK293 Cells; Herpes Simplex; Herpesvirus 1, Human; Host-Pathogen Interactions; Humans; Immunity, Innate; Lysine; Macrophages; Male; Membrane Proteins; Mice; Mice, Knockout; Primary Cell Culture; Protein Aggregates; RNA, Small Interfering; Ubiquitin-Protein Ligases; Ubiquitination

Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Dogs; Hypoglycemic Agents; Injections; Insulin; Insulin Glargine; Lysine; Male; Rats; Rats, Sprague-Dawley; Streptozocin

Topics: Animals; Brain Neoplasms; Disease Models, Animal; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Lysine; Methylation; Mice, Knockout; Proto-Oncogene Proteins c-myc; ras Proteins; Tumor Suppressor Protein p53

Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Glomerular Filtration Rate; Histocompatibility Antigens Class I; Kidney Tubules, Proximal; Liver; Lysine; Male; Microscopy, Fluorescence, Multiphoton; Protein Binding; Protein Carbamylation; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Fc; Renal Insufficiency, Chronic; Scattering, Small Angle; Serum Albumin; Tandem Mass Spectrometry; Time Factors; X-Ray Diffraction

Topics: Animals; Anti-Infective Agents; Disease Models, Animal; Humans; Lysine; Macrophages; Mice

Topics: Acyltransferases; Amino Acid Metabolism, Inborn Errors; Animals; Disease Models, Animal; Glutarates; Humans; Lysine; Metabolic Diseases; Mice; Mice, Inbred Strains; Oxidoreductases; Phenotype; Transferases

Topics: Acetylation; Animals; Cell Line; Diabetic Nephropathies; Disease Models, Animal; Down-Regulation; Epithelial Cells; Epithelial-Mesenchymal Transition; Glucose; Humans; Inflammation; Kidney Tubules; Lysine; Male; Mice, Inbred C57BL; Mitochondrial Proteins; Nerve Tissue Proteins; Oxidative Stress; Proteinuria; Reactive Oxygen Species; Streptozocin; Superoxide Dismutase; Ubiquitination

Topics: Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; Cell Line, Tumor; Disease Models, Animal; Humans; Lysine; Male; Mice; Positron-Emission Tomography; Prostate-Specific Antigen; Prostatic Neoplasms; Urea; Xenograft Model Antitumor Assays

Topics: Amino Acid Metabolism, Inborn Errors; Animals; Arginine; Brain; Brain Diseases, Metabolic; Creatine; Disease Models, Animal; Gene Knock-In Techniques; Gliosis; Glutaryl-CoA Dehydrogenase; Humans; Lysine; Metabolism, Inborn Errors; Rats

Topics: Adaptor Proteins, Signal Transducing; Animals; Cardiovirus Infections; Cell Line, Tumor; Disease Models, Animal; Encephalomyocarditis virus; Gene Knockdown Techniques; HEK293 Cells; Humans; Immunity, Innate; Interferon Type I; Lysine; Male; Mice; Mice, Knockout; Protein Processing, Post-Translational; RAW 264.7 Cells; Recombinant Proteins; Respirovirus Infections; Sendai virus; Signal Transduction; Tripartite Motif Proteins; Ubiquitin Thiolesterase; Ubiquitin-Protein Ligases; Ubiquitination

Topics: Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Glycation End Products, Advanced; Glycosylation; Gold; Guanidines; Lysine; Male; Metal Nanoparticles; Proteins; Pyruvaldehyde; Rats; Rats, Wistar

Topics: Animals; Animals, Newborn; Chondrocytes; Chondrogenesis; Collagen Type I; Disease Models, Animal; Fibrosis; Gait; Gene Deletion; Gene Expression Regulation; Hedgehog Proteins; Hydroxylation; Inflammation; Joints; Ligaments; Lysine; Mice; Models, Biological; Motor Activity; Ossification, Heterotopic; Osteogenesis; Osteogenesis Imperfecta; Peptides; Sequence Analysis, RNA; Signal Transduction; Tacrolimus Binding Proteins; Tendons

Topics: Acetylation; Animals; Cell Cycle Proteins; Cellular Senescence; Disease Models, Animal; Herpes Simplex; Herpesvirus 1, Human; Histone Chaperones; Histone Deacetylase 1; Histones; Lysine; Models, Biological; Neurons; Rats, Wistar; Recurrence; Sin3 Histone Deacetylase and Corepressor Complex; Transcription Factors; Virus Latency

Topics: Animals; Cell Differentiation; Cell Lineage; Cell Polarity; Cell Proliferation; Chromatin; Citric Acid Cycle; Colitis; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Epigenome; Histones; Inflammation; Lymphocyte Subsets; Lysine; Mice; Mice, Inbred C57BL; Ornithine Decarboxylase; Polyamines; T-Lymphocytes, Helper-Inducer; Th17 Cells; Transcription Factors

Topics: A549 Cells; Amino Acid Sequence; Animals; Disease Models, Animal; Dogs; Gene Knockdown Techniques; HEK293 Cells; HeLa Cells; Hemagglutinin Glycoproteins, Influenza Virus; Host Microbial Interactions; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Lysine; Lysosomes; Madin Darby Canine Kidney Cells; Male; Mice; Ubiquitin-Protein Ligases; Ubiquitination; Viral Matrix Proteins; Virus Replication

Topics: Animals; Aorta, Thoracic; Arterial Pressure; Disease Models, Animal; Energy Metabolism; Fibrosis; Hypertrophy, Left Ventricular; Ligation; Lysine; Male; Metabolome; Metabolomics; Myocardium; Proteolysis; Rats, Sprague-Dawley; Time Factors; Ventricular Function, Left; Ventricular Remodeling

Topics: Animals; Bacterial Proteins; Burkholderia pseudomallei; Cell Line; Disease Models, Animal; DNA, Bacterial; Female; Gene Expression Regulation, Bacterial; Genes, Bacterial; Humans; Lysine; Macrophages; Melioidosis; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Multigene Family; Mutagenesis, Insertional; Mutation; Neutrophils; Peptide Synthases; Polyketide Synthases; Proteasome Inhibitors; Sequence Deletion; Survival; Virulence; Virulence Factors

Topics: Acetylation; Animals; Carcinoma, Hepatocellular; Cell Death; Disease Models, Animal; Histones; Humans; Liver Neoplasms; Lysine; Mice; Non-alcoholic Fatty Liver Disease

Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetylation; Acetyltransferases; Acyl-CoA Dehydrogenase; Animals; Cell Line; Diet, High-Fat; Disease Models, Animal; Energy Metabolism; Fatty Acids; Gene Expression Regulation, Enzymologic; Lysine; Male; Mice, Inbred C57BL; Mitochondria, Heart; Mitochondrial Proteins; Myocytes, Cardiac; Nerve Tissue Proteins; Obesity; Oxidation-Reduction; Protein Processing, Post-Translational; Pyruvate Dehydrogenase Complex; Rats; RNA Interference; Sirtuin 3; Sirtuins; Time Factors; Transfection

Topics: Animals; Carcinogenesis; Disease Models, Animal; Female; Intestinal Mucosa; Lysine; Metaplasia; Rats; Urinary Bladder; Urinary Diversion

Topics: Acetylation; Adult; Animals; Cardiomyopathies; Disease Models, Animal; Frataxin; Friedreich Ataxia; Heart Failure; Humans; Iron-Binding Proteins; Lysine; Male; Mice; Middle Aged; Mitochondria; Mitochondrial Proteins; Sirtuin 3

Topics: Alanine; Animals; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Female; Gene Expression Regulation; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Phosphorylation; Protein Kinase C; Receptors, AMPA; Stress, Psychological; Swimming

Topics: Animals; Aspergillosis; Aspergillus fumigatus; Bacterial Proteins; Biological Factors; Disease Models, Animal; Insecta; Lysine; Mice; Secondary Metabolism; Siderophores; Transferases (Other Substituted Phosphate Groups); Virulence Factors

Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Apoptosis; Calcium; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Endocytosis; Female; Humans; Hydrophobic and Hydrophilic Interactions; Leucine; Lysine; MCF-7 Cells; Membrane Potential, Mitochondrial; Mice; Peptides; Permeability; Protein Binding; Reactive Oxygen Species; Xenograft Model Antitumor Assays

Topics: Animals; Antigens, Bacterial; Bacterial Outer Membrane Proteins; Bacterial Proteins; Disease Models, Animal; Disease Reservoirs; Female; Host-Parasite Interactions; Humans; Leptospira interrogans; Leptospirosis; Lipoproteins; Lysine; Protein Processing, Post-Translational; Proteome; Rats; Rats, Sprague-Dawley; Zoonoses

Topics: 5-Methylcytosine; Acetyl Coenzyme A; Acetylation; Animals; Antibiotics, Antineoplastic; Cardiotoxicity; Disease Models, Animal; DNA Methylation; DNA, Mitochondrial; Doxorubicin; Epigenesis, Genetic; Heart Diseases; Histone Deacetylases; Lysine; Male; Mitochondria, Heart; Mitochondrial Proteins; Organelle Biogenesis; Protein Processing, Post-Translational; Rats, Wistar; RNA, Messenger; Transcription, Genetic

Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Glucose; Glycation End Products, Advanced; Humans; Inflammation; Inflammation Mediators; Inflammatory Bowel Diseases; Intestines; Lipid Peroxidation; Lysine; Male; Rats; Rats, Wistar

Topics: Aldehyde Dehydrogenase; Animals; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Gene Knockout Techniques; Humans; Lysine; Mutation; Pyridoxine; Seizures; Vitamin B 6; Zebrafish

Topics: Abnormalities, Multiple; Animals; Cell Survival; Disease Models, Animal; Face; Female; Gene Expression Regulation, Developmental; HEK293 Cells; Hematologic Diseases; Histone Demethylases; Humans; Lysine; Male; Mice, Knockout; Mice, Transgenic; Mutation; Neural Crest; Nuclear Proteins; Skull; Vestibular Diseases

Topics: alpha-Synuclein; Animals; Bromodeoxyuridine; Caspase 3; Cell Proliferation; Disease Models, Animal; Doublecortin Domain Proteins; Gene Expression Regulation; Glutamic Acid; Hippocampus; Lysine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Mutation; Neurodegenerative Diseases; Neurogenesis; Neurons; Neuropeptides; Phosphopyruvate Hydratase; SOXB1 Transcription Factors

Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; CD36 Antigens; Cell Migration Inhibition; Cell Movement; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Foam Cells; Glycation End Products, Advanced; Lysine; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; RAW 264.7 Cells

Topics: Animals; Bradycardia; Coronary Artery Disease; Death, Sudden, Cardiac; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Lysine; Metabolomics; Myocardial Ischemia; Purines; Rats

Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic; CD3 Complex; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutaryl-CoA Dehydrogenase; Inflammation; Lysine; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Quinolinic Acid; S100 Calcium Binding Protein beta Subunit; Statistics, Nonparametric; Time Factors; Tyrosine

Topics: Amines; Animals; Carotid Arteries; Dipeptides; Disease Models, Animal; Fibrinogen; Fibrinolysis; Fucose; Glucose; Humans; Intravital Microscopy; Lysine; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Polysaccharides; Serum Albumin; Sulfates; Thrombelastography; Thrombosis; Tissue Plasminogen Activator; Venous Thrombosis

Topics: Animals; Cornea; Disease Models, Animal; Dry Eye Syndromes; Female; Lacrimal Apparatus; Lysine; Male; Mice; Mice, Inbred C57BL; Tears

Topics: Acetylation; Animals; Aorta; Aortic Diseases; Atherosclerosis; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Female; Histones; Humans; Intercellular Adhesion Molecule-1; Interleukins; Lysine; Lysophosphatidylcholines; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Mitochondria; Protein Processing, Post-Translational; Reactive Oxygen Species; Receptors, Interleukin; Transcription Factor AP-1

Topics: Adenosine; Amino Acid Motifs; Animals; Calpain; Disease Models, Animal; Epigenesis, Genetic; Female; Histones; Humans; Lysine; Male; Methylation; Mice; Mice, Inbred ICR; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Retina; Retinal Degeneration

Topics: Animals; Aspartic Acid; Brain; Cell Respiration; Cuprizone; Disease Models, Animal; Electron Transport Complex III; Erythropoietin; Hemoglobins; Histones; Lysine; Male; Methylation; Mice, Inbred C57BL; Mitochondria; Models, Biological; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neurons; Up-Regulation

Topics: Animals; Antineoplastic Agents; Carcinoma in Situ; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Diabetes Complications; Disease Models, Animal; Disease Progression; Genes, ras; Humans; Lysine; Mice, Inbred C57BL; Mice, Transgenic; Pancreatic Neoplasms; Peptides; Receptor for Advanced Glycation End Products; Risk Factors; Signal Transduction; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays

Topics: Animals; Animals, Newborn; Cadherins; Chromosome Deletion; Chromosomes, Human, Pair 9; Cognitive Dysfunction; Craniofacial Abnormalities; Disease Models, Animal; Gene Expression Regulation; Heart Defects, Congenital; Hippocampus; Histone-Lysine N-Methyltransferase; Histones; Intellectual Disability; Lysine; Male; Methylation; Mice, Knockout

Topics: Aged; Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Cholesterol; Choline; Disease Models, Animal; Feces; Female; Gastrointestinal Microbiome; Genome-Wide Association Study; Humans; Lysine; Male; Metabolomics; Methylamines; Mice; Mice, Inbred C57BL; Middle Aged; Nutrients; Risk Factors; Thrombosis

Topics: Acute-On-Chronic Liver Failure; Animals; Biocatalysis; Chromatin; Cytokines; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Female; Histones; Humans; Indoles; Inflammation Mediators; Kupffer Cells; Lipopolysaccharides; Liver; Lysine; Methylation; Mice, Inbred C57BL; NF-kappa B; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Pyridones; Signal Transduction; Tumor Necrosis Factor-alpha

Topics: Aging; Alanine Transaminase; Animals; Blood Glucose; Carnitine O-Palmitoyltransferase; Cholesterol; Diet; Dietary Supplements; Disease Models, Animal; Liver; Lysine; Male; Metabolic Syndrome; Mice; Non-alcoholic Fatty Liver Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Proto-Oncogene Proteins c-akt; Risk Factors; RNA, Messenger; Triglycerides

Topics: A549 Cells; Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Humans; Lung Neoplasms; Lysine; Male; Mice; Protein Carbonylation; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor for Advanced Glycation End Products

Topics: ADAM10 Protein; Analysis of Variance; Animals; Denervation; Disease Models, Animal; Fibroblasts; HMGB1 Protein; Hypertension; Kidney; Leukocytes, Mononuclear; Ligands; Lysine; Male; Metabolic Syndrome; Myocardium; Obesity; Protein Isoforms; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Adrenergic, beta; Statistics, Nonparametric; Sympathetic Nervous System; Up-Regulation

Topics: Amino Acid Sequence; Amino Acids; Animals; Blood Glucose; Collagen Type I; Cross-Linking Reagents; Diabetes Mellitus, Type 2; Disease Models, Animal; Glycated Hemoglobin; Glycation End Products, Advanced; Glycosylation; Hydroxylation; Hydroxylysine; Lysine; Male; Mass Spectrometry; Mice; Obesity; Protein-Lysine 6-Oxidase; Tail; Tendons

Topics: Acetylation; Animals; Cell Cycle; Cell Hypoxia; Cell Line; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Histones; Homeodomain Proteins; Lysine; Male; Mice, Inbred C57BL; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Protein Processing, Post-Translational; Pulmonary Arterial Hypertension; Pulmonary Artery; RNA, Long Noncoding; Signal Transduction; Up-Regulation

Topics: Acetylation; Animals; Brain Ischemia; Disease Models, Animal; Epigenesis, Genetic; Hippocampus; Histones; Hyperhomocysteinemia; Lysine; Male; Rats; Rats, Wistar

Topics: Actins; Adult; Animals; Arginine; Cardiomyopathy, Dilated; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Glycolysis; Heart Failure; Heart Ventricles; Humans; Lysine; Male; Mice; Middle Aged; Myosins; Pyruvaldehyde; Sarcomeres; Single-Cell Analysis

Topics: Animals; Brain Stem Neoplasms; Cells, Cultured; Child; Chromatin; Disease Models, Animal; Embryonic Stem Cells; Glioma; Histones; Humans; Lysine; Mice; Polycomb Repressive Complex 2

Topics: Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Models, Animal; Epigenesis, Genetic; Glucose Transporter Type 4; Histones; Humans; Insulin; Lysine; Male; Methylation; Mice; Muscle, Skeletal; Promoter Regions, Genetic; Rats; Resveratrol

Topics: Alzheimer Disease; Animals; Chromosome Deletion; Cognition; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Hippocampus; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Memory Disorders; Methylation; Mice; Mice, Transgenic; Prefrontal Cortex; Synapses

Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Female; Glutamic Acid; Hippocampus; Lysine; Microdialysis; Neurotransmitter Agents; Pilocarpine; Rats; Scopolamine; Seizures; Status Epilepticus; Temporal Lobe

Topics: Acetylation; Animals; Blotting, Western; Cells, Cultured; Disease Models, Animal; Humans; Isothiocyanates; Lysine; Melanoma; Methylation; Mice

Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Myelin Sheath; NF-E2-Related Factor 2; Optic Nerve; Oxidative Stress; Retinal Ganglion Cells; Vision Disorders

Topics: Animals; Cataract; Cyanobacteria; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Glycation End Products, Advanced; Lens, Crystalline; Lysine; Male; Mice, Inbred Strains; Oxidative Stress; Streptozocin; Tandem Mass Spectrometry

Topics: Animals; Azoxymethane; Carcinogens; Colorectal Neoplasms; Disease Models, Animal; Gum Arabic; Lysine; Male; Oxidative Stress; Precancerous Conditions; Propolis; Rats; Rats, Wistar

Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Disease Models, Animal; Forkhead Transcription Factors; Gene Expression Regulation; Lysine; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Knockout; T-Lymphocytes, Regulatory; TNF Receptor-Associated Factor 6; Ubiquitination

Topics: Animals; Bile Acids and Salts; Cholesterol; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fatty Acids; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipid Metabolism; Liver; Liver Function Tests; Lysine; Mice; Triglycerides

Topics: Acetylation; Animals; Cardiomyopathy, Restrictive; Cell Nucleus; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; DNA-Binding Proteins; Epigenesis, Genetic; Heart; Histone Deacetylase 1; Histones; Lysine; Methylation; Mice; Muscle Proteins; Mutation; Myocytes, Cardiac; Promoter Regions, Genetic; Transcription Factors; Troponin I

Topics: Action Potentials; Angiogenesis Inhibitors; Animals; Chloroquine; Disease Models, Animal; In Vitro Techniques; Interneurons; Luminescent Proteins; Lysine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle Proteins; Nitrobenzoates; p-Methoxy-N-methylphenethylamine; Patch-Clamp Techniques; Proto-Oncogene Proteins c-fos; Pruritus; Somatostatin; Spinal Cord; tau Proteins

Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; Lysine; Male; Mice; Mice, Transgenic; Molecular Docking Simulation; Protein Isoforms; Sirtuin 2; Structure-Activity Relationship; Thiourea

Topics: Acetylation; Amidohydrolases; Animals; Aspergillus fumigatus; Candida albicans; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Female; Fungal Proteins; Host-Pathogen Interactions; Humans; Lysine; Mice; Mice, Inbred C57BL; Peptide Chain Elongation, Translational; Peptides; Protein Processing, Post-Translational; Proteomics; Saccharomyces cerevisiae; Survival Analysis; Virulence

Topics: Animals; Corpus Striatum; Disease Models, Animal; Glutarates; Glutaryl-CoA Dehydrogenase; Lysine; Mice, Knockout; Neostriatum; Oxidation-Reduction; Oxidative Stress; Signal Transduction

Topics: Acetylation; Animals; Chromatin Immunoprecipitation Sequencing; Colitis; Dextran Sulfate; Disease Models, Animal; Enhancer Elements, Genetic; Epigenesis, Genetic; Histones; Inflammation; Inflammatory Bowel Diseases; Lysine; Male; Mice; Mice, Inbred C57BL; RNA-Seq; Transcription Factors; Up-Regulation

Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic; Carnitine; Corpus Striatum; Diet; Disease Models, Animal; Glutaryl-CoA Dehydrogenase; Glutathione Peroxidase; Lysine; Mice; Mice, Knockout; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase

Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adrenergic Agents; Anesthetics, Local; Animals; Animals, Newborn; Bicuculline; Biophysics; Calcium; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; Feedback, Physiological; GABA Antagonists; gamma-Aminobutyric Acid; Green Fluorescent Proteins; In Vitro Techniques; Lidocaine; Lysine; Male; Mice; Mice, Transgenic; Monte Carlo Method; Neostriatum; Neural Inhibition; Neural Pathways; Neurons; Oxidopamine; Parkinsonian Disorders; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Wistar; Reaction Time; Receptors, Dopamine D1; Receptors, Dopamine D2; Synaptic Transmission; Time Factors; Valine

Topics: Action Potentials; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Functional Laterality; Ganglia, Spinal; Hyperalgesia; Lysine; Male; NAV1.6 Voltage-Gated Sodium Channel; Pain Measurement; Pain Threshold; Physical Stimulation; Psychophysics; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sensory Receptor Cells; Up-Regulation

Topics: Animals; Disease Models, Animal; DNA Damage; DNA Repair; Enzyme Stability; Fibroblasts; HEK293 Cells; Heterochromatin; Histones; Humans; Lamin Type A; Longevity; Lysine; Methylation; Methyltransferases; Mice; Nuclear Proteins; Progeria; Protein Binding; Protein Precursors; Protein Processing, Post-Translational; Repressor Proteins

Topics: Amino Acid Substitution; Animals; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; DNA Mutational Analysis; Encephalitis Virus, Eastern Equine; Encephalomyelitis, Equine; Heparitin Sulfate; Lysine; Mice; Mutagenesis, Site-Directed; Protein Binding; Receptors, Virus; Static Electricity; Viral Envelope Proteins; Virus Attachment

Topics: Aging; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anthraquinones; Brain; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Glutathione Peroxidase; Interleukin-6; Lysine; Male; Malondialdehyde; Mice; Oxidative Stress; Sirtuin 1; Superoxide Dismutase; Tumor Necrosis Factor-alpha

Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; Disease Models, Animal; DNA-Binding Proteins; Genes; Histones; Humans; Lysine; Male; Mice; Oncogene Proteins; Phenotype; Principal Component Analysis; Prostate; Prostatic Neoplasms; Proto-Oncogene Proteins c-ets; PTEN Phosphohydrolase; Receptors, Androgen; Signal Transduction; Transcription Factors; Transcriptional Regulator ERG; Transcriptome

Topics: Adult; Aged; Animals; Anti-Bacterial Agents; Cathepsin G; Cystic Fibrosis; Disease Models, Animal; DNA; Female; Flow Cytometry; Humans; Leukocyte Elastase; Lung; Lysine; Male; Mice; Middle Aged; Neutrophils; Peptide Hydrolases; Proteolysis; Pseudomonas aeruginosa; Sputum; Staphylococcus aureus

Topics: Analysis of Variance; Animals; Corpus Striatum; Dendritic Spines; Disease Models, Animal; Exercise Test; Green Fluorescent Proteins; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; MPTP Poisoning; Neurons; Physical Conditioning, Animal; Receptors, Dopamine D2; Silver Staining; Time Factors

Topics: Animals; Animals, Genetically Modified; Biophysical Phenomena; Biophysics; Calcium; Calcium Channels; Calcium Channels, N-Type; Computer Simulation; Disease Models, Animal; Drosophila; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; HEK293 Cells; Humans; Intracellular Fluid; Lysine; Membrane Potentials; Migraine with Aura; Models, Biological; Mutation; Neuromuscular Junction; Patch-Clamp Techniques; Quinones; Serine; Transfection

Topics: alpha 1-Antitrypsin; Animals; Biomarkers; Disease Models, Animal; Endoplasmic Reticulum; Glutamic Acid; Humans; Interleukin-6; Lysine; Macrophages; Mice; Mice, Transgenic; Mutation; Neutrophils; NF-kappa B; Oxidative Stress; Phenotype; Pulmonary Disease, Chronic Obstructive; Tobacco Smoke Pollution; Trypsin Inhibitors; Tumor Necrosis Factor-alpha

Topics: Acetylation; Analgesics; Animals; Brain-Derived Neurotrophic Factor; Curcumin; Cyclooxygenase 2; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Histones; Lysine; Male; Neuralgia; Nociception; p300-CBP Transcription Factors; Promoter Regions, Genetic; Protein Transport; Rats; Rats, Sprague-Dawley; Spinal Cord

Topics: alpha-Synuclein; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Gene Expression Regulation; Glutamic Acid; Humans; Lewy Body Disease; Lysine; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Synapses; Thy-1 Antigens

Topics: Albumins; Animals; Arginine; Birds; Diabetes Mellitus, Type 2; Disease Models, Animal; Fructosamine; Glucose; Glycation End Products, Advanced; Lysine; Maillard Reaction; Pyruvaldehyde; Taurine

Topics: Animals; Cysteine Proteinase Inhibitors; Disease Models, Animal; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Leupeptins; Lysine; Matrix Metalloproteinase 13; Mice, Inbred C57BL; Mice, Transgenic; Osteoarthritis; Proteasome Endopeptidase Complex; Signal Transduction; Ubiquitination; Zinc Fingers

Topics: Animals; B-Lymphocytes; Blotting, Western; Bone Marrow Cells; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Flow Cytometry; Gene Expression Profiling; Histones; Humans; Kaplan-Meier Estimate; Lymphoma; Lymphoma, B-Cell; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Polycomb Repressive Complex 2; Proto-Oncogene Proteins c-myc; Spleen

Topics: 3T3 Cells; Alleles; Animals; Caenorhabditis elegans; Cell Proliferation; Cell Transformation, Neoplastic; Cellular Senescence; Disease Models, Animal; Embryo Loss; Embryonic Development; Eukaryotic Translation Initiation Factor 5A; Fibroblasts; Gene Knockout Techniques; Hydroxylation; Lysine; Mice; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Phenotype; Protein Biosynthesis; Proto-Oncogene Proteins c-myc; ras Proteins; RNA-Binding Proteins

Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Methylation; Mice; Mitogen-Activated Protein Kinases; Oncogene Protein p21(ras); Pancreatic Neoplasms; Protein Phosphatase 2; Proto-Oncogene Proteins A-raf; Signal Transduction

Topics: Animals; Buffers; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Humans; Hydrogen-Ion Concentration; Lysine; Melanoma, Experimental; Mice; Neoplasm Metastasis; Neoplasms

Topics: 2-Aminoadipic Acid; Animal Structures; Animals; Candida albicans; Candidiasis; Colony Count, Microbial; Culture Media; Disease Models, Animal; Fungal Proteins; Gene Knockout Techniques; Lysine; Mice; Virulence

Topics: Animals; Disease Models, Animal; ELAV Proteins; ELAV-Like Protein 3; Gene Expression Regulation; LIM-Homeodomain Proteins; Locomotion; Lysine; Morpholinos; Nerve Regeneration; Phosphoprotein Phosphatases; Recovery of Function; RNA, Messenger; Spinal Cord Injuries; Swimming; Time Factors; Transcription Factors; Zebrafish; Zebrafish Proteins

Topics: Animals; Anti-Bacterial Agents; Antioxidants; Bandages; Benzaldehydes; Burns; Disease Models, Animal; Escherichia coli; Hydrogels; Lysine; Materials Testing; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Polyvinyl Alcohol; Rats; Staphylococcus aureus; Tensile Strength; Wound Healing

Topics: Amino Acid Metabolism, Inborn Errors; Analysis of Variance; Animals; Animals, Newborn; Brain; Brain Diseases, Metabolic; Brain Injuries; Catalase; Disease Models, Animal; Glutaryl-CoA Dehydrogenase; Glutathione; Glutathione Peroxidase; Lysine; Mice; Mice, Transgenic; Neuroprotective Agents; Oxidation-Reduction; Oxidative Stress; Superoxide Dismutase

Topics: Aminoglycosides; Animals; Apoptosis; Benzamidines; Caspase 3; Cyclopropanes; Cytoprotection; Disease Models, Animal; Hair Cells, Auditory; Histone Demethylases; Histones; Lysine; Methylation; Mice, Inbred C57BL; Neomycin; Organ of Corti; Phenyl Ethers; Piperazines

Topics: Amino Acid Substitution; Animals; Chromatin; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Gene Silencing; Glioma; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methionine; Methylation; Mutation; Signal Transduction

Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain; Brain Diseases, Metabolic; Deamination; Disease Models, Animal; Genetic Predisposition to Disease; Glutaryl-CoA Dehydrogenase; Liver; Lysine; Mice, Knockout; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Peroxisomes; Phenotype; Pipecolic Acids

Topics: Animals; Antineoplastic Agents, Alkylating; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Cyclophosphamide; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Humans; Lymphocyte Activation; Lymphocyte Depletion; Lymphocytes, Tumor-Infiltrating; Lysine; Mice; Mice, Knockout; Myeloid Cells; Neoplasms; Nitric Oxide Synthase Type II; T-Lymphocytes, Regulatory; Transcription, Genetic; Transforming Growth Factor beta1; Tumor Burden

Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Liver; Lysine; Mice, Inbred C57BL; Obesity; Protein Processing, Post-Translational; Proteins

Topics: Action Potentials; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Computer Simulation; Dendrites; Disease Models, Animal; Electric Stimulation; Female; Hippocampus; Humans; In Vitro Techniques; Lysine; Male; Mice; Mice, Transgenic; Models, Neurological; Mutation; Nerve Degeneration; Neurons; Presenilin-1

Topics: Amino Acids; Animals; Arginine; Body Water; Bone and Bones; Bone Matrix; Collagen; Diaphyses; Disease Models, Animal; Femur; Lysine; Male; Rats; Renal Insufficiency, Chronic; Stress, Mechanical

Topics: Animals; Cell Size; Cell Survival; Dendrites; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; Female; Immunohistochemistry; Lysine; Male; Mice, Transgenic; Miniature Postsynaptic Potentials; Mossy Fibers, Hippocampal; Patch-Clamp Techniques; Pilocarpine; Receptors, AMPA; Tissue Culture Techniques

Topics: Aconitate Hydratase; Amino Acid Metabolism, Inborn Errors; Animals; Brain; Brain Diseases, Metabolic; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Energy Metabolism; Female; Genetic Predisposition to Disease; Glutarates; Glutaryl-CoA Dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenases; Ketoglutarate Dehydrogenase Complex; Lysine; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Risk Factors; Sex Factors; Spectrophotometry

Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Dentate Gyrus; Disease Models, Animal; Epilepsies, Myoclonic; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hyperthermia, Induced; In Vitro Techniques; Lysine; Male; Mice; Mice, Transgenic; Models, Molecular; Mutation; NAV1.1 Voltage-Gated Sodium Channel; Nerve Net; Neurons; Seizures

Topics: Alcohol Oxidoreductases; Animals; Arginine; Brain; Brain Diseases, Metabolic, Inborn; Cells, Cultured; Disease Models, Animal; Female; Glutarates; Ketone Oxidoreductases; Lysine; Male; Mice; Mice, Knockout; Testis

Topics: Animals; Cell Polarity; Disease Models, Animal; Interferon Regulatory Factors; Lysine; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cells; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenotype; S-Nitroso-N-Acetylpenicillamine; Shock, Septic

Topics: Animals; Cardiovascular Agents; Cerebral Cortex; Dendrites; Disease Models, Animal; Excitatory Postsynaptic Potentials; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Lysine; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Neuralgia; Neurons; Pain Measurement; Potassium Channels; Pyrimidines; Receptors, Serotonin; Serotonin; Serotonin Agents; Time Factors

Topics: Animals; Brain; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation; Heterocyclic Compounds, 1-Ring; Hormone Antagonists; Iopanoic Acid; Lysine; Nerve Regeneration; Nerve Tissue Proteins; Neurogenesis; Optic Nerve Injuries; Retina; Signal Transduction; Superior Colliculi; Thyroid Hormones; Time Factors; Tyrosine 3-Monooxygenase; Zebrafish

Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases; Brain Diseases, Metabolic; Cerebral Cortex; Corpus Striatum; Diet; Disease Models, Animal; Energy Metabolism; Glutaryl-CoA Dehydrogenase; Isocitrate Dehydrogenase; Lactic Acid; Lysine; Membrane Potential, Mitochondrial; Mice, 129 Strain; Mice, Knockout; Oxygen Consumption

Topics: Acetylation; Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Electron Transport Complex I; Fatty Acids; Heart; Lipid Metabolism; Lysine; Male; Mitochondria, Heart; Mitochondrial Proteins; Oxidation-Reduction; Rats, Inbred Lew

Topics: Animals; Annexin A1; Bothrops; Crotalid Venoms; Disease Models, Animal; Inflammation; Lysine; Male; Molecular Mimicry; Peptides; Phospholipases A2; Rats; Rats, Wistar

Topics: Acetylation; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Cell Death; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Female; Flow Cytometry; Histones; Humans; Lysine; Male; Mice; Mice, Transgenic; Monocytes; Mutation; Presenilin-1; tau Proteins

Topics: Adenosine Triphosphatases; Analysis of Variance; Animals; Arginine; Blood Vessels; Brain; Disease Models, Animal; Humans; Hyperplasia; Image Processing, Computer-Assisted; Lysine; Magnetic Resonance Angiography; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Moyamoya Disease; Mutation; Time Factors; Ubiquitin-Protein Ligases

Topics: Animals; Arginine; Bone Density; Bone Density Conservation Agents; Collagen; Cross-Linking Reagents; Disease Models, Animal; Female; Glycation End Products, Advanced; Humans; Indoles; Lumbar Vertebrae; Lysine; Macaca fascicularis; Osteoporosis, Postmenopausal; Ovariectomy; Selective Estrogen Receptor Modulators; X-Ray Microtomography

Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Blotting, Western; Catechin; Disease Models, Animal; Female; Fibroblasts; Humans; Immunoprecipitation; In Vitro Techniques; Interleukin-1 Receptor-Associated Kinases; Interleukin-1beta; Interleukin-6; Interleukin-8; Lysine; MAP Kinase Kinase Kinases; Molecular Docking Simulation; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Rats; Rats, Inbred Lew; Synovial Membrane; TNF Receptor-Associated Factor 6; Ubiquitination

Topics: Acetylation; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Disease Models, Animal; Gene Expression Regulation; Glutamate-Cysteine Ligase; Glutathione; Humans; Lysine; Mice; Mice, Knockout; Neurons; Protein Biosynthesis; Protein Processing, Post-Translational; Proteomics; Reactive Oxygen Species

Topics: Adult; Aged; Aged, 80 and over; Animals; Apolipoproteins A; Apolipoproteins B; Binding Sites; Disease Models, Animal; Female; Humans; Immunohistochemistry; Lipoprotein(a); Lysine; Macula Lutea; Macular Degeneration; Male; Mice; Mice, Transgenic; Middle Aged; Oxidation-Reduction; Oxidative Stress; Phenotype; Phospholipids; Retina

Topics: Alkylation; Animals; Anti-Bacterial Agents; Biofilms; Dermis; Disease Models, Animal; Drug Resistance, Bacterial; Kinetics; Lysine; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Microbial Viability; Plankton; Skin Diseases, Infectious

Topics: Aggression; Animals; Brain; CpG Islands; Dendritic Spines; Disease Models, Animal; Gene Expression Regulation; Genes, X-Linked; Histone Demethylases; Histones; Intellectual Disability; Lysine; Memory; Methylation; Mice, Knockout; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; Social Behavior; Transcription, Genetic

Topics: Analysis of Variance; Animals; Axons; Disease Models, Animal; ELAV-Like Protein 3; Glial Fibrillary Acidic Protein; LIM-Homeodomain Proteins; Locomotion; Lysine; Morpholinos; Neural Cell Adhesion Molecule L1; Recovery of Function; RNA, Messenger; Spinal Cord Injuries; Spinal Cord Regeneration; Swimming; Transcription Factors; Up-Regulation; Zebrafish

Topics: Animals; Chromosomes, Human, Pair 14; Disease Models, Animal; Ethylnitrosourea; Female; Ganglia; Genetic Association Studies; Hirschsprung Disease; Humans; Intestinal Obstruction; Lysine; Male; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Mutation, Missense; Protein Domains; Receptor, Endothelin B; Receptors, G-Protein-Coupled

Topics: Acetylation; Alzheimer Disease; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila; Female; Humans; Lysine; Neurotoxins; Protein Aggregation, Pathological; Protein Processing, Post-Translational; tau Proteins

Topics: Adaptor Proteins, Signal Transducing; Animals; Arsenic Trioxide; Arsenicals; Cell Death; Chemical and Drug Induced Liver Injury; Cytoskeletal Proteins; Disease Models, Animal; Heart Failure; Heat-Shock Proteins; HEK293 Cells; Homeostasis; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Liver; Lysine; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Oxidation-Reduction; Oxidative Stress; Oxides; Protein Binding; Protein Interaction Domains and Motifs; Protein Multimerization; Ribonucleoproteins; RNA Interference; Sequestosome-1 Protein; Signal Transduction; Time Factors; Transfection; Ubiquitination

Topics: Acetylation; Amino Acid Sequence; Animals; Bacterial Proteins; Disease Models, Animal; DNA-Binding Proteins; Gene Expression Regulation, Bacterial; Humans; Lysine; Macrophages; Mice; Molecular Sequence Data; Phagocytosis; Phosphorylation; Protein Structure, Tertiary; Salmonella Infections; Salmonella typhimurium; Sequence Alignment; Sequence Deletion; Virulence

Topics: Amputation, Surgical; Animal Fins; Animals; Annexins; Blotting, Western; Disease Models, Animal; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histones; Lysine; Methylation; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Regeneration; Zebrafish

Topics: Animals; Binding Sites; Chromatin Assembly and Disassembly; Diabetic Ketoacidosis; Disease Models, Animal; Energy Metabolism; Epigenesis, Genetic; Fatty Acids; Gene Expression Regulation; Glucose; HEK293 Cells; Histones; Humans; Hydroxybutyrates; Liver; Lysine; Mice, Inbred C57BL; Promoter Regions, Genetic; Protein Processing, Post-Translational; Starvation; Streptozocin

Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; Disease Models, Animal; DNA-Binding Proteins; F-Box Proteins; Female; Gene Expression Regulation, Leukemic; Heterografts; High-Throughput Nucleotide Sequencing; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intercellular Signaling Peptides and Proteins; Jumonji Domain-Containing Histone Demethylases; Leukemia; Lysine; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Transcription Factors

Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Gene Expression; Gene Knockdown Techniques; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Mutation; Neoplastic Stem Cells; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53

Topics: Acetylation; Animals; Disease Models, Animal; Fatty Acids; HEK293 Cells; Humans; Lipid Metabolism; Lysine; Mice; Mitochondrial Proteins; Mitochondrial Trifunctional Protein, alpha Subunit; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Protein Stability; Sirtuins; Ubiquitination

Topics: Acinetobacter baumannii; Animals; Anti-Bacterial Agents; beta-Lactamases; Biofilms; Burns; Disease Models, Animal; Drug Resistance, Bacterial; Female; Lysine; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Wound Infection

Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cellular Senescence; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Gene Expression; Gene Knockdown Techniques; Heterografts; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Mice; Neoplastic Stem Cells; Ovarian Neoplasms; Proto-Oncogene Proteins c-bcl-2; SOXB1 Transcription Factors; Tumor Suppressor Protein p53

Topics: Amyotrophic Lateral Sclerosis; Animals; Antibodies; Calcium-Binding Proteins; Disease Models, Animal; DNA-Binding Proteins; Dogs; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; HEK293 Cells; Humans; Immunoprecipitation; Lysine; Microfilament Proteins; Mutation; Spinal Cord; Superoxide Dismutase-1; Transfection

Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Gene Knockout Techniques; Histones; Humans; Lysine; Male; Mice; Prostate; Prostatic Neoplasms; Protein Stability; PTEN Phosphohydrolase; S-Phase Kinase-Associated Proteins; TNF Receptor-Associated Factor 6; Tumor Suppressor Protein p53; Ubiquitination

Topics: Aberrant Crypt Foci; Animals; Carcinogenesis; Colon, Sigmoid; Disease Models, Animal; Female; Intestinal Mucosa; Intestinal Neoplasms; Lysine; Rats; Rats, Wistar; Surgical Stomas; Ureterostomy; Urinary Bladder Neoplasms; Urinary Diversion; Urologic Neoplasms

Topics: Animals; Biomarkers; Chromatography, Liquid; Discriminant Analysis; Disease Models, Animal; Disease Progression; Isotope Labeling; Joints; Least-Squares Analysis; Lysine; Metabolome; Metabolomics; Osteoarthritis; Principal Component Analysis; Rats, Sprague-Dawley; Tandem Mass Spectrometry

Topics: Action Potentials; Afferent Pathways; Animals; Brain; Brain Injuries; Cell Line, Transformed; Cerebral Cortex; Disease Models, Animal; Evoked Potentials, Somatosensory; Humans; Induced Pluripotent Stem Cells; Lysine; Male; Neurons; Phosphopyruvate Hydratase; Rats; Rats, Nude; Rats, Sprague-Dawley; Stroke; Synapses; Ventral Thalamic Nuclei

Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Kallikreins; Lysine; Mice; Mice, Inbred C57BL; Prostate-Specific Antigen; Urinary Bladder Neoplasms

Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Brain; Deoxyguanosine; Disease Models, Animal; Glycation End Products, Advanced; Infarction, Middle Cerebral Artery; Inflammation Mediators; Lysine; Male; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Time Factors

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylation; alpha-Synuclein; Animals; Autophagy; Cell Membrane; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dopaminergic Neurons; Gene Deletion; Gene Knockdown Techniques; HEK293 Cells; Humans; Lysine; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neuroprotection; Parkinson Disease; Protein Aggregates; Protein Binding; Sirtuin 2

Topics: Animals; Antibodies, Antinuclear; Disease Models, Animal; Enzyme Inhibitors; Female; Glomerulonephritis, Membranoproliferative; Lupus Nephritis; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mice, Knockout; Nitric Oxide Synthase Type II; Proteinuria

Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Ascorbic Acid; Aspartate Aminotransferases; Camellia sinensis; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Drug Combinations; Food; Kidney; Liver; Lysine; Male; Mice; Mice, Inbred ICR; Organ Size; Plant Extracts; Proline

Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Animals; Antibodies, Bacterial; Benzoates; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Female; Guanylate Cyclase; Imidazoles; Immunity, Cellular; Immunization; Immunoglobulin G; Interferon-gamma; Interleukin-4; Lipopolysaccharides; Lysine; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Skin Diseases, Bacterial; Spleen; Th1 Cells

Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Basic Helix-Loop-Helix Transcription Factors; Chronic Disease; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Female; Fetal Hypoxia; Gestational Age; Guinea Pigs; Heart; Hypoxia-Inducible Factor 1, alpha Subunit; Lysine; Myocardium; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Pregnancy; RNA, Messenger; Up-Regulation

Topics: Aldehyde Reductase; Animals; Benzofurans; Blood Glucose; Cataract; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Disease Models, Animal; Glyceraldehyde; Hydantoins; Lens, Crystalline; Lysine; Male; Pyridinium Compounds; Rats; Rats, Wistar

Topics: Animals; Congenital Abnormalities; Disease Models, Animal; Embryo, Mammalian; Female; Glycation End Products, Advanced; Heart Defects, Congenital; Humans; Infant, Newborn; Lysine; Pregnancy; Pregnancy in Diabetics; Rats; Rats, Sprague-Dawley; Risk Factors; Smad2 Protein; Vascular Endothelial Growth Factor A; Wound Healing

Topics: Animals; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Disease Models, Animal; Down-Regulation; Fibroblasts; Hydrogen Peroxide; Lipid Peroxidation; Lipids; Lysine; Male; Microarray Analysis; Molar; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Periodontal Ligament; Periodontitis; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Superoxide Dismutase-1

Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arginine; Carcinoma; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Female; Humans; Immune Tolerance; Immunologic Factors; Killer Cells, Natural; Lysine; Male; Mice; Mice, Inbred BALB C; Neoplasms; Neuroimmunomodulation; Rats; Rats, Wistar; Spleen; Sympathetic Nervous System; Treatment Outcome

Topics: Alanine; Animals; Animals, Newborn; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Dextrans; Disease Models, Animal; Dynamin I; Endocytosis; Excitatory Amino Acid Agonists; Fluorescein-5-isothiocyanate; Gene Products, tat; Green Fluorescent Proteins; Horseradish Peroxidase; Injections, Intraventricular; Lysine; Male; Mutation; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Transfection; Vesicular Transport Proteins

Topics: Analysis of Variance; Animals; Cerebral Cortex; Creatine Kinase; Disease Models, Animal; Electron Transport; Energy Metabolism; Glutathione; Hyperlysinemias; Isoenzymes; Lysine; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase

Topics: alpha-Synuclein; Animals; Autophagy; Cell Line, Tumor; Cells, Cultured; Cytoprotection; Disease Models, Animal; Drosophila melanogaster; Humans; Lewy Bodies; Lysine; Lysosomes; Nerve Degeneration; Neurons; Parkinson Disease; Polymers; Proteasome Endopeptidase Complex; Protein Folding; Substantia Nigra; Ubiquitin; Ubiquitination

Topics: Animals; Arginine; Bone and Bones; Bone Density; Bone Density Conservation Agents; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Glycation End Products, Advanced; Hyperhomocysteinemia; Lysine; Methionine; Osteoporosis; Rabbits; Raloxifene Hydrochloride; Stress, Mechanical

Topics: Analysis of Variance; Animals; Atropine Derivatives; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; GABA Antagonists; In Vitro Techniques; Lysine; Male; Muscarinic Agonists; Muscarinic Antagonists; Nerve Net; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Pilocarpine; Propanolamines; Rats; Rats, Sprague-Dawley; Synaptic Potentials; Synaptophysin; Time Factors

Topics: Animals; Brain Infarction; Dendrites; Dentate Gyrus; Disease Models, Animal; Hypoxia-Ischemia, Brain; Lysine; Male; Nerve Degeneration; Neural Pathways; Neuronal Plasticity; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Staining and Labeling

Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Calcium Channels; Coronary Vessels; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Disease Models, Animal; Drug Synergism; Glycation End Products, Advanced; In Vitro Techniques; Lysine; Male; Rats; Rats, Wistar; Stimulation, Chemical; Streptozocin; Superoxides; Vasoconstriction

Topics: Animals; Cell Proliferation; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Disease Models, Animal; DNA; Lymphocyte Activation; Lysine; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrrolidines; Spleen; T-Lymphocytes; Thiazoles

Topics: Animals; Disease Models, Animal; Humans; Inflammation; Lysine; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Serum Albumin

Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; DNA Damage; Epididymis; Glycation End Products, Advanced; Infertility, Male; Lysine; Male; Mice; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Spermatozoa; Streptozocin; Testis

Topics: Alanine; Amino Acids, Diamino; Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Cyanobacteria Toxins; Disease Models, Animal; Dose-Response Relationship, Drug; Drosophila melanogaster; Female; Glutamic Acid; Leucine; Longevity; Lysine; Male; Neurotoxicity Syndromes; Neurotoxins

Topics: Animals; Animals, Genetically Modified; Basic Helix-Loop-Helix Transcription Factors; Cell Polarity; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation; Green Fluorescent Proteins; Hedgehog Proteins; Lysine; Motor Neurons; Nerve Regeneration; Nerve Tissue Proteins; Neuroglia; Oligodendrocyte Transcription Factor 2; Recovery of Function; RNA, Messenger; Signal Transduction; Spinal Cord Injuries; Statistics, Nonparametric; Transcription Factors; Veratrum Alkaloids; Zebrafish; Zebrafish Proteins

Topics: Animals; Axotomy; Dihydrotestosterone; Disease Models, Animal; Electric Stimulation; Estradiol; Facial Nerve Diseases; Leucine; Lysine; Male; Nerve Regeneration; Rats; Rats, Sprague-Dawley; Steroids; Testosterone Propionate; Time Factors; Tritium

Topics: Animals; Anti-Bacterial Agents; Bacteria; Calorimetry; Cell Wall; Disease Models, Animal; Drug Design; Kinetics; Lysine; Mice; Microbial Sensitivity Tests; Structure-Activity Relationship; Surface Plasmon Resonance

Topics: Animals; Anticoagulants; Aspirin; Blood Coagulation Disorders; Disease Models, Animal; Endoscopy; Gastrointestinal Hemorrhage; Gelatin Sponge, Absorbable; Hemostatics; Heparin; Lysine; Platelet Aggregation Inhibitors; Swine

Topics: Animals; Cells, Cultured; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation, Enzymologic; Kidney Tubules; Lysine; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Reactive Nitrogen Species; RNA, Messenger; Sepsis

Topics: Animals; Animals, Newborn; Biophysics; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Dosage; Hippocampus; Humans; In Vitro Techniques; Linear Models; Lysine; Male; Membrane Potentials; Mice; Mice, Knockout; Neurons; Patch-Clamp Techniques; Pyridazines; Seizures; Succinate-Semialdehyde Dehydrogenase

Topics: Animals; Candida albicans; Candidiasis; Culture Media; Disease Models, Animal; Female; Gene Knockout Techniques; Genes, Fungal; Lysine; Mice; Oxo-Acid-Lyases; Survival Analysis; Virulence; Virulence Factors

Topics: Animals; Asparagine; Cluster Analysis; Disease Models, Animal; Genotype; Humans; Influenza A Virus, H5N1 Subtype; Influenza, Human; Lysine; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Orthomyxoviridae Infections; Phylogeny; RNA-Dependent RNA Polymerase; RNA, Viral; Sequence Analysis, DNA; Sequence Homology; Vietnam; Viral Proteins; Virulence; Virulence Factors

Topics: Animals; Arginine; Contracture; Cross-Linking Reagents; Disease Models, Animal; Extracellular Matrix; Glycation End Products, Advanced; Hindlimb Suspension; Knee Joint; Lysine; Male; Range of Motion, Articular; Rats; Rats, Sprague-Dawley; Time Factors

Topics: alpha-Synuclein; Animals; Corpus Striatum; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Glycation End Products, Advanced; Lysine; Mice; Mice, Inbred C57BL; MPTP Poisoning; Parkinson Disease; Substantia Nigra; Tyrosine 3-Monooxygenase

Topics: Animals; Atherosclerosis; Carbon Monoxide; Cholesterol, Dietary; Diet, Atherogenic; Disease Models, Animal; Heme; Heme Oxygenase-1; HSC70 Heat-Shock Proteins; Lysine; Male; Rabbits; RNA, Messenger

Topics: Acetylation; Animals; Disease Models, Animal; Ischemic Preconditioning, Myocardial; Lysine; Male; Mice; Mice, Inbred C57BL; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; NAD; Sirtuin 1

Topics: Alveolar Bone Loss; Animals; Antioxidants; Camellia sinensis; Catechin; Connective Tissue; Dentifrices; Disease Models, Animal; Epithelial Attachment; Gingiva; Gingival Recession; Lipid Peroxidation; Lysine; Male; NF-kappa B; Oxidative Stress; Periodontitis; Random Allocation; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Tyrosine

Topics: Animals; Arginine; Bone Density; Bone Density Conservation Agents; Calcium; Collagen; Compressive Strength; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Glycation End Products, Advanced; Lumbar Vertebrae; Lysine; Macaca fascicularis; Osteoporosis; Ovariectomy; Phosphates; Teriparatide; X-Ray Microtomography

Topics: Action Potentials; Animals; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Lysine; Neural Pathways; Neurons; Patch-Clamp Techniques; Pilocarpine

Topics: Acetylation; Age Factors; Aging; Amino Acid Sequence; Animals; Cardiomegaly; Cyclophilins; Cyclosporine; Disease Models, Animal; Humans; Lysine; Mice; Mice, 129 Strain; Mice, Knockout; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Swelling; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Myocytes, Cardiac; Peptidyl-Prolyl Isomerase F; Protein Conformation; Sirtuin 3; Structure-Activity Relationship; Time Factors

Topics: Animals; Brain; Brain Mapping; Carbon Isotopes; Cognition Disorders; Consciousness; Disease Models, Animal; Dose-Response Relationship, Drug; Lysine; Macaca mulatta; Magnetic Resonance Imaging; Male; Maleimides; Muscarinic Antagonists; Neuropsychological Tests; Photic Stimulation; Positron-Emission Tomography; Reaction Time; Receptors, Muscarinic; Scopolamine; Time Factors

Topics: Analysis of Variance; Animals; Brain Stem; Cell Count; Choline O-Acetyltransferase; Disease Models, Animal; Humans; Indoles; Lysine; Membrane Glycoproteins; Motor Activity; Motor Neurons; Nerve Regeneration; Neural Pathways; Oligodeoxyribonucleotides, Antisense; Recovery of Function; RNA, Messenger; Spinal Cord Injuries; Synapses; Tenascin; Transcription Factors; Up-Regulation; Zebrafish; Zebrafish Proteins

Topics: Animals; Dietary Fats; Disease Models, Animal; DNA Fragmentation; Epididymis; Glycation End Products, Advanced; Gonadotropin-Releasing Hormone; Hyperglycemia; Hypogonadism; Lysine; Male; Metabolic Syndrome; Rabbits; Random Allocation; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Semen Analysis; Spermatogenesis; Spermatozoa; Testis; Triptorelin Pamoate

Topics: Animals; Caco-2 Cells; Central Nervous System Depressants; Disease Models, Animal; Epithelial Cells; Ethanol; Humans; Intestinal Mucosa; Liver Diseases, Alcoholic; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Targeted Therapy; Nitric Oxide Synthase Type II; p21-Activated Kinases; Permeability; RNA, Small Interfering; Signal Transduction; Snail Family Transcription Factors; Transcription Factors

Topics: Acetylation; Animals; Cell Line; Chromatin Immunoprecipitation; CREB-Binding Protein; Disease Models, Animal; DNA, Ribosomal; Huntington Disease; Lysine; Male; Mice; Mice, Transgenic; Mutation; Pol1 Transcription Initiation Complex Proteins; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering; Transcription, Genetic

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Arginine; Cardiac Surgical Procedures; Disease Models, Animal; Fasting; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Neopterin; Rabbits; Stroke Volume; Thrombolytic Therapy; Time Factors; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Function, Left; Young Adult

Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Convulsants; Disease Models, Animal; Doublecortin Domain Proteins; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Functional Laterality; Hippocampus; Kainic Acid; Luminescent Proteins; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Motor Activity; Neurogenesis; Neuropeptides; Patch-Clamp Techniques; Picrotoxin

Topics: Acetylation; Animals; Aorta, Thoracic; Apoptosis; Atherosclerosis; Benzopyrans; Caspase 3; Cells, Cultured; Diet, High-Fat; Disease Models, Animal; Endothelium, Vascular; Hypolipidemic Agents; Lipids; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Polyphenols; Signal Transduction; Sirtuin 1; Superoxides; Tumor Suppressor Protein p53

Topics: Acetylation; Aging; Aging, Premature; Animals; Cells, Cultured; Cellular Senescence; Chromosomal Proteins, Non-Histone; Disease Models, Animal; DNA Repair; DNA-Binding Proteins; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histones; Humans; Lamin Type A; Lysine; Membrane Proteins; Metalloendopeptidases; Mice; Mice, Knockout; Nuclear Matrix; Nuclear Proteins; Protein Precursors; RNA, Small Interfering; Tumor Suppressor p53-Binding Protein 1

Topics: Animals; CD13 Antigens; CD4-Positive T-Lymphocytes; Cells, Cultured; Chemokine CXCL12; Chemotaxis; Dipeptidyl Peptidase 4; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Humans; Hydroxamic Acids; Lymphocyte Activation; Lysine; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Pyrroles; Pyrrolidines; Thiazoles; Transgenes

Topics: Analysis of Variance; Animals; Avoidance Learning; Biophysical Phenomena; Corpus Striatum; Disease Models, Animal; Dopamine; Electric Stimulation; Excitatory Postsynaptic Potentials; Exploratory Behavior; Green Fluorescent Proteins; Long-Term Synaptic Depression; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neurons; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Dopamine D1; Receptors, Dopamine D2; Substance P

Topics: Action Potentials; Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; In Vitro Techniques; Lysine; Male; Methylazoxymethanol Acetate; Neocortex; Neurons; Periventricular Nodular Heterotopia; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Teratogens

Topics: Animals; Disease Models, Animal; Humans; Hypertension, Pulmonary; Lung; Lysine; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Pulmonary Alveoli; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Smoking

Topics: 8-Hydroxy-2'-Deoxyguanosine; Analysis of Variance; Animals; Antipyrine; Behavioral Symptoms; Deoxyguanosine; Disease Models, Animal; DNA Damage; Edaravone; Free Radical Scavengers; Gerbillinae; Hippocampus; In Situ Nick-End Labeling; Ischemic Attack, Transient; Lysine; Oxidative Stress; Prosencephalon; Time Factors

Topics: Acetylation; Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Brain; Butyrates; Disease Models, Animal; Histone Deacetylase Inhibitors; Histones; Iron; Lysine; Memory Disorders; Rats; Rats, Wistar; Recognition, Psychology; Statistics, Nonparametric

Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Enzyme Activation; Glycation End Products, Advanced; Humans; Inflammation; Lysine; Memory Disorders; Mice; Mice, Knockout; Neurons; Oxidation-Reduction; Protein Multimerization; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides

Topics: Animals; Apoptosis; Carboxymethylcellulose Sodium; Cell Proliferation; Collagen; Disease Models, Animal; Hyaluronic Acid; Immunohistochemistry; Injections; Isocyanates; Ki-67 Antigen; Lysine; Male; Polyethylene Glycols; Polyurethanes; Rats, Sprague-Dawley; Rheology; Tissue Scaffolds; Wound Healing; Wounds and Injuries

Topics: Age Factors; Animals; Cells, Cultured; Cerebellum; Chromatography, Affinity; Copper; Copper Sulfate; Creutzfeldt-Jakob Syndrome; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Glutamic Acid; Humans; Imidazoles; Lysine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Prions; Protein Binding

Topics: Animals; Astrocytes; Brain Injuries; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Growth Inhibitors; Lysine; Male; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley

Topics: Animals; Arginine; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Dogs; Female; Glycation End Products, Advanced; Lysine; Osteoarthritis; Synovitis

Topics: Animals; Carrier Proteins; Cell Cycle; Cell Line; Chromatin; Congenital Microtia; Crystallography, X-Ray; Disease Models, Animal; DNA Replication; Dwarfism; Ear; Growth Disorders; Histones; Humans; Lysine; Methylation; Micrognathism; Models, Molecular; Origin Recognition Complex; Patella; Protein Structure, Tertiary; Replication Origin; Zebrafish; Zebrafish Proteins

Topics: Animals; Antigens, CD34; Apoptosis; CD11b Antigen; Cell Differentiation; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Female; Flow Cytometry; Gene Expression Regulation; Histone Demethylases; Humans; Leukemia, Myeloid, Acute; Lysine; Mice; Mice, Inbred NOD; Mice, SCID; RNA, Small Interfering; Stem Cell Factor; Time Factors; Transplants; Tranylcypromine; Tretinoin

Topics: Animals; Arthritis, Experimental; Biological Availability; Chemistry, Pharmaceutical; Chickens; Disease Models, Animal; Dogs; Drug Carriers; Female; Gout Suppressants; Half-Life; Haplorhini; Humans; Injections, Intravenous; Injections, Subcutaneous; Kidney Diseases; Lysine; Male; Metabolic Clearance Rate; Molecular Weight; Polyethylene Glycols; Rabbits; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Technology, Pharmaceutical; Tissue Distribution; Urate Oxidase; Uric Acid

Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain; Brain Diseases, Metabolic; Creatine Kinase; Disease Models, Animal; Electron Transport; Glutaryl-CoA Dehydrogenase; Heart; Ketoglutarate Dehydrogenase Complex; Lysine; Mice; Mice, Knockout; Muscle, Skeletal; Myocardium; Sodium-Potassium-Exchanging ATPase

Topics: Animals; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Hydrogen; Lipoproteins, LDL; Lysine; Male; Oxidative Stress; Periodontitis; Rats; Rats, Wistar; Reactive Oxygen Species; Statistics, Nonparametric; Tyrosine; Water

Topics: Animals; Aristolochic Acids; Creatine; Disease Models, Animal; Female; Kidney; Lysine; Mice; Mice, Inbred C3H; Nephritis, Interstitial; Pyruvaldehyde

Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Female; Gene Deletion; Gene Regulatory Networks; Genetic Testing; Humans; Lymphoma, B-Cell; Lysine; Mice; Mice, Inbred C57BL; Polyamines; Reproducibility of Results; RNA, Small Interfering; Tumor Suppressor Proteins

Topics: Acetylation; Amino Acid Sequence; Animals; Breast Neoplasms; Cadherins; Casein Kinase I; Cell Line, Tumor; Cell Movement; Cytoplasm; Disease Models, Animal; Humans; Lysine; Male; Mice; Molecular Sequence Data; p300-CBP Transcription Factors; Prostatic Neoplasms; Protein Processing, Post-Translational; Protein Sorting Signals; S-Phase Kinase-Associated Proteins; Sequence Alignment; Ubiquitination

Topics: Acoustic Stimulation; Age Factors; Alcohol Oxidoreductases; Animals; Animals, Newborn; Asparagine; Barium; Biophysical Phenomena; Cadherins; Cell Line, Transformed; Cochlea; Disease Models, Animal; DNA-Binding Proteins; Evoked Potentials, Auditory, Brain Stem; Green Fluorescent Proteins; Hair Cells, Auditory; Humans; Lysine; Mechanoreceptors; Membrane Potentials; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron, Scanning; Mutation; Nerve Fibers; Organ Culture Techniques; Patch-Clamp Techniques; Physical Stimulation; Psychoacoustics; Pyridinium Compounds; Quaternary Ammonium Compounds; Receptors, AMPA; Synapses; Transfection; Usher Syndromes

Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Biological Availability; Dermatitis, Allergic Contact; Disease Models, Animal; Dose-Response Relationship, Drug; Econazole; Gels; Glycyrrhetinic Acid; Inflammation; Liposomes; Lysine; Male; Mice; Mice, Inbred ICR; Skin Absorption; Swine; Triamcinolone Acetonide

Topics: Angiogenesis Inhibitors; Animals; Butylhydroxybutylnitrosamine; Carcinoma; Disease Models, Animal; Female; Lysine; Neovascularization, Pathologic; Plant Extracts; Propolis; Rats; Rats, Wistar; Time Factors; Treatment Outcome; Urinary Bladder Neoplasms; Water

Topics: Acetylation; Animals; Chronic Disease; Diabetes Mellitus, Type 1; Diabetic Cardiomyopathies; Disease Models, Animal; Lysine; Male; Mice; Mitochondria, Heart

Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Biophysical Phenomena; Biophysics; Brain Injuries; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Cortex; Cyclic Nucleotide-Gated Cation Channels; Disease Models, Animal; Electric Capacitance; Electric Stimulation; Electroencephalography; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channels; Light; Luminescent Proteins; Lysine; Membrane Potentials; Microscopy, Confocal; Models, Neurological; Neural Inhibition; Neural Pathways; Neurons; Optogenetics; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Seizures; Spectrum Analysis; Thalamus; Wakefulness

Topics: Animals; Carboxylic Acids; Disease Models, Animal; Fluorescent Dyes; Glutamate Carboxypeptidase II; Humans; Kinetics; Lysine; Male; Membrane Glycoproteins; Mice; Mice, Nude; Molecular Imaging; Molecular Weight; Polyethylene Glycols; Prostate; Prostatic Neoplasms; Spectroscopy, Near-Infrared

Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antiparasitic Agents; Blood-Testis Barrier; Brain; Cells, Cultured; Cytochrome P-450 Enzyme System; Dendritic Spines; Disease Models, Animal; Electric Stimulation; Exploratory Behavior; Long-Term Potentiation; Lysine; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Neurons; Protein Isoforms; Synaptic Transmission; tau Proteins

Topics: Animals; Biocompatible Materials; Cells, Cultured; Delayed-Action Preparations; Disease Models, Animal; Dogs; Feasibility Studies; Lysine; Male; Materials Testing; Nerve Growth Factor; Nerve Regeneration; Neural Conduction; Polyesters; Reverse Transcriptase Polymerase Chain Reaction; Tibial Nerve

Topics: Alcohol Drinking; Animals; Caco-2 Cells; Cell Line, Tumor; Disease Models, Animal; Electric Impedance; Enzyme Activation; Ethanol; Humans; Intestinal Mucosa; Lysine; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Permeability; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; RNA Interference; RNA, Messenger; RNA, Small Interfering

Topics: Aldehydes; Animals; Apoptosis; Cross-Linking Reagents; Disease Models, Animal; Epitopes; Humans; Immunohistochemistry; Lysine; Malondialdehyde; Oxygen; Rabbits

Topics: Animals; Disease Models, Animal; Embryonic and Fetal Development; Female; Fetal Weight; Fever; Lysine; Mice; Pregnancy; Pregnancy, Animal; Taurine; Teratogens; Zinc

Topics: Animals; Atropine Derivatives; Axons; Dendrites; Disease Models, Animal; Epilepsy, Temporal Lobe; Feedback; gamma-Aminobutyric Acid; Interneurons; Lysine; Male; Mossy Fibers, Hippocampal; Pilocarpine; Rats; Rats, Sprague-Dawley; Synapses

Topics: Adaptation, Biological; Animals; Candida albicans; Candidiasis; Disease Models, Animal; Humans; Lysine; Macrophages; Mice; Mice, Inbred BALB C; Mutation; Oxidative Stress; Protective Agents; Superoxide Dismutase; Superoxide Dismutase-1; Virulence; Vitamin K 3

Topics: Animals; Arginine; Cationic Amino Acid Transporter 1; Cationic Amino Acid Transporter 2; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Glomerular Mesangium; In Vitro Techniques; Ion Transport; Kidney Glomerulus; Lipopolysaccharides; Lysine; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; RNA, Messenger; Sepsis; Sodium

Topics: Age Factors; Animals; Antibodies, Monoclonal; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Glomerular Mesangium; Glycation End Products, Advanced; Kidney; Kidney Glomerulus; Lysine; Rats; Rats, Inbred OLETF; Rats, Inbred Strains; Thiadiazoles; Thiazolidines

Topics: Animals; Antihypertensive Agents; Arginine; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Glycation End Products, Advanced; Hydralazine; Hypertension, Renal; Imidazoles; Immunohistochemistry; In Vitro Techniques; Kidney; Lipids; Lysine; Male; Olmesartan Medoxomil; Oxidation-Reduction; Proteinuria; Rats; Tetrazoles

Topics: Animals; Arginine; Cell Membrane; Disease Models, Animal; Hydrolases; Isoproterenol; Lysine; Lysosomes; Male; Myocardial Infarction; Myocardium; Phosphoric Monoester Hydrolases; Rats; Rats, Wistar; Reference Values

Topics: Amino Acid Sequence; Amino Acid Transport Systems, Basic; Amino Acids; Animals; Arginine; Carrier Proteins; Chromosome Mapping; Cystine; Cystinuria; Disease Models, Animal; Ethylnitrosourea; Female; Genotype; Lysine; Male; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Mutation; Ornithine; Phenotype; Sequence Homology, Amino Acid; Urinary Bladder Calculi; Urinary Calculi

Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Animals, Newborn; Axons; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Lysine; Membrane Potentials; Microscopy, Confocal; Microscopy, Electron; Nerve Net; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptophysin; Tetrodotoxin; Time Factors

Topics: Animals; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Graft Rejection; Heart Transplantation; Hemeproteins; Lysine; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Time Factors; Transplantation, Homologous

Topics: Animals; Azoles; Blood Urea Nitrogen; Catechin; Copper; Creatinine; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Isoindoles; Japan; Kidney; Lipopolysaccharides; Lysine; Male; Nitric Oxide; Organoselenium Compounds; Peroxidase; Phytotherapy; Plant Extracts; Plant Roots; Proteinuria; Rats; Rats, Wistar; Reperfusion Injury; Rheum; Superoxide Dismutase; Tyrosine; Uric Acid; Zinc

Topics: Acute Disease; Animals; Aortic Aneurysm, Abdominal; Aortic Rupture; Blood Pressure; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Interleukin-6; Intestinal Mucosa; Lung; Lung Diseases; Lysine; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osmolar Concentration; Permeability; Peroxidase; Rats; Rats, Sprague-Dawley; Receptor, Anaphylatoxin C5a; Resuscitation; RNA, Messenger; Tumor Necrosis Factor-alpha

Topics: Action Potentials; Animals; Atrophy; Cell Membrane; Chronic Disease; Dendrites; Disease Models, Animal; Hippocampus; Homeostasis; Lysine; Male; Nerve Degeneration; Neuronal Plasticity; Patch-Clamp Techniques; Pyramidal Cells; Stress, Psychological; Synaptic Transmission; Tupaia

Topics: Animals; Arthritis, Experimental; Cyclooxygenase 2; Disease Models, Animal; Enzyme Inhibitors; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Hindlimb; Lysine; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygenases; Prostaglandin-Endoperoxide Synthases; Protoporphyrins; Rats; Rats, Inbred Lew; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Acute Disease; Amino Acids; Amylases; Animals; Central Venous Pressure; Disease Models, Animal; Enzyme Inhibitors; Female; Hematocrit; Lipase; Lysine; Male; Nitric Oxide Synthase Type II; Pancreatitis; Quinazolines; Trichosurus; Water-Electrolyte Balance

Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Animals; Atorvastatin; Blood Pressure; Body Weight; Deoxyguanosine; Disease Models, Animal; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Infarction, Middle Cerebral Artery; Lipids; Lysine; Oxidative Stress; Pyrroles; Quinolines; Rats; Rats, Inbred SHR; Simvastatin; Survival Analysis

Topics: Animals; Bicuculline; Cell Count; Dendrites; Dendritic Spines; Disease Models, Animal; Epilepsy, Temporal Lobe; Fluoresceins; GABA Antagonists; Hippocampus; In Vitro Techniques; Lysine; Membrane Potentials; Muscarinic Agonists; Nerve Net; Patch-Clamp Techniques; Pilocarpine; Pyramidal Cells; Rats; Rats, Wistar; Staining and Labeling

Topics: Amides; Animals; Anti-Bacterial Agents; Binding, Competitive; Cell Line; Cytokines; Disease Models, Animal; Female; Humans; Lipopolysaccharides; Lysine; Mice; Nitric Oxide; Polyamines; Sepsis; Spermine; Structure-Activity Relationship

Topics: Adaptation, Physiological; Animals; Animals, Newborn; Auditory Cortex; Cell Count; Cochlear Nucleus; Disease Models, Animal; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Gerbillinae; Hearing Loss; Immunohistochemistry; In Vitro Techniques; Lysine; Microscopy, Immunoelectron; Neural Inhibition; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission

Topics: Animals; Central Nervous System Stimulants; Cerebral Cortex; Disease Models, Animal; Dopamine; Efferent Pathways; Gerbillinae; Glutamic Acid; Lysine; Male; Methamphetamine; Models, Neurological; Parietal Lobe; Prefrontal Cortex; Presynaptic Terminals; Schizophrenia; Social Isolation; Synaptic Transmission

Topics: Acute Kidney Injury; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase Inhibitors; Caspases; Disease Models, Animal; Enzyme Activation; Interferon-gamma; Kidney Cortex; Lipopolysaccharides; Lysine; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase Type II; Renal Circulation; Tumor Necrosis Factor-alpha

Topics: Animals; Biomarkers; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Lysine; Male; Myocardial Contraction; Myocardium; Rats; Rats, Zucker; Severity of Illness Index; Ventricular Dysfunction, Left

Topics: Animals; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diet, Fat-Restricted; Disease Models, Animal; Female; Follow-Up Studies; Glycation End Products, Advanced; Immunohistochemistry; Kidney; Lysine; Male; Microscopy, Electron; Obesity; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Wistar

Topics: Animals; Bacterial Infections; Blood Pressure; Blood-Air Barrier; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Hypoxia; In Vitro Techniques; Lipopolysaccharides; Lung; Lysine; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Organ Size; Perfusion; Pulmonary Circulation; Pulmonary Edema; Rats; Rats, Wistar; Tidal Volume; Vasoconstriction; Venous Pressure

Topics: Acute Disease; Animals; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Graft Rejection; Heart Transplantation; Lysine; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxynitrous Acid; Protein Processing, Post-Translational; Rats; Rats, Inbred Lew; Rats, Inbred WF; Superoxide Dismutase; Tyrosine

Topics: Alzheimer Disease; Animals; Asparagine; Avoidance Learning; Chromosomes, Human, Pair 17; Cognition Disorders; Disease Models, Animal; Hippocampus; Humans; Lysine; Maze Learning; Mice; Mice, Transgenic; Mutation, Missense; Nerve Tissue Proteins; Neurofibrillary Tangles; Phosphorylation; tau Proteins

Topics: Analysis of Variance; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biopsy, Needle; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Hypertension, Renal; Immunohistochemistry; In Vitro Techniques; Kidney; Lysine; Male; Rats; Rats, Inbred SHR; Sensitivity and Specificity; Statistics, Nonparametric

Topics: Amino Acid Metabolism, Inborn Errors; Animals; Blood-Brain Barrier; Capillary Permeability; Corpus Striatum; Diet; Dietary Proteins; Disease Models, Animal; Female; Glutarates; Lysine; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Neurons; Survival Analysis; Tissue Culture Techniques

Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic, Inborn; Diet; Disease Models, Animal; Glutarates; Lysine; Mice

Topics: Animals; Cell Death; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Dogs; Epithelial Cells; Fibrosis; Hydronephrosis; Kidney Tubules; Lysine; Macrophage Activation; Mice; Nephritis, Interstitial; Nitric Oxide; Nitric Oxide Synthase Type II

Topics: Acute Disease; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Glycine; HL-60 Cells; HSP90 Heat-Shock Proteins; Humans; Inhibitor of Apoptosis Proteins; K562 Cells; Leukemia, Myeloid; Lysine; Male; Mice; Mice, SCID; Microscopy, Fluorescence; Microtubule-Associated Proteins; Neoplasm Proteins; Peptide Fragments; Research Design; Survivin; Transplantation, Heterologous; U937 Cells

Topics: Amino Acid Transport System y+; Amino Acid Transport System y+L; Animals; Arginine; Citrulline; Disease Models, Animal; Erythrocytes; Kinetics; Leucine; Lysine; Male; Nephrectomy; Ornithine; Rats; Rats, Wistar; Uremia

Topics: Animals; Apoptosis; Brain Injuries; Cell Survival; Disease Models, Animal; Female; Lysine; Nerve Degeneration; Neurons; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Time Factors; Tyrosine

Topics: Adult; Animals; Calgranulin A; Calgranulin B; Cell Extracts; Disease Models, Animal; Endothelial Cells; Female; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Lysine; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Receptor for Advanced Glycation End Products; Receptors, Immunologic

Topics: Acetylglucosaminidase; Animals; Creatinine; Disease Models, Animal; Enzyme Inhibitors; Gentamicins; Glomerular Filtration Rate; Kidney; Kidney Diseases; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley

Topics: Adenocarcinoma; Animals; Breast; Breast Neoplasms; Chelating Agents; Chromatography, High Pressure Liquid; Chromatography, Paper; Chromatography, Thin Layer; Disease Models, Animal; Feasibility Studies; Female; Lysine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Radiometry; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Inbred F344; Technetium Tc 99m Dimercaptosuccinic Acid; Tumor Cells, Cultured

Topics: Amino Acid Transport Systems, Basic; Amino Acids; Animals; Arginine; Behavior, Animal; Biological Transport; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Hallucinogens; Lysine; Male; Mice; Nitric Oxide; Phencyclidine; Reflex; Reflex, Startle; Schizophrenia

Topics: Acid-Base Equilibrium; Animals; Bacteremia; Blood Coagulation; Cardiovascular System; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Fibrinogen; Lysine; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Pseudomonas aeruginosa; Pseudomonas Infections; Swine; Time Factors

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Catechin; Dietary Supplements; Disease Models, Animal; Female; Liver Neoplasms, Experimental; Lysine; Mice; Mice, Inbred A; Neuroblastoma; Proline

Topics: Amino Acid Metabolism, Inborn Errors; Amino Acid Transport System y+; Amino Acid Transport System y+L; Animals; Arginine; Dietary Proteins; Disease Models, Animal; Down-Regulation; Fetal Growth Retardation; Gene Expression; Gene Expression Profiling; Genotype; Insulin-Like Growth Factor I; Intestinal Mucosa; Intestines; Liver; Lysine; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Phenotype; Polymerase Chain Reaction; Urea

Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Dipyrone; Disease Models, Animal; Dose-Response Relationship, Drug; Hot Temperature; Injections, Intradermal; Injections, Intraperitoneal; Ketorolac; Lysine; Male; Mice; Mice, Inbred BALB C; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Reaction Time; Sodium Salicylate; Tail; Time Factors

Topics: Acute Disease; Animals; Capillaries; Cecum; Disease Models, Animal; Enzyme Inhibitors; Kidney Diseases; Kidney Tubules; Lysine; Male; Mice; Mice, Inbred C57BL; Microscopy, Video; Nitric Oxide; Nitric Oxide Synthase Type II; Reactive Nitrogen Species; Reactive Oxygen Species; Renal Circulation; Sepsis

Topics: Amino Acids; Animals; Biological Transport; Cystine; Cystinuria; Disease Models, Animal; Dogs; Glycine; Humans; Intestinal Mucosa; Jejunum; Kidney Cortex; Lysine; Urinary Calculi

Topics: Animals; Brain; Disease Models, Animal; Humans; Huntington Disease; Inclusion Bodies; Lysine; Mice; Mice, Transgenic; Polyubiquitin; Proteasome Endopeptidase Complex; Ubiquitin

Topics: Anesthetics, Local; Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; GABA Antagonists; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lysine; Male; Midline Thalamic Nuclei; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tetrodotoxin

Topics: Animals; Blood Pressure; Capillary Permeability; Cyclic GMP; Disease Models, Animal; Embolism, Air; Enzyme Inhibitors; Hypertension; Interleukin-1beta; Lung; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitroprusside; Organ Size; Perfusion; Proteins; Pulmonary Artery; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Respiratory Distress Syndrome; S-Nitroso-N-Acetylpenicillamine; Tumor Necrosis Factor-alpha

Topics: Aging; Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic, Inborn; Child; Diet; Disease Models, Animal; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glucose; Glutamic Acid; Glutarates; Glutaryl-CoA Dehydrogenase; Homoarginine; Humans; Lysine; Mice; Mice, Knockout; Mitochondria; Neurons; Nuclear Magnetic Resonance, Biomolecular; Tryptophan

Topics: Actins; Animals; Collagen Type I; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Fibroblasts; Fibrosis; Humans; Keloid; Lysine; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrrolidines; Skin; Thiazoles; Transforming Growth Factor beta1

Topics: Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinase Kinases; Animals; Diet; Disease Models, Animal; Enzyme Inhibitors; Insulin Receptor Substrate Proteins; Insulin Resistance; Lysine; Male; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Obesity; Physical Conditioning, Animal; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; S-Nitrosoglutathione; Signal Transduction

Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Chloramines; Disease Models, Animal; Lipid Peroxidation; Lipopolysaccharides; Liver; Lysine; Male; Organ Size; Peroxidase; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Tumor Necrosis Factor-alpha

Topics: Animals; Cell Line; Chronic Disease; Colitis; Disease Models, Animal; Female; I-kappa B Kinase; Interleukin-10; Lipopolysaccharides; Lysine; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Peptides; Protein Kinase Inhibitors; Signal Transduction; Transduction, Genetic; Tumor Necrosis Factor-alpha

Topics: Animals; Calcium Signaling; Cardiomyopathy, Hypertrophic, Familial; Diacetyl; Disease Models, Animal; Guinea Pigs; Humans; Kinetics; Lysine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle Contraction; Muscle Strength; Myofibrils; Papillary Muscles; Protein Conformation; Sarcomeres; Sequence Deletion; Troponin I; Ventricular Dysfunction, Left

Topics: Acetylation; Animals; Disease Models, Animal; Gene Expression Regulation; Humans; Leukemia; Lysine; Mice; Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Protein c-ets-1; SUMO-1 Protein; Ubiquitin

Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lipopolysaccharides; Lysine; Male; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitroprusside; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Streptozocin

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Brain; Cerebrovascular Circulation; Child; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lysine; Male; Middle Aged; Rats; Rats, Wistar

Topics: Alcoholic Intoxication; Amino Acids; Animals; Blood Glucose; Blood Urea Nitrogen; Disease Models, Animal; Ethanol; Hepatectomy; Humans; Intestinal Absorption; Lactates; Lysine; Pyruvates; Rats; Tryptophan

Topics: Animals; Antibody Formation; Disease Models, Animal; Drug Hypersensitivity; Glutamates; Haptens; Hemocyanins; Immune Tolerance; Immunoglobulin E; Lysine; Mice; Mice, Inbred BALB C; Phthalic Anhydrides; Rats; Syndrome

Topics: Amino Acid Metabolism, Inborn Errors; Animals; Disease Models, Animal; Half-Life; Humans; Lysine; Myelin Proteins; Myelin Sheath; Phenylalanine; Phenylketonurias; Rats; Rats, Inbred Strains

Topics: Animals; Animals, Newborn; Body Weight; Disease Models, Animal; Female; Guinea Pigs; Hydroxyl Radical; Hyperoxia; Lung; Lung Diseases; Lysine; Male; Oxidative Stress; Pregnancy; Survival Rate; Tyrosine

Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Brain Ischemia; Buspirone; Carbon Isotopes; Disease Models, Animal; Hypoxia, Brain; In Vitro Techniques; Lysine; Male; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Trichloroacetic Acid

Topics: Animals; Cerebellar Nuclei; Disease Models, Animal; Epilepsy, Complex Partial; Hippocampus; Lysine; Male; Neuronal Plasticity; Pilocarpine; Rats; Rats, Sprague-Dawley; Synapses

Topics: Aldehydes; Animals; Anticholesteremic Agents; Antigen-Antibody Complex; Basement Membrane; Cholesterol; Collagen; Disease Models, Animal; Epithelial Cells; Glomerulonephritis; Kidney Glomerulus; Lipid Peroxidation; Lovastatin; Lysine; Male; Malondialdehyde; Probucol; Proteinuria; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Simvastatin

Topics: 4-Aminobenzoic Acid; Animals; Aspergillosis; Aspergillus nidulans; Blood; Crosses, Genetic; Culture Media; Disease Models, Animal; Eating; Lung; Lung Diseases, Fungal; Lysine; Male; Mice; Mutation; Neutropenia; Virulence

Topics: Animals; Benzopyrans; Bone and Bones; Bone Development; Collagen; Deficiency Diseases; Disease Models, Animal; Female; Glycosylation; Hydroxylation; Knee Joint; Lysine; Male; Mice; Mice, Inbred Strains; Osteoarthritis; Proline; Protein Denaturation; Protein Processing, Post-Translational; Reproduction; Selenium; Skin; Tensile Strength; Tibia; Trypsin

Topics: Animals; Arterioles; Aspirin; Disease Models, Animal; Embolism; Lasers; Lysine; Male; Platelet Aggregation; Rats; Rats, Wistar; Thrombosis; Time Factors

Topics: Administration, Topical; Anaphylaxis; Animals; Ascaris; Conjunctivitis, Allergic; Disease Models, Animal; Haptens; Lysine; Male; Rats; Rats, Sprague-Dawley; Skin Tests

Topics: Acetylcholine; Animals; Carbocysteine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation; Interleukin-1; Lysine; Rats; Respiratory Hypersensitivity; Respiratory System

Topics: Abdomen; Aging; Analysis of Variance; Animals; Arginine; Blood Glucose; Body Weight; Collagen; Diabetes Mellitus, Type 1; Disease Models, Animal; Glycated Hemoglobin; Glycation End Products, Advanced; Glycosylation; Hydroxyproline; Hypoglycemic Agents; Insulin; Lipid Peroxidation; Lysine; Male; Oxidation-Reduction; Random Allocation; Rats; Rats, Inbred BB; Spectrometry, Fluorescence

Topics: Acylation; Animals; Blood Glucose; Chromatography, Gel; Diabetes Mellitus, Experimental; Disease Models, Animal; Dogs; Fatty Acids, Nonesterified; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Lysine; Palmitic Acid; Protein Binding; Serum Albumin; Time Factors

Topics: Animals; Arginine; Collagen; Disease Models, Animal; Glycosylation; Hypertriglyceridemia; Lipid Peroxidation; Lysine; Male; Protein Processing, Post-Translational; Rats; Rats, Wistar; Skin; Spectrometry, Fluorescence

Topics: Animals; Arthritis, Rheumatoid; Boronic Acids; Cells, Cultured; Collagen; Diamines; Dipeptides; Dipeptidyl Peptidase 4; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Hydroxylamines; Immunosuppressive Agents; Lymphocyte Activation; Lysine; Models, Immunological; Rats; Rats, Inbred F344; Rats, Inbred Lew; Serine Proteinase Inhibitors; T-Lymphocytes; Thiazoles

Topics: Animals; Base Sequence; Basement Membrane; Cyclooxygenase Inhibitors; Disease Models, Animal; DNA Primers; Eicosanoids; Enzyme Induction; Enzyme Inhibitors; Gene Expression; Glomerulonephritis; Humans; Immunization; Kidney Glomerulus; Lysine; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Sprague-Dawley; RNA, Messenger

Topics: Animals; Aorta; Apolipoproteins A; Binding Sites; Disease Models, Animal; Evolution, Molecular; Feedback; Hedgehogs; Humans; Kringles; Lipids; Lipoprotein(a); Lysine; Mice; Mice, Transgenic; Mutagenesis, Site-Directed; Plasminogen; Protein Binding; Sequence Homology

Topics: Animals; Anorexia; Chickens; Diet; Disease Models, Animal; Eating; Escherichia coli; Female; Lipopolysaccharides; Lysine; Proteins; Threonine; Weight Gain

Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Fructosamine; Hydroxylation; Kidney; Lysine; Malondialdehyde; Mice; Rats; Rats, Inbred BB; Rats, Sprague-Dawley; Streptozocin; Tyrosine

Topics: Animals; Cell Size; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Iontophoresis; Lysine; Male; Pilocarpine; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus

Topics: Acute Disease; Animals; Ascitic Fluid; Blotting, Western; Cell Movement; Disease Models, Animal; Enzyme Induction; Female; Glycogen; Inflammation; Lysine; Neutrophils; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Ostreidae; Peritonitis; Rats; Rats, Inbred Lew

Topics: Aging; Animals; Avoidance Learning; Cell Division; Disease Models, Animal; Enzyme Inhibitors; Erythrocytes; Female; Galactose; Glucose; Glycation End Products, Advanced; Guanidines; Hydroxyproline; Interleukin-2; Learning; Lymphocytes; Lysine; Memory; Mice; Mice, Inbred C57BL; Motor Activity; Nervous System Diseases; Skin; Superoxide Dismutase

Topics: Animals; Disease Models, Animal; Fibrosis; Glycation End Products, Advanced; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Immunohistochemistry; Kidney; Lysine; Male; Membrane Proteins; Mice; Oxidative Stress; RNA, Messenger; Ureteral Obstruction

Topics: Animals; Cartilage, Articular; Culture Techniques; Cyclooxygenase 2; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Immunohistochemistry; Interleukin-1; Isoenzymes; Lysine; Metalloendopeptidases; Nitric Oxide; Nitric Oxide Synthase; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; Sensitivity and Specificity; Statistics, Nonparametric; Synovial Membrane; Tyrosine

Topics: Animals; Blood Pressure Determination; Blotting, Northern; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glomerular Filtration Rate; Hemodynamics; Isoenzymes; Kidney Function Tests; Kidney Glomerulus; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Streptozocin

Topics: Animals; Axons; Dentate Gyrus; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; In Vitro Techniques; Kainic Acid; Lysine; Male; Membrane Potentials; Microscopy, Electron; Mossy Fibers, Hippocampal; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Synapses

Topics: Administration, Oral; Animals; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Genetic Predisposition to Disease; Guanidines; Interferon gamma Receptor; Interferon-gamma; Lysine; Male; Mice; Mice, Inbred DBA; Mice, Knockout; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Receptors, Interferon; Weight Loss

Topics: Animals; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Lysine; Male; Mossy Fibers, Hippocampal; Nerve Degeneration; Neuronal Plasticity; Pilocarpine; Rats; Status Epilepticus

Topics: Animals; Astrocytes; Behavior, Animal; Cell Count; Cytoplasmic Granules; Disease Models, Animal; Electroencephalography; Epilepsy; Excitatory Postsynaptic Potentials; Flurothyl; Hippocampus; Homozygote; Immunohistochemistry; Interneurons; Lysine; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Neocortex; Nerve Tissue Proteins; Nervous System Malformations; Pyramidal Cells; Reaction Time; Sensory Thresholds

Topics: Amidines; Animals; Benzylamines; Chemokine CXCL2; Chemokines; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Glomerular Mesangium; Glomerulonephritis; Interleukin-1; Kidney Glomerulus; Lysine; Mutagenesis, Site-Directed; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; Rats; Recombinant Fusion Proteins

Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Death; Colitis; Colon; Disease Models, Animal; Epithelial Cells; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; Lysine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Superoxides; Trinitrobenzenesulfonic Acid; Tyrosine

Topics: Action Potentials; Analgesics, Opioid; Animals; Behavior, Animal; Biological Clocks; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Fentanyl; Immunohistochemistry; Lysine; Male; Neural Pathways; Neurons; Rats; Rats, Wistar; Sleep Stages; Thalamus; Wakefulness

Topics: Animals; Arthritis; Body Weight; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Female; Hot Temperature; Hyperalgesia; Indomethacin; Lysine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Physical Stimulation; Rats; Rats, Inbred Lew

Topics: alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Substitution; Animals; Dihydro-beta-Erythroidine; Disease Models, Animal; Electrophysiology; Female; Ganglionic Stimulants; Heterozygote; Hippocampus; Lysine; Male; Mice; Mice, Inbred C57BL; Neuroanatomy; Nicotine; Phenotype; Receptors, Nicotinic; Seizures; Threonine

Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Asthma; Cell Division; Cyclophilin A; Cyclosporine; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Immunosuppressive Agents; Indoles; Injections, Intraperitoneal; Injections, Subcutaneous; Leukocytes, Mononuclear; Lysine; Male; Peptidylprolyl Isomerase; Rats; Rats, Inbred BN; Rats, Inbred Lew; Th1 Cells; Th2 Cells

Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain Ischemia; Carbon Radioisotopes; Cell Death; Dementia; Disease Models, Animal; Hippocampus; Lysine; Macaca; Maleimides; Neurons; Receptors, GABA-A; Receptors, Muscarinic; Tomography, Emission-Computed

Topics: Acute Disease; Animals; Arthritis, Experimental; Cell Adhesion Molecules; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Female; Image Processing, Computer-Assisted; Lysine; Mice; Mice, Inbred BALB C; Microcirculation; Microscopy, Fluorescence; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Selectins; Stifle; Synovial Membrane

Topics: Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Kidney; Lysine; Mice; Mice, Mutant Strains; Oxidation-Reduction; Oxidative Stress; Tyrosine

Topics: Animals; Arginine; Cromolyn Sodium; Disease Models, Animal; Hindlimb; Histamine Release; Inflammation; Irritants; Lysine; Male; Melitten; Oligopeptides; Peptide Fragments; Rats; Venoms

Topics: Amino Acids; Animals; Brain; Disease Models, Animal; Female; Fenclonine; Glycine; Humans; Leucine; Lysine; Male; Nerve Tissue Proteins; Phenylalanine; Phenylketonurias; Rats

Topics: Amino Acids; Animals; Basement Membrane; Diabetes Mellitus; Disease Models, Animal; Hydroxylysine; In Vitro Techniques; Kidney Glomerulus; Lysine; Rats; Streptozocin

Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Disease Models, Animal; Hypertension; Lysine; Pituitary Gland; Rats

Topics: Animals; Aspirin; Basement Membrane; Disease Models, Animal; Female; Glomerulonephritis; Immune Sera; Indomethacin; Kidney Glomerulus; Lysine; Proteinuria; Rabbits; Rats

Topics: Animals; Antigen-Antibody Reactions; Borrelia; Borrelia Infections; Cytotoxicity Tests, Immunologic; Disease Models, Animal; Female; Haplorhini; Hemagglutination Tests; Immunoglobulins; Immunologic Techniques; Lymph Nodes; Lysine; Male; Peptide Biosynthesis; RNA; Species Specificity

Topics: Animals; Cell Division; Chemical and Drug Induced Liver Injury; Disease Models, Animal; DNA; Endoplasmic Reticulum; Galactosamine; Hemorrhage; Hepatitis; Liver Regeneration; Lysine; Mice; Microscopy, Electron; RNA

Topics: Animals; Cell Degranulation; Conjunctiva; Conjunctivitis, Allergic; Disease Models, Animal; Female; Freund's Adjuvant; gamma-Globulins; Guinea Pigs; Lysine; Mast Cells

Topics: Amino Acids; Animals; Brain; Chromatography, Ion Exchange; Chromatography, Thin Layer; Disease Models, Animal; Liver; Lysine; Methylation; Microscopy, Electron; Neuronal Ceroid-Lipofuscinoses; Pancreatin; Proteins; Sheep; Spectrometry, Mass, Fast Atom Bombardment

Topics: Anaphylaxis; Animals; Conjunctiva; Disease Models, Animal; Edema; Eye Diseases; Eyelids; Female; gamma-Globulins; Guinea Pigs; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Lysine; Passive Cutaneous Anaphylaxis; Regression Analysis; Vaccination

Topics: Animals; Arrhythmias, Cardiac; Aspirin; Disease Models, Animal; Drug Synergism; Female; Guinea Pigs; Imidazoles; Lysine; Ouabain; Platelet Activating Factor; Thromboxane-A Synthase

Topics: Animals; Conjunctivitis; Disease Models, Animal; Eyelids; Female; Guinea Pigs; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Immunization, Passive; Immunoglobulin G; Leukocyte Count; Lysine

Topics: Animals; Chymotrypsin; Cricetinae; Desmosine; Disease Models, Animal; Elastin; Female; Isodesmosine; Lung; Lysine; Mesocricetus; Pancreatic Elastase; Protein-Lysine 6-Oxidase; Pulmonary Emphysema; Trypsin

Topics: Animals; Antibody Formation; Antibody-Producing Cells; Carbon Isotopes; Disease Models, Animal; DNA; Escherichia coli Infections; Female; gamma-Globulins; Haplorhini; Ileum; Immunoglobulins; Intestines; Lysine; Male; Opsonin Proteins; Peptide Hydrolases; Protein Biosynthesis; Protein Deficiency; Ribosomes; RNA; Species Specificity; Thymidine; Tritium

Topics: Adenylyl Cyclases; Animals; Collagen; Cyclic AMP; Disease Models, Animal; Guinea Pigs; Heart Ventricles; Lysine; Myocardial Contraction; Myocardial Infarction; Myocardium; Myoglobin; Myosins; Proline

Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Cerebral Cortex; Cobalt; Disease Models, Animal; Epilepsy; Ethanolamines; Glutamates; Lysine; Male; Parietal Lobe; Rats; Taurine

Topics: Acetates; Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Body Weight; Dietary Proteins; Disease Models, Animal; Glutaminase; Liver; Lysine; Quaternary Ammonium Compounds; Time Factors

Topics: Animals; Arginine; Cattle; Cornea; Culture Techniques; Cytopathogenic Effect, Viral; Depression, Chemical; Disease Models, Animal; Herpesviridae; Histones; Keratitis, Dendritic; Lysine; Rabbits; Thymus Gland