Compounds > lysine
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lysine and Diabetic Retinopathy

lysine has been researched along with Diabetic Retinopathy in 53 studies

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.89)18.7374
1990's12 (22.64)18.2507
2000's20 (37.74)29.6817
2010's18 (33.96)24.3611
2020's2 (3.77)2.80

Authors

AuthorsStudies
Chen, K; Li, C; Li, L; Liu, L; Yang, K; Yang, X; Yu, H; Zhang, H1
Guo, F; Li, Z; Liu, J; Liu, Y; Ma, X; Meng, D; Qin, G; Wang, J; Wu, L; Xu, L; Zhang, H; Zhang, L; Zhao, D; Zhao, S; Zhao, Y1
Ando, R; Dong, Y; Dong, Z; Ishida, S; Kanda, A; Kawasaki, A; Mori, S; Murata, M; Noda, K; Saito, M; Saito, W; Yoshida, S1
Bharathidevi, SR; Coral, K; Ramya, R; Sulochana, KN; Vidhya, S1
Augustine, J; Barabas, P; Chen, M; Chevallier, O; Curtis, TM; McCarron, P; McDowell, RE; McGeown, JG1
Chua, KH; Iqbal, T; Kuppusamy, UR; Ng, ZX2
Borsos, AM; M'bemba, J; Peyroux, J; Selam, JL; Slama, G; Sternberg, M; Urios, P1
Khanna, VK; Kruzliak, P; Meyer, CH; Mishra, N; Saxena, S; Shukla, RK; Singh, V1
Gaspar, L; Khanna, V; Kruzliak, P; Mishra, N; Prasad, S; Ruia, S; Saxena, S; Singh, V; Staffa, R1
Dong, Y; Ishida, S; Kanda, A; Murata, M; Noda, K; Saito, W; Yoshida, S1
Fokkens, BT; Los, LI; Mulder, DJ; Schalkwijk, CG; Scheijen, JL; Smit, AJ1
Curtis, TM; Gardiner, TA; Lai, Y; McCance, DR; McDonald, DM; Stitt, AW; Uchida, K; Zhang, X1
Grossin, N; Guillausseau, PJ; Massin, P; Meas, T; Wautier, JL; Wautier, MP1
Baum, L; Chan, JC; Chan, WM; Chan, YM; Choy, KW; Fan, BJ; Fung, NS; Lam, DS; Li, H; Liu, DT; Louey, JW; Pang, CP1
Osredkar, J; Petrovic, D; Petrovic, MG; Saraga-Babić, M1
Al-Zawahary, WM; Mansour, DE; Radwan, AA; Salman, AG; Swelem, AH1
Hara, H; Ikeda, T; Izuta, H; Matsunaga, N; Shimazawa, M; Sugiyama, T1
Curtis, TM; Limb, GA; Medina, RJ; Stitt, AW; Uchida, K; Yong, PH; Zong, H1
Kim, CS; Kim, J; Kim, JS; Sohn, E1
Aiello, LP; Asztalos, BF; Cavallerano, JD; Doria, A; Keenan, HA; King, GL; Monnier, VM; Schaefer, EJ; Sell, DR; Strauch, CM; Sun, JK1
Nagaoka, T; Sato, E; Takahashi, A; Yokota, H; Yoshida, A1
Ben Yahya, S; Bouzidi, H; Hammami, M; Kerkeni, M; Saïdi, A1
Ben Yahia, S; Bouzidi, H; Hammami, M; Kerkeni, M; Letaief, A; Saïdi, A1
Bhadhuri, G; Bhattacharya, B; Choudhuri, S; Chowdhury, IH; Dutta, D; Mitra, B; Mondal, LK; Saha, A; Sen, A1
Alderson, NL; Anderson, NL; Baynes, JW; Boyle, C; Canning, P; Chachich, M; Duffy, N; Frizzell, N; Gardiner, TA; Januszewski, AS; Stitt, A; Thorpe, SR1
Biswas, J; Kumar, SK; Miriam, KC; Nagaraj, RH; Ramakrishnan, S; Sulochana, KN; Swamy-Mruthinti, S1
Fujinami, A; Hasegawa, G; Ikeda, T; Imamura, Y; Kinoshita, S; Nakamura, N; Nakano, K; Obayashi, H; Ogata, M; Ohta, M; Watanabe, A; Yamazaki, M; Yoshikawa, T1
Chiavaroli, C; Garay, RP; Hannaert, P; Rota, R1
Boehm, BO; Kientsch-Engel, R; Lang, GE; Lang, GK; Rosinger, S; Schilling, S; Stahl, P1
Hirata, K; Kubo, K1
De Rojas Silva, MV; Rodríguez-García, J; Rodríguez-Segade, S; Sánchez-Salorio, M; Tomé, CC1
Berkowitz, BA; Connor, JR; Hohman, TC; Knoerzer, DL; Luan, H; Peysakhov, J; Roberts, R1
Cleary, P; Dahms, W; Genuth, S; Malone, J; Monnier, VM; Sell, DR; Sivitz, W; Sun, W1
Fukuhara, M; Fukui, M; Hasegawa, G; Ikeda, T; Nakamura, N; Obayashi, H; Ohta, M; Oku, H; Okuno, T; Sugiyama, T1
Khosrof, S; Nagaraj, R; Sady, C1
Bailie, KE; Baynes, JW; Dunn, JA; Dyer, DG; Lyons, TJ; McCance, DR; Thorpe, SR1
Brandt, R; Hanschke, R; Hartmann, K; Hehmke, B; Jäger, B; Kasbohm, J; Krantz, S; Landmesser, C; Michaelis, D; Vogt, L1
Blanco, MC; Camejo, M; Contreras, I; Giansante, E; Gonzalez, F; Lopez, T; Martinez, N; Molina, M; Postalian, S; Reiser, KM; Sanchez, MR; Suarez, N1
Horiuchi, S; Ikeda, K; Inomuta, H; Ishibashi, T; Murata, T; Nagai, R1
Arai, K; Chikuda, M; Hashimoto, H; Obara, Y1
Kawashima, S; Kurokawa, K; Maeda, K; Miyata, T; Sugiyama, S; Tanaka, H; Ueda, Y; Van Ypersele de Strihou, C1
Aotaki-Keen, A; Handa, JT; Hjelmeland, LM; Lutty, GA; Matsunaga, H; Miyata, T; te Koppele, JM; Verzijl, N1
Bretzel, RG; Brownlee, M; Hammes, HP; Lin, J; Schleicher, E1
Hamada, Y; Horiuchi, S; Hotta, N; Kasuya, Y; Kato, K; Komori, T; Nagai, R; Nakamura, J; Naruse, K1
Fedele, D; Lapolla, A; Traldi, P1
Engerman, RL; Kern, TS1
Endo, M; Higuchi, M; Koike, T; Makita, Z; Matsuda, A; Matsushita, T; Okamoto, T; Takeuchi, M; Tsuchida, K; Yanagisawa, K1
Matsumoto, Y; Ogata, M; Takahashi, M1
Fogarty, J; Lapolla, A; Monnier, VM; Odetti, P; Sell, DR1
Buckingham, B; Charles, MA; Reiser, K; Sebag, J1
Baynes, JW; Dunn, JA; Dyer, DG; Lyons, TJ; Silvestri, G1
Baba, S; Hata, F; Hatanaka, H; Kitamura, Y; Maeda, Y; Matsumoto, S; Nishimoto, S; Oimomi, M1

Reviews

1 review(s) available for lysine and Diabetic Retinopathy

ArticleYear
AGE in micro- and macroangiopathy.
    Contributions to nephrology, 2001, Issue:131

    Topics: Aging; Animals; Arginine; Arteriosclerosis; Cell Adhesion; Collagen; Cross-Linking Reagents; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Neuropathies; Diabetic Retinopathy; Gene Expression Regulation; Glycation End Products, Advanced; Humans; Interferon-gamma; Lysine; Membrane Proteins; Microcirculation; Rats; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; Scavenger Receptors, Class B; T-Lymphocytes; Vascular Diseases

2001

Trials

3 trial(s) available for lysine and Diabetic Retinopathy

ArticleYear
Soluble receptor for advanced glycation end-product (sRAGE)/pentosidine ratio: a potential risk factor determinant for type 2 diabetic retinopathy.
    International journal of molecular sciences, 2013, Apr-03, Volume: 14, Issue:4

    Topics: Adult; Advanced Oxidation Protein Products; Aged; Arginine; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Glutathione Peroxidase; Humans; Lysine; Male; Middle Aged; Receptor for Advanced Glycation End Products; Risk Factors; Superoxide Dismutase

2013
Effects of aspirin or basic amino acids on collagen cross-links and complications in NIDDM.
    Diabetes care, 1997, Volume: 20, Issue:5

    Topics: Analysis of Variance; Arginine; Aspirin; Biopsy; Blood Glucose; Collagen; Cross-Linking Reagents; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Double-Blind Method; Glycated Hemoglobin; Lysine; Placebos; Skin

1997
Plasma levels of pentosidine in diabetic patients: an advanced glycation end product.
    Journal of the American Society of Nephrology : JASN, 1998, Volume: 9, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Analysis of Variance; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Creatinine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Female; Humans; Lysine; Male; Middle Aged; Myocardial Ischemia; Regression Analysis; Sensitivity and Specificity; Severity of Illness Index

1998

Other Studies

49 other study(ies) available for lysine and Diabetic Retinopathy

ArticleYear
Metagenomic shotgun sequencing and metabolomic profiling identify specific human gut microbiota associated with diabetic retinopathy in patients with type 2 diabetes.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Gastrointestinal Microbiome; Humans; Lysine

2022
Long noncoding RNA Hotair facilitates retinal endothelial cell dysfunction in diabetic retinopathy.
    Clinical science (London, England : 1979), 2020, 09-18, Volume: 134, Issue:17

    Topics: Animals; Antigens, CD; Cadherins; Diabetic Retinopathy; Endothelial Cells; Gene Expression Regulation; Gene Knockdown Techniques; Glucose; Histone Demethylases; Histones; Hypoxia-Inducible Factor 1, alpha Subunit; Lysine; Male; Methylation; Mice, Inbred C57BL; Promoter Regions, Genetic; Retina; Retinal Vessels; RNA, Long Noncoding; Vascular Endothelial Growth Factor A

2020
Soluble Vascular Adhesion Protein-1 Mediates Spermine Oxidation as Semicarbazide-Sensitive Amine Oxidase: Possible Role in Proliferative Diabetic Retinopathy.
    Current eye research, 2017, Volume: 42, Issue:12

    Topics: Acrolein; Aged; Amine Oxidase (Copper-Containing); Blotting, Western; Cell Adhesion Molecules; Cell Survival; Cells, Cultured; Diabetic Retinopathy; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Glutathione; Humans; Hydrogen Peroxide; Lysine; Male; Middle Aged; Oxidation-Reduction; Retinal Vessels; Spermine; Vitreous Body

2017
Free amino acids hydroxyproline, lysine, and glycine promote differentiation of retinal pericytes to adipocytes: A protective role against proliferative diabetic retinopathy.
    Experimental eye research, 2018, Volume: 173

    Topics: Adipocytes; Adiponectin; Animals; Cattle; Cell Differentiation; Cells, Cultured; Chromatography, High Pressure Liquid; Diabetic Retinopathy; Glycine; Glycoproteins; Humans; Hydroxyproline; Intercellular Signaling Peptides and Proteins; Lysine; Pericytes; PPAR gamma; Real-Time Polymerase Chain Reaction; Retinal Perforations; Retinal Vessels; Vitreous Body

2018
Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine.
    Diabetologia, 2018, Volume: 61, Issue:12

    Topics: Acrolein; Animals; Cell Survival; Chromatography, Liquid; Diabetic Retinopathy; Electroretinography; Enzyme-Linked Immunosorbent Assay; Ependymoglial Cells; Free Radical Scavengers; Immunohistochemistry; Lysine; Male; Mass Spectrometry; Oxidative Stress; Rats; Rats, Sprague-Dawley

2018
Receptor for advanced glycation end-product (RAGE) gene polymorphism 2245G/A is associated with pro-inflammatory, oxidative-glycation markers and sRAGE in diabetic retinopathy.
    Gene, 2013, Jun-01, Volume: 521, Issue:2

    Topics: Adult; Advanced Oxidation Protein Products; Aged; Arginine; Biomarkers; Chemokine CCL2; Diabetic Retinopathy; Female; Genotype; Glutathione Peroxidase; Glycation End Products, Advanced; Humans; Inflammation; Lysine; Male; Middle Aged; NF-kappa B; Polymorphism, Genetic; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Superoxide Dismutase

2013
Skin collagen pentosidine and fluorescence in diabetes were predictors of retinopathy progression and creatininemia increase already 6years after punch-biopsy.
    Clinical biochemistry, 2016, Volume: 49, Issue:3

    Topics: Adult; Albuminuria; Arginine; Biomarkers; Biopsy; Case-Control Studies; Collagen; Creatinine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Disease Progression; Female; Fluorescence; Humans; Longitudinal Studies; Lysine; Male; Middle Aged; Skin; Spectrometry, Fluorescence

2016
Association of serum N(ε)-Carboxy methyl lysine with severity of diabetic retinopathy.
    Journal of diabetes and its complications, 2016, Volume: 30, Issue:3

    Topics: Adult; Aged; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Humans; Lysine; Male; Middle Aged; Severity of Illness Index

2016
Increased levels of N(ε)- Carboxy methyl lysine (N(ε)-CML) are associated with topographic alterations in retinal pigment epithelium: A preliminary study.
    Journal of diabetes and its complications, 2016, Volume: 30, Issue:5

    Topics: Adult; Biomarkers; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Disease Progression; Female; Glycated Hemoglobin; Humans; Lysine; Male; Middle Aged; Prospective Studies; Regression Analysis; Retinal Pigment Epithelium; Severity of Illness Index; Tertiary Care Centers; Up-Regulation; Vitreoretinopathy, Proliferative

2016
Localization of Acrolein-Lysine Adduct in Fibrovascular Tissues of Proliferative Diabetic Retinopathy.
    Current eye research, 2017, Volume: 42, Issue:1

    Topics: Acrolein; Actins; Adult; Aged; Antigens, CD34; Cell Proliferation; Cell Survival; Cells, Cultured; Diabetic Retinopathy; Endothelium, Vascular; Female; Fluorescent Antibody Technique, Indirect; Glial Fibrillary Acidic Protein; Heme Oxygenase-1; Humans; Lysine; Male; Middle Aged; Paraffin Embedding; Real-Time Polymerase Chain Reaction; Retinal Neovascularization; Retinal Vessels; RNA, Messenger; Young Adult

2017
Vitreous advanced glycation endproducts and α-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Case-Control Studies; Deoxyglucose; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Retinal Detachment

2017
Evaluation of N (epsilon)-(3-formyl-3,4-dehydropiperidino)lysine as a novel biomarker for the severity of diabetic retinopathy.
    Diabetologia, 2008, Volume: 51, Issue:9

    Topics: Antibodies, Monoclonal; Biomarkers; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Humans; Hyperglycemia; Lysine; Reference Values; Severity of Illness Index; White People

2008
Severity of diabetic microvascular complications is associated with a low soluble RAGE level.
    Diabetes & metabolism, 2008, Volume: 34, Issue:4 Pt 1

    Topics: Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lysine; Male; Middle Aged; Receptor for Advanced Glycation End Products; Receptors, Immunologic

2008
EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes.
    Molecular vision, 2008, Sep-15, Volume: 14

    Topics: Age of Onset; Aged; Asparagine; Case-Control Studies; China; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Endothelin-1; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; Lysine; Male; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Regression Analysis

2008
K469E polymorphism of the intracellular adhesion molecule 1 gene is associated with proliferative diabetic retinopathy in Caucasians with type 2 diabetes.
    Clinical & experimental ophthalmology, 2008, Volume: 36, Issue:5

    Topics: Aged; Alanine; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Glycine; Humans; Intercellular Adhesion Molecule-1; Lysine; Male; Middle Aged; Polymorphism, Genetic; Slovenia; White People

2008
Pentosidine - a new biochemical marker in diabetic retinopathy.
    Ophthalmic research, 2009, Volume: 42, Issue:2

    Topics: Adult; Arginine; Biomarkers; Blood Glucose; Blood Proteins; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Disease Progression; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged

2009
Proliferative diabetic retinopathy and relations among antioxidant activity, oxidative stress, and VEGF in the vitreous body.
    Molecular vision, 2010, Jan-29, Volume: 16

    Topics: Antioxidants; Diabetic Retinopathy; Female; Humans; Lysine; Male; Middle Aged; Oxidative Stress; Retinal Perforations; Vascular Endothelial Growth Factor A; Vitreous Body

2010
Evidence supporting a role for N-(3-formyl-3,4-dehydropiperidino)lysine accumulation in Müller glia dysfunction and death in diabetic retinopathy.
    Molecular vision, 2010, Dec-02, Volume: 16

    Topics: Animals; Antibody Specificity; Cell Death; Diabetic Retinopathy; Epitopes; Flow Cytometry; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glycated Hemoglobin; Immunohistochemistry; Inflammation; Lipids; Lysine; Male; Models, Biological; Neuroglia; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Retina; Time Factors

2010
Elevated Nε-(carboxymethyl)lysine is associated with apoptosis of retinal pericytes in streptozotocin-induced diabetic rats.
    Ophthalmic research, 2011, Volume: 46, Issue:2

    Topics: Animals; Apoptosis; Caspase 3; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Fluorescent Antibody Technique, Indirect; Glycation End Products, Advanced; In Situ Nick-End Labeling; Lysine; NF-kappa B; Pericytes; Rats; Rats, Sprague-Dawley; Retinal Vessels

2011
Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study.
    Diabetes care, 2011, Volume: 34, Issue:4

    Topics: Aged; Arginine; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabetic Retinopathy; Female; Humans; Lysine; Male; Middle Aged

2011
Correlation between plasma pentosidine concentrations and retinal hemodynamics in patients with type 2 diabetes.
    American journal of ophthalmology, 2012, Volume: 153, Issue:5

    Topics: Arginine; Blood Flow Velocity; Blood Glucose; Body Constitution; Cholesterol; Cross-Linking Reagents; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Hemodynamics; Humans; Laser-Doppler Flowmetry; Lysine; Male; Middle Aged; Prospective Studies; Retinal Artery

2012
Elevated serum levels of AGEs, sRAGE, and pentosidine in Tunisian patients with severity of diabetic retinopathy.
    Microvascular research, 2012, Volume: 84, Issue:3

    Topics: Aged; Arginine; Biomarkers; Case-Control Studies; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Regression Analysis; Tunisia

2012
Pentosidine as a biomarker for microvascular complications in type 2 diabetic patients.
    Diabetes & vascular disease research, 2013, Volume: 10, Issue:3

    Topics: Aged; Arginine; Biomarkers; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Glycation End Products, Advanced; Humans; Hyperlipidemias; Hypertension; Lysine; Male; Microvessels; Middle Aged; Prospective Studies; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Severity of Illness Index; Up-Regulation

2013
Role of N-ε- carboxy methyl lysine, advanced glycation end products and reactive oxygen species for the development of nonproliferative and proliferative retinopathy in type 2 diabetes mellitus.
    Molecular vision, 2013, Volume: 19

    Topics: Adult; Aged; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Glycation End Products, Advanced; Humans; Leukocytes, Mononuclear; Lysine; Male; Middle Aged; Reactive Oxygen Species; Sulfhydryl Compounds; Vitreous Body

2013
The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes.
    Diabetes, 2002, Volume: 51, Issue:9

    Topics: Animals; Capillaries; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Extracellular Matrix; Female; Glycation End Products, Advanced; Laminin; Lysine; Pyridoxamine; Rats; Rats, Sprague-Dawley; Retina; Retinal Vessels; RNA, Messenger

2002
Immunolocalization and quantification of advanced glycation end products in retinal neovascular membranes and serum: a possible role in ocular neovascularization.
    Current eye research, 2002, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Blood Glucose; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Epiretinal Membrane; Female; Glycation End Products, Advanced; Humans; Immunoenzyme Techniques; Lysine; Male; Middle Aged; Pyruvaldehyde; Retinal Neovascularization; Retinal Vasculitis

2002
Increased concentration of pentosidine, an advanced glycation end product, and interleukin-6 in the vitreous of patients with proliferative diabetic retinopathy.
    Diabetes research and clinical practice, 2003, Volume: 61, Issue:2

    Topics: Adult; Aged; Arginine; Cohort Studies; Cross-Linking Reagents; Diabetic Retinopathy; Female; Glycation End Products, Advanced; Humans; Interleukin-6; Lysine; Male; Middle Aged; Retina; Vitreous Body

2003
Reduction of retinal albumin leakage by the antioxidant calcium dobesilate in streptozotocin-diabetic rats.
    European journal of pharmacology, 2004, Jul-14, Volume: 495, Issue:2-3

    Topics: Albumins; Animals; Antioxidants; Blood-Retinal Barrier; Calcium Dobesilate; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Glycation End Products, Advanced; Hemostatics; Immunohistochemistry; Lysine; Male; Rats; Rats, Wistar; Retina; Vascular Endothelial Growth Factor A

2004
Elevated serum levels of N(epsilon)-carboxymethyl-lysine, an advanced glycation end product, are associated with proliferative diabetic retinopathy and macular oedema.
    Diabetologia, 2004, Volume: 47, Issue:8

    Topics: Biomarkers; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Lysine; Macular Degeneration; Male; Middle Aged

2004
Relationship between blood levels of N-carboxymethyl-lysine and pentosidine and the severity of microangiopathy in type 2 diabetes.
    Endocrine journal, 2004, Volume: 51, Issue:6

    Topics: Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged

2004
Levels of pentosidine in the vitreous of eyes with proliferative diabetic retinopathy, proliferative vitreoretinopathy and retinal detachment.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2005, Volume: 243, Issue:12

    Topics: Arginine; Biomarkers; Chromatography, High Pressure Liquid; Diabetic Retinopathy; Glycation End Products, Advanced; Glycosylation; Humans; In Vitro Techniques; Lysine; Middle Aged; Retinal Detachment; Severity of Illness Index; Vitrectomy; Vitreoretinopathy, Proliferative; Vitreous Body

2005
Drug intervention can correct subnormal retinal oxygenation response in experimental diabetic retinopathy.
    Investigative ophthalmology & visual science, 2005, Volume: 46, Issue:8

    Topics: Animals; Blood Glucose; Carbon Dioxide; Celecoxib; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Inhibitors; Lysine; Magnetic Resonance Imaging; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Oxygen Consumption; Partial Pressure; Pyrazoles; Rats; Retina; Sulfonamides

2005
Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications p
    Diabetes, 2005, Volume: 54, Issue:11

    Topics: Adult; Biopsy; Collagen; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabetic Retinopathy; Disease Progression; Disease Susceptibility; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Prognosis; Skin; Time Factors

2005
Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes.
    Experimental eye research, 2007, Volume: 85, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Arginine; Benzimidazoles; Biphenyl Compounds; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Drug Evaluation, Preclinical; Electroretinography; Gene Expression Regulation; Glycation End Products, Advanced; Lysine; Male; Rats; Rats, Sprague-Dawley; Retina; Reverse Transcriptase Polymerase Chain Reaction; Tetrazoles; Vascular Endothelial Growth Factor A

2007
Advanced Maillard reaction and crosslinking of corneal collagen in diabetes.
    Biochemical and biophysical research communications, 1995, Sep-25, Volume: 214, Issue:3

    Topics: Antioxidants; Arginine; Collagen; Cornea; Cross-Linking Reagents; Diabetes Mellitus; Diabetic Retinopathy; Glycation End Products, Advanced; Humans; Hydroxyproline; Lysine; Maillard Reaction; Pepsin A; Pyridines

1995
Maillard reaction products and their relation to complications in insulin-dependent diabetes mellitus.
    The Journal of clinical investigation, 1993, Volume: 91, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Collagen; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Female; Humans; Lysine; Maillard Reaction; Male; Microcirculation; Middle Aged; Skin

1993
Differential expression of fructosyllysine-specific receptors on monocytes and macrophages and possible pathophysiological significance.
    Diabetologia, 1996, Volume: 39, Issue:10

    Topics: Adult; Age of Onset; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Female; Fructosamine; Glycated Hemoglobin; Humans; Lysine; Macrophages; Male; Membrane Proteins; Middle Aged; Monocytes; Nuclear Proteins; Probability; Rats; Rats, Inbred BB; Reference Values; RNA-Binding Proteins

1996
The relationship between accumulation of advanced glycation end products and expression of vascular endothelial growth factor in human diabetic retinas.
    Diabetologia, 1997, Volume: 40, Issue:7

    Topics: Aged; Aged, 80 and over; Antibodies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Endothelial Growth Factors; Epitopes; Female; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lymphokines; Lysine; Male; Middle Aged; Retina; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

1997
[Relationship between vascular endothelial growth factors and advanced glycation end products in the human vitreous].
    Nippon Ganka Gakkai zasshi, 1998, Volume: 102, Issue:7

    Topics: Adult; Arginine; Cytokines; Diabetic Retinopathy; Disease Progression; Endothelial Growth Factors; Glycation End Products, Advanced; Humans; Lymphokines; Lysine; Middle Aged; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vitreous Body

1998
Increase in the advanced glycation end product pentosidine in Bruch's membrane with age.
    Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Arginine; Bruch Membrane; Choroid; Chromatography, High Pressure Liquid; Diabetic Retinopathy; Glycation End Products, Advanced; Humans; Immunoenzyme Techniques; Infant; Lysine; Middle Aged; Pigment Epithelium of Eye; Retinal Drusen

1999
Diabetic retinopathy risk correlates with intracellular concentrations of the glycoxidation product Nepsilon-(carboxymethyl) lysine independently of glycohaemoglobin concentrations.
    Diabetologia, 1999, Volume: 42, Issue:5

    Topics: Adult; Deoxyglucose; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Leukocyte Common Antigens; Lysine; Male; Middle Aged; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Pyruvaldehyde; Risk Factors; T-Lymphocytes

1999
Epalrestat, an aldose reductase ihibitor, reduces the levels of Nepsilon-(carboxymethyl)lysine protein adducts and their precursors in erythrocytes from diabetic patients.
    Diabetes care, 2000, Volume: 23, Issue:10

    Topics: Aldehyde Reductase; Blood Glucose; Blood Proteins; Deoxyglucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic Retinopathy; Enzyme Inhibitors; Erythrocytes; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Reference Values; Rhodanine; Thiazolidines

2000
Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin.
    Diabetes, 2001, Volume: 50, Issue:7

    Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dogs; Glycated Hemoglobin; Glycation End Products, Advanced; Glycosuria; Guanidines; Kidney; Lysine; Neural Conduction; Platelet Aggregation; Random Allocation; Retinal Vessels; Ulnar Nerve

2001
Increased levels of vascular endothelial growth factor and advanced glycation end products in aqueous humor of patients with diabetic retinopathy.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2001, Volume: 33, Issue:5

    Topics: Aged; Aqueous Humor; Biomarkers; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Endothelial Growth Factors; Female; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lymphokines; Lysine; Male; Middle Aged; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2001
[Relationship between glycoxidation and cytokines in the vitreous of eyes with diabetic retinopathy].
    Nippon Ganka Gakkai zasshi, 2001, Volume: 105, Issue:7

    Topics: Arginine; Cytokines; Diabetic Retinopathy; Glycation End Products, Advanced; Humans; Hydrogen Peroxide; Lysine; Vitreous Body

2001
Pentosidine formation in skin correlates with severity of complications in individuals with long-standing IDDM.
    Diabetes, 1992, Volume: 41, Issue:10

    Topics: Adult; Arginine; Collagen; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabetic Retinopathy; Female; Humans; Lysine; Male; Models, Biological; Reference Values; Skin; Skin Aging

1992
Biochemical abnormalities in vitreous of humans with proliferative diabetic retinopathy.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1992, Volume: 110, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Collagen; Diabetic Retinopathy; Dipeptides; Female; Fluorometry; Humans; Lysine; Male; Middle Aged; Vitreous Body

1992
Role of glycation in modification of lens crystallins in diabetic and nondiabetic senile cataracts.
    Diabetes, 1991, Volume: 40, Issue:8

    Topics: Aged; Arginine; Cataract; Cataract Extraction; Crystallins; Diabetic Retinopathy; Female; Glycosylation; Humans; Lysine; Male

1991
Glycosylation levels of nail proteins in diabetic patients with retinopathy and neuropathy.
    The Kobe journal of medical sciences, 1985, Volume: 31, Issue:5

    Topics: Adult; Aged; Diabetes Mellitus; Diabetic Neuropathies; Diabetic Retinopathy; Female; Humans; Lysine; Male; Middle Aged; Nails

1985