Compounds > lysine
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lysine and Diabetic Glomerulosclerosis

lysine has been researched along with Diabetic Glomerulosclerosis in 102 studies

Research

Studies (102)

TimeframeStudies, this research(%)All Research%
pre-19905 (4.90)18.7374
1990's19 (18.63)18.2507
2000's40 (39.22)29.6817
2010's29 (28.43)24.3611
2020's9 (8.82)2.80

Authors

AuthorsStudies
Fan, H; Fan, Y; Huang, L; Li, P; Liu, Q; Zhou, Y1
Balakrishna, S; Dias, CG; Venkataswamy, L1
Ardjmand, A; Ghavipanjeh, G; Jozi, F; Kheiripour, N; Nasehi, Z; Shahaboddin, ME; Taheri, MA1
Chavan, A; Dwivedi, S; Paul, AT1
Choi, CW; Chung, YH; Ha, SK; Han, EH; Huh, YH; Hyon, JY; Jeong Ha, S; Jeong, HG; Jung, SK; Kim, HJ; Kim, Y; Lee, H; Lee, J; Min, JY; Park, J; Yun, SH1
Kastberger, B; Schwarzbauer, JE; Vega, ME; Wehrle-Haller, B1
Correa-Giannella, MLC; Lira, ALA; Minanni, CA; Nakandakare, ER; Passarelli, M; Pinto, RS; Queiroz, MS; Ronsein, GE; Santana, MFM; Sawada, MIBAC; Silva, ARM1
Cui, Z; Feng, H; Gu, X; Li, C; Liu, Y; Lu, Y; Lv, T; Sheng, W; Wan, Q; Yang, Z; Zhu, S1
Barozzino, M; Casagrande, V; Castellano, G; Cinefra, C; Conserva, F; Divella, C; Federici, M; Gallone, A; Gesualdo, L; Giorgino, F; Menghini, R; Pesce, F; Pontrelli, P; Rossini, M; Simone, S; Stallone, G; Stasi, A1
An, X; He, M; Li, L; Wang, B; Yao, Q; Zhang, J; Zhang, L1
Gao, C; Li, N; Liang, K; Liu, M; Peng, J; Su, H; Sun, Y; Wang, X; Wang, Z; Wei, X; Yi, F; Zhang, C; Zhang, Y; Zhen, J; Zhou, M; Zhou, Z1
Barozzino, M; Castellano, G; Conserva, F; Divella, C; Fiore, MG; Gallone, A; Gesualdo, L; Giorgino, F; Laviola, L; Oranger, A; Papale, M; Piscitelli, D; Pontrelli, P; Rossi, R; Simone, S1
Ahmad, B; Chiew, Y; Kadir, KA; Tan, SMQ1
Nakaya, I; Nakayama, K; Nakayama, M; Soma, J; Tezuka, Y; Yahata, M1
Abdollahi, M; Das, S; Jia, Y; Lanting, L; Natarajan, R; Oh, HJ; Reddy, MA; Wang, M; Yuan, H; Zhang, E1
Aa, J; Cao, B; Ge, Y; Li, M; Liu, L; Liu, Z; Qin, W; Shi, J; Wang, G; Wang, X; Yu, X; Zha, W; Zhao, C; Zheng, T1
Dahl-Jørgensen, K; Fagerland, MW; Hanssen, KF; Jørum, E; Karimé, B; Mellgren, SI; Monnier, VM; Sveen, KA1
Amann, K; Bondeva, T; Daniel, C; Franke, S; Liebisch, M; Wolf, G1
Hedayati, M; Hosseinpanah, F; Nafar, M; Noori, N; Tabibi, H1
Cui, WP; Guo, QY; Miao, LN; Sun, GD1
Cui, W; Kong, L; Li, X; Luo, M; Miao, L; Tan, Y; Wu, H; Xu, F; Zhou, S1
Poretsky, L; Striker, GE; Vlassara, H; Woodward, M; Yubero-Serrano, EM1
Jing, Z; Kuang, L; Liu, N; Yang, J1
Borsos, AM; M'bemba, J; Peyroux, J; Selam, JL; Slama, G; Sternberg, M; Urios, P1
Sun, H; Sun, Z; Yuan, Y1
Beisswenger, PJ; Howell, S; Knowler, WC; Lemley, KV; Mauer, M; Nelson, RG; Saulnier, PJ; Tanamas, SK; Weil, EJ; Wheelock, KM; Yee, B1
Cui, P; Guo, Q; Han, H; Li, C; Li, Q; Li, X; Liu, S; Sun, G1
Gaikwad, AB; Goru, SK; Kadakol, A; Malek, V; Pandey, A; Sharma, N1
Aoki, T; Funabiki, K; Gohda, T; Gotoh, H; Matsumoto, M; Moon, JY; Ohsawa, I; Shibata, T; Tanimoto, M; Tomino, Y1
Grossin, N; Guillausseau, PJ; Massin, P; Meas, T; Wautier, JL; Wautier, MP1
Chang, CJ; Liou, SS; Liu, IM; Tzeng, TF1
An, XF; Gao, F; Gu, WJ; Huang, S; Liu, JS; Ten, SC; Wang, X; Yu, JY; Zhao, Y1
Erhard, P; Genuth, S; Kern, EF; Sun, W; Weiss, MF1
Burrell, LM; Cooper, ME; Coughlan, MT; Forbes, JM; Jerums, G; MacIsaac, RJ; Patel, SK; Penfold, SA; Sourris, KC; Srivastava, PM; Steer, D; Thomas, MC; Webster, DE1
Kang, KS; Kim, HY; Park, JH; Yamabe, N; Yokozawa, T1
Aiello, LP; Asztalos, BF; Cavallerano, JD; Doria, A; Keenan, HA; King, GL; Monnier, VM; Schaefer, EJ; Sell, DR; Strauch, CM; Sun, JK1
Coughlan, MT; Forbes, JM1
Ishii, M; Miyazaki, A; Sanaka, T1
Lin, CY; Yin, MC1
Ben Yahia, S; Bouzidi, H; Hammami, M; Kerkeni, M; Letaief, A; Saïdi, A1
Berger, S; Blackburn, MR; Borok, Z; Chen, L; Jin, J; Li, JM; Liu, M; Wang, Y; Wu, H; Xia, Y; Xiao, Z; Yin, H; Zhang, W; Zhang, X; Zhou, B; Zhou, Q1
Brammar, G; Burns, WC; Cao, Z; Cooper, ME; Forbes, JM; MCLennan, SV; Twigg, SM1
Abd el Baki, RF; Andrassy, M; Bierhaus, A; Dugi, KA; Haering, HU; Hamann, A; Kasper, M; Kloeting, I; Mentz, S; Merz, W; Morcos, M; Nawroth, PP; Sayed, AA; Schleicher, E; Schmidt, AM; Schwenger, V; Stern, D; Tritschler, H; van der Woude, F; Waldherr, R; Yard, B; Ziegler, R1
Koo, JR; Vaziri, ND1
Aoyama, I; Enomoto, A; Nakamura, S; Niwa, T; Tachikawa, T; Takayama, F; Tobita, K1
Blazícek, P; Dzúrik, R; Gazdíková, K; Heidland, A; Schinzel, R; Sebeková, K; Spustová, V; Syrová, D1
Bárány, P; Heimburger, O; Hoff, CM; Holmes, CJ; Lindholm, B; Marchlewska, A; Nordfors, L; Pecoits-Filho, R; Schalling, M; Stenvinkel, P; Suliman, M1
Inagi, R; Ishikawa, N; Koike, H; Kurokawa, K; Miyata, T; Mizuno, M; Nangaku, M; Sada, T; Ueda, Y; van Ypersele de Strihou, C; Yuzawa, H1
Burns, WC; Cooper, ME; Forbes, JM; Founds, HW; Jerums, G; Thallas, V; Thomas, MC1
Abe, M; Hisano, S; Horiuchi, S; Iwasaki, H; Nangaku, M; Sakata, N; Uesugi, N1
Aso, Y; Inukai, T; Sekine, K; Takanashi, K; Takebayashi, K; Yoshida, N; Yoshihara, K1
Hirata, K; Kubo, K1
Bassal, S; Cooper, ME; Deemer, ER; El-Osta, A; Forbes, JM; Jerums, G; Long, DM; Osicka, TM; Panagiotopoulos, S; Pete, J; Thallas-Bonke, V; Thomas, MC; Thorpe, SR1
Hosokawa, T; Sanaka, T1
Baynes, JW; Bleich, M; Busch, AE; Deemer, EK; Dingermann, T; Huber, J; Münch, G; Schäfer, S; Schmid, K; Somoza, V; Wihler, C1
Inagi, R; Izuhara, Y; Kurokawa, K; Miyata, T; Nangaku, M; Shibata, T; Sugiyama, S; Usuda, N; van Ypersele de Strihou, C1
Cleary, P; Dahms, W; Genuth, S; Malone, J; Monnier, VM; Sell, DR; Sivitz, W; Sun, W1
Cottalasso, D; Furfaro, AL; Marinari, UM; Menini, S; Odetti, P; Patriarca, S; Pesce, C; Pronzato, MA; Traverso, N1
Słowik-Zyłka, D1
Basgen, J; Brem, H; Cai, W; Li, Z; Peppa, M; Uribarri, J; Vlassara, H; Zhang, JG1
Brandstädt, A; Busch, M; Franke, S; Gerth, J; Hunsicker, LG; Ott, U; Stein, G; Wolf, G1
Aoki, T; Gohda, T; Hagiwara, S; Horikoshi, S; Ito, T; Kaneko, S; Matsumoto, M; Murakoshi, M; Tanimoto, M; Tomino, Y; Yamada, K1
Busch, M; Franke, S; Stein, G; Wolf, G1
Bach, LA; Cooper, ME; Coughlan, MT; Forbes, JM; Fukami, K; Penfold, SA; Sourris, KC; Thallas-Bonke, V; Thorpe, SR; Yap, FY1
Izuhara, Y; Miyata, T; Nangaku, M; Ohtomo, S; Strihou, Cv; Takizawa, S1
Calabrese, V; Calafato, S; Castellino, P; Cornelius, C; Di Mauro, M; Finocchiaro, M; Mancuso, C; Mangiameli, A; Puleo, E; Sapienza, M; Stella, AM1
Kang, KS; Kim, HY; Yamabe, N; Yokozawa, T1
Busch, M; Franke, S; Rohde, RD; Stein, G; Wolf, G1
Monnier, VM; Sell, DR; Shen, W; Strauch, CM1
Mogensen, CE; Sølling, K; Vittinghus, E1
Denda, M; Inoue, T; Ishihara, C; Kushida, K; Takahashi, M1
Friedlander, MA; Hricik, DE; Monnier, VM; Schulak, JA; Wu, YC1
Beisswenger, PJ; Brinck-Johnsen, T; Curphey, TJ; Moore, LL1
Fogarty, JF; Hricik, DE; Monnier, VM; Schulak, JA; Sell, DR1
Bailie, KE; Baynes, JW; Dunn, JA; Dyer, DG; Lyons, TJ; McCance, DR; Thorpe, SR1
Iida, Y; Kurokawa, K; Maeda, K; Miyata, T; Shinzato, T; Tanaka, S; Ueda, Y; van Ypersele de Strihou, C1
Brandt, R; Hanschke, R; Hartmann, K; Hehmke, B; Jäger, B; Kasbohm, J; Krantz, S; Landmesser, C; Michaelis, D; Vogt, L1
Horie, K; Iida, Y; Maeda, K; Miyata, T; Sugiyama, S; Tanaka, H; Tsuyuki, M1
Blanco, MC; Camejo, M; Contreras, I; Giansante, E; Gonzalez, F; Lopez, T; Martinez, N; Molina, M; Postalian, S; Reiser, KM; Sanchez, MR; Suarez, N1
Izumi, G; Kobayashi, N; Kumano, K; Sakai, T; Shibata, K; Wang, H; Yokota, S; Yoshida, A; Yoshihara, T1
Horie, K; Kurokawa, K; Maeda, K; Miyata, S; Miyata, T; Monnier, VM; Sakai, H; Sugiyama, S; van Ypersole de Strihou, C; Witztum, JL1
Hricik, DE; Justice, AC; Rodby, RA; Weiss, MF1
Kawashima, S; Kurokawa, K; Maeda, K; Miyata, T; Sugiyama, S; Tanaka, H; Ueda, Y; Van Ypersele de Strihou, C1
Horiuchi, S; Imanaga, Y; Meng, J; Nagai, R; Sakata, N; Tachikawa, Y; Takebayashi, S1
Horie, K; Inagi, R; Izuhara, Y; Kurokawa, K; Miyata, T; Sakai, H; Saotome, N; Suzuki, D; Uchida, K; Yagame, M; Yasuda, Y1
Aoyama, I; Katsuzaki, T; Miyazaki, T; Niwa, T; Shimokata, K; Takayama, F; Tsukushi, S1
Daimon, M; Eguchi, H; Hirata, A; Igarashi, M; Kato, T; Manaka, H; Ohnuma, H; Ono, Y; Saito, T; Yamaguchi, H1
Inagi, R; Kurokawa, K; Miyata, T; Sugiyama, S; Suzuki, D1
Böhmer, KP; Haas, A; Hartner, A; Hilgers, KF; Sterzel, RB; Veelken, R1
D'Agati, VD; Fu, C; Kislinger, T; Markowitz, GS; Pischetsrieder, M; Schmidt, AM; Stern, D; Taguchi, A; Tanji, N1
Aricó, CN; Bernich, P; Fedele, D; Gammaro, L; Lapolla, A; Tessitore, N1
Jyothirmayi, GN; Modak, R; Reddi, AS1
Horiuchi, S; Imanaga, Y; Meng, J; Nagai, R; Sakata, N; Takebayashi, S1
Bakala, H; Depreux, P; Fourmaintraux, E; Schwedler, SB; Striker, GE; Striker, LJ; Verbeke, P; Vilar, J; Weiss, MF1
Heidland, A; Kientsch-Engel, R; Mazák, I; Nagy, J; Schinzel, R; Wagner, Z; Wittmann, I1
Horiuchi, S; Meng, J; Nagai, R; Saito, T; Sakata, N; Takebayashi, S; Takeya, M; Uesugi, N1
Antolini, F; Buoncristiani, U; Fagugli, RM; Floridi, A; Floridi, E; Galli, F1
Mogensen, CE1
Munakata, H; Sato, T; Yoshinaga, K; Yosizawa, Z1
Fogarty, J; Lapolla, A; Monnier, VM; Odetti, P; Sell, DR1
Bassiouny, AR; McDonald, TL; Rosenberg, H; Thiele, GM1
Oguma, S; Sato, T; Yoshinaga, K1

Reviews

6 review(s) available for lysine and Diabetic Glomerulosclerosis

ArticleYear
SET7, a lysine-specific methyl transferase: An intriguing epigenetic target to combat diabetic nephropathy.
    Drug discovery today, 2023, Volume: 28, Issue:10

    Topics: Animals; Diabetes Mellitus; Diabetic Nephropathies; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Lysine; Transferases

2023
Histone lysine methylation in diabetic nephropathy.
    Journal of diabetes research, 2014, Volume: 2014

    Topics: Animals; Blood Glucose; Chromatin Assembly and Disassembly; Diabetic Nephropathies; Gene Expression Regulation; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Signal Transduction

2014
The role of microRNAs in diabetic nephropathy.
    Journal of diabetes research, 2014, Volume: 2014

    Topics: Acetylation; Animals; Chromatin; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Dogs; Epigenesis, Genetic; Epigenomics; Histones; Humans; Inflammation; Kidney; Lysine; Methylation; Mice; Mice, Transgenic; MicroRNAs; Rats

2014
[Measurement of plasma pentosidine and the clinical significance in diagnosis of diabetic nephropathies].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 6

    Topics: Arginine; Biomarkers; Diabetic Nephropathies; Enzyme-Linked Immunosorbent Assay; Female; Glycation End Products, Advanced; Humans; Kidney Failure, Chronic; Lysine; Male; Oxidative Stress; Reagent Kits, Diagnostic; ROC Curve; Sensitivity and Specificity

2005
Advanced glycation end-products in diabetic nephropathy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1996, Volume: 11 Suppl 5

    Topics: Animals; Arginine; Blood Glucose; Diabetic Nephropathies; Glycation End Products, Advanced; Glycosylation; Humans; Immunohistochemistry; Lysine; Norleucine; Proteins; Pyrroles

1996
Hemodialysis techniques and advanced glycation end products.
    Contributions to nephrology, 2001, Issue:131

    Topics: Arginine; Blood Proteins; Chromatography, High Pressure Liquid; Diabetic Nephropathies; Glycation End Products, Advanced; Hemodiafiltration; Hemodialysis Solutions; Hemofiltration; Humans; Kidney Failure, Chronic; Lysine; Membranes, Artificial; Molecular Weight; Renal Dialysis; Ultrafiltration; Uremia

2001

Trials

10 trial(s) available for lysine and Diabetic Glomerulosclerosis

ArticleYear
Tocotrienol-Rich Vitamin E from Palm Oil (Tocovid) and Its Effects in Diabetes and Diabetic Nephropathy: A Pilot Phase II Clinical Trial.
    Nutrients, 2018, Sep-17, Volume: 10, Issue:9

    Topics: Aged; Albuminuria; Biomarkers; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Kidney; Lysine; Malaysia; Male; Middle Aged; Pilot Projects; Prospective Studies; Time Factors; Tocotrienols; Treatment Outcome

2018
Effects of combined lipoic acid and pyridoxine on albuminuria, advanced glycation end-products, and blood pressure in diabetic nephropathy.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2013, Volume: 83, Issue:2

    Topics: Adult; Aged; Albuminuria; Arginine; Blood Pressure; Creatinine; Diabetic Nephropathies; Double-Blind Method; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Pyridoxine; Thioctic Acid

2013
Effects of sevelamer carbonate on advanced glycation end products and antioxidant/pro-oxidant status in patients with diabetic kidney disease.
    Clinical journal of the American Society of Nephrology : CJASN, 2015, May-07, Volume: 10, Issue:5

    Topics: Adiponectin; Age Factors; Aged; Albuminuria; Chelating Agents; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dinoprost; Estrogen Receptor alpha; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Intention to Treat Analysis; Lysine; Male; Metformin; Middle Aged; NF-E2-Related Factor 2; Pyruvaldehyde; Receptor for Advanced Glycation End Products; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Sevelamer; Sex Factors; Single-Blind Method; Sirtuin 1; White People

2015
Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes.
    Diabetes, 2016, Volume: 65, Issue:12

    Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glomerular Filtration Rate; Glycation End Products, Advanced; Humans; Imidazoles; Indians, North American; Kidney; Kidney Glomerulus; Losartan; Lysine; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Pyruvaldehyde

2016
[Reduction of carbonyl stress with renal replacement therapy in chronic renal failure].
    Annales Academiae Medicae Stetinensis, 2004, Volume: 50, Issue:2

    Topics: Adult; Arginine; Body Mass Index; Diabetic Nephropathies; Humans; Kidney Failure, Chronic; Kidney Transplantation; Lysine; Oxidative Stress; Renal Dialysis; Treatment Outcome; Ultrafiltration

2004
Serum levels of the advanced glycation end products Nepsilon-carboxymethyllysine and pentosidine are not influenced by treatment with the angiotensin receptor II type 1 blocker irbesartan in patients with type 2 diabetic nephropathy and hypertension.
    Nephron. Clinical practice, 2008, Volume: 108, Issue:4

    Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Arginine; Biphenyl Compounds; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Glomerular Filtration Rate; Glycation End Products, Advanced; Humans; Hypertension; Irbesartan; Linear Models; Lysine; Male; Middle Aged; Statistics, Nonparametric; Tetrazoles

2008
Effects of aspirin or basic amino acids on collagen cross-links and complications in NIDDM.
    Diabetes care, 1997, Volume: 20, Issue:5

    Topics: Analysis of Variance; Arginine; Aspirin; Biopsy; Blood Glucose; Collagen; Cross-Linking Reagents; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Double-Blind Method; Glycated Hemoglobin; Lysine; Placebos; Skin

1997
Free pentosidine and neopterin as markers of progression rate in diabetic nephropathy. Collaborative Study Group.
    Kidney international, 1998, Volume: 54, Issue:1

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomarkers; Captopril; Creatinine; Cross-Linking Reagents; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Progression; Double-Blind Method; Female; Glycated Hemoglobin; Humans; Lysine; Male; Neopterin; Predictive Value of Tests; Survival Analysis

1998
Plasma levels of pentosidine in diabetic patients: an advanced glycation end product.
    Journal of the American Society of Nephrology : JASN, 1998, Volume: 9, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Analysis of Variance; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Creatinine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Female; Humans; Lysine; Male; Middle Aged; Myocardial Ischemia; Regression Analysis; Sensitivity and Specificity; Severity of Illness Index

1998
Immunohistochemical evidence for an increased oxidative stress and carbonyl modification of proteins in diabetic glomerular lesions.
    Journal of the American Society of Nephrology : JASN, 1999, Volume: 10, Issue:4

    Topics: Adult; Biomarkers; Biopsy, Needle; Culture Techniques; Diabetic Nephropathies; Female; Glomerular Mesangium; Glomerulonephritis, IGA; Glycation End Products, Advanced; Humans; Immunohistochemistry; Kidney Function Tests; Lysine; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Protein Denaturation; Reference Values; Sensitivity and Specificity

1999

Other Studies

86 other study(ies) available for lysine and Diabetic Glomerulosclerosis

ArticleYear
Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis.
    Bioengineered, 2022, Volume: 13, Issue:5

    Topics: Animals; Apoptosis; Creatinine; Diabetes Mellitus; Diabetic Nephropathies; Female; Lysine; Male; Mice; Mitogens; Protein Kinases; Protein Serine-Threonine Kinases; Rats, Sprague-Dawley; Saponins; Triterpenes

2022
Diabetic nephropathy patients show hyper-responsiveness to N6-carboxymethyllysine.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2022, Volume: 55

    Topics: Culture Media, Conditioned; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Lysine; NF-kappa B

2022
L-Lysine Ameliorates Diabetic Nephropathy in Rats with Streptozotocin-Induced Diabetes Mellitus.
    BioMed research international, 2022, Volume: 2022

    Topics: Animals; Antioxidants; Blood Glucose; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycation End Products, Advanced; Insulin; Kidney; Lipids; Lysine; Male; Oxidative Stress; Rats; Rats, Wistar; Streptozocin; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A

2022
Mitochondrial carnitine palmitoyltransferase 2 is involved in N
    Pharmacological research, 2020, Volume: 152

    Topics: Animals; Blood Glucose; Carnitine O-Palmitoyltransferase; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Glycated Hemoglobin; Humans; Kidney; Lysine; Male; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Mitochondria

2020
Stimulation of Fibronectin Matrix Assembly by Lysine Acetylation.
    Cells, 2020, 03-08, Volume: 9, Issue:3

    Topics: Acetylation; Animals; Diabetic Nephropathies; Extracellular Matrix; Fibronectins; Humans; Lysine; Mice

2020
Enrichment of apolipoprotein A-IV and apolipoprotein D in the HDL proteome is associated with HDL functions in diabetic kidney disease without dialysis.
    Lipids in health and disease, 2020, Sep-14, Volume: 19, Issue:1

    Topics: Aged; Aged, 80 and over; Albuminuria; Apolipoproteins A; Apolipoproteins D; Arginine; Case-Control Studies; Diabetic Nephropathies; Female; Gene Expression; Glomerular Filtration Rate; Glycation End Products, Advanced; Humans; Interleukin-6; Kidney; Lipopolysaccharides; Lipoproteins, HDL; Lysine; Macrophages; Male; Middle Aged; Primary Cell Culture; Protein Carbamylation; Proteome; Renal Dialysis; Risk Factors; Tumor Necrosis Factor-alpha

2020
General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease.
    Oxidative medicine and cellular longevity, 2021, Volume: 2021

    Topics: Acetylation; Animals; Cell Line; Diabetic Nephropathies; Disease Models, Animal; Down-Regulation; Epithelial Cells; Epithelial-Mesenchymal Transition; Glucose; Humans; Inflammation; Kidney Tubules; Lysine; Male; Mice, Inbred C57BL; Mitochondrial Proteins; Nerve Tissue Proteins; Oxidative Stress; Proteinuria; Reactive Oxygen Species; Streptozocin; Superoxide Dismutase; Ubiquitination

2021
Inhibition of Lysine 63 Ubiquitination Prevents the Progression of Renal Fibrosis in Diabetic DBA/2J Mice.
    International journal of molecular sciences, 2021, May-14, Volume: 22, Issue:10

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Therapy, Combination; Female; Fibrosis; Lysine; Mice; Mice, Inbred DBA; Nitrofurans; Ramipril; Sulfones; Ubiquitination

2021
The receptor for advanced glycation endproducts mediates podocyte heparanase expression through NF-κB signaling pathway.
    Molecular and cellular endocrinology, 2018, 07-15, Volume: 470

    Topics: Animals; Base Sequence; Cattle; Diabetic Nephropathies; Glucuronidase; Glycation End Products, Advanced; HMGB1 Protein; Kidney Cortex; Lysine; Mice, Inbred C57BL; NF-kappa B; Phosphorylation; Podocytes; Promoter Regions, Genetic; Protein Binding; Proteinuria; Receptor for Advanced Glycation End Products; S100 Proteins; Serum Albumin, Bovine; Signal Transduction; Transcription Factor RelA; Up-Regulation

2018
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
    Nature communications, 2017, 09-04, Volume: 8, Issue:1

    Topics: Acetylation; Animals; Apoptosis; Autophagy; Biopsy; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Down-Regulation; Doxorubicin; Gene Deletion; Histones; Humans; Inflammation; Integrases; Kidney; Lysine; Male; Mice, Knockout; Podocytes; Promoter Regions, Genetic; Proteinuria; Rats; Receptors, Notch; Signal Transduction; Sirtuins

2017
Deregulation of autophagy under hyperglycemic conditions is dependent on increased lysine 63 ubiquitination: a candidate mechanism in the progression of diabetic nephropathy.
    Journal of molecular medicine (Berlin, Germany), 2018, Volume: 96, Issue:7

    Topics: Adult; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Diabetic Nephropathies; Disease Progression; Epithelial Cells; Female; Fluorescent Antibody Technique; Gene Expression; Gene Silencing; Humans; Hyperglycemia; Immunohistochemistry; Kidney Tubules; Lysine; Male; Microtubule-Associated Proteins; Middle Aged; Ubiquitination

2018
Methylglyoxal as a prognostic factor in patients with chronic kidney disease.
    Nephrology (Carlton, Vic.), 2019, Volume: 24, Issue:9

    Topics: Aged; Arginine; Biomarkers; Cardiovascular Diseases; Deoxyglucose; Diabetic Nephropathies; Disease Progression; Female; Humans; Japan; Kidney Failure, Chronic; Lysine; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Pyruvaldehyde; Renal Insufficiency, Chronic; Risk Factors; Time Factors; Up-Regulation

2019
Dysregulation of histone H3 lysine 27 trimethylation in transforming growth factor-β1-induced gene expression in mesangial cells and diabetic kidney.
    The Journal of biological chemistry, 2019, 08-23, Volume: 294, Issue:34

    Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Gene Expression Regulation; Histones; Humans; Injections, Intraperitoneal; Lysine; Male; Mesangial Cells; Methylation; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Streptozocin; Transforming Growth Factor beta1

2019
GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy.
    American journal of physiology. Renal physiology, 2013, Jun-01, Volume: 304, Issue:11

    Topics: 3-Hydroxybutyric Acid; Albuminuria; Allantoin; Amino Acids; Animals; Arachidonic Acid; Biomarkers; Cholesterol; Citric Acid; Citric Acid Cycle; Diabetic Nephropathies; Gas Chromatography-Mass Spectrometry; Glycolysis; Hydrogen-Ion Concentration; Lipid Metabolism; Lysine; Malates; Male; Metabolomics; Mice; Mice, Inbred C57BL; Succinic Acid; Urine

2013
Small- and large-fiber neuropathy after 40 years of type 1 diabetes: associations with glycemic control and advanced protein glycation: the Oslo Study.
    Diabetes care, 2013, Volume: 36, Issue:11

    Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Follow-Up Studies; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Imidazoles; Lysine; Male; Middle Aged; Nerve Fibers; Pyruvaldehyde; Sensory Thresholds; Young Adult

2013
Activation of the receptor for advanced glycation end products induces nuclear inhibitor of protein phosphatase-1 suppression.
    Kidney international, 2014, Volume: 86, Issue:1

    Topics: Animals; Apoptosis; Case-Control Studies; Cell Cycle Checkpoints; Cell Enlargement; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Diabetic Nephropathies; Down-Regulation; Endoribonucleases; Glycation End Products, Advanced; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Mice; Necrosis; NF-kappa B; Phosphoprotein Phosphatases; Podocytes; Receptor for Advanced Glycation End Products; RNA-Binding Proteins; RNA, Messenger; RNA, Small Interfering; Serum Albumin, Bovine

2014
LC-MS/MS for the simultaneous determination of polar endogenous ADMA and CML in plasma and urine from diabetics.
    Bioanalysis, 2015, Volume: 7, Issue:10

    Topics: Arginine; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Linear Models; Lysine; Retrospective Studies; Tandem Mass Spectrometry

2015
Skin collagen pentosidine and fluorescence in diabetes were predictors of retinopathy progression and creatininemia increase already 6years after punch-biopsy.
    Clinical biochemistry, 2016, Volume: 49, Issue:3

    Topics: Adult; Albuminuria; Arginine; Biomarkers; Biopsy; Case-Control Studies; Collagen; Creatinine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Disease Progression; Female; Fluorescence; Humans; Longitudinal Studies; Lysine; Male; Middle Aged; Skin; Spectrometry, Fluorescence

2016
Update on Mechanisms of Renal Tubule Injury Caused by Advanced Glycation End Products.
    BioMed research international, 2016, Volume: 2016

    Topics: ATP Binding Cassette Transporter 1; Cell Line; Cholesterol; Diabetic Nephropathies; Endoplasmic Reticulum Stress; Epithelial Cells; Foam Cells; Glycation End Products, Advanced; Humans; Kidney Tubules; Lipid Metabolism; Liver X Receptors; Lysine; Receptors, LDL; Sterol Regulatory Element Binding Protein 2

2016
Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions.
    Journal of diabetes research, 2016, Volume: 2016

    Topics: Animals; Antibodies; Blotting, Western; Cyclin-Dependent Kinase Inhibitor p21; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Gene Expression Regulation; Glucose; Histone Code; Histone-Lysine N-Methyltransferase; In Vitro Techniques; Kidney Glomerulus; Lysine; Male; Mesangial Cells; Methylation; Promoter Regions, Genetic; Rats; Rats, Wistar; Transforming Growth Factor beta1

2016
H2AK119 monoubiquitination regulates Angiotensin II receptor mediated macrophage infiltration and renal fibrosis in type 2 diabetic rats.
    Biochimie, 2016, Volume: 131

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blotting, Western; Chemokine CCL2; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Fibrosis; Histones; Imidazoles; Kidney; Lysine; Macrophages; Male; Promoter Regions, Genetic; Pyridines; Rats, Wistar; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; Telmisartan; Transforming Growth Factor beta1; Ubiquitination

2016
Increased serum endogenous secretory receptor for advanced glycation end-product (esRAGE) levels in type 2 diabetic patients with decreased renal function.
    Diabetes research and clinical practice, 2008, Volume: 81, Issue:2

    Topics: Aged; Arginine; Carotid Arteries; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Lysine; Male; Middle Aged; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Renal Dialysis; Severity of Illness Index; Tunica Intima; Tunica Media; Ultrasonography

2008
Severity of diabetic microvascular complications is associated with a low soluble RAGE level.
    Diabetes & metabolism, 2008, Volume: 34, Issue:4 Pt 1

    Topics: Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lysine; Male; Middle Aged; Receptor for Advanced Glycation End Products; Receptors, Immunologic

2008
The amelioration of streptozotocin diabetes-induced renal damage by Wu-Ling-San (Hoelen Five Herb Formula), a traditional Chinese prescription.
    Journal of ethnopharmacology, 2009, Jul-15, Volume: 124, Issue:2

    Topics: Albuminuria; Animals; Blood Glucose; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drugs, Chinese Herbal; Fibronectins; Glycation End Products, Advanced; Hypoglycemic Agents; Kidney; Lysine; Magnoliopsida; Male; Mitochondria; NF-kappa B; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiobarbituric Acid Reactive Substances; Transforming Growth Factor beta1

2009
Plasma sRAGE is not associated with urinary microalbumin excretion in type 2 diabetic nephropathy at the early stage.
    Diabetes research and clinical practice, 2010, Volume: 87, Issue:2

    Topics: Age of Onset; Aged; Albuminuria; Blood Glucose; Blood Pressure; Body Mass Index; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme-Linked Immunosorbent Assay; Female; Glomerular Filtration Rate; Glycated Hemoglobin; Humans; Lipids; Lysine; Male; Middle Aged; Patient Selection; Receptor for Advanced Glycation End Products; Receptors, Immunologic

2010
Early urinary markers of diabetic kidney disease: a nested case-control study from the Diabetes Control and Complications Trial (DCCT).
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2010, Volume: 55, Issue:5

    Topics: Acetylglucosaminidase; Adolescent; Adult; Albuminuria; Arginine; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Predictive Value of Tests; Young Adult

2010
Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy.
    Kidney international, 2010, Volume: 78, Issue:3

    Topics: Aged; Antibodies, Neutralizing; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme-Linked Immunosorbent Assay; Female; HMGB1 Protein; Humans; Ligands; Lysine; Male; Middle Aged; Molecular Weight; Protein Kinase C-alpha; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Transcription, Genetic

2010
Effects of heat-processed ginseng and its active component ginsenoside 20(S)-Rg3 on the progression of renal damage and dysfunction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:6

    Topics: Animals; Antioxidants; Blood Glucose; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Ginsenosides; Glycation End Products, Advanced; Hypoglycemic Agents; Kidney; Kidney Diseases; Lipid Peroxidation; Lipids; Lysine; Male; Nitric Oxide Synthase Type II; Oxidative Stress; Panax; Phytotherapy; Plant Extracts; Proteinuria; Rats; Rats, Inbred OLETF; Thiobarbituric Acid Reactive Substances

2010
Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study.
    Diabetes care, 2011, Volume: 34, Issue:4

    Topics: Aged; Arginine; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabetic Retinopathy; Female; Humans; Lysine; Male; Middle Aged

2011
Temporal increases in urinary carboxymethyllysine correlate with albuminuria development in diabetes.
    American journal of nephrology, 2011, Volume: 34, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Animals; Biomarkers; Cytosol; Deoxyguanosine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Gene Expression; Glomerular Filtration Rate; Glycation End Products, Advanced; Kidney Cortex; Lysine; Male; Mitochondria; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA, Messenger; Streptozocin; Time Factors

2011
[Pentosidine].
    Nihon rinsho. Japanese journal of clinical medicine, 2010, Volume: 68 Suppl 9

    Topics: Arginine; Diabetic Nephropathies; Enzyme-Linked Immunosorbent Assay; Humans; Lysine

2010
Renal protective effects of extracts from guava fruit (Psidium guajava L.) in diabetic mice.
    Plant foods for human nutrition (Dordrecht, Netherlands), 2012, Volume: 67, Issue:3

    Topics: Aldehyde Reductase; Animals; Anti-Inflammatory Agents; Antioxidants; Arginine; Blood Glucose; Blood Urea Nitrogen; Cytokines; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Response Relationship, Drug; Fructose; Fruit; Hypoglycemic Agents; Insulin; Kidney; Lysine; Male; Mice; Mice, Inbred BALB C; Phytotherapy; Plant Extracts; Psidium; Reactive Oxygen Species

2012
Pentosidine as a biomarker for microvascular complications in type 2 diabetic patients.
    Diabetes & vascular disease research, 2013, Volume: 10, Issue:3

    Topics: Aged; Arginine; Biomarkers; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Glycation End Products, Advanced; Humans; Hyperlipidemias; Hypertension; Lysine; Male; Microvessels; Middle Aged; Prospective Studies; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Severity of Illness Index; Up-Regulation

2013
Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Amino Acid Sequence; Animals; Aquaporin 2; Aquaporin 5; Base Sequence; Cell Nucleus; Chromatin Immunoprecipitation; Diabetic Nephropathies; Endoplasmic Reticulum; Golgi Apparatus; Histone-Lysine N-Methyltransferase; Histones; Humans; Kidney; Lysine; Methylation; Methyltransferases; Mice; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Polyuria; Protein Binding; Protein Transport; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Transcription, Genetic; Up-Regulation

2013
Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine.
    Endocrinology, 2002, Volume: 143, Issue:12

    Topics: Animals; Cells, Cultured; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibronectins; Gene Expression; Glomerular Mesangium; Glycation End Products, Advanced; Guanidines; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Lysine; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Serum Albumin, Bovine

2002
Activation of tubular epithelial cells in diabetic nephropathy.
    Diabetes, 2002, Volume: 51, Issue:12

    Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Epithelium; Glycation End Products, Advanced; Humans; Kidney; Kidney Tubules; Lysine; NF-kappa B; Rats; Rats, Brattleboro; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reference Values; Serum Albumin; Transcription, Genetic; Urine

2002
Effects of diabetes, insulin and antioxidants on NO synthase abundance and NO interaction with reactive oxygen species.
    Kidney international, 2003, Volume: 63, Issue:1

    Topics: Animals; Antioxidants; Blood Pressure; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Insulin; Lysine; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tyrosine

2003
An inhibitor of advanced glycation end product formation reduces N epsilon-(carboxymethyl)lysine accumulation in glomeruli of diabetic rats.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003, Volume: 41, Issue:3 Suppl 1

    Topics: Age Factors; Animals; Antibodies, Monoclonal; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Glomerular Mesangium; Glycation End Products, Advanced; Kidney; Kidney Glomerulus; Lysine; Rats; Rats, Inbred OLETF; Rats, Inbred Strains; Thiadiazoles; Thiazolidines

2003
Effects of ramipril in nondiabetic nephropathy: improved parameters of oxidatives stress and potential modulation of advanced glycation end products.
    Journal of human hypertension, 2003, Volume: 17, Issue:4

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Biomarkers; Blood Glucose; Blood Pressure; Creatinine; Cystatin C; Cystatins; Diabetic Nephropathies; Female; Glomerulonephritis; Glycation End Products, Advanced; Homocysteine; Humans; Lipofuscin; Lysine; Male; Malondialdehyde; Middle Aged; Nephritis, Interstitial; Oxidative Stress; Polycystic Kidney Diseases; Ramipril; Severity of Illness Index; Statistics as Topic; Treatment Outcome

2003
A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients.
    Kidney international. Supplement, 2003, Issue:84

    Topics: Arginine; Arteriosclerosis; Chlamydia Infections; Chlamydophila pneumoniae; Diabetic Nephropathies; Female; Genotype; Humans; Kidney Failure, Chronic; Lysine; Male; Middle Aged; Oxidative Stress; Peroxidase; Polymorphism, Single Nucleotide; Risk Factors

2003
Anti-hypertensive agents inhibit in vivo the formation of advanced glycation end products and improve renal damage in a type 2 diabetic nephropathy rat model.
    Journal of the American Society of Nephrology : JASN, 2003, Volume: 14, Issue:5

    Topics: Animals; Antihypertensive Agents; Arginine; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Glycation End Products, Advanced; Hydralazine; Hypertension, Renal; Imidazoles; Immunohistochemistry; In Vitro Techniques; Kidney; Lipids; Lysine; Male; Olmesartan Medoxomil; Oxidation-Reduction; Proteinuria; Rats; Tetrazoles

2003
The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:12

    Topics: Albuminuria; Animal Population Groups; Animals; Blood Pressure; Collagen; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Glycation End Products, Advanced; Immediate-Early Proteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kidney; Kinetics; Lysine; Models, Biological; Rats; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Solubility; Thiazoles; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrosine

2003
Possible mechanism for medial smooth muscle cell injury in diabetic nephropathy: glycoxidation-mediated local complement activation.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2004, Volume: 44, Issue:2

    Topics: Acrolein; Adult; Aged; Aged, 80 and over; Arteriosclerosis; Complement Activation; Complement Membrane Attack Complex; Diabetic Nephropathies; Female; Glomerulosclerosis, Focal Segmental; Glycation End Products, Advanced; Humans; Hypertension; Kidney; Kidney Glomerulus; Lysine; Male; Middle Aged; Models, Biological; Nephrosclerosis; Oxidation-Reduction; Tunica Media

2004
Dissociation between urinary pyrraline and pentosidine concentrations in diabetic patients with advanced nephropathy.
    The Journal of laboratory and clinical medicine, 2004, Volume: 144, Issue:2

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Arginine; beta 2-Microglobulin; Biomarkers; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glycated Hemoglobin; Humans; Lysine; Pyrroles; Reference Values; Regression Analysis

2004
Relationship between blood levels of N-carboxymethyl-lysine and pentosidine and the severity of microangiopathy in type 2 diabetes.
    Endocrine journal, 2004, Volume: 51, Issue:6

    Topics: Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged

2004
Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy.
    Journal of the American Society of Nephrology : JASN, 2005, Volume: 16, Issue:8

    Topics: Alternative Splicing; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Arginine; Blotting, Western; Cattle; Cells, Cultured; Collagen; Diabetic Nephropathies; DNA Primers; Endothelium, Vascular; Glycation End Products, Advanced; Humans; Immunohistochemistry; Immunoprecipitation; Kidney Cortex; Lysine; Male; Microscopy, Fluorescence; Molecular Weight; Peptidyl-Dipeptidase A; Ramipril; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; Skin; Time Factors; Up-Regulation

2005
Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: effect of angiotensin-converting enzyme and vasopeptidase inhibition.
    Diabetologia, 2005, Volume: 48, Issue:8

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Ascorbic Acid; Blood Glucose; Chromatography, High Pressure Liquid; Creatine; Deoxyglucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glycated Hemoglobin; Glycation End Products, Advanced; Heterocyclic Compounds, 3-Ring; Kidney; Lysine; Male; Oxidation-Reduction; Protease Inhibitors; Ramipril; Rats; Rats, Zucker; Spectrometry, Fluorescence

2005
In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005, Volume: 20, Issue:12

    Topics: Animals; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diet, Fat-Restricted; Disease Models, Animal; Female; Follow-Up Studies; Glycation End Products, Advanced; Immunohistochemistry; Kidney; Lysine; Male; Microscopy, Electron; Obesity; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Wistar

2005
Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications p
    Diabetes, 2005, Volume: 54, Issue:11

    Topics: Adult; Biopsy; Collagen; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabetic Retinopathy; Disease Progression; Disease Susceptibility; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Prognosis; Skin; Time Factors

2005
HNE-dependent molecular damage in diabetic nephropathy and its possible prevention by N-acetyl-cysteine and oxerutin.
    BioFactors (Oxford, England), 2005, Volume: 24, Issue:1-4

    Topics: Acetylcysteine; Aldehydes; Animals; Apoptosis; Cell Division; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycation End Products, Advanced; Hydroxyethylrutoside; Immunohistochemistry; Kidney Glomerulus; Lipid Peroxidation; Lysine; Male; Rats; Rats, Wistar; Taurine

2005
Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711).
    American journal of nephrology, 2006, Volume: 26, Issue:5

    Topics: Animals; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Lysine; Mice; Mice, Mutant Strains; Thiazoles

2006
The advanced glycation end product N(epsilon)-carboxymethyllysine is not a predictor of cardiovascular events and renal outcomes in patients with type 2 diabetic kidney disease and hypertension.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006, Volume: 48, Issue:4

    Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Disease Progression; Female; Glycation End Products, Advanced; Humans; Hypertension; Lysine; Male; Middle Aged; Multivariate Analysis; Oxidative Stress; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Risk Factors

2006
Effect of pyridoxamine (K-163), an inhibitor of advanced glycation end products, on type 2 diabetic nephropathy in KK-A(y)/Ta mice.
    Metabolism: clinical and experimental, 2007, Volume: 56, Issue:2

    Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dose-Response Relationship, Drug; Glycation End Products, Advanced; Immunohistochemistry; Laminin; Lysine; Male; Mice; Pyridoxamine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Schiff Bases; Transforming Growth Factor beta1; Tyrosine

2007
[Is the serum concentration of pentosidine a predictor of cardiovascular events in patients with type 2 diabetes and kidney disease?].
    Deutsche medizinische Wochenschrift (1946), 2007, Volume: 132, Issue:36

    Topics: Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Humans; Lipoproteins, LDL; Lysine; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Prospective Studies; Risk Factors; Time Factors

2007
Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway.
    Diabetes, 2008, Volume: 57, Issue:2

    Topics: Acetophenones; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Glomerular Mesangium; Glycation End Products, Advanced; Lysine; Male; NADPH Oxidases; Protein Kinase C-alpha; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Superoxides

2008
Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:4

    Topics: Animals; Antimutagenic Agents; Arginine; Basic Helix-Loop-Helix Transcription Factors; Blood Pressure; Blotting, Western; Chromatography, High Pressure Liquid; Cobalt; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Gene Expression; Glycation End Products, Advanced; Hypertension; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immediate-Early Proteins; Insulin-Like Growth Factor Binding Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Lysine; Male; NADPH Oxidases; Obesity; Oxidative Stress; Polymerase Chain Reaction; Rats; Rats, Inbred SHR; RNA, Messenger; Transforming Growth Factor beta

2008
Oxidative stress and cellular stress response in diabetic nephropathy.
    Cell stress & chaperones, 2007,Winter, Volume: 12, Issue:4

    Topics: Aldehydes; Arginine; Chaperonin 60; Diabetic Nephropathies; F2-Isoprostanes; Female; Heat-Shock Response; Heme Oxygenase-1; HSP70 Heat-Shock Proteins; Humans; Lymphocytes; Lysine; Male; Middle Aged; Oxidative Stress; Protein Carbonylation; Renal Insufficiency; Thioredoxin Reductase 1

2007
Role of maltol in advanced glycation end products and free radicals: in-vitro and in-vivo studies.
    The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:4

    Topics: Animals; Blood Glucose; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Glycated Serum Albumin; Glycation End Products, Advanced; Guanidines; Lysine; Male; Proteinuria; Pyrones; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Serum Albumin; Streptozocin; Transcription Factor RelA

2008
Aging, diabetes, and renal failure catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen: evidence for metal-catalyzed oxidation mediated by alpha-dicarbonyls.
    Annals of the New York Academy of Sciences, 2008, Volume: 1126

    Topics: 2-Aminoadipic Acid; Adolescent; Adult; Aging; Child; Child, Preschool; Collagen; Diabetes Mellitus; Diabetic Nephropathies; Humans; Infant; Infant, Newborn; Lysine; Middle Aged; Oxidation-Reduction; Skin; Skin Aging

2008
Studies on mechanisms of proteinuria using amino-acid-induced inhibition of tubular reabsorption in normal and diabetic man.
    Contributions to nephrology, 1981, Volume: 26

    Topics: Albuminuria; Amino Acids; beta 2-Microglobulin; Diabetic Nephropathies; Humans; Kidney Tubules; Lysine; Male; Proteinuria

1981
Plasma pentosidine levels in uremic patients before and after hemodialysis.
    Scandinavian journal of urology and nephrology, 1995, Volume: 29, Issue:2

    Topics: Arginine; beta 2-Microglobulin; Cross-Linking Reagents; Diabetic Nephropathies; Glycosylation; Humans; Kidney; Kidney Failure, Chronic; Lysine; Metabolic Clearance Rate; Renal Dialysis; Uremia

1995
Influence of dialysis modality on plasma and tissue concentrations of pentosidine in patients with end-stage renal disease.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1995, Volume: 25, Issue:3

    Topics: Arginine; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Diabetic Nephropathies; Female; Humans; Kidney Failure, Chronic; Linear Models; Lysine; Male; Middle Aged; Peritoneal Dialysis; Peritoneum; Renal Dialysis; Skin

1995
Increased collagen-linked pentosidine levels and advanced glycosylation end products in early diabetic nephropathy.
    The Journal of clinical investigation, 1993, Volume: 92, Issue:1

    Topics: Adult; Age Factors; Arginine; Collagen; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Sex Factors; Time Factors

1993
Effects of kidney or kidney-pancreas transplantation on plasma pentosidine.
    Kidney international, 1993, Volume: 43, Issue:2

    Topics: Adult; Arginine; Diabetic Nephropathies; Female; Glycated Hemoglobin; Humans; Kidney Failure, Chronic; Kidney Transplantation; Lysine; Male; Middle Aged; Models, Chemical; Pancreas Transplantation; Time Factors

1993
Maillard reaction products and their relation to complications in insulin-dependent diabetes mellitus.
    The Journal of clinical investigation, 1993, Volume: 91, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Collagen; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Female; Humans; Lysine; Maillard Reaction; Male; Microcirculation; Middle Aged; Skin

1993
Accumulation of albumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure: renal implications in the pathophysiology of pentosidine.
    Journal of the American Society of Nephrology : JASN, 1996, Volume: 7, Issue:8

    Topics: Animals; Arginine; beta 2-Microglobulin; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diet; Glomerulonephritis; Humans; Kidney Failure, Chronic; Lysine; Maillard Reaction; Nephrectomy; Oxidation-Reduction; Protein Binding; Rats; Rats, Wistar; Serum Albumin; Uremia

1996
Differential expression of fructosyllysine-specific receptors on monocytes and macrophages and possible pathophysiological significance.
    Diabetologia, 1996, Volume: 39, Issue:10

    Topics: Adult; Age of Onset; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Female; Fructosamine; Glycated Hemoglobin; Humans; Lysine; Macrophages; Male; Membrane Proteins; Middle Aged; Monocytes; Nuclear Proteins; Probability; Rats; Rats, Inbred BB; Reference Values; RNA-Binding Proteins

1996
Kinetic analysis of furosine and pentosidine in CAPD patients.
    Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, 1997, Volume: 13

    Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Diabetes Mellitus; Diabetic Nephropathies; Dialysis Solutions; Glycation End Products, Advanced; Humans; In Vitro Techniques; Kidney Failure, Chronic; Lysine; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Proteins; Renal Dialysis

1997
Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy.
    The Journal of clinical investigation, 1997, Dec-15, Volume: 100, Issue:12

    Topics: Adolescent; Adult; Aged; Animals; Antibodies; Arginine; Collagen; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Humans; Immunoenzyme Techniques; Kidney Glomerulus; Lipid Peroxidation; Lysine; Male; Malondialdehyde; Mice; Middle Aged; Nephrotic Syndrome; Norleucine; Pyrroles; Rabbits

1997
Increased advanced glycation end products in atherosclerotic lesions of patients with end-stage renal disease.
    Atherosclerosis, 1999, Volume: 142, Issue:1

    Topics: Aged; Aorta; Apolipoproteins B; Arteriosclerosis; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Humans; Immunohistochemistry; Kidney Failure, Chronic; Lysine; Male; Middle Aged

1999
Increased erythrocyte 3-DG and AGEs in diabetic hemodialysis patients: role of the polyol pathway.
    Kidney international, 1999, Volume: 55, Issue:5

    Topics: Adult; Aged; Aldehyde Reductase; Arginine; Creatinine; Deoxyglucose; Diabetic Nephropathies; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Female; Glycation End Products, Advanced; Hemoglobins; Humans; Imidazoles; In Vitro Techniques; Lysine; Male; Middle Aged; Polymers; Renal Dialysis; Sorbitol; Uremia

1999
Increased serum levels of pentosidine, but not carboxymethyl lysine, in type 2 diabetes without obvious diabetic nephropathy.
    Diabetes care, 1999, Volume: 22, Issue:5

    Topics: Albuminuria; Arginine; Biomarkers; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Lysine; Middle Aged; Reference Values

1999
Increased carbonyl modification by lipids and carbohydrates in diabetic nephropathy.
    Kidney international. Supplement, 1999, Volume: 71

    Topics: Animals; Carbohydrate Metabolism; Cells, Cultured; Diabetic Nephropathies; Glycation End Products, Advanced; Humans; Immunohistochemistry; Kidney Glomerulus; Lipid Metabolism; Lipid Peroxidation; Lysine; Malondialdehyde; Oxidation-Reduction; Rats

1999
Nitric oxide synthase isoforms and glomerular hyperfiltration in early diabetic nephropathy.
    Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:1

    Topics: Animals; Blood Pressure Determination; Blotting, Northern; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glomerular Filtration Rate; Hemodynamics; Isoenzymes; Kidney Function Tests; Kidney Glomerulus; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Streptozocin

2000
Expression of advanced glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease.
    Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:9

    Topics: Adult; Antibodies; Arginine; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Humans; Immunohistochemistry; Kidney Diseases; Lysine; Male; Middle Aged; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reference Values; RNA, Messenger

2000
L-lysine reduces nonenzymatic glycation of glomerular basement membrane collagen and albuminuria in diabetic rats.
    Nephron, 2001, Volume: 87, Issue:2

    Topics: Albuminuria; Animals; Basement Membrane; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycated Hemoglobin; Glycosylation; Kidney Glomerulus; Lysine; Male; Rats; Rats, Wistar

2001
Carboxymethyllysine in dermal tissues of diabetic and nondiabetic patients with chronic renal failure: relevance to glycoxidation damage.
    Nephron, 2001, Volume: 88, Issue:1

    Topics: Aged; Animals; Antibodies, Monoclonal; Collagen; Dermis; Diabetic Nephropathies; Endopeptidases; Enzyme-Linked Immunosorbent Assay; Female; Glycation End Products, Advanced; Humans; Kidney Failure, Chronic; Lysine; Male; Mice; Mice, Inbred BALB C; Middle Aged

2001
N-phenacylthiazolium bromide decreases renal and increases urinary advanced glycation end products excretion without ameliorating diabetic nephropathy in C57BL/6 mice.
    Diabetes, obesity & metabolism, 2001, Volume: 3, Issue:4

    Topics: Animals; Arginine; Collagen; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Glomerular Mesangium; Glycation End Products, Advanced; Kidney; Kidney Glomerulus; Lysine; Mice; Mice, Inbred C57BL; Proteinuria; Thiazoles

2001
N(epsilon)-(carboxymethyl)lysine levels in patients with type 2 diabetes: role of renal function.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2001, Volume: 38, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Oxidative Stress

2001
Glycoxidation-modified macrophages and lipid peroxidation products are associated with the progression of human diabetic nephropathy.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2001, Volume: 38, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Diabetic Nephropathies; Female; Glycosylation; Humans; Immunohistochemistry; Kidney Glomerulus; Leukocyte Common Antigens; Lipid Peroxidation; Lysine; Macrophages; Male; Middle Aged; Oxidation-Reduction; Phosphatidylcholines; Receptors, Immunologic; Receptors, Scavenger; Scavenger Receptors, Class A; Severity of Illness Index

2001
Daily haemodialysis improves indices of protein glycation.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2002, Volume: 17, Issue:5

    Topics: Adult; Aged; Arginine; Circadian Rhythm; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Humans; Kidney Failure, Chronic; Longitudinal Studies; Lysine; Male; Middle Aged; Molecular Weight; Prospective Studies; Renal Dialysis

2002
Renal function changes in diabetes.
    Diabetes, 1976, Volume: 25, Issue:2 SUPPL

    Topics: Antihypertensive Agents; Arginine; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Glomerular Filtration Rate; Glucose; Humans; Insulin; Kidney; Kidney Function Tests; Kidney Glomerulus; Lysine; Male; Organ Size; Proteinuria

1976
Comparison of the chemical composition of glomerular and tubular basement membranes obtained from human kidneys of diabetics and non-diabetics.
    Clinica chimica acta; international journal of clinical chemistry, 1975, Jun-02, Volume: 61, Issue:2

    Topics: Adult; Aged; Amino Acids; Basement Membrane; Carbohydrates; Cystine; Diabetes Mellitus; Diabetic Nephropathies; Female; Humans; Hydroxylation; Hydroxylysine; Kidney Glomerulus; Kidney Tubules; Lysine; Male; Middle Aged; Phospholipids

1975
Pentosidine formation in skin correlates with severity of complications in individuals with long-standing IDDM.
    Diabetes, 1992, Volume: 41, Issue:10

    Topics: Adult; Arginine; Collagen; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabetic Retinopathy; Female; Humans; Lysine; Male; Models, Biological; Reference Values; Skin; Skin Aging

1992
Accelerated onset of albuminuria in diabetic rats preimmunized with glucosylated rat serum albumin.
    Journal of clinical & laboratory immunology, 1985, Volume: 18, Issue:2

    Topics: Albuminuria; Animals; Antibody Formation; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Response Relationship, Immunologic; Enzyme-Linked Immunosorbent Assay; Epitopes; Immunization; Lysine; Rats; Serum Albumin; Streptozocin

1985
Studies on amino acid composition of renal glomeruli from the diabetics.
    The Tohoku journal of experimental medicine, 1985, Volume: 147, Issue:1

    Topics: Aged; Amino Acids; Collagen; Diabetes Mellitus; Diabetic Nephropathies; Female; Humans; Hydroxylysine; Hydroxyproline; Kidney Glomerulus; Lysine; Male; Middle Aged; Proline

1985