lysine has been researched along with Diabetes Mellitus, Type 2 in 227 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (8.37) | 18.7374 |
| 1990's | 23 (10.13) | 18.2507 |
| 2000's | 69 (30.40) | 29.6817 |
| 2010's | 84 (37.00) | 24.3611 |
| 2020's | 32 (14.10) | 2.80 |
| Authors | Studies |
|---|---|
| Bhadada, SK; Goni, VG; Karn, S; Kumar, N; Mehandia, V; Neradi, D; Pal, R; Rao, SD; Sharma, S; Sihota, P; Yadav, RN | 1 |
| Akhtar, A; Chatterjee, A; Pessoa Rodrigues, C; Shvedunova, M; Stehle, T; Szymanski, W; Wiese, M | 1 |
| Dhaliwal, R; Ewing, SK; Schwartz, AV; Semba, RD; Vashishth, D | 1 |
| Berendschot, TT; de Goei, EE; Eussen, SJ; Hanssen, H; Houben, AJ; Linkens, AM; Mari, A; Niessen, PM; Schalkwijk, CG; Scheijen, JL; Stehouwer, CD; Streese, L; Van den Eynde, MD; van den Waarenburg, MP; van Dongen, MC; van Gool, CC; Wijckmans, NE | 1 |
| Burke, C; Carrillo-Sepulveda, MA; Johnson, CM; Kramer, B; Lutz, O; Maddie, N; Persand, D; Yakoub, B | 1 |
| Kuang, Y; Liu, Y; Wang, D; Xiao, K; Zhang, G | 1 |
| Beauloye, C; Bertrand, L; Bouzin, C; Bultot, L; De Loof, M; Fourny, N; Ginion, A; Horman, S; Poüs, C; Renguet, E | 1 |
| Chen, QJ; Chen, S; Dai, Y; Ding, FH; Li, FF; Li, LY; Lu, L; Shen, WF; Shen, Y; Wang, XQ; Wu, ZM | 1 |
| Balakrishna, S; Dias, CG; Venkataswamy, L | 1 |
| Chen, K; Li, C; Li, L; Liu, L; Yang, K; Yang, X; Yu, H; Zhang, H | 1 |
| Ahmad, S; Alenazi, F; Alharbi, MS; Ashraf, JM; Hagbani, TA; Khaja, ASS; Qamar, M; Rafi, Z; Saleem, M; Zafar, M | 1 |
| Gordts, PLSM; Harrington, AR; Nora, C; Omar, I; Pollow, DP; Ramms, B; Sander, M; Wortham, M; Zhu, H | 1 |
| Abdel-Wahab, YHA; Attoub, S; Casciaro, B; Conlon, JM; Hunter, L; Mechkarska, M | 1 |
| Di, Z; Ji, Z; Lin, J; Yan, C; Zeng, S; Zhang, Y | 1 |
| An, M; Hoffman, BG; Luciani, DS; Lynn, FC; Maeshima, N; McDonald, CL; Pasula, DJ; Suresh, P; Vanderkruk, B | 1 |
| Hisamatsu, T; Ida, Y; Kato, Y; Miyoshi, S; Nakamura, H; Ohnishi, H; Okamoto, S; Tokunaga, K; Toue, S; Yoneyama, R | 1 |
| Auwerx, J; Baek, S; Fang, S; Jeon, J; Jeon, JH; Jung, HY; Kim, B; Kim, KT; Kim, MJ; Lee, D; Lee, IK; Lim, CW; Oh, CJ; Park, BY; Park, O; Ryu, D | 1 |
| Du, SC; Jiang, FL; Jiang, P; Liu, XY; Liu, Y | 1 |
| Chen, H; Chen, S; Chu, Y; Dong, D; Li, C; Liu, X; Lu, J; Ren, G; Wan, Y; Wang, X; Xiang, S; Yang, X; Yao, S; Yin, R; Yu, M; Zhao, C; Zhao, L | 1 |
| Bravo, SB; Chantada-Vazquez, P; Coppari, R; da Silva Lima, N; Delgado, TC; Diaz-Moreno, I; Diaz-Quintana, A; Dieguez, C; Fernández, U; Fondevila, MF; Frühbeck, G; Gonzalez-Rellan, MJ; Guallar, D; Lopez, M; Martinez-Chantar, ML; Nogueiras, R; Novoa, E; Parracho, T; Perez-Mejias, G; Prevot, V; Ramos, L; Riobello, C; Rodríguez, A; Schwaninger, M; Serrano-Maciá, M; Tovar, S; Veyrat-Durebex, C; Woodhoo, A | 1 |
| Guo, Z; Li, Y; Liang, Y; Liu, Y; Qu, L; Sun, G; Wang, H; Wang, Y; Zhang, C | 1 |
| Bouxsein, M; Dawson-Hughes, B; Shea, K | 1 |
| Berska, J; Bugajska, J; Gotfryd-Bugajska, K; Pasternak, A; Sztefko, K; Szura, M | 1 |
| Ambrósio, AR; Andrade, VFC; Bavia, L; Borba, VZC; Cavalheiro, DDDS; Chula, DC; da Costa, CRV; Dos Reis, LM; Moreira, CA; Sabbag, FP | 1 |
| Dayon, L; Santo-Domingo, J; Wiederkehr, A | 1 |
| Alonso-Gómez, A; Clish, CB; Corella, D; Dennis, C; Estruch, R; Fitó, M; Gómez-Gracia, E; Guasch-Ferré, M; Hu, FB; Lapetra, J; Li, J; Liang, L; Martínez-González, MA; Pierce, KA; Razquin, C; Romaguera, D; Ros, E; Ruiz-Canela, M; Salas-Huetos, A; Salas-Salvadó, J; Serra-Majem, L; Toledo, E | 1 |
| Cardelo, MP; de la Cruz-Ares, S; García-Rios, A; Gutiérrez-Mariscal, FM; Katsiki, N; López-Miranda, J; Malagón, MM; Pérez-Martínez, P; Torres-Peña, JD; Yubero-Serrano, EM | 1 |
| Colvin, SC; Mastracci, TL; Mirmira, RG; Padgett, LR | 1 |
| Achenbach, SJ; Atkinson, EJ; Bondar, OP; Drake, MT; Eckhardt, BA; Farr, JN; Hines, JM; Khosla, S; O'Grady, KL; Singh, RJ; Thicke, BS; Tweed, AJ; Volkman, TL | 1 |
| Chan, AC; Tu, LH; Wu, MH | 1 |
| Alizadeh, M; Esmaeili, F; Kheirouri, S; Maleki, V | 1 |
| Hu, J; Li, J; Liu, X; Wang, L; Zhang, X | 1 |
| Bararpour, N; Darrous, L; Froguel, P; Gasser, M; Gilardi, F; Kutalik, Z; Marques-Vidal, P; Porcu, E; Thomas, A; Waeber, G; Yengo, L | 1 |
| Du, Y; Liu, J; Lu, A; Ye, X; Zhang, Q; Zhang, X | 1 |
| Chen, L; Cui, C; Guo, X; He, Q; Hou, X; Hu, H; Li, D; Li, X; Liang, K; Song, J; Wang, C; Wang, X; Yan, F; Zang, N | 1 |
| Clifton, PM; Keogh, JB; Kim, Y | 1 |
| Amouzegar, A; Azizi, F; Hedayati, M; Mirmiran, P; Sahranavard, S; Talaei, B | 1 |
| Furey, A; Likhodii, S; Liu, M; Randell, EW; Sun, G; Zhai, G; Zhang, W | 1 |
| Gaikwad, AB; Goru, SK; Kadakol, A; Malek, V | 1 |
| Chen, X; Chen, Y; He, R; He, Y; Li, J; Liu, Y; Su, T; Wei, Y; Xu, Y | 1 |
| Bao, Z; Dai, Z; Jing, L; Li, L; Shao, C; Sun, Z; Wang, Z; Xu, S; Yan, J; Ye, F; Zhu, J | 1 |
| Clifton, PM; Deo, P; Keogh, JB; Price, NJ | 1 |
| Choi, YJ; Chung, Y-; Jin, Y; Kim, SH; Lee, JS; Ock, SY | 1 |
| Berge, RK; Flygel, MR; Lysne, V; Løland, KH; Nygård, O; Pedersen, ER; Rebnord, EW; Strand, E; Svardal, A; Svingen, GFT; Tell, GS | 1 |
| Faraji, E; Houjeghani, S; Jafarabadi, MA; Kheirouri, S | 1 |
| Clay Bunn, R; Creecy, A; Nyman, JS; Unal, M; Uppuganti, S; Voziyan, P | 1 |
| Falgayrac, G; Kerckhofs, G; Luyten, F; Marin, C; Papantonakis, G; Penel, G; Sels, K; Van der Schueren, B; van Lenthe, GH; Vandamme, K; Vangoitsenhoven, R | 1 |
| Gao, J; Guo, Y; Ji, L; Li, J; Li, L; Liu, D; Liu, P; Pan, B; Pennathur, S; Su, J; Wang, Y; Willard, B; Xiang, S; Xu, L; Zhang, D; Zhao, M; Zheng, L | 1 |
| Archer, M; Eyre, DR; Hudson, DM; King, KB | 1 |
| An, X; Liu, J; Liu, S; Xu, W; Yu, J; Yu, X; Zhao, Y | 1 |
| Ahmad, B; Chiew, Y; Kadir, KA; Tan, SMQ | 1 |
| Blair, CA; Campbell, KS; Holewinski, RJ; Kirk, JA; Li, A; Martin, TG; Moravec, CS; Papadaki, M; Previs, SB; Stachowski, MJ; Van Eyk, JE; Warshaw, DM | 1 |
| Ahmad, J; Alam, K; Arif, Z; Neelofar, K | 1 |
| Alves-Wagner, AB; Correa-Giannella, ML; Esteves, JV; Giannella-Neto, D; Machado, UF; Okamoto, MM; Yonamine, CY | 1 |
| Chua, KH; Iqbal, T; Kuppusamy, UR; Ng, ZX | 1 |
| Dekker, JM; Engelen, L; Ferreira, I; Hanssen, NM; Huijberts, MS; Nijpels, G; Schalkwijk, CG; Scheijen, JL; Stehouwer, CD; van der Kallen, CJ; van Greevenbroek, MM | 1 |
| González-Borrachero, ML; González-Fernández, FA; Ropero-Gradilla, P; Vergara-Chozas, JM | 1 |
| Barzilay, JI; Fonseca, V; Goldfine, AB; Jablonski, KA; Monnier, VM; Shoelson, SE; Strauch, C | 1 |
| Aubert, CE; Bourron, O; Fonfrede, M; Gillery, P; Hartemann, A; Jaisson, S; Michel, PL; Morel, F | 1 |
| Miller, CB; Szwergold, BS | 1 |
| Hu, G; Li, KJ; Lin, YJ; Wei, J; Zhao, YF; Zhen, YZ | 1 |
| Beggiato, E; Bisi, M; Dosio, E; Gaita, F; Grimaldi, R; Lococo, MF; Lonni, E; Presutti, DG; Tagliabue, M; Valpreda, A | 1 |
| Chen, WC; Lee, MR; Lee, WJ; Liang, KW; Lin, LY; Lin, SY; Liu, SH; Shen, CC; Sheu, ML; Sheu, WH; Tien, HR; Tsai, YC; Yang, TJ; Yeh, HY; Yi, YC | 1 |
| Cai, T; Du, Y; He, X; Li, T; Liu, P; Wei, P; Wei, T; Xue, P; Yang, F; Zhou, B | 1 |
| Poretsky, L; Striker, GE; Vlassara, H; Woodward, M; Yubero-Serrano, EM | 1 |
| Jing, Z; Kuang, L; Liu, N; Yang, J | 1 |
| Daniel, H; Ecker, J; Giesbertz, P; Höfle, AS; Padberg, I; Rein, D; Spanier, B | 1 |
| Brismar, K; Kärvestedt, L; Malmstedt, J; Swedenborg, J | 1 |
| Chae, SY; Kim, K; Lee, KC; Lim, SM; Na, DH; Park, EJ; Son, S | 1 |
| Borsos, AM; M'bemba, J; Peyroux, J; Selam, JL; Slama, G; Sternberg, M; Urios, P | 1 |
| Kanazawa, I; Sugimoto, T; Tanaka, K | 1 |
| Yamauchi, M | 1 |
| Khanna, VK; Kruzliak, P; Meyer, CH; Mishra, N; Saxena, S; Shukla, RK; Singh, V | 1 |
| Bathaie, SZ; Ebadi, M; Gerayesh-Nejad, S; Kebriaeezadeh, A; Khaghani, S; Mirmiranpour, H; Nakhjavani, M; Zangooei, M | 1 |
| Ali, A; Habib, S; Mir, AR; Siddiqui, SS | 1 |
| Ge, YS; Lin, YZ; Liu, Y; Sha, L; Shen, QF; Sun, CK; Wang, C; Xu, HZ; Zhang, JH | 1 |
| He, J; Jing, Z; Kuang, L; Liu, N; Sun, Z; Wang, Y; Yang, J | 1 |
| Gaspar, L; Khanna, V; Kruzliak, P; Mishra, N; Prasad, S; Ruia, S; Saxena, S; Singh, V; Staffa, R | 1 |
| Brunner-La Rocca, HP; Dekker, JM; Henry, RM; Linssen, PB; Nijpels, G; Schalkwijk, CG; Stehouwer, CD | 1 |
| Beelman, RB; Cai, W; Calvo, MS; Goh, BC; Kalaras, MD; Mehrotra, A; Nadkarni, G; Uribarri, J; Wang, L | 1 |
| Andican, A; Andican, G; Burcak, G; Kurt, A; Siva, ZO | 1 |
| Dagnelie, PC; Henry, RM; Koster, A; Kroon, AA; Schalkwijk, CG; Schaper, N; Scheijen, J; Schram, MT; Sep, SJ; Smit, AJ; Stehouwer, CD; van der Kallen, CJ; van Eupen, MG; van Sloten, TT | 1 |
| Beisswenger, PJ; Howell, S; Knowler, WC; Lemley, KV; Mauer, M; Nelson, RG; Saulnier, PJ; Tanamas, SK; Weil, EJ; Wheelock, KM; Yee, B | 1 |
| Gaikwad, AB; Goru, SK; Kadakol, A; Malek, V; Pandey, A; Sharma, N | 1 |
| Berriche, O; Bouzidi, H; Haddad, M; Hammami, M; Kerkeni, M; Knani, I | 1 |
| Chattipakorn, N; Kongtawelert, P; Phimphilai, M; Pothacharoen, P | 1 |
| Bachschmid, MM; Irani, K; Jacobs, JS; Kassan, M; Kim, YR; Kumar, A; Kumar, S; Kumar, V; Li, Q; Naqvi, A; Vikram, A | 1 |
| Bahn, G; Beisswenger, PJ; Howell, S; Reaven, PD; Saremi, A; Schwenke, DC | 1 |
| Fokkens, BT; Los, LI; Mulder, DJ; Schalkwijk, CG; Scheijen, JL; Smit, AJ | 1 |
| Feng, K; Huang, G; Liao, B; Liu, Y; Xiang, Q | 1 |
| Emoto, M; Inaba, M; Ishimura, E; Nagayama, H; Nishizawa, Y; Okabe, R; Okazaki, S | 1 |
| Aoki, T; Funabiki, K; Gohda, T; Gotoh, H; Matsumoto, M; Moon, JY; Ohsawa, I; Shibata, T; Tanimoto, M; Tomino, Y | 1 |
| Curtis, TM; Gardiner, TA; Lai, Y; McCance, DR; McDonald, DM; Stitt, AW; Uchida, K; Zhang, X | 1 |
| Aller, R; Conde, R; de Luis, DA; Gonzalez Sagrado, M; Izaola, O | 1 |
| Lanting, L; Natarajan, R; Reddy, MA; Villeneuve, LM; Wang, M | 1 |
| Grossin, N; Guillausseau, PJ; Massin, P; Meas, T; Wautier, JL; Wautier, MP | 1 |
| Baum, L; Chan, JC; Chan, WM; Chan, YM; Choy, KW; Fan, BJ; Fung, NS; Lam, DS; Li, H; Liu, DT; Louey, JW; Pang, CP | 1 |
| Osredkar, J; Petrovic, D; Petrovic, MG; Saraga-Babić, M | 1 |
| Arakaki, RF; Florez, JC; Goldstein, BJ; Hanson, RL; Jablonski, KA; Kahn, SE; Kitabchi, AE; Knowler, WC; Mason, CC; McAteer, JB; Moore, AF | 1 |
| Chen, AS; Miwa, I; Taguchi, T | 1 |
| Alam, K; Ali, A; Ansari, NA | 1 |
| Bauer, DC; Black, DM; Cummings, SR; Feingold, KR; Garnero, P; Harris, TB; Hillier, TA; Resnick, HE; Schwartz, AV; Sellmeyer, DE; Strotmeyer, ES; Tylavsky, FA | 1 |
| Bao, Y; Jia, W; Qiu, Y; Su, M; Wang, X; Zhao, T | 1 |
| Sugimoto, T; Yamaguchi, T; Yamamoto, M; Yamauchi, M | 1 |
| Chaudhuri, BS; Ray, M; Ray, S; Talukdar, D | 1 |
| An, XF; Gao, F; Gu, WJ; Huang, S; Liu, JS; Ten, SC; Wang, X; Yu, JY; Zhao, Y | 1 |
| Chen, X; Gong, ZC; Huang, Q; Liu, ZQ; Ren, HY; Sheng, FF; Wu, J; Xu, XJ; Yin, JY; Yu, M; Zhou, HH | 1 |
| Chae, SY; Choi, YG; Jung, SY; Lee, DS; Lee, KC; Son, S | 1 |
| Burrell, LM; Cooper, ME; Coughlan, MT; Forbes, JM; Jerums, G; MacIsaac, RJ; Patel, SK; Penfold, SA; Sourris, KC; Srivastava, PM; Steer, D; Thomas, MC; Webster, DE | 1 |
| Frolov, A; Hoffmann, R | 1 |
| Fortpied, J; Van Schaftingen, E; Vertommen, D | 1 |
| Kang, KS; Kim, HY; Park, JH; Yamabe, N; Yokozawa, T | 1 |
| Cai, W; Chen, X; Mericq, V; Piccardo, C; Striker, GE; Uribarri, J; Vlassara, H; Zhu, L | 1 |
| Kang, KS; Noh, JS; Park, CH; Shibahara, N; Tanaka, T; Yamabe, N; Yokozawa, T | 1 |
| Hashim, Z; Zarina, S | 1 |
| Chen, Z; Feng, G; He, L; Liu, Y; Liu, Z; Xu, H; Yang, Y; Yu, L; Zhang, D; Zhang, Z; Zhao, T; Zhou, D | 1 |
| Boehnke, M; Boyle, AP; Chines, PS; Collins, FS; Crawford, GE; Erdos, MR; Furey, TS; Margulies, EH; Parker, SC; Pearson, DS; Scott, LJ; Sethupathy, P; Song, L; Stitzel, ML; Welch, R | 1 |
| Ataei, F; Bakhtiyari, S; Gerayesh-Nejad, S; Gulkho, S; Hanachi, P; Larijani, B; Meshkani, R; Mohammadi, M; Mohammadtaghvaei, N; Parvaneh, L; Saberi, H; Zargari, M | 1 |
| Engelen, L; Ferreira, I; Hovind, P; Parving, HH; Persson, F; Rossing, P; Schalkwijk, CG; Stehouwer, CD; Teerlink, T | 1 |
| Basta, G; Del Turco, S; Gastaldelli, A; Navarra, T | 1 |
| Kanazawa, I; Sugimoto, T; Yamaguchi, T; Yamamoto, M | 1 |
| Aertgeerts, K; Asakawa, T; Banno, Y; Funami, M; Ikedo, K; Kataoka, O; Kosaka, T; Maezaki, H; Miyamoto, Y; Moritoh, Y; Moritou, Y; Oi, S; Sasaki, M; Suzuki, N; Takeuchi, K; Tani, A; Tawada, M; Tsubotani, S; Yamamoto, Y; Yano, J | 1 |
| Wolf, DH | 1 |
| Brown, L; Fairlie, DP; Iyer, A | 1 |
| Nagaoka, T; Sato, E; Takahashi, A; Yokota, H; Yoshida, A | 1 |
| Bathaie, SZ; Kebriaeezadeh, A; Khaghani, S; Mirmiranpour, H; Nakhjavani, M | 1 |
| Manolopoulos, VG; Petridis, I; Ragia, G; Tavridou, A | 1 |
| Yamamoto, M | 1 |
| Ben Yahia, S; Bouzidi, H; Hammami, M; Kerkeni, M; Letaief, A; Saïdi, A | 1 |
| Matsui, J; Matsuki, K; Matsumura, K; Murakami, H; Suda, T; Tamasawa, N; Tanabe, J; Yamashita, M | 1 |
| Bhadhuri, G; Bhattacharya, B; Choudhuri, S; Chowdhury, IH; Dutta, D; Mitra, B; Mondal, LK; Saha, A; Sen, A | 1 |
| Abd el Baki, RF; Andrassy, M; Bierhaus, A; Dugi, KA; Haering, HU; Hamann, A; Kasper, M; Kloeting, I; Mentz, S; Merz, W; Morcos, M; Nawroth, PP; Sayed, AA; Schleicher, E; Schmidt, AM; Schwenger, V; Stern, D; Tritschler, H; van der Woude, F; Waldherr, R; Yard, B; Ziegler, R | 1 |
| Berg, TJ; Birkeland, KI; Brownlee, M; Giardino, I; Hanssen, KF; Kilhovd, BK; Thornalley, PJ; Torjesen, PA | 1 |
| Aoyama, I; Enomoto, A; Nakamura, S; Niwa, T; Tachikawa, T; Takayama, F; Tobita, K | 1 |
| Boulanger, E; Guillausseau, PJ; Huijberts, M; Laloi-Michelin, M; Levy, B; Massin, P; Wautier, JL; Wautier, MP | 1 |
| Inagi, R; Ishikawa, N; Koike, H; Kurokawa, K; Miyata, T; Mizuno, M; Nangaku, M; Sada, T; Ueda, Y; van Ypersele de Strihou, C; Yuzawa, H | 1 |
| Daimon, M; Hirata, A; Igarashi, M; Kameda, W; Kato, T; Ohnuma, H; Oizumi, T; Saitoh, T; Sugiyama, K; Yamaguchi, H | 1 |
| Braun, A; Busch, M; Fleck, C; Franke, S; Müller, A; Müller, UA; Schiel, R; Stein, G | 1 |
| Almgren, P; Altshuler, D; Burtt, N; Daly, MJ; de Bakker, PI; Florez, JC; Gaudet, D; Groop, L; Hirschhorn, JN; Holmkvist, J; Hudson, TJ; Schaffner, SF; Tuomi, T | 1 |
| Barker, DJ; Eriksson, JG; Forsen, T; Kubaszek, A; Laakso, M; Markkanen, A; Osmond, C | 1 |
| Cervin, C; Cilio, CM; Groop, L; Heikkinen, S; Liljeström, B; Tapanainen, JS; Tuomi, T | 1 |
| Alderson, NL; Baynes, JW; Gans, ROB; Graaff, R; Jager, JJ; Links, TP; Meerwaldt, R; Oomen, PHN; Smit, AJ; Thorpe, SR | 1 |
| Boehm, BO; Kientsch-Engel, R; Lang, GE; Lang, GK; Rosinger, S; Schilling, S; Stahl, P | 1 |
| Aso, Y; Inukai, T; Sekine, K; Takanashi, K; Takebayashi, K; Yoshida, N; Yoshihara, K | 1 |
| Eriksson, J; Hämäläinen, H; Ilanne-Parikka, P; Keinänen-Kiukaanniemi, S; Laakso, M; Laukkanen, O; Lindström, J; Pihlajamäki, J; Tuomilehto, J; Uusitupa, M; Valle, TT | 1 |
| Hirata, K; Kubo, K | 1 |
| Biemel, KM; Lederer, MO; Monnier, VM; Reihl, O; Sell, DR; Strauch, CM | 1 |
| Aso, Y; Okumura, K; Yoshida, N | 1 |
| Andersen, G; Borch-Johnsen, K; Carstensen, B; Drivsholm, T; Ek, J; Glümer, C; Hansen, SK; Hansen, T; Jørgensen, T; Mouritzen, P; Nielsen, EM; Pedersen, O | 1 |
| Fujimoto, M; Kaneki, M; Kunii, K; Martyn, JA; Shimizu, N; Ueki, K | 1 |
| Bierhaus, A; Haslbeck, KM; Haslbeck, M; Heuss, D; Nawroth, P; Neundörfer, B; Schleicher, E | 1 |
| Lapolla, A; Ragazzi, E; Reitano, R; Sartore, G; Seraglia, R; Traldi, P | 1 |
| Baccarin, L; Fedele, D; Lapolla, A; Plebani, M; Reitano, R; Sartore, G | 1 |
| Baynes, JW; Bleich, M; Busch, AE; Deemer, EK; Dingermann, T; Huber, J; Münch, G; Schäfer, S; Schmid, K; Somoza, V; Wihler, C | 1 |
| Busch, AE; Huber, J; Linz, W; Rütten, H; Schäfer, S; Wihler, C | 1 |
| Inagi, R; Izuhara, Y; Kurokawa, K; Miyata, T; Nangaku, M; Shibata, T; Sugiyama, S; Usuda, N; van Ypersele de Strihou, C | 1 |
| Albrechtsen, A; Borch-Johnsen, K; Ek, J; Glümer, C; Grarup, N; Hansen, T; Jørgensen, T; Pedersen, O; Urhammer, SA | 1 |
| Gonzalez-Reche, LM; Kraus, T; Kucharczyk, A; Musiol, AK | 1 |
| Basta, G; Buzzigoli, E; Casolaro, A; Del Turco, S; Ferrannini, E; Gastaldelli, A; Lazzerini, G; Natali, A; Sironi, AM | 1 |
| Brandstädt, A; Busch, M; Franke, S; Gerth, J; Hunsicker, LG; Ott, U; Stein, G; Wolf, G | 1 |
| Milutinović, A; Petrovic, D | 1 |
| Aoki, T; Gohda, T; Hagiwara, S; Horikoshi, S; Ito, T; Kaneko, S; Matsumoto, M; Murakoshi, M; Tanimoto, M; Tomino, Y; Yamada, K | 1 |
| Altshuler, D; Dabelea, D; Florez, JC; Franks, PW; Hamman, RF; Jablonski, KA; Kahn, SE; Knowler, WC; Nathan, DM | 1 |
| Flatt, PR; Gault, VA; Green, BD; Greer, B; Harriott, P; Hunter, K; Irwin, N; O'Harte, FP | 1 |
| Ahmad, TS; Kuppusamy, UR; Mahmood, AA; Nazratun, N; Tan, SY | 1 |
| Fukuhara, M; Fukui, M; Hasegawa, G; Ikeda, T; Nakamura, N; Obayashi, H; Ohta, M; Oku, H; Okuno, T; Sugiyama, T | 1 |
| Baatz, JE; Baynes, JW; Bethard, J; Blatnik, M; Brock, JW; Frizzell, N; Nagai, R; Thorpe, SR; Walla, MD | 1 |
| Busch, M; Franke, S; Stein, G; Wolf, G | 1 |
| Izuhara, Y; Miyata, T; Nangaku, M; Ohtomo, S; Strihou, Cv; Takizawa, S | 1 |
| Chae, SY; Jin, CH; Lee, KC; Lee, S; Shin, HJ; Youn, YS | 1 |
| Sugimoto, T; Yamaguchi, T; Yamamoto, M; Yamauchi, M; Yano, S | 1 |
| Heine, RJ; Niessen, HW; Schalkwijk, CG; Simsek, S; van Deutekom, AW | 1 |
| Busch, M; Franke, S; Rohde, RD; Stein, G; Wolf, G | 1 |
| Baba, S; Hatanaka, H; Ishikawa, K; Kubota, S; Oimomi, M; Yoshimura, Y | 1 |
| Baynes, JW; Feather, MS; Lyons, TJ; McCance, DR; Thorpe, SR; Wells-Knecht, KJ | 1 |
| Orekhov, AN; Sobenin, IA; Tertov, VV | 1 |
| Contreras, I; Giansante, E; Gonzalez-Mujica, F; Lopez, T; Martinez, N; Molina, M; Postalian, S; Reiser, KM; Sanchez, MR; Suarez, N | 1 |
| Carlson, EC; Monnier, VM; Sell, DR | 1 |
| Aoshima, H; Horiuchi, K; Inoue, T; Kawana, K; Kushida, K; Ohishi, T; Takahashi, M | 1 |
| Bailie, KE; Baynes, JW; Dunn, JA; Dyer, DG; Lyons, TJ; McCance, DR; Thorpe, SR | 1 |
| Aronica, R; Baldo, L; Catinella, S; Fedele, D; Lapolla, A; Seraglia, R; Traldi, P | 1 |
| Best, JD; Dragicevic, G; Grieve, G; O'Neal, D; Rae, D | 1 |
| Iida, Y; Kurokawa, K; Maeda, K; Miyata, T; Shinzato, T; Tanaka, S; Ueda, Y; van Ypersele de Strihou, C | 1 |
| Blanco, MC; Camejo, M; Contreras, I; Giansante, E; Gonzalez, F; Lopez, T; Martinez, N; Molina, M; Postalian, S; Reiser, KM; Sanchez, MR; Suarez, N | 1 |
| Horiuchi, S; Ikeda, K; Inomuta, H; Ishibashi, T; Murata, T; Nagai, R | 1 |
| Horie, K; Kurokawa, K; Maeda, K; Miyata, S; Miyata, T; Monnier, VM; Sakai, H; Sugiyama, S; van Ypersole de Strihou, C; Witztum, JL | 1 |
| Block, C; Ferguson, K; Fogarty, J; Haas, C; Hampel, N; Ni, Z; Polak, J; Razmjouei, K; Seftel, AD; Vaziri, ND; Wang, RZ | 1 |
| Horiuchi, S; Nishizawa, Y; Sugimoto, K; Yagihashi, S | 1 |
| Ishiguro, N; Ito, T; Iwata, H; Kurokawa, K; Miyata, T; Nangaku, M; Yasuda, Y | 1 |
| Horiuchi, S; Ikeda, K; Kushiro, M; Makino, H; Shikata, K; Sugimoto, H | 1 |
| Kawashima, S; Kurokawa, K; Maeda, K; Miyata, T; Sugiyama, S; Tanaka, H; Ueda, Y; Van Ypersele de Strihou, C | 1 |
| Birnbacher, R; Herkner, K; Kampel, D; Krapfenbauer, K; Lubec, G; Vierhapper, H | 1 |
| LePage, K; Newkirk, MM; Niwa, T; Rubin, L | 1 |
| Maeda, K; Matsumoto, Y; Odani, H; Shinzato, T; Usami, J | 1 |
| Daimon, M; Eguchi, H; Hirata, A; Igarashi, M; Kato, T; Manaka, H; Ohnuma, H; Ono, Y; Saito, T; Yamaguchi, H | 1 |
| Kameda, Y; Koike, T; Makita, Z; Takeuchi, M; Yanagisawa, K | 1 |
| Berg, TJ; Birkeland, KI; Hanssen, KF; Kilhovd, BK; Thorsby, P | 1 |
| Agersø, H; Huusfeldt, PO; Johansen, NL; Knudsen, LB; Madsen, K; Nielsen, PF; Pedersen, FZ; Thøgersen, H; Wilken, M | 1 |
| Danielsson, R; Fogarty, JF; Frank, A; Monnier, VM; Sell, DR | 1 |
| Bucala, R; Kameda, Y; Koike, T; Makita, Z; Suzuki, T; Takeuchi, M | 1 |
| Karimian-Teherani, D; Melling, M; Menzel, EJ; Pfeiler, W; Schnallinger, M; Sobal, G; Zangerle, C | 1 |
| Hamada, Y; Horiuchi, S; Hotta, N; Kasuya, Y; Kato, K; Komori, T; Nagai, R; Nakamura, J; Naruse, K | 1 |
| Haas, OA; Muhr, D; Niederle, B; Scheuba, C; Schlegl, R; Vierhapper, H; Wagner, T; Weinhaeusel, A | 1 |
| Albano, E; Allochis, G; Bellomo, G; Cusaro, C; Mottaran, E; Rolla, R; Vay, D; Vidali, M | 1 |
| Endo, M; Higuchi, M; Koike, T; Makita, Z; Matsuda, A; Matsushita, T; Okamoto, T; Takeuchi, M; Tsuchida, K; Yanagisawa, K | 1 |
| Heidland, A; Kientsch-Engel, R; Mazák, I; Nagy, J; Schinzel, R; Wagner, Z; Wittmann, I | 1 |
| Rajesh, M; Ramakrishnan, S; Sulochana, KN | 1 |
| Arokiasamy, T; Lakshmi, S; Natarajan Sulochana, K; Punitham, R; Ramakrishnan, S; Sukumar, B | 1 |
| Favretto, D; Fedele, D; Garbeglio, M; Lapolla, A; Senesi, A; Seraglia, R; Tonani, R; Traldi, P | 1 |
| Baba, S; Hata, F; Igaki, N; Kitamura, Y; Maeda, S; Nishimoto, S; Oimomi, M | 1 |
| Pensa, M; Rinaldi, E; Simonelli, F | 1 |
| Baba, S; Nishimoto, S; Oimomi, M | 1 |
| Baba, S; Hata, F; Igaki, N; Maeda, Y; Masuta, S; Nakamichi, T; Ohara, T; Oimomi, M; Sakai, M | 1 |
| Cha, T; Fukuda, M; Hashimoto, F; Hirota, M; Noma, Y; Ohboshi, C; Tahara, Y; Yamamoto, Y; Yamato, E; Yoneda, H | 1 |
| Baba, S; Hata, F; Hatanaka, H; Kitamura, Y; Maeda, Y; Matsumoto, S; Nishimoto, S; Oimomi, M | 1 |
| Baba, S; Hata, F; Hatanaka, H; Iga, T; Inoue, M; Kitamura, Y; Maeda, Y; Matsumoto, S; Oimomi, M; Yamamoto, M | 1 |
| Baba, S; Hatanaka, H; Kitamura, Y; Matsumoto, S; Nishimoto, S; Oimomi, M | 1 |
| Gerbitz, KD; Mayer, R; Schleicher, ED; Wagner, EM | 1 |
| Baba, S; Hata, F; Iga, T; Kitamura, Y; Maeda, Y; Matsumoto, S; Oimomi, M; Yamamoto, M | 1 |
| Hata, F; Hatanaka, H; Igaki, N; Kitamura, Y; Maeda, Y; Masuta, S; Matsumoto, S; Nakamichi, T; Nishimoto, S; Oimomi, M | 1 |
| Baba, S; Hata, F; Igaki, N; Masuda, S; Matsumoto, S; Nakamichi, T; Oimomi, M | 1 |
| Hata, F; Igaki, N; Kitamura, Y; Maeda, Y; Masuta, S; Matsumoto, S; Nakamichi, T; Nishimoto, S; Oohara, T; Sakai, M | 1 |
| Baba, S; Hata, F; Hatanaka, H; Kitamura, Y; Maeda, Y; Matsumoto, S; Oimomi, M | 1 |
| Ceriello, A; D'Onofrio, F; Giugliano, D; Paolisso, G; Quatraro, A; Saccomanno, F | 1 |
| Baba, S; Hatanaka, H; Ishikawa, K; Kitamura, Y; Matsumoto, S; Nishimoto, S; Oimomi, M | 1 |
| Aoki, S; Komori, K; Kuroda, Y; Misawa, K; Nakagawa, S; Nakayama, H; Taneda, S; Tsushima, S | 1 |
| Ceriello, A; D'Onofrio, F; Di Pinto, P; Giugliano, D; Passariello, N; Saccomanno, F | 1 |
6 review(s) available for lysine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Lysine-Specific Demethylase 1 in Energy Metabolism: A Novel Target for Obesity.
Topics: Diabetes Mellitus, Type 2; Energy Metabolism; Glucose; Histone Demethylases; Humans; Lysine; Obesity | 2022 |
Protein Lysine Acetylation: Grease or Sand in the Gears of β-Cell Mitochondria?
Topics: Acetylation; Animals; Diabetes Mellitus, Type 2; Insulin-Secreting Cells; Lysine; Mitochondria; Mitochondrial Proteins; NAD; Oxidative Phosphorylation; Oxidative Stress; Protein Processing, Post-Translational; Sirtuin 3 | 2020 |
[The assessment of bone quality in lifestyle-related diseases].
Topics: Arginine; Biomarkers; Bone and Bones; Bone Remodeling; Collagen; Diabetes Mellitus, Type 2; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Lysine; Osteoporosis; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Risk; Tomography, X-Ray Computed | 2016 |
Lysine acetylation in obesity, diabetes and metabolic disease.
Topics: Acetylation; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Energy Metabolism; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Lysine; Obesity | 2012 |
[Diabetes mellitus and osteoporosis. Predictive candidate markers for fracture risk in diabetic patients].
Topics: Arginine; Diabetes Mellitus, Type 2; Fractures, Bone; Humans; Lysine; Osteoporosis; Risk Factors | 2012 |
Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.
Topics: ATP-Binding Cassette Transporters; Chromosome Mapping; Diabetes Mellitus, Type 2; Genotype; Glutamic Acid; Haplotypes; Humans; Islets of Langerhans; Lysine; Models, Genetic; Phenotype; Polymorphism, Single Nucleotide; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 2004 |
27 trial(s) available for lysine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals.
Topics: Diabetes Mellitus, Type 2; Diet; Glucose; Glycation End Products, Advanced; Humans; Inflammation; Insulin Resistance; Lipids; Lysine; Male; Obesity | 2022 |
Endothelial Dysfunction and Advanced Glycation End Products in Patients with Newly Diagnosed Versus Established Diabetes: From the CORDIOPREV Study.
Topics: Biomarkers; Carotid Artery Diseases; Coronary Disease; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diet, Healthy; Endothelium, Vascular; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Olive Oil; Pyruvaldehyde; Single-Blind Method; Vasodilation | 2020 |
The Effects of Taurine Supplementation on Metabolic Profiles, Pentosidine, Soluble Receptor of Advanced Glycation End Products and Methylglyoxal in Adults With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adult; Arginine; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Method; Female; Follow-Up Studies; Glycation End Products, Advanced; Humans; Lysine; Male; Metabolome; Prognosis; Pyruvaldehyde; Taurine | 2021 |
Effects of Two Different Dietary Patterns on Inflammatory Markers, Advanced Glycation End Products and Lipids in Subjects without Type 2 Diabetes: A Randomised Crossover Study.
Topics: Adult; Biomarkers; Cholesterol; Cross-Over Studies; Diabetes Mellitus, Type 2; Diet, Healthy; Diet, Western; Feeding Behavior; Female; Food Handling; Glycation End Products, Advanced; Humans; Inflammation; Insulin Resistance; Lipids; Lysine; Male; Middle Aged; Plasminogen Inactivators; Reference Values; Triglycerides; Young Adult | 2017 |
Effects of Cinnamon Consumption on Glycemic Indicators, Advanced Glycation End Products, and Antioxidant Status in Type 2 Diabetic Patients.
Topics: Aged; Antioxidants; Blood Glucose; Cinnamomum zeylanicum; Diabetes Mellitus, Type 2; Double-Blind Method; Glycated Hemoglobin; Glycation End Products, Advanced; Homeostasis; Humans; Insulin; Lysine; Malondialdehyde; Middle Aged | 2017 |
l-Carnosine supplementation attenuated fasting glucose, triglycerides, advanced glycation end products, and tumor necrosis factor-α levels in patients with type 2 diabetes: a double-blind placebo-controlled randomized clinical trial.
Topics: Adipose Tissue; Adult; Arginine; Blood Glucose; Body Composition; Carnosine; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Method; Fasting; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Triglycerides; Tumor Necrosis Factor-alpha | 2018 |
The improvement of oxidative stress by two proprietary herbal medicines in type 2 diabetes.
Topics: Aged; Biomarkers; Blood Pressure; Diabetes Mellitus, Type 2; Dinoprost; Drugs, Chinese Herbal; Female; Ginkgo biloba; Humans; Lysine; Male; Middle Aged; Oxidative Stress; Plant Extracts | 2018 |
Tocotrienol-Rich Vitamin E from Palm Oil (Tocovid) and Its Effects in Diabetes and Diabetic Nephropathy: A Pilot Phase II Clinical Trial.
Topics: Aged; Albuminuria; Biomarkers; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Kidney; Lysine; Malaysia; Male; Middle Aged; Pilot Projects; Prospective Studies; Time Factors; Tocotrienols; Treatment Outcome | 2018 |
Soluble receptor for advanced glycation end-product (sRAGE)/pentosidine ratio: a potential risk factor determinant for type 2 diabetic retinopathy.
Topics: Adult; Advanced Oxidation Protein Products; Aged; Arginine; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Glutathione Peroxidase; Humans; Lysine; Male; Middle Aged; Receptor for Advanced Glycation End Products; Risk Factors; Superoxide Dismutase | 2013 |
The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes.
Topics: Adiponectin; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Pyruvaldehyde; Salicylates | 2014 |
Laboratory aspirin resistance reversibility in diabetic patients: a pilot study using different pharmaceutical formulations.
Topics: Aged; Aspirin; Chemistry, Pharmaceutical; Diabetes Mellitus, Type 2; Drug Resistance; Female; Humans; Laboratories; Lysine; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors | 2014 |
Effects of sevelamer carbonate on advanced glycation end products and antioxidant/pro-oxidant status in patients with diabetic kidney disease.
Topics: Adiponectin; Age Factors; Aged; Albuminuria; Chelating Agents; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dinoprost; Estrogen Receptor alpha; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Intention to Treat Analysis; Lysine; Male; Metformin; Middle Aged; NF-E2-Related Factor 2; Pyruvaldehyde; Receptor for Advanced Glycation End Products; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Sevelamer; Sex Factors; Single-Blind Method; Sirtuin 1; White People | 2015 |
Elevated Serum Pentosidine and Decreased Serum IGF-I Levels are Associated with Loss of Muscle Mass in Postmenopausal Women with Type 2 Diabetes Mellitus.
Topics: Aged; Arginine; Diabetes Mellitus, Type 2; Female; Humans; Insulin-Like Growth Factor I; Lysine; Middle Aged; Muscle, Skeletal; Postmenopause; Sarcopenia | 2016 |
The Preventive Effect of L-Lysine on Lysozyme Glycation in Type 2 Diabetes.
Topics: Adult; Diabetes Mellitus, Type 2; Dietary Supplements; Female; Glucose; Glycation End Products, Advanced; Glycosylation; Humans; Lysine; Male; Muramidase; Protein Conformation | 2016 |
Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glomerular Filtration Rate; Glycation End Products, Advanced; Humans; Imidazoles; Indians, North American; Kidney; Kidney Glomerulus; Losartan; Lysine; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Pyruvaldehyde | 2016 |
The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.
Topics: Chromans; Combined Modality Therapy; Diabetes Mellitus, Type 2; Exercise Therapy; Female; Gene Frequency; Genetic Linkage; Genetic Predisposition to Disease; Glutamic Acid; Humans; Hypoglycemic Agents; Incidence; Lysine; Male; Metformin; Middle Aged; Phosphoric Diester Hydrolases; Polymorphism, Single Nucleotide; Pyrophosphatases; Risk Reduction Behavior; Thiazolidinediones; Troglitazone | 2009 |
KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes.
Topics: Adult; Alleles; Amino Acid Substitution; Asian People; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Female; Glutamic Acid; Humans; Lysine; Male; Middle Aged; Piperidines; Polymorphism, Genetic; Potassium Channels, Inwardly Rectifying; Risk Factors; TCF Transcription Factors; Transcription Factor 7-Like 2 Protein; Treatment Outcome | 2010 |
Irbesartan treatment does not influence plasma levels of the advanced glycation end products N(epsilon)(1-carboxymethyl)lysine and N(epsilon)(1-carboxyethyl)lysine in patients with type 2 diabetes and microalbuminuria. A randomized controlled trial.
Topics: Adult; Aged; Albuminuria; Angiotensin Receptor Antagonists; Biomarkers; Biphenyl Compounds; Diabetes Complications; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glycation End Products, Advanced; Humans; Hypertension; Irbesartan; Lysine; Male; Middle Aged; Prognosis; Tetrazoles | 2011 |
Effects of metformin and pioglitazone on serum pentosidine levels in type 2 diabetes mellitus.
Topics: Aged; Arginine; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Lysine; Male; Metformin; Middle Aged; Pioglitazone; Thiazolidinediones; Time Factors | 2011 |
Investigation of the mechanism(s) involved in decreasing increased fibrinogen activity in hyperglycemic conditions using L-lysine supplementation.
Topics: Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dietary Supplements; Female; Fibrinogen; Glucose; Humans; Hypoglycemic Agents; Lysine; Male; Middle Aged; Protein Binding; Treatment Outcome | 2012 |
Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study.
Topics: Adenine; Adult; Alleles; ATP-Binding Cassette Transporters; Confidence Intervals; Diabetes Mellitus, Type 2; Disease Progression; Genetic Predisposition to Disease; Glucose Intolerance; Guanine; Haplotypes; Humans; Linkage Disequilibrium; Lysine; Middle Aged; Odds Ratio; Polymorphism, Genetic; Potassium Channels; Potassium Channels, Inwardly Rectifying; Promoter Regions, Genetic; Receptors, Drug; Sulfonylurea Receptors | 2004 |
Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.
Topics: Alleles; ATP-Binding Cassette Transporters; Diabetes Mellitus, Type 2; Disease Progression; Female; Genetic Predisposition to Disease; Genotype; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Lysine; Male; Metformin; Middle Aged; Mutation, Missense; Polymorphism, Genetic; Potassium Channels; Potassium Channels, Inwardly Rectifying; Proportional Hazards Models; Receptors, Drug; Sulfonylurea Receptors; Treatment Outcome | 2007 |
Serum levels of the advanced glycation end products Nepsilon-carboxymethyllysine and pentosidine are not influenced by treatment with the angiotensin receptor II type 1 blocker irbesartan in patients with type 2 diabetic nephropathy and hypertension.
Topics: Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Arginine; Biphenyl Compounds; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Glomerular Filtration Rate; Glycation End Products, Advanced; Humans; Hypertension; Irbesartan; Linear Models; Lysine; Male; Middle Aged; Statistics, Nonparametric; Tetrazoles | 2008 |
Effects of aspirin or basic amino acids on collagen cross-links and complications in NIDDM.
Topics: Analysis of Variance; Arginine; Aspirin; Biopsy; Blood Glucose; Collagen; Cross-Linking Reagents; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Double-Blind Method; Glycated Hemoglobin; Lysine; Placebos; Skin | 1997 |
Plasma levels of pentosidine in diabetic patients: an advanced glycation end product.
Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Analysis of Variance; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Creatinine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Female; Humans; Lysine; Male; Middle Aged; Myocardial Ischemia; Regression Analysis; Sensitivity and Specificity; Severity of Illness Index | 1998 |
Serum levels of advanced glycation end products are increased in patients with type 2 diabetes and coronary heart disease.
Topics: Aged; Coronary Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Epitopes; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Multivariate Analysis; Risk Factors | 1999 |
Effect of oral supplementation of free amino acids in type 2 diabetic patients-- a pilot clinical trial.
Topics: Administration, Oral; Adult; Amino Acids; Antioxidants; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Insulin; Lysine; Male; Middle Aged; Pilot Projects | 2002 |
194 other study(ies) available for lysine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Can fingernail quality predict bone damage in Type 2 diabetes mellitus? a pilot study.
Topics: Aged; Arthroplasty, Replacement, Hip; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Femoral Neck Fractures; Femur Neck; Humans; Lysine; Middle Aged; Nails; Osteoporosis, Postmenopausal; Pilot Projects; Spectroscopy, Fourier Transform Infrared; X-Ray Microtomography | 2021 |
Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice.
Topics: Acetylation; Adipocytes; Adipose Tissue; Amino Acids; Animals; Carbon; Diabetes Mellitus, Type 2; Diet, High-Fat; Gene Expression Regulation; Genetic Predisposition to Disease; Glucose; Glucose Transporter Type 4; Haploinsufficiency; Histone Acetyltransferases; Histones; Lipid Metabolism; Lysine; Mice; Obesity; PPAR gamma | 2021 |
Greater Carboxy-Methyl-Lysine Is Associated With Increased Fracture Risk in Type 2 Diabetes.
Topics: Aged; Bone Density; Diabetes Mellitus, Type 2; Fractures, Bone; Humans; Lysine; Risk Factors; Spinal Fractures | 2022 |
Vascular hyperacetylation is associated with vascular smooth muscle dysfunction in a rat model of non-obese type 2 diabetes.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Glucose; Lysine; Male; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Rats, Wistar; Reactive Oxygen Species | 2022 |
α-Tubulin acetylation on lysine 40 controls cardiac glucose uptake.
Topics: Acetylation; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Glucose; Glucose Transport Proteins, Facilitative; Glucose Transporter Type 4; Insulin; Lysine; Mice; Myocytes, Cardiac; Protein Transport; Rats; Tubulin | 2022 |
High serum levels of N-epsilon-carboxymethyllysine are associated with poor coronary collateralization in type 2 diabetic patients with chronic total occlusion of coronary artery.
Topics: Collateral Circulation; Coronary Angiography; Coronary Circulation; Coronary Occlusion; Coronary Vessels; Diabetes Mellitus, Type 2; Humans; Lysine | 2022 |
Diabetic nephropathy patients show hyper-responsiveness to N6-carboxymethyllysine.
Topics: Culture Media, Conditioned; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Lysine; NF-kappa B | 2022 |
Metagenomic shotgun sequencing and metabolomic profiling identify specific human gut microbiota associated with diabetic retinopathy in patients with type 2 diabetes.
Topics: Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Gastrointestinal Microbiome; Humans; Lysine | 2022 |
Metformin encapsulated gold nanoparticles (MTF-GNPs): A promising antiglycation agent.
Topics: Arginine; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Gold; Humans; Hypoglycemic Agents; Lysine; Metal Nanoparticles; Metformin; Ribose; Serum Albumin, Bovine | 2022 |
Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity.
Topics: Animals; Diabetes Mellitus, Type 2; Histone Demethylases; Inflammation; Insulin; Insulin Resistance; Lipid Metabolism; Lipids; Liver; Lysine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity | 2022 |
Antimicrobial, cytotoxic, and insulin-releasing activities of the amphibian host-defense peptide ocellatin-3N and its L-lysine-substituted analogs.
Topics: Amphibian Proteins; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antimicrobial Cationic Peptides; Antineoplastic Agents; Anura; Carcinoma, Non-Small-Cell Lung; Diabetes Mellitus, Type 2; Endothelial Cells; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Insulin; Lung Neoplasms; Lysine; Mice; Skin | 2023 |
Overexpression of Tfap2a in Mouse Oocytes Impaired Spindle and Chromosome Organization.
Topics: Animals; Chromosomes; Diabetes Mellitus, Type 2; Histones; Lysine; Mice; Oocytes; Transcription Factor AP-2 | 2022 |
Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice.
Topics: Animals; Diabetes Mellitus, Type 2; Histone-Lysine N-Methyltransferase; Histones; Insulins; Lysine; Methylation; Mice | 2023 |
Plasma free amino acid profiles are associated with serum high molecular weight adiponectin levels in Japanese medical check-up population without type 2 diabetes mellitus.
Topics: Adiponectin; Amino Acids; Cross-Sectional Studies; Diabetes Mellitus, Type 2; East Asian People; Glutamates; Humans; Insulin Resistance; Lysine; Molecular Weight; Tryptophan | 2023 |
CycloZ Improves Hyperglycemia and Lipid Metabolism by Modulating Lysine Acetylation in KK-Ay Mice.
Topics: Acetylation; Animals; Diabetes Mellitus, Type 2; Hyperglycemia; Lipid Metabolism; Lysine; Mice; NAD; Sirtuin 1 | 2023 |
Regulation mechanism of human insulin fibrillation by L-lysine carbon dots: low concentration accelerates but high concentration inhibits the fibrillation process.
Topics: Carbon; Diabetes Mellitus, Type 2; Humans; Insulin; Lysine; Quantum Dots | 2023 |
Lysine 117 Residue Is Essential for the Function of the Hepatocyte Nuclear Factor 1α.
Topics: Animals; Diabetes Mellitus, Type 2; DNA; Fanconi Syndrome; Glucose Intolerance; Hepatocyte Nuclear Factor 1-alpha; Humans; Insulins; Lysine; Mice; Mutation | 2023 |
Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism.
Topics: Animals; Diabetes Mellitus, Type 2; Glucose; Liver; Lysine; Mice; Phosphoenolpyruvate; Proteins | 2023 |
Dietary intakes of methionine, threonine, lysine, arginine and histidine increased risk of type 2 diabetes in Chinese population: does the mediation effect of obesity exist?
Topics: Amino Acids; Arginine; Diabetes Mellitus, Type 2; Diet; East Asian People; Histidine; Humans; Lysine; Male; Methionine; Obesity; Racemethionine; Risk Factors; Threonine | 2023 |
Bone material strength in normoglycemic and hyperglycemic black and white older adults.
Topics: Absorptiometry, Photon; Aged; Arginine; Black or African American; Blood Glucose; Bone Density; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Femur Neck; Humans; Hyperglycemia; Lysine; Male; Middle Aged; Prediabetic State; Tibia; United States; White People | 2019 |
Characteristics of amino acid profiles and incretin hormones in patients with gallstone disease: a pilot study.
Topics: Adult; Aged; Cholecystolithiasis; Diabetes Mellitus, Type 2; Female; Humans; Incretins; Isoleucine; Leucine; Lysine; Male; Metabolic Diseases; Middle Aged; Pilot Projects; Valine | 2019 |
Bone Histomorphometry in Young Patients With Type 2 Diabetes is Affected by Disease Control and Chronic Complications.
Topics: Adult; Arginine; Blood Glucose; Bone Development; Bone Diseases; Cancellous Bone; Chronic Disease; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Insulin-Like Growth Factor I; Lysine; Male | 2020 |
Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort studies.
Topics: 2-Aminoadipic Acid; Aged; Aged, 80 and over; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diet, Mediterranean; Female; Humans; Incidence; Lysine; Male; Middle Aged; Pipecolic Acids; Primary Prevention; Prospective Studies; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Risk Reduction Behavior; Time Factors; Treatment Outcome | 2019 |
Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes.
Topics: Adult; Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Eukaryotic Translation Initiation Factor 5A; Female; Humans; Insulin-Secreting Cells; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Middle Aged; Pancreas; Pancreatic Polypeptide-Secreting Cells; Peptide Initiation Factors; RNA-Binding Proteins; Spleen; Young Adult | 2020 |
Development and Application of Mass Spectroscopy Assays for Nε-(1-Carboxymethyl)-L-Lysine and Pentosidine in Renal Failure and Diabetes.
Topics: Arginine; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Humans; Lysine; Mass Spectrometry; Renal Insufficiency; Reproducibility of Results | 2020 |
Role of lysine residue of islet amyloid polypeptide in fibril formation, membrane binding, and inhibitor binding.
Topics: Amino Acid Sequence; Amyloid; Amyloidosis; Cell Membrane; Diabetes Mellitus, Type 2; DNA Mutational Analysis; Humans; Islet Amyloid Polypeptide; Kinetics; Lysine; Membrane Lipids; Mutant Proteins; Polyphenols; Protein Aggregates; Protein Binding | 2020 |
Mal-Prec: computational prediction of protein Malonylation sites via machine learning based feature integration : Malonylation site prediction.
Topics: Amino Acid Sequence; Computational Biology; Diabetes Mellitus, Type 2; Humans; Lysine; Machine Learning; Protein Processing, Post-Translational; Support Vector Machine | 2020 |
Triangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes.
Topics: Adult; Aged; Betaine; Biomarkers; Carnitine; Case-Control Studies; Diabetes Mellitus, Type 2; Early Diagnosis; Female; Genetic Predisposition to Disease; Glutamic Acid; Humans; Leucine; Lysine; Male; Mannose; Mendelian Randomization Analysis; Metabolome; Middle Aged; Valine | 2021 |
Elevated serum pentosidine is independently associated with the high prevalence of sarcopenia in Chinese middle-aged and elderly men with type 2 diabetes mellitus.
Topics: Aged; Arginine; China; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Geriatric Assessment; Hand Strength; Humans; Lysine; Male; Middle Aged; Prevalence; Risk Assessment; Risk Factors; Sarcopenia | 2021 |
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Topics: Acetylation; Animals; Apoptosis; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet; Gene Regulatory Networks; Glucagon-Secreting Cells; Glucose Intolerance; Histone Acetyltransferases; Histones; Lysine; Mice, Inbred C57BL; Obesity; Proprotein Convertase 1; Salicylates | 2021 |
Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes.
Topics: Aged; Biomarkers; Chromatography, Liquid; Diabetes Mellitus, Type 2; Female; Glycation End Products, Advanced; Humans; Hyperglycemia; Lysine; Male; Middle Aged; Osteoarthritis; Phosphatidylcholines; Synovial Fluid; Tandem Mass Spectrometry | 2017 |
Esculetin ameliorates vascular perturbation by intervening in the occupancy of H2BK120Ub at At1, At2, Tgfβ1 and Mcp1 promoter gene in thoracic aorta of IR and T2D rats.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Blood Vessels; Chemokine CCL2; Diabetes Mellitus, Type 2; Gene Expression Regulation; Hemodynamics; Histones; Insulin Resistance; Lysine; Muscle Relaxation; Myocardial Contraction; Promoter Regions, Genetic; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Transforming Growth Factor beta1; Ubiquitin; Umbelliferones | 2017 |
d-Ribose as a Contributor to Glycated Haemoglobin.
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Glycosylation; Humans; Hyperglycemia; Lysine; Male; Rats; Rats, Zucker; Ribose | 2017 |
CML/CD36 accelerates atherosclerotic progression via inhibiting foam cell migration.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; CD36 Antigens; Cell Migration Inhibition; Cell Movement; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Foam Cells; Glycation End Products, Advanced; Lysine; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; RAW 264.7 Cells | 2018 |
Effects of Weight Loss on Advanced Glycation End Products in Subjects with and without Diabetes: A Preliminary Report.
Topics: Diabetes Mellitus, Type 2; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Overweight; Prediabetic State; Weight Loss | 2017 |
Urinary Pentosidine levels negatively associates with trabecular bone scores in patients with type 2 diabetes mellitus.
Topics: Absorptiometry, Photon; Aged; Arginine; Biomarkers; Bone Density; Cancellous Bone; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Humans; Lumbar Vertebrae; Lysine; Male; Middle Aged; Osteoporotic Fractures; Spinal Fractures | 2018 |
Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris.
Topics: Aged; Angina, Stable; Betaine; Body Mass Index; Carnitine; Chromatography, Liquid; Coronary Artery Disease; Diabetes Mellitus, Type 2; Esters; Female; Humans; Logistic Models; Lysine; Male; Middle Aged; Odds Ratio; Prospective Studies; Risk Factors | 2018 |
Low bone toughness in the TallyHO model of juvenile type 2 diabetes does not worsen with age.
Topics: Aging; Animals; Arginine; Bone Density; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Femur; Fractures, Bone; Lysine; Male; Mice; Spectrum Analysis, Raman; X-Ray Microtomography | 2018 |
Unraveling the compromised biomechanical performance of type 2 diabetes- and Roux-en-Y gastric bypass bone by linking mechanical-structural and physico-chemical properties.
Topics: Animals; Arginine; Biomechanical Phenomena; Bone and Bones; Diabetes Mellitus, Type 2; Female; Fractures, Bone; Gastric Bypass; Glycation End Products, Advanced; Humans; Lysine; Male; Mice; Mice, Obese; Obesity; Skeleton; Tomography, X-Ray Computed; Weight Loss | 2018 |
Lysine glycation of apolipoprotein A-I impairs its anti-inflammatory function in type 2 diabetes mellitus.
Topics: Aged; Amino Acid Substitution; Analysis of Variance; Apolipoprotein A-I; Chromatography, Liquid; Diabetes Mellitus, Type 2; Glucose; Glutamic Acid; Glycosylation; Humans; Inflammation; Interleukin-1beta; Lipopolysaccharides; Lipoproteins, HDL; Lysine; Middle Aged; NF-kappa B; Protein Conformation; Protein Disulfide-Isomerases; Tandem Mass Spectrometry; THP-1 Cells; Tumor Necrosis Factor-alpha | 2018 |
Glycation of type I collagen selectively targets the same helical domain lysine sites as lysyl oxidase-mediated cross-linking.
Topics: Amino Acid Sequence; Amino Acids; Animals; Blood Glucose; Collagen Type I; Cross-Linking Reagents; Diabetes Mellitus, Type 2; Disease Models, Animal; Glycated Hemoglobin; Glycation End Products, Advanced; Glycosylation; Hydroxylation; Hydroxylysine; Lysine; Male; Mass Spectrometry; Mice; Obesity; Protein-Lysine 6-Oxidase; Tail; Tendons | 2018 |
Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function.
Topics: Actins; Adult; Animals; Arginine; Cardiomyopathy, Dilated; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Glycolysis; Heart Failure; Heart Ventricles; Humans; Lysine; Male; Mice; Middle Aged; Myosins; Pyruvaldehyde; Sarcomeres; Single-Cell Analysis | 2018 |
Inhibitory effect of silibinin on Amadori-albumin in diabetes mellitus: A multi-spectroscopic and biochemical approach.
Topics: Arginine; Circular Dichroism; Diabetes Mellitus, Type 2; Glycosylation; Humans; Lysine; Protective Agents; Serum Albumin, Human; Silybin; Spectrophotometry, Ultraviolet | 2019 |
Diabetes induces tri-methylation at lysine 9 of histone 3 at Slc2a4 gene in skeletal muscle: A new target to improve glycemic control.
Topics: Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Models, Animal; Epigenesis, Genetic; Glucose Transporter Type 4; Histones; Humans; Insulin; Lysine; Male; Methylation; Mice; Muscle, Skeletal; Promoter Regions, Genetic; Rats; Resveratrol | 2019 |
Plasma levels of advanced glycation endproducts Nε-(carboxymethyl)lysine, Nε-(carboxyethyl)lysine, and pentosidine are not independently associated with cardiovascular disease in individuals with or without type 2 diabetes: the Hoorn and CODAM studies.
Topics: Aged; Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Female; Glucose; Humans; Lysine; Male; Middle Aged | 2013 |
Hemoglobin Jerez [α2 β2 95 (FG2) Lys→Gln]: performance of HbA1c measurement with five analytical methods.
Topics: Adult; Aged; Amino Acid Substitution; Chromatography; Diabetes Mellitus, Type 2; Electrophoresis, Capillary; False Negative Reactions; False Positive Reactions; Glutamine; Glycated Hemoglobin; Hemoglobins, Abnormal; Humans; Lysine; Male | 2013 |
Association of peripheral neuropathy with circulating advanced glycation end products, soluble receptor for advanced glycation end products and other risk factors in patients with type 2 diabetes.
Topics: Aged; Arterial Occlusive Diseases; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Neuropathies; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Paris; Peripheral Nervous System; Prevalence; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Risk Factors; Severity of Illness Index; Sex Factors; Solubility; Waist Circumference | 2014 |
Potential of birds to serve as pathology-free models of type 2 diabetes, part 2: do high levels of carbonyl-scavenging amino acids (e.g., taurine) and low concentrations of methylglyoxal limit the production of advanced glycation end-products?
Topics: Albumins; Animals; Arginine; Birds; Diabetes Mellitus, Type 2; Disease Models, Animal; Fructosamine; Glucose; Glycation End Products, Advanced; Lysine; Maillard Reaction; Pyruvaldehyde; Taurine | 2014 |
The protection of Rhein lysinate to liver in diabetic mice induced by high-fat diet and streptozotocin.
Topics: Animals; Anthraquinones; Blood Glucose; Diabetes Mellitus, Type 2; Diet, High-Fat; Fatty Liver; Liver; Lysine; Male; Mice; Mice, Inbred C57BL; Reactive Oxygen Species; Streptozocin | 2015 |
Nε-carboxymethyllysine-mediated endoplasmic reticulum stress promotes endothelial cell injury through Nox4/MKP-3 interaction.
Topics: Animals; Apoptosis; Cell Line, Transformed; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Dual Specificity Phosphatase 6; Endoplasmic Reticulum Stress; Endothelial Cells; Gene Expression Regulation; Humans; Lysine; Male; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; NADPH Oxidase 4; NADPH Oxidases; Protein Binding; RNA, Small Interfering; Signal Transduction | 2014 |
Lysine malonylation is elevated in type 2 diabetic mouse models and enriched in metabolic associated proteins.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Liver; Lysine; Mice, Inbred C57BL; Obesity; Protein Processing, Post-Translational; Proteins | 2015 |
LC-MS/MS for the simultaneous determination of polar endogenous ADMA and CML in plasma and urine from diabetics.
Topics: Arginine; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Linear Models; Lysine; Retrospective Studies; Tandem Mass Spectrometry | 2015 |
Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes.
Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Animals; Diabetes Mellitus, Type 2; Fatty Acids; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation; Glyoxylates; Insulin Resistance; Leptin; Liver; Lysine; Male; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Obese; Muscle, Skeletal; Obesity; Phosphotyrosine; Signal Transduction; Sorbitol | 2015 |
The receptor for advanced glycation end products and risk of peripheral arterial disease, amputation or death in type 2 diabetes: a population-based cohort study.
Topics: Aged; Amputation, Surgical; Biomarkers; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Progression; Disease-Free Survival; Female; Humans; Incidence; Kaplan-Meier Estimate; Lysine; Male; Middle Aged; Peripheral Arterial Disease; Proportional Hazards Models; Receptor for Advanced Glycation End Products; Risk Assessment; Risk Factors; S100A12 Protein; Sweden; Time Factors | 2015 |
Mono-lithocholated exendin-4-loaded glycol chitosan nanoparticles with prolonged antidiabetic effects.
Topics: Animals; Chitosan; Diabetes Mellitus, Type 2; Drug Carriers; Drug Liberation; Exenatide; Hypoglycemic Agents; Lithocholic Acid; Lysine; Mice; Nanoparticles; Particle Size; Peptides; Succinimides; Venoms | 2015 |
Skin collagen pentosidine and fluorescence in diabetes were predictors of retinopathy progression and creatininemia increase already 6years after punch-biopsy.
Topics: Adult; Albuminuria; Arginine; Biomarkers; Biopsy; Case-Control Studies; Collagen; Creatinine; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Disease Progression; Female; Fluorescence; Humans; Longitudinal Studies; Lysine; Male; Middle Aged; Skin; Spectrometry, Fluorescence | 2016 |
Association of serum N(ε)-Carboxy methyl lysine with severity of diabetic retinopathy.
Topics: Adult; Aged; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Humans; Lysine; Male; Middle Aged; Severity of Illness Index | 2016 |
Neo-epitopes on methylglyoxal modified human serum albumin lead to aggressive autoimmune response in diabetes.
Topics: Autoimmunity; Case-Control Studies; Diabetes Mellitus, Type 2; Epitopes; Female; Humans; Hydrophobic and Hydrophilic Interactions; Immunoglobulin G; Lysine; Male; Protein Conformation; Pyruvaldehyde; Serum Albumin | 2016 |
Nε-(carboxymethyl)-lysine, White Matter, and Cognitive Function in Diabetes Patients.
Topics: Aged; Anisotropy; Case-Control Studies; Cognition Disorders; Diabetes Mellitus, Type 2; Diffusion Magnetic Resonance Imaging; Female; Humans; Image Processing, Computer-Assisted; Leukoencephalopathies; Lysine; Male; Mental Status Schedule; Neuropsychological Tests | 2016 |
ADMA: a specific biomarker for pathologic progress in diabetic microvascular complications?
Topics: Adult; Aged; Area Under Curve; Arginine; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Logistic Models; Lysine; Male; Middle Aged; Odds Ratio; Prediabetic State; ROC Curve; Tandem Mass Spectrometry | 2016 |
Increased levels of N(ε)- Carboxy methyl lysine (N(ε)-CML) are associated with topographic alterations in retinal pigment epithelium: A preliminary study.
Topics: Adult; Biomarkers; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Disease Progression; Female; Glycated Hemoglobin; Humans; Lysine; Male; Middle Aged; Prospective Studies; Regression Analysis; Retinal Pigment Epithelium; Severity of Illness Index; Tertiary Care Centers; Up-Regulation; Vitreoretinopathy, Proliferative | 2016 |
Serum advanced glycation endproducts are associated with left ventricular dysfunction in normal glucose metabolism but not in type 2 diabetes: The Hoorn Study.
Topics: Aged; Arginine; Biomarkers; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Echocardiography; Female; Glycation End Products, Advanced; Humans; Linear Models; Lysine; Male; Middle Aged; Myocardial Contraction; Netherlands; Predictive Value of Tests; Prognosis; Risk Assessment; Risk Factors; Ventricular Dysfunction, Left; Ventricular Function, Left | 2016 |
A Retrospective Study in Adults with Metabolic Syndrome: Diabetic Risk Factor Response to Daily Consumption of Agaricus bisporus (White Button Mushrooms).
Topics: Adiponectin; Adult; Agaricus; Antioxidants; beta-Glucans; Biomarkers; Body Mass Index; Chitin; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Diet; Dinoprost; Ergothioneine; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Insulin Resistance; Leptin; Linear Models; Lysine; Male; Metabolic Syndrome; Middle Aged; Multivariate Analysis; Oxidative Stress; Polyphenols; Pyruvaldehyde; Retrospective Studies; Risk Factors; Triglycerides; Vitamin D | 2016 |
The effects of n-3 long-chain polyunsaturated fatty acid supplementation on AGEs and sRAGE in type 2 diabetes mellitus.
Topics: Aged; Animals; Arginine; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Dietary Supplements; Fasting; Fatty Acids, Omega-3; Female; Gene Expression Regulation; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Lysine; Male; Middle Aged; NF-kappa B; Receptor for Advanced Glycation End Products; Signal Transduction; Waist Circumference | 2016 |
Skin Autofluorescence and Pentosidine Are Associated With Aortic Stiffening: The Maastricht Study.
Topics: Adult; Aged; Analysis of Variance; Arginine; Blood Pressure; Cardiovascular Diseases; Chi-Square Distribution; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Glucose; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Linear Models; Lysine; Middle Aged; Optical Imaging; Prospective Studies; Pulse Wave Analysis; Skin; Vascular Stiffness | 2016 |
H2AK119 monoubiquitination regulates Angiotensin II receptor mediated macrophage infiltration and renal fibrosis in type 2 diabetic rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blotting, Western; Chemokine CCL2; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Fibrosis; Histones; Imidazoles; Kidney; Lysine; Macrophages; Male; Promoter Regions, Genetic; Pyridines; Rats, Wistar; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; Telmisartan; Transforming Growth Factor beta1; Ubiquitination | 2016 |
Plasma Levels of Pentosidine, Carboxymethyl-Lysine, Soluble Receptor for Advanced Glycation End Products, and Metabolic Syndrome: The Metformin Effect.
Topics: Adult; Arginine; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Hypoglycemic Agents; Lysine; Male; Metabolic Syndrome; Metformin; Middle Aged; Prognosis; Receptor for Advanced Glycation End Products | 2016 |
Impaired osteogenic differentiation and enhanced cellular receptor of advanced glycation end products sensitivity in patients with type 2 diabetes.
Topics: Apoptosis; Arginine; Biomarkers; Cell Differentiation; Cell Membrane; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Gene Expression Profiling; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Osteogenesis; Receptor for Advanced Glycation End Products; Risk Factors | 2017 |
Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction.
Topics: Acetylation; Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Endothelium, Vascular; Glucose; HEK293 Cells; Humans; Lysine; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Stress; RNA Interference; Sirtuin 1; Src Homology 2 Domain-Containing, Transforming Protein 1 | 2017 |
Advanced Glycation End Products, Oxidation Products, and the Extent of Atherosclerosis During the VA Diabetes Trial and Follow-up Study.
Topics: Aged; Atherosclerosis; Blood Glucose; Carotid Intima-Media Thickness; Cholesterol; Deoxyglucose; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glycation End Products, Advanced; Humans; Imidazoles; Lysine; Male; Middle Aged; Oxidation-Reduction; Pyruvaldehyde; Triglycerides | 2017 |
Vitreous advanced glycation endproducts and α-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Biomarkers; Case-Control Studies; Deoxyglucose; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Retinal Detachment | 2017 |
Prediction of Lysine Malonylation Sites Based on Pseudo Amino Acid.
Topics: Algorithms; Amino Acids; Computational Biology; Databases, Protein; Diabetes Mellitus, Type 2; Humans; Lysine; Proteins | 2017 |
Glycated albumin as an improved indicator of glycemic control in hemodialysis patients with type 2 diabetes based on fasting plasma glucose and oral glucose tolerance test.
Topics: Aged; Area Under Curve; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Glycated Hemoglobin; Glycated Serum Albumin; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Renal Dialysis; Serum Albumin | 2009 |
Increased serum endogenous secretory receptor for advanced glycation end-product (esRAGE) levels in type 2 diabetic patients with decreased renal function.
Topics: Aged; Arginine; Carotid Arteries; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Lysine; Male; Middle Aged; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Renal Dialysis; Severity of Illness Index; Tunica Intima; Tunica Media; Ultrasonography | 2008 |
Evaluation of N (epsilon)-(3-formyl-3,4-dehydropiperidino)lysine as a novel biomarker for the severity of diabetic retinopathy.
Topics: Antibodies, Monoclonal; Biomarkers; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Humans; Hyperglycemia; Lysine; Reference Values; Severity of Illness Index; White People | 2008 |
Influence of Lys656Asn polymorphism of leptin receptor gene on insulin resistance in patients with diabetes mellitus type 2.
Topics: Amino Acid Substitution; Asparagine; Body Mass Index; Cytokines; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Lysine; Obesity; Polymorphism, Genetic; Receptors, Leptin | 2008 |
Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice.
Topics: Animals; Diabetes Mellitus, Type 2; Histone Demethylases; Histones; Humans; Inflammation Mediators; Lysine; Male; Methylation; Mice; Mice, Knockout; Mice, Mutant Strains; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidoreductases, N-Demethylating; Phenotype | 2008 |
Severity of diabetic microvascular complications is associated with a low soluble RAGE level.
Topics: Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lysine; Male; Middle Aged; Receptor for Advanced Glycation End Products; Receptors, Immunologic | 2008 |
EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes.
Topics: Age of Onset; Aged; Asparagine; Case-Control Studies; China; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Endothelin-1; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; Lysine; Male; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Regression Analysis | 2008 |
K469E polymorphism of the intracellular adhesion molecule 1 gene is associated with proliferative diabetic retinopathy in Caucasians with type 2 diabetes.
Topics: Aged; Alanine; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Glycine; Humans; Intercellular Adhesion Molecule-1; Lysine; Male; Middle Aged; Polymorphism, Genetic; Slovenia; White People | 2008 |
Glyceraldehyde is present in rat lens and its level is increased in diabetes mellitus.
Topics: Aldehyde Reductase; Animals; Benzofurans; Blood Glucose; Cataract; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Disease Models, Animal; Glyceraldehyde; Hydantoins; Lens, Crystalline; Lysine; Male; Pyridinium Compounds; Rats; Rats, Wistar | 2009 |
Preferential recognition of Amadori-rich lysine residues by serum antibodies in diabetes mellitus: role of protein glycation in the disease process.
Topics: Adult; Animals; Antibodies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Fructosamine; Furaldehyde; Glycosylation; Humans; Lysine; Male; Middle Aged; Polylysine; Rabbits | 2009 |
Pentosidine and increased fracture risk in older adults with type 2 diabetes.
Topics: Aged; Arginine; Bone Density; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Fractures, Bone; Humans; Incidence; Lysine; Male; Prevalence; Risk Factors; Spinal Fractures | 2009 |
Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers.
Topics: Carbamates; Diabetes Mellitus, Type 2; Gas Chromatography-Mass Spectrometry; Humans; Hypoglycemic Agents; Lactic Acid; Lysine; Metabolomics; Metformin; Piperidines; Rosiglitazone; Thiazolidinediones; Uric Acid; Valine | 2009 |
Low serum level of the endogenous secretory receptor for advanced glycation end products (esRAGE) is a risk factor for prevalent vertebral fractures independent of bone mineral density in patients with type 2 diabetes.
Topics: Age of Onset; Aged; Aged, 80 and over; Albuminuria; Arginine; Blood Glucose; Bone Density; Creatinine; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Lysine; Male; Middle Aged; Postmenopause; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Regression Analysis; Risk Factors; Spinal Fractures | 2009 |
Critical evaluation of toxic versus beneficial effects of methylglyoxal.
Topics: Animals; Arginine; Cataract; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Delivery Systems; Glycation End Products, Advanced; Humans; Kidney Failure, Chronic; Lysine; Maillard Reaction; Oxidative Stress; Protein Conformation; Protein Folding; Pyruvaldehyde; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serum Albumin | 2009 |
Plasma sRAGE is not associated with urinary microalbumin excretion in type 2 diabetic nephropathy at the early stage.
Topics: Age of Onset; Aged; Albuminuria; Blood Glucose; Blood Pressure; Body Mass Index; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme-Linked Immunosorbent Assay; Female; Glomerular Filtration Rate; Glycated Hemoglobin; Humans; Lipids; Lysine; Male; Middle Aged; Patient Selection; Receptor for Advanced Glycation End Products; Receptors, Immunologic | 2010 |
The fatty acid conjugated exendin-4 analogs for type 2 antidiabetic therapeutics.
Topics: Animals; Antigens; Diabetes Mellitus; Diabetes Mellitus, Type 2; Exenatide; Fatty Acids; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Half-Life; Hypoglycemic Agents; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Palmitic Acid; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Venoms | 2010 |
Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy.
Topics: Aged; Antibodies, Neutralizing; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme-Linked Immunosorbent Assay; Female; HMGB1 Protein; Humans; Ligands; Lysine; Male; Middle Aged; Molecular Weight; Protein Kinase C-alpha; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Transcription, Genetic | 2010 |
Identification and relative quantification of specific glycation sites in human serum albumin.
Topics: Binding Sites; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Glycosylation; Humans; Lysine; Serum Albumin; Tandem Mass Spectrometry | 2010 |
Binding of mannose-binding lectin to fructosamines: a potential link between hyperglycaemia and complement activation in diabetes.
Topics: Animals; Blood Glucose; Chromatography, Affinity; Complement Activation; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Humans; Lysine; Mannose-Binding Lectin; Phosphotransferases (Alcohol Group Acceptor) | 2010 |
Effects of heat-processed ginseng and its active component ginsenoside 20(S)-Rg3 on the progression of renal damage and dysfunction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats.
Topics: Animals; Antioxidants; Blood Glucose; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Ginsenosides; Glycation End Products, Advanced; Hypoglycemic Agents; Kidney; Kidney Diseases; Lipid Peroxidation; Lipids; Lysine; Male; Nitric Oxide Synthase Type II; Oxidative Stress; Panax; Phytotherapy; Plant Extracts; Proteinuria; Rats; Rats, Inbred OLETF; Thiobarbituric Acid Reactive Substances | 2010 |
Maternally transmitted and food-derived glycotoxins: a factor preconditioning the young to diabetes?
Topics: Adiponectin; Adolescent; Adult; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Glycation End Products, Advanced; Humans; Infant; Infant Food; Infant, Newborn; Insulin; Isoprostanes; Lysine; Pyruvaldehyde; Risk Factors; Young Adult | 2010 |
Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice.
Topics: Animals; Biomarkers; Body Weight; Cholesterol; Cornus; Cyclooxygenase 2; Diabetes Mellitus, Type 2; Drinking; Fatty Acids; Gene Expression Regulation, Enzymologic; Glucose; Glycation End Products, Advanced; Hematologic Tests; Inflammation; Iridoids; Kidney; Lipid Metabolism; Liver; Lysine; Male; Mice; Nitric Oxide Synthase Type II; Organ Size; Oxidative Stress; PPAR alpha; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Transcription Factor RelA; Triglycerides | 2010 |
Advanced glycation end products in diabetic and non-diabetic human subjects suffering from cataract.
Topics: Aged; beta-Crystallins; Cataract; Diabetes Mellitus, Type 2; Female; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lens, Crystalline; Lysine; Male; Middle Aged | 2011 |
The ENPP1 K121Q polymorphism is not associated with type 2 diabetes or obesity in the Chinese Han population.
Topics: Aged; Amino Acid Substitution; Asian People; Diabetes Mellitus, Type 2; Female; Genetics, Population; Genome-Wide Association Study; Glutamic Acid; Humans; Lysine; Male; Middle Aged; Obesity; Phosphoric Diester Hydrolases; Polymorphism, Single Nucleotide; Pyrophosphatases | 2011 |
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci.
Topics: CCCTC-Binding Factor; Deoxyribonuclease I; Diabetes Mellitus, Type 2; Epigenomics; Genetic Loci; Genome-Wide Association Study; HeLa Cells; Histones; Humans; Islets of Langerhans; Lysine; Methylation; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Repressor Proteins | 2010 |
The ENPP1 K121Q polymorphism is not associated with type 2 diabetes and related metabolic traits in an Iranian population.
Topics: Adult; Aged; Amino Acid Substitution; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic Predisposition to Disease; Genetics, Population; Genotype; Glutamic Acid; Humans; Insulin Resistance; Iran; Lysine; Male; Metabolic Diseases; Middle Aged; Phosphoric Diester Hydrolases; Polymorphism, Single Nucleotide; Pyrophosphatases; Young Adult | 2011 |
Protective role of adiponectin on endothelial dysfunction induced by AGEs: a clinical and experimental approach.
Topics: Adiponectin; Adult; Cells, Cultured; Diabetes Mellitus, Type 2; E-Selectin; Endothelial Cells; Endothelium, Vascular; Female; Glucose Tolerance Test; Glycation End Products, Advanced; Humans; Insulin Resistance; Lysine; Male; Middle Aged; Vascular Cell Adhesion Molecule-1 | 2011 |
Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554.
Topics: Animals; Caco-2 Cells; Cell Line; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dogs; Female; Humans; Hypoglycemic Agents; Lysine; Quinolines; Rats; Rats, Wistar | 2011 |
The ubiquitin clan: A protein family essential for life.
Topics: Animals; Diabetes Mellitus, Type 2; Humans; Lysine; Neoplasms; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Ubiquitin; Ubiquitination | 2011 |
Correlation between plasma pentosidine concentrations and retinal hemodynamics in patients with type 2 diabetes.
Topics: Arginine; Blood Flow Velocity; Blood Glucose; Body Constitution; Cholesterol; Cross-Linking Reagents; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Hemodynamics; Humans; Laser-Doppler Flowmetry; Lysine; Male; Middle Aged; Prospective Studies; Retinal Artery | 2012 |
Association of KCNJ11 E23K gene polymorphism with hypoglycemia in sulfonylurea-treated type 2 diabetic patients.
Topics: Adult; Aged; Alleles; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Diabetes Mellitus, Type 2; Female; Genotype; Gliclazide; Glutamic Acid; Glycated Hemoglobin; Greece; Humans; Hypoglycemia; Lysine; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Potassium Channels, Inwardly Rectifying; Sulfonylurea Compounds | 2012 |
Pentosidine as a biomarker for microvascular complications in type 2 diabetic patients.
Topics: Aged; Arginine; Biomarkers; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Glycation End Products, Advanced; Humans; Hyperlipidemias; Hypertension; Lysine; Male; Microvessels; Middle Aged; Prospective Studies; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Severity of Illness Index; Up-Regulation | 2013 |
Reduction of paraoxonase-1 activity may contribute the qualitative impairment of HDL particles in patients with type 2 diabetes.
Topics: Aged; Apolipoprotein A-I; Aryldialkylphosphatase; Atherosclerosis; Biological Transport; Biomarkers; Cell Line; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Lipoproteins, HDL; Lysine; Macrophages; Male; Middle Aged; Serum Amyloid A Protein | 2013 |
Role of N-ε- carboxy methyl lysine, advanced glycation end products and reactive oxygen species for the development of nonproliferative and proliferative retinopathy in type 2 diabetes mellitus.
Topics: Adult; Aged; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Glycation End Products, Advanced; Humans; Leukocytes, Mononuclear; Lysine; Male; Middle Aged; Reactive Oxygen Species; Sulfhydryl Compounds; Vitreous Body | 2013 |
Activation of tubular epithelial cells in diabetic nephropathy.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Epithelium; Glycation End Products, Advanced; Humans; Kidney; Kidney Tubules; Lysine; NF-kappa B; Rats; Rats, Brattleboro; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reference Values; Serum Albumin; Transcription, Genetic; Urine | 2002 |
Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Humans; Imidazoles; Immunoassay; Lysine; Pyruvaldehyde; Sensitivity and Specificity | 2003 |
An inhibitor of advanced glycation end product formation reduces N epsilon-(carboxymethyl)lysine accumulation in glomeruli of diabetic rats.
Topics: Age Factors; Animals; Antibodies, Monoclonal; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Glomerular Mesangium; Glycation End Products, Advanced; Kidney; Kidney Glomerulus; Lysine; Rats; Rats, Inbred OLETF; Rats, Inbred Strains; Thiadiazoles; Thiazolidines | 2003 |
N(carboxymethyl)lysine as a biomarker for microvascular complications in type 2 diabetic patients.
Topics: Biomarkers; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Microcirculation; Middle Aged | 2003 |
Anti-hypertensive agents inhibit in vivo the formation of advanced glycation end products and improve renal damage in a type 2 diabetic nephropathy rat model.
Topics: Animals; Antihypertensive Agents; Arginine; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Glycation End Products, Advanced; Hydralazine; Hypertension, Renal; Imidazoles; Immunohistochemistry; In Vitro Techniques; Kidney; Lipids; Lysine; Male; Olmesartan Medoxomil; Oxidation-Reduction; Proteinuria; Rats; Tetrazoles | 2003 |
Increased urinary levels of pentosidine, pyrraline and acrolein adduct in type 2 diabetes.
Topics: Acrolein; Adult; Arginine; Blood Pressure; Diabetes Mellitus, Type 2; Female; Humans; Hyperglycemia; Lysine; Male; Middle Aged; Norleucine; Pyrroles; Smoking | 2003 |
Effect of smoking on risk factors for cardiovascular disease in patients with diabetes mellitus and renal insufficiency.
Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Glycation End Products, Advanced; Homocysteine; Humans; Kidney Transplantation; Lysine; Middle Aged; Renal Dialysis; Renal Insufficiency; Risk Factors; Smoking | 2003 |
The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth.
Topics: Aged; Alleles; Birth Weight; Diabetes Mellitus, Type 2; Female; Glutamine; Humans; Hypertension; Lysine; Male; Phosphoric Diester Hydrolases; Plasma Cells; Polymorphism, Genetic; Pyrophosphatases | 2004 |
Cosegregation of MIDD and MODY in a pedigree: functional and clinical consequences.
Topics: Adolescent; Adult; Aged; Chromosome Segregation; Deafness; Diabetes Mellitus; Diabetes Mellitus, Type 2; DNA-Binding Proteins; DNA, Mitochondrial; Female; HeLa Cells; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Humans; Lysine; Male; Methionine; Middle Aged; Mutation; Nuclear Proteins; Pedigree; Transcription Factors; Transcription, Genetic | 2004 |
Simple non-invasive assessment of advanced glycation endproduct accumulation.
Topics: Adult; Arginine; Biopsy; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Fluorescence; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Reference Values; Regression Analysis; Skin | 2004 |
Elevated serum levels of N(epsilon)-carboxymethyl-lysine, an advanced glycation end product, are associated with proliferative diabetic retinopathy and macular oedema.
Topics: Biomarkers; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Lysine; Macular Degeneration; Male; Middle Aged | 2004 |
Dissociation between urinary pyrraline and pentosidine concentrations in diabetic patients with advanced nephropathy.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Arginine; beta 2-Microglobulin; Biomarkers; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glycated Hemoglobin; Humans; Lysine; Pyrroles; Reference Values; Regression Analysis | 2004 |
Relationship between blood levels of N-carboxymethyl-lysine and pentosidine and the severity of microangiopathy in type 2 diabetes.
Topics: Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged | 2004 |
Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Arginine; Azepines; Basement Membrane; Cellular Senescence; Chromatography, High Pressure Liquid; Collagen; Cross-Linking Reagents; Diabetes Mellitus, Type 2; Extracellular Matrix; Female; Humans; Imidazoles; Kidney Failure, Chronic; Kidney Glomerulus; Lysine; Male; Middle Aged; Models, Chemical; Protein Binding; Regression Analysis; Renal Insufficiency; Skin; Time Factors | 2005 |
High serum pentosidine concentrations are associated with increased arterial stiffness and thickness in patients with type 2 diabetes.
Topics: Aged; Analysis of Variance; Arginine; Arteries; Biomechanical Phenomena; Brachial Artery; Cardiovascular Diseases; Carotid Arteries; Diabetes Mellitus, Type 2; Female; Glycation End Products, Advanced; Humans; Linear Models; Lysine; Male; Middle Aged; Pulse; Tunica Intima; Tunica Media; Ultrasonography | 2005 |
Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes.
Topics: Adult; Alanine; Amino Acid Substitution; Body Mass Index; Cohort Studies; Diabetes Mellitus, Type 2; Female; Genetic Variation; Glutamine; Humans; Lysine; Male; Middle Aged; Mutation, Missense; Potassium Channels, Inwardly Rectifying; PPAR gamma; Proline; Risk Factors | 2005 |
A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Fasting; Hepatocytes; Hyperglycemia; Insulin; Insulin Resistance; Liver; Lysine; Male; Mice; Mice, Obese; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Signal Transduction | 2005 |
The AGE/RAGE/NF-(kappa)B pathway may contribute to the pathogenesis of polyneuropathy in impaired glucose tolerance (IGT).
Topics: Aged; Biopsy; Charcot-Marie-Tooth Disease; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Glucose Intolerance; Glycation End Products, Advanced; Humans; Lysine; Middle Aged; NF-kappa B; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Sural Nerve | 2005 |
Evaluation of advanced glycation end products and carbonyl compounds in patients with different conditions of oxidative stress.
Topics: Aged; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Dialysis Solutions; Glycated Hemoglobin; Glycation End Products, Advanced; Glyoxal; Humans; Kidney Failure, Chronic; Lysine; Middle Aged; Oxidative Stress; Peritoneal Dialysis; Pyruvaldehyde | 2005 |
Pentosidine plasma levels and relation with metabolic control in diabetic patients.
Topics: Aged; Arginine; Blood Glucose; Blood Glucose Self-Monitoring; Chromatography, Liquid; Diabetes Complications; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Linear Models; Lysine; Male; Middle Aged | 2005 |
Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: effect of angiotensin-converting enzyme and vasopeptidase inhibition.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Ascorbic Acid; Blood Glucose; Chromatography, High Pressure Liquid; Creatine; Deoxyglucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glycated Hemoglobin; Glycation End Products, Advanced; Heterocyclic Compounds, 3-Ring; Kidney; Lysine; Male; Oxidation-Reduction; Protease Inhibitors; Ramipril; Rats; Rats, Zucker; Spectrometry, Fluorescence | 2005 |
Impaired left ventricular relaxation in type 2 diabetic rats is related to myocardial accumulation of N(epsilon)-(carboxymethyl) lysine.
Topics: Animals; Biomarkers; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Lysine; Male; Myocardial Contraction; Myocardium; Rats; Rats, Zucker; Severity of Illness Index; Ventricular Dysfunction, Left | 2006 |
In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy.
Topics: Animals; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diet, Fat-Restricted; Disease Models, Animal; Female; Follow-Up Studies; Glycation End Products, Advanced; Immunohistochemistry; Kidney; Lysine; Male; Microscopy, Electron; Obesity; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Wistar | 2005 |
Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.
Topics: Adult; Aged; Blood Glucose; Body Mass Index; Case-Control Studies; Cohort Studies; Denmark; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genotype; Glucose Tolerance Test; Glutamine; Humans; Insulin Resistance; Lysine; Male; Middle Aged; Obesity; Odds Ratio; Phosphoric Diester Hydrolases; Polymorphism, Genetic; Pyrophosphatases; Regression Analysis; White People | 2006 |
Determination of N epsilon-(carboxymethyl)lysine in exhaled breath condensate using isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometry.
Topics: Aged; Biomarkers; Breath Tests; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Humans; Lysine; Middle Aged; Pneumonia; Pulmonary Disease, Chronic Obstructive; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2006 |
Circulating soluble receptor for advanced glycation end products is inversely associated with glycemic control and S100A12 protein.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; C-Reactive Protein; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Inflammation Mediators; Lysine; Male; Middle Aged; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Risk Factors; S100 Proteins; S100A12 Protein; Statistics as Topic | 2006 |
The advanced glycation end product N(epsilon)-carboxymethyllysine is not a predictor of cardiovascular events and renal outcomes in patients with type 2 diabetic kidney disease and hypertension.
Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Disease Progression; Female; Glycation End Products, Advanced; Humans; Hypertension; Lysine; Male; Middle Aged; Multivariate Analysis; Oxidative Stress; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Risk Factors | 2006 |
The K469E polymorphism of the intracellular adhesion molecule 1 (ICAM-1) gene is not associated with myocardial infarction in Caucasians with type 2 diabetes.
Topics: Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease; Genotype; Glutamine; Humans; Intercellular Adhesion Molecule-1; Lysine; Male; Middle Aged; Myocardial Infarction; Polymorphism, Single Nucleotide; White People | 2006 |
Effect of pyridoxamine (K-163), an inhibitor of advanced glycation end products, on type 2 diabetic nephropathy in KK-A(y)/Ta mice.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dose-Response Relationship, Drug; Glycation End Products, Advanced; Immunohistochemistry; Laminin; Lysine; Male; Mice; Pyridoxamine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Schiff Bases; Transforming Growth Factor beta1; Tyrosine | 2007 |
Characterisation and glucoregulatory actions of a novel acylated form of the (Pro3)GIP receptor antagonist in type 2 diabetes.
Topics: Acylation; Animals; Binding Sites; Cyclic AMP; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucose; Insulin; Insulin Secretion; Lysine; Mice; Mice, Obese; Palmitic Acid; Receptors, Gastrointestinal Hormone; Structure-Activity Relationship; Time Factors | 2007 |
Diabetes mellitus exacerbates advanced glycation end product accumulation in the veins of end-stage renal failure patients.
Topics: Adult; Aged; Arginine; Brachiocephalic Veins; Diabetes Mellitus, Type 2; Female; Glycation End Products, Advanced; Humans; Hypertension; Immunohistochemistry; Kidney Failure, Chronic; Lysine; Male; Middle Aged; Radial Artery | 2006 |
Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Arginine; Benzimidazoles; Biphenyl Compounds; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Drug Evaluation, Preclinical; Electroretinography; Gene Expression Regulation; Glycation End Products, Advanced; Lysine; Male; Rats; Rats, Sprague-Dawley; Retina; Reverse Transcriptase Polymerase Chain Reaction; Tetrazoles; Vascular Endothelial Growth Factor A | 2007 |
Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress.
Topics: 3T3 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Animals; Biomarkers; Cell Differentiation; Citric Acid Cycle; Cysteine; Diabetes Complications; Diabetes Mellitus, Type 2; Fibroblasts; Fumarates; Humans; Insulin Resistance; Lysine; Mice; Mitochondria; Obesity; Protein Processing, Post-Translational; Risk Factors; Stress, Physiological; Succinic Acid; Sulfhydryl Compounds | 2007 |
[Is the serum concentration of pentosidine a predictor of cardiovascular events in patients with type 2 diabetes and kidney disease?].
Topics: Arginine; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Cohort Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Humans; Lipoproteins, LDL; Lysine; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Prospective Studies; Risk Factors; Time Factors | 2007 |
Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model.
Topics: Animals; Antimutagenic Agents; Arginine; Basic Helix-Loop-Helix Transcription Factors; Blood Pressure; Blotting, Western; Chromatography, High Pressure Liquid; Cobalt; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Gene Expression; Glycation End Products, Advanced; Hypertension; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immediate-Early Proteins; Insulin-Like Growth Factor Binding Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Lysine; Male; NADPH Oxidases; Obesity; Oxidative Stress; Polymerase Chain Reaction; Rats; Rats, Inbred SHR; RNA, Messenger; Transforming Growth Factor beta | 2008 |
Preparation, characterization, and application of biotinylated and biotin-PEGylated glucagon-like peptide-1 analogues for enhanced oral delivery.
Topics: Absorption; Administration, Oral; Animals; Binding Sites; Biotin; Biotinylation; Blood Glucose; Diabetes Mellitus, Type 2; Enzyme Stability; Glucagon-Like Peptide 1; Hypoglycemic Agents; Injections, Intraperitoneal; Intestinal Mucosa; Lysine; Mice; Peptide Hydrolases; Polyethylene Glycols; Rats; Sensitivity and Specificity | 2008 |
Serum pentosidine levels are positively associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes.
Topics: Aged; Aged, 80 and over; Arginine; Bone Density; Diabetes Mellitus, Type 2; Female; Humans; Logistic Models; Lysine; Male; Middle Aged; Postmenopause; Spinal Fractures | 2008 |
Increased Nepsilon-(carboxymethyl)-lysine levels in cerebral blood vessels of diabetic patients and in a (streptozotocin-treated) rat model of diabetes mellitus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Brain; Cerebrovascular Circulation; Child; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lysine; Male; Middle Aged; Rats; Rats, Wistar | 2008 |
Increased fructose-lysine of nail protein in diabetic patients.
Topics: Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Lysine; Nails | 1984 |
3-Deoxyfructose concentrations are increased in human plasma and urine in diabetes.
Topics: Adolescent; Adult; Aged; Biomarkers; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Ketoses; Lysine; Middle Aged; Reference Values; Regression Analysis | 1994 |
Characterization of chemical composition of native and modified low density lipoprotein occurring in the blood of diabetic patients.
Topics: Cells, Cultured; Cholesterol; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Lipids; Lipoproteins, LDL; Lysine; N-Acetylneuraminic Acid; Phospholipids; Sialic Acids | 1994 |
Pentosidine content in skin collagen from type II diabetic patients.
Topics: Adult; Analysis of Variance; Arginine; Biomarkers; Collagen; Cross-Linking Reagents; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Dipeptides; Humans; Lysine; Middle Aged; Reference Values; Skin | 1994 |
Differential effects of type 2 (non-insulin-dependent) diabetes mellitus on pentosidine formation in skin and glomerular basement membrane.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Arginine; Basement Membrane; Biomarkers; Child; Cross-Linking Reagents; Diabetes Mellitus, Type 2; Female; Humans; Infant; Kidney Glomerulus; Lysine; Male; Middle Aged; Skin; Skin Aging | 1993 |
The Maillard protein cross-link pentosidine in urine from diabetic patients.
Topics: Aged; Arginine; Chromatography, Gel; Chromatography, High Pressure Liquid; Creatinine; Cross-Linking Reagents; Diabetes Mellitus, Type 2; Female; Humans; Hydroxyproline; Lysine; Maillard Reaction; Male; Middle Aged; Reference Values | 1993 |
Maillard reaction products and their relation to complications in insulin-dependent diabetes mellitus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Collagen; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Female; Humans; Lysine; Maillard Reaction; Male; Microcirculation; Middle Aged; Skin | 1993 |
A new effective method for the evaluation of glycated intact plasma proteins in diabetic subjects.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Blood Proteins; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Glycated Serum Proteins; Glycoproteins; Humans; Lysine; Male; Middle Aged; Reference Values | 1995 |
Factors influencing Lp[a]- particle size as determined by gradient gel electrophoresis.
Topics: Apolipoproteins A; Cholesterol, LDL; Chromatography, Affinity; Diabetes Mellitus, Type 2; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Female; Humans; Immunoblotting; Lipoprotein(a); Lysine; Male; Middle Aged; Particle Size; Sulfhydryl Reagents; Ultracentrifugation | 1996 |
Accumulation of albumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure: renal implications in the pathophysiology of pentosidine.
Topics: Animals; Arginine; beta 2-Microglobulin; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diet; Glomerulonephritis; Humans; Kidney Failure, Chronic; Lysine; Maillard Reaction; Nephrectomy; Oxidation-Reduction; Protein Binding; Rats; Rats, Wistar; Serum Albumin; Uremia | 1996 |
The relationship between accumulation of advanced glycation end products and expression of vascular endothelial growth factor in human diabetic retinas.
Topics: Aged; Aged, 80 and over; Antibodies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Endothelial Growth Factors; Epitopes; Female; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lymphokines; Lysine; Male; Middle Aged; Retina; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1997 |
Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy.
Topics: Adolescent; Adult; Aged; Animals; Antibodies; Arginine; Collagen; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Humans; Immunoenzyme Techniques; Kidney Glomerulus; Lipid Peroxidation; Lysine; Male; Malondialdehyde; Mice; Middle Aged; Nephrotic Syndrome; Norleucine; Pyrroles; Rabbits | 1997 |
Advanced glycation end products in human penis: elevation in diabetic tissue, site of deposition, and possible effect through iNOS or eNOS.
Topics: Adult; Aged; Arginine; Blotting, Western; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Electron Probe Microanalysis; Endothelium; Enzyme Induction; Erectile Dysfunction; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lysine; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Norleucine; Penis; Pyrroles | 1997 |
Localization in human diabetic peripheral nerve of N(epsilon)-carboxymethyllysine-protein adducts, an advanced glycation endproduct.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Fluorescent Antibody Technique; Glycation End Products, Advanced; Humans; Immunoenzyme Techniques; Lysine; Male; Microscopy, Immunoelectron; Middle Aged; Nerve Fibers, Myelinated; Peripheral Nerves; Proteins | 1997 |
Increased pentosidine, an advanced glycation end product, in plasma and synovial fluid from patients with rheumatoid arthritis and its relation with inflammatory markers.
Topics: Acute-Phase Proteins; Aged; Arginine; Arthritis, Rheumatoid; Biomarkers; Diabetes Mellitus, Type 2; Extracellular Matrix; Glycation End Products, Advanced; Humans; Lysine; Middle Aged; Osteoarthritis; Synovial Fluid | 1998 |
Accumulation of Nsigma-(carboxy-methyl)lysine and changes in glomerular extracellular matrix components in Otsuka Long-Evans Tokushima fatty rat: a model of spontaneous NIDDM.
Topics: Animals; Diabetes Mellitus, Type 2; Extracellular Matrix; Fluorescent Antibody Technique; Glycation End Products, Advanced; Immunoenzyme Techniques; Kidney Glomerulus; Lysine; Male; Microscopy, Electron; Rats; Rats, Inbred Strains; Time Factors; Transforming Growth Factor beta | 1998 |
Glycoxidation, and protein and DNA oxidation in patients with diabetes mellitus.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Arginine; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Deoxyguanosine; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Lysine; Middle Aged; Oxidative Stress; Statistics, Nonparametric; Tyrosine | 1998 |
Advanced glycation endproducts (AGE) on IgG, a target for circulating antibodies in North American Indians with rheumatoid arthritis (RA).
Topics: Adult; Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoantibodies; Diabetes Mellitus, Type 2; Female; Glycation End Products, Advanced; Glycosylation; Humans; Imidazoles; Immunoblotting; Immunoglobulin G; Immunoglobulin Heavy Chains; Immunoglobulin M; Indians, North American; Lysine; Male; Middle Aged; Nitroblue Tetrazolium; Ontario; Rheumatoid Factor | 1998 |
Increase in three alpha,beta-dicarbonyl compound levels in human uremic plasma: specific in vivo determination of intermediates in advanced Maillard reaction.
Topics: 2-Naphthylamine; Aging; Arginine; Chromatography, Liquid; Deoxyglucose; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Glyoxal; Humans; Kidney Failure, Chronic; Lysine; Mass Spectrometry; Matched-Pair Analysis; Middle Aged; Pyruvaldehyde; Reactive Oxygen Species; Sensitivity and Specificity; Uremia | 1999 |
Increased serum levels of pentosidine, but not carboxymethyl lysine, in type 2 diabetes without obvious diabetic nephropathy.
Topics: Albuminuria; Arginine; Biomarkers; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Lysine; Middle Aged; Reference Values | 1999 |
Detection of noncarboxymethyllysine and carboxymethyllysine advanced glycation end products (AGE) in serum of diabetic patients.
Topics: Animals; Antibodies; Cattle; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Humans; Lysine; Middle Aged; Peptides; Rabbits; Renal Dialysis | 1999 |
Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration.
Topics: Acylation; Amino Acid Sequence; Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Diabetes Mellitus, Type 2; Fatty Acids; Glucagon; Glucagon-Like Peptide 1; Kidney; Lysine; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Precursors; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Swine | 2000 |
A syndrome of molybdenosis, copper deficiency, and type 2 diabetes in the moose population of south-west Sweden.
Topics: Animals; Arginine; Case-Control Studies; Copper; Deer; Deficiency Diseases; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Kidney; Liver; Lysine; Molybdenum; Sweden | 2000 |
Immunological evidence that non-carboxymethyllysine advanced glycation end-products are produced from short chain sugars and dicarbonyl compounds in vivo.
Topics: Animals; Antibodies; Cattle; Chromatography, Affinity; Cross Reactions; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Glyceraldehyde; Glyoxal; Humans; Immunoblotting; Kidney Failure, Chronic; Lysine; Maillard Reaction; Oxidation-Reduction; Pyruvaldehyde; Rabbits; Renal Dialysis | 2000 |
Differential scanning calorimetry, biochemical, and biomechanical analysis of human skin from individuals with diabetes mellitus.
Topics: Aged; Aged, 80 and over; Anisotropy; Biomechanical Phenomena; Calorimetry, Differential Scanning; Collagen; Diabetes Mellitus, Type 2; Female; Glycation End Products, Advanced; Humans; Lysine; Protein Denaturation; Skin | 2000 |
Epalrestat, an aldose reductase ihibitor, reduces the levels of Nepsilon-(carboxymethyl)lysine protein adducts and their precursors in erythrocytes from diabetic patients.
Topics: Aldehyde Reductase; Blood Glucose; Blood Proteins; Deoxyglucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic Retinopathy; Enzyme Inhibitors; Erythrocytes; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Reference Values; Rhodanine; Thiazolidines | 2000 |
A novel mutation E179K of the MEN1 gene predisposes for multiple endocrine neoplasia-type 1 (MEN1).
Topics: Adenoma; Adolescent; Adult; Amino Acid Substitution; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Glutamic Acid; Humans; Hyperinsulinism; Hyperparathyroidism; Insulinoma; Lysine; Male; Multiple Endocrine Neoplasia Type 1; Mutation, Missense; Nuclear Family; Pancreatic Neoplasms | 2000 |
Antibodies against advanced glycation end product Nepsilon-(carboxymethyl)lysine in healthy controls and diabetic patients.
Topics: Adult; Aged; Autoantibodies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Female; Glycation End Products, Advanced; Humans; Immunoglobulin G; Lysine; Male; Middle Aged; Serum Albumin | 2000 |
Increased levels of vascular endothelial growth factor and advanced glycation end products in aqueous humor of patients with diabetic retinopathy.
Topics: Aged; Aqueous Humor; Biomarkers; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Endothelial Growth Factors; Female; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lymphokines; Lysine; Male; Middle Aged; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
N(epsilon)-(carboxymethyl)lysine levels in patients with type 2 diabetes: role of renal function.
Topics: Adult; Aged; Aged, 80 and over; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Oxidative Stress | 2001 |
Insulin receptor tyrosine kinase activity in monocytes of type 2 diabetes mellitus patients receiving oral L-lysine.
Topics: Administration, Oral; Adult; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Lysine; Male; Middle Aged; Monocytes; Precipitin Tests; Protein-Tyrosine Kinases | 2001 |
Non-enzymatic glycation of IgG: an in vivo study.
Topics: Aged; Blood Glucose; Blood Proteins; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Female; Glucose; Glycated Hemoglobin; Glycoproteins; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Lysine; Male; Middle Aged; Models, Molecular; Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2002 |
Age- and diabetes-accelerated glycation in the human aorta.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aorta; Arteriosclerosis; Diabetes Mellitus, Type 2; Female; Humans; Infant, Newborn; Lysine; Maillard Reaction; Male; Middle Aged | 1989 |
[Role of the non-enzymatic glycosylation of protein in the formation of human cataracts].
Topics: Adult; Aged; Aged, 80 and over; Aging; Cataract; Diabetes Mellitus, Type 2; Eye Proteins; Female; Glycosylation; Humans; Lysine; Male; Middle Aged; Schiff Bases | 1989 |
Glycation of collagen in the aorta and the development of aging.
Topics: Aged; Aging; Animals; Aorta, Abdominal; Collagen; Diabetes Mellitus, Type 2; Fluorescence; Glycosylation; Humans; Lysine; Maillard Reaction; Middle Aged; Rats | 1989 |
Clinical application of hair protein glycation in the assessment of blood glucose control and diabetic neuropathy.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Glycated Hemoglobin; Glycoproteins; Hair; Humans; Lysine; Male; Middle Aged; Neural Conduction | 1989 |
Radioimmunoassay of glycated serum protein using monoclonal antibody to glucitollysine and coomassie-brilliant-blue-coated polystyrene beads.
Topics: Animals; Antibodies, Monoclonal; Blood Proteins; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Glycated Serum Albumin; Glycated Serum Proteins; Glycation End Products, Advanced; Glycoproteins; Glycosylation; Humans; Indicators and Reagents; Lysine; Mice; Mice, Inbred BALB C; Polystyrenes; Radioimmunoassay; Reference Values; Rosaniline Dyes; Serum Albumin | 1989 |
Protein glycosylation as an indicator of blood glucose control using furosine determination.
Topics: Blood Glucose; Blood Proteins; Diabetes Mellitus, Type 2; Glycated Serum Proteins; Glycoproteins; Humans; Lysine; Nails | 1986 |
Nonenzymatic glycosylation of lens in diabetic patients.
Topics: Aged; Aged, 80 and over; Cataract; Diabetes Mellitus, Type 2; Female; Glycosylation; Humans; Lens, Crystalline; Lysine; Male; Middle Aged | 1986 |
Increased fructose-lysine of nail protein and blood glucose control in diabetic patients.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Diabetes Mellitus, Type 2; Female; Humans; Lysine; Male; Middle Aged; Nails | 1986 |
Is serum fructosamine assay specific for determination of glycated serum protein?
Topics: Blood Proteins; Borohydrides; Diabetes Mellitus, Type 2; Fructosamine; Glycated Hemoglobin; Glycated Serum Albumin; Glycated Serum Proteins; Glycation End Products, Advanced; Glycoproteins; Glycosylation; Hexosamines; Humans; Lysine; Serum Albumin | 1988 |
Glycation of cataractous lens in non-diabetic senile subjects and in diabetic patients.
Topics: Aged; Aged, 80 and over; Cataract; Diabetes Mellitus, Type 2; Female; Humans; Lens, Crystalline; Lysine; Male; Middle Aged | 1988 |
Determination of glycated hair protein and its clinical utility.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Glycosylation; Hair; Humans; Lysine; Male; Middle Aged; Proteins | 1988 |
Glycation of hair protein in the assessment of long-term control of blood glucose.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Hair; Humans; Lysine; Male; Middle Aged; Protein Binding; Time Factors | 1988 |
Collagen-glycation in the aorta as a developmental factor of aging and arteriosclerosis.
Topics: Aging; Aorta; Arteriosclerosis; Collagen; Diabetes Mellitus, Type 2; Glycosylation; Humans; Lysine; Maillard Reaction; Spectrometry, Fluorescence | 1988 |
Increased fructose-lysine of hair protein and blood glucose control in diabetic patients.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Hair; Humans; Lysine; Male; Middle Aged | 1988 |
Effects of salicylate, tolbutamide, and prostaglandin E2 on insulin responses to glucose in noninsulin-dependent diabetes mellitus.
Topics: Adult; Aspirin; Blood Glucose; Diabetes Mellitus, Type 2; Dinoprostone; Drug Interactions; Glucose; Humans; Insulin; Lysine; Middle Aged; Prostaglandins E; Tolbutamide | 1985 |
Increased fructose-lysine of hair protein in diabetic patients.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Hair; Humans; Lysine; Male; Middle Aged; Proteins | 1985 |
Antibodies to nonenzymatically glucosylated albumin in the human serum.
Topics: Adult; Antigens; Autoantibodies; Binding, Competitive; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin M; Lysine; Male; Mannitol; Middle Aged; Oxidation-Reduction; Serum Albumin; Sorbitol | 1985 |
Impaired insulin secretion in human diabetes mellitus. Interactions between naloxone, phentolamine and lysine acetylsalicylate upon glucose induced insulin release.
Topics: Adult; Analgesics; Aspirin; Blood Glucose; Diabetes Mellitus, Type 2; Drug Interactions; Glucose; Humans; Insulin; Insulin Secretion; Kinetics; Lysine; Middle Aged; Naloxone; Phentolamine | 1985 |