lysine has been researched along with Benign Neoplasms, Brain in 66 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 7 (10.61) | 18.7374 |
1990's | 3 (4.55) | 18.2507 |
2000's | 5 (7.58) | 29.6817 |
2010's | 38 (57.58) | 24.3611 |
2020's | 13 (19.70) | 2.80 |
Authors | Studies |
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Amé, JC; Dantzer, F; Hanini, N; Nguekeu-Zebaze, L; Noll, A; Roegel, L; Wadier, N | 1 |
Alejo, S; Brenner, AJ; Chen, Y; Clarke, K; Gilbert, AR; He, Y; Jayamohan, S; Johnson, JD; Lai, Z; Li, W; Lv, Y; Palacios, BE; Pratap, UP; Sareddy, GR; Suzuki, T; Tekmal, RR; Vadlamudi, RK; Venkata, PP; Viswanadhapalli, S; Weldon, K; Ye, Z; Zhao, W; Zheng, S; Zou, Y | 1 |
Aldape, K; Bhaduri, A; Chinnaiyan, AM; Cieslik, M; Englinger, B; Filbin, MG; Jiang, L; Joshi, PK; Nano, PR; Pfister, S; Pratt, D; Pun, M; Rao, A; Venneti, S | 1 |
Cong, H; Dong, C; Fan, B; Guo, X; Liu, Y; Sui, A | 1 |
Cao, X; Chinnaiyan, AM; Chung, C; Ding, Y; Hawes, D; Judkins, AR; Mota, M; Natarajan, SK; Parolia, A; Pun, M; Samajdar, S; Sweha, SR; Venneti, S; Xiao, L; Yang, F | 1 |
Gül, D; Krämer, OH; Reinhardt, C | 1 |
Arzt, M; Filbin, MG; Gillespie, SM; Hovestadt, V; Kambhampati, M; Lennon, JJ; Monje, M; Nagaraja, S; Nazarian, J; Quezada, MA; Suva, ML; Woo, PJ | 1 |
Amer, N; El-Ayadi, M; El-Beltagy, M; El-Naggar, S; Hassan, Z; Khorshed, EN; Mosaab, A; Refaat, A; Soror, SH; Zaghloul, MS | 1 |
Agnihotri, S; Ahmadi, M; Angers, S; Arrowsmith, CH; Bajic, A; Balin, P; Cavalli, FMG; Coutinho, FJ; Daniels, C; De Antonellis, P; Deblois, G; Delaidelli, A; Dirks, PB; Donovan, LK; El-Hamamy, I; Farooq, H; Garcia, BA; Garzia, L; Guilhamon, P; Haapasalo, J; Holgado, BL; Jabado, N; Jiang, Y; Juraschka, K; Kanshin, E; Kharas, K; Kim, LJY; Krumholtz, SL; Kumar, SA; Lee, JJY; Loukides, J; Lupien, M; Luu, B; Ly, M; Mack, SC; MacLeod, G; Malik, AA; Michealraj, KA; Ong, W; Prinos, P; Przelicki, D; Ramaswamy, V; Rasnitsyn, A; Rastan, A; Rich, JN; Richman, CM; Sánchez-Osuna, M; Saulnier, O; Schramek, D; Singh, S; Sirbu, O; Sorensen, PH; Srikanthan, D; Stein, LD; Suzuki, H; Taylor, MD; Tsai, R; Tyers, M; Van Ommeren, R; Vellanki, RN; Vladoiu, MC; Wang, EY; Weiss, S; Wojcik, JB; Wouters, BG; Wu, X | 1 |
Bush, K; Carcaboso, AM; Cervantes, V; Chen, KY; Klein, RH; Knoepfler, PS; Lechpammer, M; Lewis, N; Naqvi, A | 1 |
Alaggio, R; Alexandrescu, S; Lidov, HG; Ligon, KL; Meredith, DM; Novello, M; Vargas, SO | 1 |
A, D; Albrecht, S; Andrade, AF; Bajic, A; Bandopadhayay, P; Bassenden, AV; Berghuis, AM; Beroukhim, R; Blanchette, M; Bognar, L; Brandner, S; Chen, CCL; Coutelier, M; Dali, R; De Jay, N; Deshmukh, S; Dubois, F; Ekert, PG; Ellezam, B; Faury, D; Filbin, MG; Garcia, BA; Garzia, L; Gayden, T; Hadjadj, D; Hansford, JR; Harutyunyan, AS; Hauser, P; Hébert, S; Jabado, N; Jawhar, W; Jessa, S; Jones, DTW; Juretic, N; Karamchandani, J; Khuong-Quang, DA; Kleinman, CL; Klekner, A; Korshunov, A; Kramm, C; Krskova, L; Ligon, KL; Lisi, V; Mack, SC; Maestro, N; Marchione, DM; Mikael, LG; Pathania, M; Pfister, SM; Russo, C; Salomoni, P; Sturm, D; Sumerauer, D; Suzuki, H; Taylor, MD; Vanova, K; Vicha, A; Virga, J; Weil, AG; Woodward, E; Zamecnik, J; Zapotocky, M; Zeinieh, M; Ziegler, DS | 1 |
Agnihotri, S; Bridge, T; Hawkins, C; Huang, A; Kim, B; Li, C; Milos, S; Pajovic, S; Patel, P; Phillips, L; Rakopoulos, P; Ryall, S; Sheth, J; Siddaway, R; Srikanthan, D; Yu, M | 1 |
Alfazema, N; Bracken, AP; Bressan, RB; Brien, GL; Deevy, O; Doherty, AM; Fitzpatrick, DJ; Gannon, D; Grant, V; Healy, E; Lagan, E; Marqués-Torrejón, MA; Monger, C; Neikes, H; Pollard, SM | 1 |
Cui, J; Han, J; Ou, J; Qin, Y; Wang, RF; Zhang, C; Zhang, J; Zhi, F | 1 |
Elbabaa, SK; Guzman, M; Hawkins, C; Luu, B; Mack, SC; Ramaswamy, V; Ryall, S; Taylor, MD; Zapotocky, M | 1 |
Ferrigno, C; Holdhoff, M; Javadi, MS; Laterra, JJ; Menke, JR; Pomper, MG; Rowe, SP; Salas Fragomeni, RA; Solnes, LB; Szabo, Z | 1 |
Chen, Q; Guo, Q; He, X; Jiang, C; Jiang, X; Liu, L; Liu, Y; Lu, Y; Ruan, C; Sun, T; Wang, Q; Zhang, Y | 1 |
Brennum, J; Hamerlik, P; Jensen, KE; Michaelsen, SR; Pedersen, H; Poulsen, HS; Rasmussen, RD; Skjoth-Rasmussen, J; Staberg, M; Villingshøj, M; Vitting-Seerup, K | 1 |
Cai, J; Dinislam, M; Duan, C; Gao, F; Gao, W; Han, B; Jiang, C; Kang, C; Lin, L; Meng, X; Wang, R; Wu, P | 1 |
Arnold, EP; Haile, S; Hulleman, E; Kadapakkam, M; Labanieh, L; Mackall, CL; Majzner, RG; Monje, M; Mount, CW; Rietberg, SP; Sundaresh, S; Vogel, H; Woo, PJ | 1 |
Li, W; Shi, J; Shi, L; Shi, X; Wen, H | 1 |
Budka, H; Leske, H; Niehusmann, P; Pahnke, J; Panagopoulos, I; Rushing, E | 1 |
Anderson, B; Bruzek, A; Carcaboso, AM; Garcia, T; Garton, H; Hashizume, R; Heth, J; Koschmann, C; McMurray, KQ; Miklja, Z; Mody, R; Mullan, B; Muraszko, K; Robertson, PL; Savelieff, MG; Siada, R; Singer, BH; Stallard, S; Venneti, S; Wierzbicki, K | 1 |
Akiyama, T; Echizen, K; Funato, K; Hayashi, T; Ino, Y; Koyama-Nasu, R; Morishita, Y; Mukasa, A; Nasu-Nishimura, Y; Negishi, L; Saito, N; Shimizu, N; Tabar, V; Todo, T | 1 |
Barret, E; Castel, D; Debily, MA; Grill, J; Jones, C; Jones, DTW; Kergrohen, T; Kramm, CM; Merlevede, J; Pfister, SM; Philippe, C; Puget, S; Sainte-Rose, C; Sill, M; Varlet, P | 1 |
Bechet, D; Belle, J; Cagnone, G; Chen, CCL; Chen, H; Cheung, WA; De Jay, N; Deshmukh, S; Ellezam, B; Faury, D; Garcia, BA; Harutyunyan, AS; Hu, B; Jabado, N; Jain, SU; Kleinman, CL; Krug, B; Lewis, PW; Li, R; Lu, C; Majewski, J; Marchione, DM; McConechy, MK; Mikael, LG; Mohammadnia, A; Montpetit, A; Nikbakht, H; Papillon-Cavanagh, S; Pastinen, T; Pathania, M; Salomoni, P; Weil, AG; Zeinieh, M | 1 |
Garimella, MT; Heguy, A; Huse, JT; Judkins, AR; Martinez, D; Santi, M; Sullivan, LM; Thompson, CB; Venneti, S | 1 |
Michan, S | 1 |
Allis, CD; Banaszynski, LA; Becher, OJ; Cordero, F; Garcia, BA; Koletsky, MS; Lewis, PW; Lin, S; Muir, TW; Müller, MM | 1 |
Hatanaka, A; Ishikawa, Y; Issa, JP; Ito, M; Katsushima, K; Kim, SU; Kondo, Y; Natsume, A; Ohka, F; Okano, H; Sato, S; Sekido, Y; Shimogawa, H; Shinjo, K; Takahashi, S; Takeuchi, I; Uesugi, M; Wakabayashi, T | 1 |
Byun, HS; Choi, SW; Hong, JH; Huang, SM; Hur, GM; Jeon, J; Kim, JM; Kim, SH; Lee, JH; Lee, Y; Li, Y; Liu, ZG; Lu, T; Park, J; Park, KA; Ro, H; Shen, HM; Sohn, KC; Stark, GR; Zhang, T | 1 |
Adamopoulos, C; Dalagiorgou, G; Gargalionis, A; Lea, RW; Papavassiliou, AG; Papavassiliou, KA; Piperi, C; Spyropoulou, A | 1 |
Allis, CD; Lewis, PW | 1 |
Feng, D; Hu, Q; Li, H; Ma, H; Su, Y; Tao, H; Wang, X; Zhang, C | 1 |
Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW | 2 |
Butterfield, LH; Connelly, AK; Dibridge, SA; Hamilton, RL; Jakacki, RI; Okada, H; Panigrahy, A; Pollack, IF; Potter, DM; Whiteside, TL | 1 |
Felicella, MM; Judkins, AR; Lewis, PW; Martinez, D; Perry, A; Phillips, JJ; Santi, M; Sullivan, LM; Thompson, CB; Venneti, S; Yarilin, D | 1 |
Biffoni, M; Cappellari, M; De Maria, R; Grande, S; Guidoni, L; Luciani, AM; Pallini, R; Palma, A; Ricci-Vitiani, L; Rosi, A; Runci, D; Viti, V | 1 |
Daniels, D; Han, J; Huang, H; Zhang, R; Zhang, Z | 1 |
Chen, S; De Marco, V; Gamblin, SJ; Haire, LF; Justin, N; Martin, SR; Reinberg, D; Tarricone, C; Underwood, E; Walker, PA; Wilson, JR; Zhang, Y | 1 |
Luo, D; Luo, K; Wen, H | 1 |
Jang, JH; Kim, J; Kim, MS; Kim, YZ; Lee, EH; Lee, SH | 1 |
Cui, J; Ou, J; Xia, X; Yang, Z; Zhang, J; Zhi, F | 1 |
Bae, Y; Choi, JS; Han, J; Ko, KS; Lee, S; Rhim, HS | 1 |
Berger, MS; Lin, C; Lin, CA; Phillips, JJ; Rhodes, CT | 1 |
Akcan, M; Clark, RJ; Craik, DJ; Daly, NL; Hansen, SJ; Olson, JM; Stroud, MR | 1 |
Karst, A; Lehnus, M; Pehar, M; Puglielli, L | 1 |
Beyerlein, M; Canals, S; Engelmann, J; Logothetis, NK; Mishra, A; Schüz, A | 1 |
Amaya, MF; Arrowsmith, CH; Duan, S; Krichevsky, L; Nady, N; Ravichandran, M; Tempel, W; Zhong, N | 1 |
TOERMAE, T; VISAKORPI, JK; WASZ-HOECKERT, O | 1 |
KOREY, SR; SUZUKI, K; TERRY, RD | 1 |
MCQUEEN, JD; MEGO, JL | 1 |
Barth, RF; Ciesielski, MJ; Fenstermaker, RA; Kazim, AL | 1 |
Bulte, JW; Gilad, AA; McMahon, MT; Raman, V; Skoglund, CM; van Laarhoven, HW; van Zijl, PC; Walczak, P; Winnard, PT | 1 |
Badn, W; Darabi, A; Esbjörnsson, M; Fellert, MA; Hegardt, P; Janelidze, S; Salford, LG; Siesjö, P; Smith, KE; Visse, E | 1 |
Badn, W; Darabi, A; Salford, LG; Siesjö, P; Smith, KE; Visse, E | 1 |
Busek, P; Krepela, E; Sedo, A; Stremeňová, J | 1 |
Baserga, R; Burgaud, JL; Resnicoff, M | 1 |
Debinski, W; Gibo, DM; Kealiher, A; Obiri, NI; Puri, RK | 1 |
Berens, ME; Djawaheri, J; Giese, A; Hagel, C; Kim, EL; Westphal, M; Zapf, S | 1 |
Mayama, T | 1 |
Espiner, EA; Jagger, PI; Lauler, DP; Thorn, GW; Tucci, JR | 1 |
Iversen, LL; Snodgrass, SR | 1 |
Bernard-Weil, E; Olivier, L; Piette, C | 1 |
1 review(s) available for lysine and Benign Neoplasms, Brain
Article | Year |
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Acetylome regulation by sirtuins in the brain: from normal physiology to aging and pathology.
Topics: Acetylation; Aging; Animals; Autophagy; Brain; Brain Neoplasms; Cellular Senescence; Circadian Rhythm; DNA Damage; Emotions; Humans; Lysine; Neurodegenerative Diseases; Neurogenesis; NF-kappa B; Oxidative Stress; Proteome; Sirtuins | 2013 |
1 trial(s) available for lysine and Benign Neoplasms, Brain
Article | Year |
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Antigen-specific immune responses and clinical outcome after vaccination with glioma-associated antigen peptides and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in children with newly diagnosed malignant brainstem and n
Topics: Adolescent; Antigens, Neoplasm; Brain Neoplasms; Brain Stem Neoplasms; Cancer Vaccines; Carboxymethylcellulose Sodium; Child; Child, Preschool; Disease-Free Survival; Drug Carriers; Enzyme-Linked Immunospot Assay; Epitopes; Female; Glioma; Humans; Immunohistochemistry; Immunotherapy, Active; Infant; Inhibitor of Apoptosis Proteins; Injections, Subcutaneous; Interferon Inducers; Interleukin-13 Receptor alpha1 Subunit; Kaplan-Meier Estimate; Lysine; Magnetic Resonance Imaging; Male; Poly I-C; Receptor, EphA2; Receptors, Interleukin-13; Survivin; Young Adult | 2014 |
64 other study(ies) available for lysine and Benign Neoplasms, Brain
Article | Year |
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PARP3 supervises G9a-mediated repression of adhesion and hypoxia-responsive genes in glioblastoma cells.
Topics: Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Cell Cycle Proteins; Complement C9; Glioblastoma; Histones; Humans; Hypoxia; Lysine; Methyltransferases; Poly(ADP-ribose) Polymerases; Tumor Suppressor Proteins | 2022 |
Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; DNA; DNA Breaks, Double-Stranded; DNA Repair; Drug Resistance, Neoplasm; Glioblastoma; Glioma; Histone Demethylases; Lysine; Mice; Tandem Mass Spectrometry; Temozolomide; Xenograft Model Antitumor Assays | 2023 |
Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways.
Topics: Brain Neoplasms; Ependymoma; Fluorocarbons; Glioma; Histones; Humans; Lysine; Mutation; Rhombencephalon | 2023 |
Dimethylation of histone H3 lysine 36 (H3K36me2) as a potential biomarker for glioma diagnosis, grading, and prognosis.
Topics: Biomarkers; Brain Neoplasms; DNA Methylation; Glioma; Histones; Humans; Isocitrate Dehydrogenase; Lysine; Middle Aged; Mutation; Neoplasm Grading; Prognosis | 2023 |
Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas.
Topics: Adenosine Triphosphatases; Brain Neoplasms; Child; Chromatin; Diffuse Intrinsic Pontine Glioma; DNA Helicases; Glioma; Histones; Humans; Lysine; Mutation; Nuclear Proteins; Transcription Factors | 2023 |
Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment.
Topics: Brain Neoplasms; Glioblastoma; Humans; Lysine | 2023 |
Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State.
Topics: Brain; Brain Neoplasms; Cellular Reprogramming; Diffuse Intrinsic Pontine Glioma; Enhancer Elements, Genetic; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Lysine; Mutation; Pons; Signal Transduction; Transcriptome | 2019 |
Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas.
Topics: Brain; Brain Neoplasms; Child; Child, Preschool; Clinical Decision-Making; Disease-Free Survival; DNA Mutational Analysis; Egypt; Female; Follow-Up Studies; Genetic Testing; Glioma; Histones; Humans; Kaplan-Meier Estimate; Lysine; Male; Medical Oncology; Mutation; Neoplasm Grading; Practice Guidelines as Topic; Prognosis; Risk Assessment | 2020 |
Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.
Topics: Animals; Brain Neoplasms; Cell Line; Cell Proliferation; DNA Methylation; Ependymoma; Epigenome; Epigenomics; Histones; Humans; Infant; Infratentorial Neoplasms; Lysine; Male; Mice, Inbred C57BL; Mutation | 2020 |
Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Cell Proliferation; Child; Female; Gene Editing; Gene Expression Regulation, Neoplastic; Glioma; Glycine; Histones; Humans; Lysine; Male; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Receptors, Notch; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
Loss of histone H3 trimethylation on lysine 27 and nuclear expression of transducin-like enhancer 1 in primary intracranial sarcoma, DICER1-mutant.
Topics: Adolescent; Aged; Biomarkers, Tumor; Brain Neoplasms; Child; DEAD-box RNA Helicases; Female; High-Throughput Nucleotide Sequencing; Histones; Humans; Immunohistochemistry; Infant; Lysine; Male; Methylation; Mutation; Ribonuclease III; Sarcoma; Transducin | 2021 |
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.
Topics: Animals; Astrocytes; Brain Neoplasms; Carcinogenesis; Cell Lineage; Cellular Reprogramming; Chromatin; Embryo, Mammalian; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioma; Histones; Interneurons; Lysine; Mice, Inbred C57BL; Models, Biological; Mutation; Neoplasm Grading; Neural Stem Cells; Oligodendroglia; Promoter Regions, Genetic; Prosencephalon; Receptor, Platelet-Derived Growth Factor alpha; Transcription, Genetic; Transcriptome | 2020 |
Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer.
Topics: Animals; Brain Neoplasms; Disease Models, Animal; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Lysine; Methylation; Mice, Knockout; Proto-Oncogene Proteins c-myc; ras Proteins; Tumor Suppressor Protein p53 | 2020 |
Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.
Topics: Animals; Brain Neoplasms; Cell Differentiation; Cell Line; Enhancer Elements, Genetic; Enhancer of Zeste Homolog 2 Protein; Epigenome; Gene Expression Regulation, Developmental; Glioma; Histones; Humans; Lysine; Male; Mice, Inbred Strains; Mutation; Neural Stem Cells; Oncogenes; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Rhombencephalon | 2021 |
TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination.
Topics: Animals; Apoptosis; Biocatalysis; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Progression; Down-Regulation; Gene Expression Regulation, Neoplastic; Glioma; Humans; Lysine; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Protein Stability; Repressor Proteins; RNA, Messenger; Signal Transduction; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases; Ubiquitination | 2017 |
H3 K27M mutations are extremely rare in posterior fossa group A ependymoma.
Topics: Brain Neoplasms; Child; Ependymoma; Histones; Humans; Lysine; Magnetic Resonance Imaging; Male; Methionine; Mutation | 2017 |
Prostate-Specific Membrane Antigen-Targeted Imaging With [18F]DCFPyL in High-Grade Gliomas.
Topics: Antigens, Surface; Brain Neoplasms; Glioma; Glutamate Carboxypeptidase II; Humans; Lysine; Magnetic Resonance Imaging; Male; Neoplasm Grading; Positron-Emission Tomography; Urea | 2017 |
Substance P Mediated DGLs Complexing with DACHPt for Targeting Therapy of Glioma.
Topics: Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Drug Delivery Systems; Glioma; Humans; Lysine; Substance P | 2017 |
Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B.
Topics: Antineoplastic Agents; Apoptosis; Astrocytes; Brain Neoplasms; Cell Line; DNA Damage; Drug Resistance, Neoplasm; Etoposide; F-Box Proteins; Glioblastoma; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lomustine; Lysine; Neoplastic Stem Cells; Primary Cell Culture | 2018 |
Loss of ATRX suppresses ATM dependent DNA damage repair by modulating H3K9me3 to enhance temozolomide sensitivity in glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Brain Neoplasms; Cell Line, Tumor; Cell Survival; DNA Damage; DNA Repair; Female; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Glioma; Histones; Humans; Lysine; Methylation; Mice, Nude; Temozolomide; X-linked Nuclear Protein; Xenograft Model Antitumor Assays | 2018 |
Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M
Topics: Animals; Brain Neoplasms; Gangliosides; Glioma; Histones; Humans; Immunotherapy, Adoptive; Lysine; Methylation; Mice; Receptors, Antigen, T-Cell; Xenograft Model Antitumor Assays | 2018 |
Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis.
Topics: Bone Neoplasms; Brain Neoplasms; Child; Epigenesis, Genetic; Giant Cell Tumor of Bone; Glioblastoma; HeLa Cells; Histones; Humans; Lysine; Methylation; Mutation | 2018 |
K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution.
Topics: Brain Neoplasms; DNA Mutational Analysis; Glioma; Glycine; Histones; Humans; Lysine; Mutation | 2018 |
CSF H3F3A K27M circulating tumor DNA copy number quantifies tumor growth and in vitro treatment response.
Topics: Adolescent; Brain Neoplasms; Cell Proliferation; Child; Circulating Tumor DNA; DNA Copy Number Variations; Female; Glioma; Histones; Humans; In Vitro Techniques; Lysine; Magnetic Resonance Imaging; Male; Methionine; Mutation | 2018 |
SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity.
Topics: Acetylation; Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Furans; Gene Knockdown Techniques; Glioblastoma; Humans; Lysine; Mice, Nude; Neoplastic Stem Cells; Quinolines; Sirtuin 2; Tumor Cells, Cultured; Tumor Protein p73; Xenograft Model Antitumor Assays | 2018 |
Transcriptomic and epigenetic profiling of 'diffuse midline gliomas, H3 K27M-mutant' discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location.
Topics: Adolescent; Brain; Brain Neoplasms; Child; Child, Preschool; DNA Methylation; Epigenomics; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Lysine; Male; Methionine; Mutation; Principal Component Analysis; Transcriptome; Tumor Cells, Cultured | 2018 |
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.
Topics: Adolescent; Aged; Animals; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Child; Chromatin; CpG Islands; CRISPR-Cas Systems; DNA Methylation; Epigenesis, Genetic; Female; Gene Editing; Gene Expression Regulation, Neoplastic; Glioblastoma; HEK293 Cells; Histone Code; Histones; Humans; Lysine; Male; Methionine; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Neurogenesis; Polycomb Repressive Complex 2; Xenograft Model Antitumor Assays | 2019 |
Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas.
Topics: Adolescent; Brain Neoplasms; Child; Cohort Studies; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Lysine; Male; Methionine; Mutation; Neuroglia; Polycomb Repressive Complex 2 | 2013 |
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.
Topics: Amino Acid Substitution; Animals; Brain Neoplasms; Child; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Glioblastoma; HEK293 Cells; Histones; Humans; Lysine; Methionine; Methylation; Mice; Mutation, Missense; Polycomb Repressive Complex 2; Transgenes | 2013 |
Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma.
Topics: Animals; Apoptosis; Bone Morphogenetic Protein 5; Brain Neoplasms; Cell Differentiation; Cell Line; Chromatin; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Glioblastoma; Heterografts; Histones; Humans; Lysine; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neural Stem Cells; Neuronal Plasticity; Polycomb Repressive Complex 2; Transcription Factors; Wnt1 Protein | 2013 |
PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Brain Neoplasms; DNA-Binding Proteins; Glioma; HEK293 Cells; HeLa Cells; Humans; Immunohistochemistry; Lysine; Methylation; Models, Biological; Phosphorylation; Protein Binding; Protein Phosphatase 2; Signal Transduction; Transcription Factor RelA; Transcription Factors; Tumor Necrosis Factor-alpha | 2013 |
Role of histone lysine methyltransferases SUV39H1 and SETDB1 in gliomagenesis: modulation of cell proliferation, migration, and colony formation.
Topics: Apoptosis; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Cell Division; Cell Line, Tumor; Cell Movement; Enzyme Induction; Glioblastoma; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Methyltransferases; Neoplasm Grading; Neoplasm Proteins; Protein Methyltransferases; Protein Processing, Post-Translational; Repressor Proteins; RNA Interference; RNA, Small Interfering; Tumor Stem Cell Assay; Up-Regulation | 2014 |
Poisoning the "histone code" in pediatric gliomagenesis.
Topics: Brain Neoplasms; Child; Exome; Glioma; Histone Code; Histones; Humans; Lysine; Models, Biological; Mutation; Polycomb Repressive Complex 2 | 2013 |
Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.
Topics: AC133 Antigen; Antigens, CD; Azepines; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioma; Glycoproteins; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplastic Stem Cells; Peptides; Promoter Regions, Genetic; Quinazolines; Signal Transduction; SOXB1 Transcription Factors; Transfection | 2014 |
Modulation of uPA, MMPs and their inhibitors by a novel nutrient mixture in human glioblastoma cell lines.
Topics: Arginine; Ascorbic Acid; Brain Neoplasms; Camellia sinensis; Cell Line, Tumor; Copper; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Lysine; Manganese; Matrix Metalloproteinases; Micronutrients; Plant Extracts; Proline; Selenium; Tissue Inhibitor of Metalloproteinases; Urokinase-Type Plasminogen Activator | 2014 |
A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Child, Preschool; Cohort Studies; DNA Mutational Analysis; Female; Glioblastoma; Histones; Humans; Infant, Newborn; Lysine; Male; Methionine; Mutation; Pediatrics; Proportional Hazards Models; Sensitivity and Specificity; Young Adult | 2014 |
(1) H NMR spectroscopy of glioblastoma stem-like cells identifies alpha-aminoadipate as a marker of tumor aggressiveness.
Topics: 2-Aminoadipic Acid; Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Cell Survival; Female; Glioblastoma; Humans; Kaplan-Meier Estimate; Lysine; Male; Metabolic Networks and Pathways; Mitochondria; Multivariate Analysis; Neoplasm Invasiveness; Neoplastic Stem Cells; Proton Magnetic Resonance Spectroscopy; Signal Processing, Computer-Assisted | 2015 |
Detecting the H3F3A mutant allele found in high-grade pediatric glioma by real-time PCR.
Topics: Animals; Brain Neoplasms; Child; DNA Mutational Analysis; Gene Library; Glioma; Histones; Humans; Lysine; Male; Methionine; Mice; Mutation; Real-Time Polymerase Chain Reaction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
A nutrient mixture inhibits glioblastoma xenograft U-87 MG growth in male nude mice.
Topics: Animals; Ascorbic Acid; Brain; Brain Neoplasms; Cell Line, Tumor; Dietary Supplements; Glioblastoma; Humans; Lysine; Male; Mice; Mice, Nude; Proline; Tea | 2016 |
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Topics: Brain Neoplasms; Carcinogenesis; Catalytic Domain; Crystallography, X-Ray; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Lysine; Methylation; Models, Molecular; Mutation; Oncogenes; Polycomb Repressive Complex 2; Protein Binding; Protein Domains | 2016 |
Homeobox genes gain trimethylation of histone H3 lysine 4 in glioblastoma tissue.
Topics: Brain Neoplasms; Cadherins; Chromatin Immunoprecipitation; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, Homeobox; Glioblastoma; Histones; Humans; Lysine; Methylation; Middle Aged; Promoter Regions, Genetic | 2016 |
Increased expression of the histone H3 lysine 4 methyltransferase MLL4 and the histone H3 lysine 27 demethylase UTX prolonging the overall survival of patients with glioblastoma and a methylated MGMT promoter.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Breast Neoplasms; Cell Proliferation; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA-Binding Proteins; Glioblastoma; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methyltransferases; Nuclear Proteins; Prognosis; Retrospective Studies; Tumor Suppressor Proteins | 2017 |
The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt.
Topics: Apoptosis; Bcl-2-Like Protein 11; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Progression; F-Box Proteins; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioma; Humans; Lysine; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; Ubiquitination; Up-Regulation | 2017 |
Apoptin Gene Delivery by the Functionalized Polyamidoamine Dendrimer Derivatives Induces Cell Death of U87-MG Glioblastoma Cells.
Topics: Apoptosis; Arginine; Brain Neoplasms; Capsid Proteins; Cell Line, Tumor; Cells, Cultured; Dendrimers; DNA; Genetic Therapy; Glioblastoma; Histidine; Humans; Lysine; Transfection | 2017 |
Comparative analyses identify molecular signature of MRI-classified SVZ-associated glioblastoma.
Topics: Brain Neoplasms; Cell Line, Tumor; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Isocitrate Dehydrogenase; Lateral Ventricles; Lysine; Magnetic Resonance Imaging; Methylation; Mutation; Neoplastic Stem Cells; Neural Stem Cells; Sequence Analysis, RNA | 2017 |
Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Brain Neoplasms; Carbocyanines; Fluorescent Dyes; Half-Life; Lysine; Medulloblastoma; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Sequence Data; Peptides; Peptides, Cyclic; Scorpion Venoms | 2011 |
Proteomic assessment shows that many endoplasmic reticulum (ER)-resident proteins are targeted by N(epsilon)-lysine acetylation in the lumen of the organelle and predicts broad biological impact.
Topics: Acetyl Coenzyme A; Acetylation; Brain Neoplasms; Calreticulin; Cell Line, Tumor; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Glioma; Heat-Shock Proteins; Humans; Lysine; Membrane Proteins; Plasmids; Protein Folding; Protein Processing, Post-Translational; Proteomics | 2012 |
Biocytin-derived MRI contrast agent for longitudinal brain connectivity studies.
Topics: Animals; Biotin; Brain; Brain Mapping; Brain Neoplasms; Cell Survival; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Contrast Media; Coordination Complexes; Drug Design; Gadolinium; Ligands; Lysine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Neural Pathways; Neuroblastoma; Protons; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared | 2011 |
Histone recognition by human malignant brain tumor domains.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Brain Neoplasms; Computational Biology; Crystallography, X-Ray; DNA Methylation; DNA Primers; Fluorescence Polarization; Histones; Humans; Lysine; Models, Molecular; Molecular Sequence Data; Polymerase Chain Reaction; Protein Binding | 2012 |
THE AMINO ACIDS OF CEREBROSPINAL FLUID IN VARIOUS DISEASES AFFECTING THE CENTRAL NERVOUS SYSTEM.
Topics: Adolescent; Alanine; Amino Acids; Autistic Disorder; Brain Neoplasms; Cerebrospinal Fluid; Child; Encephalitis; Friedreich Ataxia; Glutamates; Hepatic Encephalopathy; Histidine; Humans; Hydrocephalus; Infant; Infant, Newborn; Leukocytes; Lysine; Meningitis; Tuberculosis; Tuberculosis, Meningeal | 1964 |
STUDIES ON PROTEIN SYNTHESIS IN BRAIN MICROSOMAL SYSTEM.
Topics: Amino Acids; Biomedical Research; Brain; Brain Diseases; Brain Neoplasms; Dementia; Electrons; Ether; Halothane; Infarction; Lysine; Microscopy; Microscopy, Electron; Microsomes; Pentobarbital; Pharmacology; Proteins; Psychotic Disorders; Radiometry; Rats; Research; Subarachnoid Hemorrhage; Sucrose | 1964 |
AN EXPERIMENTAL STUDY OF TISSUE-CONCENTRATION RATIOS OF AS74 ARSENATE AND LABELED ORGANIC CONJUGATES.
Topics: Animals; Arsenates; Arsenic; Arsenicals; Azo Compounds; Brain Neoplasms; Ependymoma; Lysine; Metabolism; Mice; Neoplasms; Neoplasms, Experimental; Radioisotopes; Radionuclide Imaging; Research | 1964 |
Cellular antitumor immune response to a branched lysine multiple antigenic peptide containing epitopes of a common tumor-specific antigen in a rat glioma model.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Brain Neoplasms; Cancer Vaccines; Epitopes; ErbB Receptors; Glioma; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunity, Cellular; Immunotherapy; Interleukin-4; Lysine; Male; Models, Animal; Peptide Fragments; Rats; Rats, Inbred F344; Spleen; Survival Rate; T-Lymphocytes; T-Lymphocytes, Cytotoxic; Th2 Cells; Vaccination | 2005 |
Artificial reporter gene providing MRI contrast based on proton exchange.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Contrast Media; Genes, Reporter; Glioma; Image Enhancement; Lysine; Magnetic Resonance Imaging; Mice; Protons; Recombinant Proteins | 2007 |
Inhibition of inducible nitric oxide synthase enhances anti-tumour immune responses in rats immunized with IFN-gamma-secreting glioma cells.
Topics: Animals; B-Lymphocytes; Brain Neoplasms; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Enzyme Inhibitors; Flow Cytometry; Glioma; Immunotherapy; Interferon-gamma; Lysine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Rats; Rats, Inbred F344 | 2007 |
Postimmunization with IFN-gamma-secreting glioma cells combined with the inducible nitric oxide synthase inhibitor mercaptoethylguanidine prolongs survival of rats with intracerebral tumors.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Enzyme Inhibitors; Glioma; Guanidines; Immunization; Immunotherapy, Adoptive; Interferon-gamma; Lymph Nodes; Lysine; Nitric Oxide Synthase Type II; Rats; Rats, Inbred F344; Spleen; Survival; T-Lymphocytes | 2007 |
Modulation of substance P signaling by dipeptidyl peptidase-IV enzymatic activity in human glioma cell lines.
Topics: Brain Neoplasms; Calcium Signaling; Chemokine CXCL12; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glioma; Humans; Lysine; Mifepristone; Oligopeptides; Pyrrolidines; Serine Proteinase Inhibitors; Substance P; Transfection; U937 Cells | 2008 |
Mutant IGF-I receptors as dominant negatives for growth and transformation.
Topics: Analysis of Variance; Animals; Apoptosis; Arginine; Binding Sites; Brain Neoplasms; Cell Division; Cell Line; Glioblastoma; Humans; Lysine; Mutagenesis, Site-Directed; Point Mutation; Rats; Receptor, IGF Type 1; Recombinant Proteins; Transfection; Tumor Cells, Cultured | 1995 |
Novel anti-brain tumor cytotoxins specific for cancer cells.
Topics: Antineoplastic Agents; Brain Neoplasms; Carrier Proteins; Cell Division; Cytotoxins; Exotoxins; Glioma; Glutamic Acid; Humans; Interleukin-13; Interleukin-13 Receptor alpha1 Subunit; Lysine; Mutation; Plasmids; Pseudomonas aeruginosa; Receptors, Cell Surface; Receptors, Interleukin; Receptors, Interleukin-13; Recombinant Fusion Proteins; Tumor Cells, Cultured | 1998 |
Thromboxane synthase regulates the migratory phenotype of human glioma cells.
Topics: Arachidonic Acids; Aspirin; Astrocytes; Benzofurans; Brain Neoplasms; Cell Adhesion; Cell Movement; Enzyme Induction; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; GTP-Binding Proteins; Humans; Imidazoles; Indomethacin; Lysine; Models, Biological; Neoplasm Proteins; Neoplastic Stem Cells; Oligodendroglia; Pentanoic Acids; Phenotype; Pyridines; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Thromboxane B2; Thromboxane-A Synthase; Tumor Cells, Cultured | 1999 |
[Clinical studies on the adrenocorticotropic hormone. II. Studies on the mechanism of pituitary corticotropin secretion with synthetic lysine vasopressin].
Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Brain Neoplasms; Circadian Rhythm; Dexamethasone; Diabetes Insipidus; Female; Hepatitis; Humans; Hydrocortisone; Injections, Intravenous; Lysine; Male; Metyrapone; Middle Aged; Pituitary Diseases; Pituitary Gland; Pituitary Neoplasms; Prednisolone; Vasopressins | 1968 |
Vasopressin in the evaluation of pituitary-adrenal function.
Topics: Acromegaly; Adenoma; Adolescent; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Anorexia Nervosa; Brain Diseases; Brain Neoplasms; Cushing Syndrome; Endocrine System Diseases; Female; Humans; Hydrocortisone; Hypothalamus; Injections, Intramuscular; Lysine; Male; Metyrapone; Middle Aged; Pituitary Neoplasms; Pituitary-Adrenal Function Tests; Vasopressins | 1968 |
Amino acid uptake into human brain tumors.
Topics: Absorption; Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Astrocytoma; Autoradiography; Brain Neoplasms; Chloromercuribenzoates; Culture Techniques; Cyanides; Ependymoma; Glutamates; Glycine; Humans; Lysine; Ouabain; Phenylalanine; Taurine; Time Factors; Tritium; Tryptophan; Valine | 1974 |
[Action of lysine-vasopressin on cellular content of ribonucleic acids. Experiments on benign cerebral tumors in culture medium].
Topics: Brain Neoplasms; DNA, Neoplasm; Humans; In Vitro Techniques; Lysine; RNA, Neoplasm; Vasopressins | 1968 |