lysine has been researched along with Alloxan Diabetes in 150 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (20.00) | 18.7374 |
| 1990's | 22 (14.67) | 18.2507 |
| 2000's | 47 (31.33) | 29.6817 |
| 2010's | 41 (27.33) | 24.3611 |
| 2020's | 10 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Inoue, Y; Iwai, M; Kadoyama, K; Matsumoto, K; Nitta, Y; Takano-Ohmuro, H; Takasugi, R; Takenokuchi, M; Taniguchi, T; Yoshida, K | 1 |
| Bolea Bailo, RM; Gu, Z; He, Y; Jiang, Y; Kong, D; López Lasaosa, F; Mao, H; Wei, J; Xu, S; Zhao, W | 1 |
| Ardjmand, A; Ghavipanjeh, G; Jozi, F; Kheiripour, N; Nasehi, Z; Shahaboddin, ME; Taheri, MA | 1 |
| Alonso, LC; Anderson-Baucum, E; Bernal-Mizrachi, E; Garcia-Ocaña, A; Levasseur, EM; Liu, Y; Maier, B; Mastracci, TL; Mirmira, RG; Mosley, AL; Orr, KS; Piñeros, AR; Scott, D; Syed, F; Tersey, SA; Wu, W; Yamada, K | 1 |
| Choi, CW; Chung, YH; Ha, SK; Han, EH; Huh, YH; Hyon, JY; Jeong Ha, S; Jeong, HG; Jung, SK; Kim, HJ; Kim, Y; Lee, H; Lee, J; Min, JY; Park, J; Yun, SH | 1 |
| Boulanger, É; Delguste, F; Foligné, B; Fremont, M; Garat, A; Guilbaud, A; Howsam, M; Lestavel, S; Maboudou, P; Niquet-Léridon, C; Onraed, B; Schraen, S; Tessier, FJ | 1 |
| Jiang, L; Li, J; Lu, J; Xiong, A; Yi, X; Zeng, Y; Zhang, H; Zhou, W; Zhu, H; Zhu, L | 1 |
| Ahmad, S; Akashah, R; Alouffi, S; Faisal, M; Khan, M; Khan, MS; Khan, S; Shahab, U | 1 |
| Barozzino, M; Casagrande, V; Castellano, G; Cinefra, C; Conserva, F; Divella, C; Federici, M; Gallone, A; Gesualdo, L; Giorgino, F; Menghini, R; Pesce, F; Pontrelli, P; Rossini, M; Simone, S; Stallone, G; Stasi, A | 1 |
| Liu, S; Wang, N; Wang, Y; Xu, P; Yao, W; Zhang, J; Zhang, Y | 1 |
| Chen, L; Cui, C; Guo, X; He, Q; Hou, X; Hu, H; Li, D; Li, X; Liang, K; Song, J; Wang, C; Wang, X; Yan, F; Zang, N | 1 |
| Gao, C; Li, N; Liang, K; Liu, M; Peng, J; Su, H; Sun, Y; Wang, X; Wang, Z; Wei, X; Yi, F; Zhang, C; Zhang, Y; Zhen, J; Zhou, M; Zhou, Z | 1 |
| Arakawa, S; Ichimaru, K; Kabata, K; Kinoshita, S; Matsuda, S; Nagai, M; Nagai, R; Ohno, RI; Shirakawa, JI; Sugawa, H | 1 |
| Bao, Z; Dai, Z; Jing, L; Li, L; Shao, C; Sun, Z; Wang, Z; Xu, S; Yan, J; Ye, F; Zhu, J | 1 |
| Kabata, K; Matsuda, S; Nagai, R; Shirakawa, JI; Sugawa, H | 1 |
| Aldavood, SJ; Bahmani, F; Bathaie, SZ; Ghahghaei, A | 1 |
| Liu, YT; Mong, MC; Pai, PY; Wang, ZH; Yang, YC; Yin, MC | 1 |
| Arvindekar, AU; Haldavnekar, VS; Joglekar, MM; Panaskar, SN; Taklikar, SS | 1 |
| Chen, X; Deng, M; He, P; Liu, H; Pang, X; Tang, Z; Yang, Y | 1 |
| Brouwers, O; de Vos-Houben, JM; Hageman, G; Janssen, BJ; Miyata, T; Niessen, PM; Schalkwijk, CG; Stehouwer, CD; van Nieuwenhoven, F | 1 |
| Chen, X; Li, L; Liang, Y; Liu, N; Wang, Z; Yan, J; Yuan, W | 1 |
| Imam, S; Jaume, JC; Mirmira, RG | 1 |
| Chang, CY; Chang, KC; Chang, RW; Chen, YS; Ko, WJ; Ko, YH; Tsai, PR; Wang, CH; Wang, SS; Young, TH | 1 |
| Advani, A; Connelly, KA; Diamandis, EP; Gilbert, RE; Kosanam, H; Thai, K; Zhang, Y | 1 |
| Chen, WC; Lee, MR; Lee, WJ; Liang, KW; Lin, LY; Lin, SY; Liu, SH; Shen, CC; Sheu, ML; Sheu, WH; Tien, HR; Tsai, YC; Yang, TJ; Yeh, HY; Yi, YC | 1 |
| Efstathiou, T; Gratas-Delamarche, A; Groussard, C; Lefeuvre-Orfila, L; Malardé, L; Vincent, S | 1 |
| Brimble, MA; Brings, S; Choong, YS; Cooper, GJ; Gong, D; Hogl, S; Kamalov, M; Middleditch, M; Zhang, S | 1 |
| Ho, JJ; Hsu, CC; Hsu, JY; Yang, HT; Yin, MC | 1 |
| Ding, J; Wu, H; Yang, J; Ye, M | 1 |
| Brings, S; Ejdesjö, A; Eriksson, UJ; Fleming, T; Fred, RG; Nawroth, PP | 1 |
| Cui, J; He, FL; Hu, G; Lin, YJ; Ren, XH; Shen, T; Wei, J; Zhen, YZ | 1 |
| Cui, P; Guo, Q; Han, H; Li, C; Li, Q; Li, X; Liu, S; Sun, G | 1 |
| Gaikwad, AB; Goru, SK; Kadakol, A; Malek, V; Pandey, A; Sharma, N | 1 |
| Gupta, D; Hansen, LM; Joseph, G; Taylor, WR; Weiss, D | 1 |
| Austin, AB; Berthiaume, JM; Chandler, MP; Depuydt, MM; Hsiung, CH; McBrayer, SP; Miyagi, M; Rosca, MG | 1 |
| Lin, CC; Yin, MC | 1 |
| Bujalska, M; Makulska-Nowak, H | 1 |
| MacLeod, KM; McNeill, JH; Nagareddy, PR | 1 |
| Kim, HY; Okamoto, T; Yokozawa, T | 1 |
| Chang, CJ; Liou, SS; Liu, IM; Tzeng, TF | 1 |
| Kumar, U; Lin, G; MacLeod, KM; McNeill, JH; Nagareddy, PR; Rajput, PS; Soliman, H | 1 |
| Kamata, K; Kobayashi, T; Matsumoto, T; Ozawa, Y | 1 |
| Hur, JM; Kang, KS; Yamabe, N; Yokozawa, T | 1 |
| Snow, LM; Thompson, LV | 1 |
| Chaudhuri, BS; Ray, M; Ray, S; Talukdar, D | 1 |
| Agbaje, I; Czerwiec, A; Glenn, J; Mallidis, C; McClure, N; O'Neill, J; Stitt, A | 1 |
| Kamata, K; Kobayashi, T; Matsumoto, T; Ozawa, Y; Taguchi, K | 1 |
| García-Salcedo, JA; Morales, S; Muñoz-Torres, M | 1 |
| Agostini, C; Albiero, M; Avogaro, A; Boscaro, E; Cosma, C; Fadini, GP; Giorgio, M; Iori, E; Lapolla, A; Menegazzo, L; Pagnin, E; Pelicci, PG; Pengo, V; Stendardo, M | 1 |
| Chen, CD; Chen, MH; Kao, SH; Lee, HM; Lo, MC; Lu, CI | 1 |
| Araki, T; Fujiwara, Y; Ikeda, T; Kiyota, N; Mera, K; Nagai, R; Nohara, T; Sakashita, N; Takeya, M; Tsurushima, K; Yoshitomi, M | 1 |
| Kim, CS; Kim, J; Kim, JS; Sohn, E | 1 |
| Coughlan, MT; Forbes, JM | 1 |
| de Assis, AM; Denardin, CC; Longoni, A; Moreira, JC; Pasquali, MA; Perry, ML; Rech, A; Rotta, LN; Souza, DO | 1 |
| An, Y; Chen, D; Jiang, Y; Liu, N; Ren, L; Wang, Z; Zhu, Y | 1 |
| Blättler, SM; Chim, H; Cunningham, JT; Gygi, SP; Haas, W; Liu, H; Puigserver, P; Romanino, K; Rüegg, MA; Shi, Y; Verdeguer, F | 1 |
| Eckert, RL; Reece, EA; Zhao, Z | 1 |
| Chen, WB; Jen, JF; Lee, MR; Lee, WJ; Liu, SH; Pan, HC; Shen, CC; Sheu, ML; Sheu, WH; Tien, HR; Yang, TJ; Yi, YC | 1 |
| Lin, CY; Yin, MC | 1 |
| Gao, C; Gao, E; Koch, W; Lau, WB; Lian, K; Liu, J; Liu, Y; Lu, X; Ma, Y; Qu, Y; Sun, L; Tao, L; Wang, H; Wang, R; Xia, C; Xu, A; Yang, L | 1 |
| Bidasee, KR; Kutty, S; Moore, CJ; Nagai, R; Shao, CH; Singh, J | 1 |
| Alderson, NL; Anderson, NL; Baynes, JW; Boyle, C; Canning, P; Chachich, M; Duffy, N; Frizzell, N; Gardiner, TA; Januszewski, AS; Stitt, A; Thorpe, SR | 1 |
| Akagawa, M; Sasaki, T; Suyama, K | 1 |
| Brammar, G; Burns, WC; Cao, Z; Cooper, ME; Forbes, JM; MCLennan, SV; Twigg, SM | 1 |
| Bach, LA; Cooper, ME; Gallicchio, M; Jerums, G; McRobert, EA | 1 |
| Burns, WC; Cooper, ME; Forbes, JM; Founds, HW; Jerums, G; Thallas, V; Thomas, MC | 1 |
| Aiba, Y; Ito, Y; Kitts, DD; Nagasawa, T; Nishizawa, N; Tabata, N | 1 |
| Ahmed, N; Babaei-Jadidi, R; Karachalias, N; Thornalley, PJ | 1 |
| Alderson, NL; Alt, N; Baynes, JW; Carson, JA; Henle, T; Nagai, R; Thorpe, SR; Wang, Y | 1 |
| Franch, HA; Price, SR; Shaoguang, J; Sooparb, S | 1 |
| Chiavaroli, C; Garay, RP; Hannaert, P; Rota, R | 1 |
| Hagino, N; Horiuchi, S; Kobayashi, S; Nagai, R; Suzuki, M; Tsuneki, H | 1 |
| Byun, Y; Kim, SK; Lee, DY; Lee, J; Lee, S; Lee, Y | 1 |
| Arai, H; Chuyen, NV; Nakanishi, T; Utsunomiya, N | 1 |
| Berkowitz, BA; Connor, JR; Hohman, TC; Knoerzer, DL; Luan, H; Peysakhov, J; Roberts, R | 1 |
| Cottalasso, D; Furfaro, AL; Marinari, UM; Menini, S; Odetti, P; Patriarca, S; Pesce, C; Pronzato, MA; Traverso, N | 1 |
| Fujii, K; Marumo, K; Mori, Y; Saito, M | 1 |
| Nagaraj, RH; Padival, S | 1 |
| Arnstein, M; Cooper, ME; Coughlan, MT; Forbes, JM; Gasser, A; Long, DM; Pete, J; Thallas-Bonke, V; Thorpe, SR; Tong, DC | 1 |
| Beals, JM; DiMarchi, RD; Kahl, SD; Kohn, WD; Li, S; Mayer, JP; Micanovic, R; Myers, SL; Shang, J; Strifler, BA; Vick, AM; Zhang, L | 1 |
| Goto, F; Kadoi, Y | 1 |
| Bach, LA; Cooper, ME; Coughlan, MT; Forbes, JM; Fukami, K; Penfold, SA; Sourris, KC; Thallas-Bonke, V; Thorpe, SR; Yap, FY | 1 |
| Izuhara, Y; Miyata, T; Nangaku, M; Ohtomo, S; Strihou, Cv; Takizawa, S | 1 |
| Fujiwara, Y; Mera, K; Nagai, R; Sakashita, N; Takeya, M; Yamagata, K | 1 |
| Kang, KS; Kim, HY; Yamabe, N; Yokozawa, T | 1 |
| Craig, GP; Kumar, U; Lin, G; Macleod, KM; McNeill, JH; Nagareddy, P; Soliman, H; Yuen, VG | 1 |
| Heine, RJ; Niessen, HW; Schalkwijk, CG; Simsek, S; van Deutekom, AW | 1 |
| Hay, AM; Waterlow, JC | 1 |
| Stephen, JM; Waterlow, JC | 1 |
| Bassiouny, AR; McDonald, TL; Rosenberg, H | 1 |
| Bates, GP; Robins, SP; Rucklidge, GJ | 1 |
| Hasslacher, C | 1 |
| Hasslacher, C; Munderloh, KH; Wahl, P | 1 |
| Oldendörp, J; Reinauer, H | 1 |
| Cohen, MP; Yu-Wu, V | 1 |
| Bürklin, E; Hasslacher, C; Kopischke, HG | 1 |
| Bailey, AJ; Le Pape, A; Muh, JP | 1 |
| Stoffel, W; Weimbs, T | 1 |
| Hoshi, S; Miyazawa, N; Myint, T; Ookawara, T; Suzuki, K; Taniguchi, N | 1 |
| Ceriello, A | 1 |
| Blantz, RC; Rasch, R; Tucker, BJ | 1 |
| Andreani, D; Celi, FS; Cristina, A; De Rossi, MG; Di Mario, U; Perrett, D; Rosati, C; Sensi, M | 1 |
| Mann, GE; Muñoz, M; Sweiry, JH | 1 |
| Engerman, RL; Fogarty, J; Kern, TS; Monnier, VM; Nagaraj, RH; Sell, DR | 1 |
| Baker, JE; Chen, VJ; Cusick, TS; Johnson, WT; Kriauciunas, A; Manetta, J; Myers, SR; Tinsley, FC; Williams, VK; Yakubu-Madus, FE | 1 |
| Katsuzaki, T; Niwa, T; Takei, Y; Tatemichi, N | 1 |
| Asano, T; Futata, T; Horiuchi, S; Ikeda, K; Meng, J; Myint, T; Nagai, R; Sakata, N; Takebayashi, S; Taniguchi, N | 1 |
| Gugliucci, A; Menini, T | 1 |
| Fujii, J; Hoshi, A; Kawasaki, Y; Miyazawa, N; Okado, A; Taniguchi, N; Tano, Y | 1 |
| Punitham, R; Ramakrishnan, S; Sulochana, KN | 1 |
| Baynes, JW; Degenhardt, TP; Fu, MX; Neidlein, R; Reiff, K; Reiter, R; Strein, K; Thorpe, SR; Voss, E | 1 |
| Monnier, VM; Obrenovich, M; Saxena, AK; Saxena, P; Weiss, MF; Wu, X | 1 |
| Abraham, EC; Green, K; Shaw, SM; Swamy-Mruthinti, S; Zhao, HR | 1 |
| Araki, N; Horiuchi, S; Nagai, R; Shibayama, R | 1 |
| Bellmunt, MJ; Cabiscol, E; Pamplona, R; Portero-Otín, M; Prat, J; Ruiz, MC | 1 |
| Böhmer, KP; Haas, A; Hartner, A; Hilgers, KF; Sterzel, RB; Veelken, R | 1 |
| Cenuse, M; Costache, G; Georgescu, A; Jinga, VV; Popov, D; Simionescu, M | 1 |
| Schmidt, AM; Stern, DM; Yan, SD; Yan, SF | 1 |
| Jyothirmayi, GN; Modak, R; Reddi, AS | 1 |
| Swamy-Mruthinti, S | 1 |
| Engerman, RL; Kern, TS | 1 |
| Dumas, F; Ghitescu, LD; Gugliucci, A | 1 |
| Bakala, H; Depreux, P; Fourmaintraux, E; Schwedler, SB; Striker, GE; Striker, LJ; Verbeke, P; Vilar, J; Weiss, MF | 1 |
| Bitsch, I; Bretzel, RG; Federlin, KF; Geyer, J; Hammes, HP; Köpcke, W; Mavrakis, K; Netzel, M; Sauerland, C; Stracke, H; Werkmann, D | 1 |
| Coppey, LJ; Davidson, EP; Dunlap, JA; Gellett, JS; Yorek, MA | 1 |
| Biemel, KM; Lederer, MO; Mally, A; Nagaraj, RH; Padayatti, PS; Sarkar, P | 1 |
| Cerami, A; Monnier, VM; Stevens, VJ | 2 |
| Cerami, A; Monnier, VM; Rouzer, CA; Stevens, VJ | 1 |
| Chichlowska, J; Fröhlich, A; Kliber, A; Maciejewska, M; Witaszek, U | 1 |
| Höger, H; Lubec, B; Lubec, G; Szalay, S; Weninger, M; Xi, Z | 1 |
| Cullum, NA; Mahon, J; McLean, WG; Stringer, K | 1 |
| Bell-Farrow, A; Cefalu, WT; Ralapati, S; Wang, ZQ | 1 |
| Mizuno, A; Shima, K; Yano, M | 1 |
| Bassiouny, AR; McDonald, TL; Rosenberg, H; Thiele, GM | 1 |
| White, MF | 1 |
| Lardy, HA; Wernette-Hammond, ME | 1 |
| Davis, DW; DeJoseph, MR; Hawkins, RA; Mans, AM | 1 |
| Baba, S; Hata, F; Hatanaka, H; Kitamura, Y; Maeda, Y; Masuda, S; Matsumoto, S; Nakamichi, T; Oimomi, M | 1 |
| Hashimoto, F; Hirota, M; Ohboshi, C; Ohe, Y; Oshima, I; Sato, M; Shima, K; Shin, S; Yano, M | 1 |
| Cerdan, S; Dölle, A; Künnecke, B; Seelig, J | 1 |
| Baba, S; Hata, F; Hatanaka, H; Kitamura, Y; Maeda, Y; Masuta, S; Matsumoto, S; Nakamichi, T; Nishimoto, S; Oimomi, M | 1 |
| Lal, D; Schedl, HP | 1 |
| Spiro, RG | 1 |
| Inoue, H; Kasper, CB; Pitot, HC | 1 |
| Gullander, S; Rucker, RB; Yep, P | 1 |
| Germaniuk, IaL; Mironenko, VI | 1 |
| Spiro, MJ; Spiro, RG | 1 |
| Germanyuk, YL; Mironenko, VI | 1 |
| Kalkhoff, RK; Kipnis, DM | 1 |
4 review(s) available for lysine and Alloxan Diabetes
| Article | Year |
|---|---|
[Pentosidine: a new biomarker in diabetes mellitus complications].
Topics: Animals; Arginine; Biomarkers; Diabetes Complications; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Glycation End Products, Advanced; Glycosylation; Humans; Hypoglycemic Agents; Inflammation; Lysine; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic | 2011 |
Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Kidney; Lysine; Mass Spectrometry; Peripheral Nerves; Rats; Retina; Streptozocin | 2003 |
The biology of the receptor for advanced glycation end products and its ligands.
Topics: Amyloidosis; Animals; Capillary Permeability; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Endothelium, Vascular; Erythrocytes; Glycation End Products, Advanced; Humans; Ligands; Lung; Lysine; Membrane Proteins; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Serum Amyloid A Protein; Tumor Cells, Cultured | 2000 |
The transport of cationic amino acids across the plasma membrane of mammalian cells.
Topics: Amino Acids; Animals; Arginine; Binding Sites; Biological Transport, Active; Cations; Cell Line; Cell Membrane; Cell Membrane Permeability; Diabetes Mellitus, Experimental; Glucagon; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; Liver Neoplasms, Experimental; Lysine; Mammals; Models, Biological; Ornithine; Rats; Sodium; Streptozocin; Substrate Specificity; Urea | 1985 |
146 other study(ies) available for lysine and Alloxan Diabetes
| Article | Year |
|---|---|
In Vitro and In Vivo Antiglycation Effects of Connarus ruber Extract.
Topics: Animals; Arginine; Collagen; Connaraceae; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Guanidines; Lipids; Lysine; Pyruvaldehyde; Rats; Streptozocin | 2022 |
Bioinspired design of mannose-decorated globular lysine dendrimers promotes diabetic wound healing by orchestrating appropriate macrophage polarization.
Topics: Animals; Dendrimers; Diabetes Mellitus, Experimental; Lysine; Macrophages; Mannose; Mice; Wound Healing | 2022 |
L-Lysine Ameliorates Diabetic Nephropathy in Rats with Streptozotocin-Induced Diabetes Mellitus.
Topics: Animals; Antioxidants; Blood Glucose; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycation End Products, Advanced; Insulin; Kidney; Lipids; Lysine; Male; Oxidative Stress; Rats; Rats, Wistar; Streptozocin; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2022 |
Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
Topics: Aged; Alleles; Animals; Cell Proliferation; Crosses, Genetic; Cyclin D2; Diabetes Mellitus, Experimental; Diet, High-Fat; Eukaryotic Translation Initiation Factor 5A; Female; Gene Deletion; Glucose; Homeostasis; Humans; Insulin-Secreting Cells; Lysine; Male; Mice; Mice, Inbred C57BL; Middle Aged; Ornithine Decarboxylase; Peptide Initiation Factors; Polyamines; Protein Kinase C; Proto-Oncogene Proteins c-myc; RNA-Binding Proteins; RNA, Messenger | 2019 |
Mitochondrial carnitine palmitoyltransferase 2 is involved in N
Topics: Animals; Blood Glucose; Carnitine O-Palmitoyltransferase; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Glycated Hemoglobin; Humans; Kidney; Lysine; Male; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Mitochondria | 2020 |
The Effect of Lactobacillus fermentum ME-3 Treatment on Glycation and Diabetes Complications.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Gastrointestinal Microbiome; Glycated Hemoglobin; Glycation End Products, Advanced; Kidney; Limosilactobacillus fermentum; Lipids; Liver; Lysine; Male; Probiotics; Receptors, Leptin; Weight Gain | 2020 |
Pharmacodynamics and pharmacokinetics of a new type of recombinant insulin Lisargine injection.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Dogs; Hypoglycemic Agents; Injections; Insulin; Insulin Glargine; Lysine; Male; Rats; Rats, Sprague-Dawley; Streptozocin | 2020 |
Gold Nanoparticle-Bioconjugated Aminoguanidine Inhibits Glycation Reaction: An
Topics: Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Glycation End Products, Advanced; Glycosylation; Gold; Guanidines; Lysine; Male; Metal Nanoparticles; Proteins; Pyruvaldehyde; Rats; Rats, Wistar | 2021 |
Inhibition of Lysine 63 Ubiquitination Prevents the Progression of Renal Fibrosis in Diabetic DBA/2J Mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Therapy, Combination; Female; Fibrosis; Lysine; Mice; Mice, Inbred DBA; Nitrofurans; Ramipril; Sulfones; Ubiquitination | 2021 |
Structural elucidation and anti-diabetic osteoporotic activity of an arabinogalactan from Phellodendron chinense Schneid.
Topics: Animals; Bone Density Conservation Agents; Diabetes Mellitus, Experimental; Galactans; Glycation End Products, Advanced; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Lysine; Male; Osteoporosis; Phellodendron; Rats, Wistar; Receptor for Advanced Glycation End Products | 2021 |
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Topics: Acetylation; Animals; Apoptosis; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet; Gene Regulatory Networks; Glucagon-Secreting Cells; Glucose Intolerance; Histone Acetyltransferases; Histones; Lysine; Mice, Inbred C57BL; Obesity; Proprotein Convertase 1; Salicylates | 2021 |
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.
Topics: Acetylation; Animals; Apoptosis; Autophagy; Biopsy; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Down-Regulation; Doxorubicin; Gene Deletion; Histones; Humans; Inflammation; Integrases; Kidney; Lysine; Male; Mice, Knockout; Podocytes; Promoter Regions, Genetic; Proteinuria; Rats; Receptors, Notch; Signal Transduction; Sirtuins | 2017 |
Aphanothece sacrum (Sur.) Okada Prevents Cataractogenesis in Type 1 Diabetic Mice.
Topics: Animals; Biomarkers; Cataract; Cyanobacteria; Diabetes Mellitus, Experimental; Diet; Freeze Drying; Lens, Crystalline; Lysine; Male; Mice; Oxidative Stress | 2017 |
CML/CD36 accelerates atherosclerotic progression via inhibiting foam cell migration.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; CD36 Antigens; Cell Migration Inhibition; Cell Movement; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Foam Cells; Glycation End Products, Advanced; Lysine; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; RAW 264.7 Cells | 2018 |
[Preventive Effects of Aphanothece sacrum on Diabetic Cataracts].
Topics: Animals; Cataract; Cyanobacteria; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Glycation End Products, Advanced; Lens, Crystalline; Lysine; Male; Mice, Inbred Strains; Oxidative Stress; Streptozocin; Tandem Mass Spectrometry | 2019 |
Prevention of α-crystallin glycation and aggregation using l-lysine results in the inhibition of in vitro catalase heat-induced-aggregation and suppression of cataract formation in the diabetic rat.
Topics: alpha-Crystallins; Animals; Antioxidants; Catalase; Cataract; Diabetes Mellitus, Experimental; Glycosylation; Hot Temperature; Lens, Crystalline; Lysine; Protein Aggregates; Rats | 2019 |
Anti-Diabetic Effects of Gynura Bicolor Aqueous Extract in Mice.
Topics: Animals; Antidiuretic Agents; Arginine; Asteraceae; Blood Glucose; Diabetes Mellitus, Experimental; Glutathione; Humans; Kidney; Liver; Lysine; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Plant Extracts; Reactive Oxygen Species | 2019 |
Aegle marmelos Correa leaf extract prevents secondary complications in streptozotocin-induced diabetic rats and demonstration of limonene as a potent antiglycating agent.
Topics: Aegle; Animals; Antioxidants; Arginine; Body Weight; Cataract; Collagen; Cyclohexenes; Diabetes Mellitus, Experimental; Eating; Glycation End Products, Advanced; Hypoglycemic Agents; Kidney; Limonene; Lysine; Male; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Terpenes | 2013 |
Poly(ester amide) blend microspheres for oral insulin delivery.
Topics: Administration, Oral; Animals; Arginine; Biological Availability; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Leucine; Lysine; Male; Microspheres; Nylons; Polyesters; Rats; Rats, Wistar | 2013 |
Mild oxidative damage in the diabetic rat heart is attenuated by glyoxalase-1 overexpression.
Topics: Animals; Chromatography, High Pressure Liquid; Deoxyglucose; Diabetes Mellitus, Experimental; Echocardiography; Fibrosis; Inflammation; Lactoylglutathione Lyase; Lysine; Myocardium; Oxidative Stress; Rats; Tandem Mass Spectrometry; Ventricular Remodeling | 2013 |
Effects of Nε-carboxymethyl-Lysine on ERS-mediated apoptosis in diabetic atherosclerosis.
Topics: Animals; Apoptosis; Atherosclerosis; Blood Glucose; Blotting, Western; Cholesterol; Diabetes Mellitus, Experimental; Endoplasmic Reticulum Stress; Glycation End Products, Advanced; Immunohistochemistry; Lysine; Male; Mice | 2014 |
Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a "humanized" transgenic mouse model of type 1 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; Female; Glutamate Decarboxylase; Guanine; HLA-DQ alpha-Chains; HLA-DQ beta-Chains; Humans; Immunity, Innate; Lysine; Mice; Mice, Transgenic; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins | 2014 |
Prevention of arterial stiffening by using low-dose atorvastatin in diabetes is associated with decreased malondialdehyde.
Topics: Animals; Arginine; Atorvastatin; Blood Glucose; Blood Pressure; Body Weight; C-Reactive Protein; Cholesterol; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fatty Acids; Glycation End Products, Advanced; Hemodynamics; Heptanoic Acids; Lysine; Male; Malondialdehyde; Organ Size; Pyrroles; Rats, Wistar; Streptozocin; Vascular Stiffness | 2014 |
Diabetes induces lysine acetylation of intermediary metabolism enzymes in the kidney.
Topics: Acetylation; Acetyltransferases; Animals; Cells, Cultured; Citric Acid Cycle; Diabetes Mellitus, Experimental; Enzymes; Glycolysis; Kidney; Lysine; Male; Protein Processing, Post-Translational; Proteome; Rats | 2014 |
Nε-carboxymethyllysine-mediated endoplasmic reticulum stress promotes endothelial cell injury through Nox4/MKP-3 interaction.
Topics: Animals; Apoptosis; Cell Line, Transformed; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Dual Specificity Phosphatase 6; Endoplasmic Reticulum Stress; Endothelial Cells; Gene Expression Regulation; Humans; Lysine; Male; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; NADPH Oxidase 4; NADPH Oxidases; Protein Binding; RNA, Small Interfering; Signal Transduction | 2014 |
Fermented soy permeate reduces cytokine level and oxidative stress in streptozotocin-induced diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Dietary Supplements; Fermentation; Galactose; Glycine max; Inflammation; Interleukins; Isoflavones; Isoprostanes; Lysine; Male; Oligosaccharides; Oxidative Stress; Phytotherapy; Plant Extracts; Rats, Wistar; Superoxide Dismutase; Uric Acid | 2015 |
Diabetes-induced alterations in tissue collagen and carboxymethyllysine in rat kidneys: Association with increased collagen-degrading proteinases and amelioration by Cu(II)-selective chelation.
Topics: Animals; Chelating Agents; Collagen; Copper; Diabetes Mellitus, Experimental; Kidney; Lysine; Male; Peptide Hydrolases; Protein Processing, Post-Translational; Rats; Rats, Wistar; Streptozocin; Trientine | 2015 |
Houttuynia cordata aqueous extract attenuated glycative and oxidative stress in heart and kidney of diabetic mice.
Topics: Animals; Arginine; Blood Glucose; Blood Urea Nitrogen; Creatine Kinase; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fructose; Glutathione; Heart; Houttuynia; Insulin; Interleukin-6; Kidney; Lysine; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NADPH Oxidase 2; NADPH Oxidases; NF-kappa B; Oxidative Stress; Plant Extracts; Plant Leaves; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Tumor Necrosis Factor-alpha | 2016 |
Endoplasmic reticulum stress-induced apoptosis: A possible role in myocardial ischemia-reperfusion injury.
Topics: Animals; Apoptosis; Atherosclerosis; Diabetes Mellitus, Experimental; Endoplasmic Reticulum Stress; Lysine; Male | 2016 |
Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dinoprost; Embryo, Mammalian; Embryonic Development; Female; Fetal Development; Fetal Resorption; Gene Expression; Liver; Lysine; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Pregnancy; Pregnancy in Diabetics; Pyruvaldehyde; Receptor for Advanced Glycation End Products | 2016 |
Rhein lysinate decreases inflammation and adipose infiltration in KK/HlJ diabetic mice with non-alcoholic fatty liver disease.
Topics: Adipose Tissue; Animals; Anthraquinones; Diabetes Mellitus, Experimental; Inflammation; Inflammation Mediators; Lysine; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2016 |
Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions.
Topics: Animals; Antibodies; Blotting, Western; Cyclin-Dependent Kinase Inhibitor p21; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Gene Expression Regulation; Glucose; Histone Code; Histone-Lysine N-Methyltransferase; In Vitro Techniques; Kidney Glomerulus; Lysine; Male; Mesangial Cells; Methylation; Promoter Regions, Genetic; Rats; Rats, Wistar; Transforming Growth Factor beta1 | 2016 |
H2AK119 monoubiquitination regulates Angiotensin II receptor mediated macrophage infiltration and renal fibrosis in type 2 diabetic rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blotting, Western; Chemokine CCL2; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Fibrosis; Histones; Imidazoles; Kidney; Lysine; Macrophages; Male; Promoter Regions, Genetic; Pyridines; Rats, Wistar; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; Telmisartan; Transforming Growth Factor beta1; Ubiquitination | 2016 |
The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice.
Topics: Animals; Blood Glucose; Collateral Circulation; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glycation End Products, Advanced; Hindlimb; HMGB1 Protein; Immunoblotting; Immunohistochemistry; Ischemia; Lipids; Lysine; Male; Mice, Inbred C57BL; Mice, Knockout; Receptor for Advanced Glycation End Products | 2017 |
Methylene blue decreases mitochondrial lysine acetylation in the diabetic heart.
Topics: Acetylation; Animals; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Lysine; Male; Methylene Blue; Mitochondria, Heart; Rats; Rats, Inbred Lew | 2017 |
Antiglycative and anti-VEGF effects of s-ethyl cysteine and s-propyl cysteine in kidney of diabetic mice.
Topics: Albuminuria; Animals; Arginine; Blood Glucose; Creatinine; Cysteine; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Kidney; Lysine; Male; Mice; Mice, Inbred BALB C; Organ Size; Vascular Endothelial Growth Factor A | 2008 |
Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Evaluation, Preclinical; Enzyme Inhibitors; Hyperalgesia; Hypoglycemic Agents; Indazoles; Lysine; Male; Nitric Oxide Synthase; Nitroarginine; Pain Measurement; Rats; Rats, Wistar; Receptors, Bradykinin; Streptozocin; Tetrahydroisoquinolines; Vincristine | 2009 |
Chronic inhibition of inducible nitric oxide synthase ameliorates cardiovascular abnormalities in streptozotocin diabetic rats.
Topics: Animals; Blood Pressure; Cardiovascular Abnormalities; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Heart Rate; Lysine; Male; Mesenteric Artery, Superior; Methoxamine; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Time Factors; Tyrosine | 2009 |
Beneficial effects of Chinese prescription Kangen-karyu on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Cholesterol; Cyclooxygenase 2; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Glycation End Products, Advanced; Hypertriglyceridemia; Hypoglycemic Agents; Hypolipidemic Agents; Liver; Lysine; Magnoliopsida; Male; Malondialdehyde; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Phytotherapy; Plants, Medicinal; Rats; Rats, Wistar; Triglycerides | 2009 |
The amelioration of streptozotocin diabetes-induced renal damage by Wu-Ling-San (Hoelen Five Herb Formula), a traditional Chinese prescription.
Topics: Albuminuria; Animals; Blood Glucose; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drugs, Chinese Herbal; Fibronectins; Glycation End Products, Advanced; Hypoglycemic Agents; Kidney; Lysine; Magnoliopsida; Male; Mitochondria; NF-kappa B; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiobarbituric Acid Reactive Substances; Transforming Growth Factor beta1 | 2009 |
Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats.
Topics: Animals; Aorta; Blood Glucose; Cardiovascular Diseases; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Enzyme Induction; Enzyme Inhibitors; Glucose; Indoles; Lysine; Male; Maleimides; Mannitol; Muscle, Smooth, Vascular; Myocytes, Cardiac; Nitric Oxide Synthase Type II; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Wistar | 2009 |
Effect of N-epsilon-(carboxymethyl)lysine on coronary vasoconstriction in isolated perfused hearts from control and streptozotocin-induced diabetic rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Calcium Channels; Coronary Vessels; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Disease Models, Animal; Drug Synergism; Glycation End Products, Advanced; In Vitro Techniques; Lysine; Male; Rats; Rats, Wistar; Stimulation, Chemical; Streptozocin; Superoxides; Vasoconstriction | 2009 |
Matcha, a powdered green tea, ameliorates the progression of renal and hepatic damage in type 2 diabetic OLETF rats.
Topics: Animals; Biomarkers; Blood Proteins; Camellia sinensis; Cholesterol; Diabetes Complications; Diabetes Mellitus, Experimental; Glucose; Glycation End Products, Advanced; Kidney; Liver; Lysine; Phytotherapy; Plant Extracts; Powders; Rats; Rats, Inbred OLETF; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Serum Albumin; Sterol Regulatory Element Binding Protein 2; Tea; Thiobarbiturates; Triglycerides | 2009 |
Influence of insulin and muscle fiber type in nepsilon-(carboxymethyl)-lysine accumulation in soleus muscle of rats with streptozotocin-induced diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Image Processing, Computer-Assisted; Insulin; Lysine; Male; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Rats; Rats, Sprague-Dawley | 2009 |
Critical evaluation of toxic versus beneficial effects of methylglyoxal.
Topics: Animals; Arginine; Cataract; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Delivery Systems; Glycation End Products, Advanced; Humans; Kidney Failure, Chronic; Lysine; Maillard Reaction; Oxidative Stress; Protein Conformation; Protein Folding; Pyruvaldehyde; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serum Albumin | 2009 |
Differences in mouse models of diabetes mellitus in studies of male reproduction.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; DNA Damage; Epididymis; Glycation End Products, Advanced; Infertility, Male; Lysine; Male; Mice; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Spermatozoa; Streptozocin; Testis | 2010 |
Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction.
Topics: Animals; Aspartic Acid Endopeptidases; Benzofurans; Blood Glucose; Body Weight; Coronary Vessels; Diabetes Mellitus, Experimental; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Enzyme Inhibitors; Glycopeptides; Heart; Lipids; Lysine; Male; Metalloendopeptidases; Myocardium; Oligopeptides; Organ Size; Organophosphonates; Peptides, Cyclic; Perfusion; Piperidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Thiorphan; Vasoconstriction | 2010 |
The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing.
Topics: Animals; Arginine; Diabetes Mellitus; Diabetes Mellitus, Experimental; Lysine; Mice; Mice, Knockout; Muscle, Skeletal; Oxidation-Reduction; Shc Signaling Adaptor Proteins; Skin; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Wound Healing | 2010 |
Glycoxidative stress-induced mitophagy modulates mitochondrial fates.
Topics: Animals; Cattle; Cell Death; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Hyperglycemia; Insulinoma; Lysine; Mice; Mitochondria; Models, Biological; Oxidative Stress; Phagosomes; Rats; Reactive Oxygen Species; Serum Albumin | 2010 |
Natural compounds containing a catechol group enhance the formation of Nε-(carboxymethyl)lysine of the Maillard reaction.
Topics: Animals; Catechols; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Free Radicals; Glutathione Peroxidase; Glycation End Products, Advanced; Glycosylation; Humans; Hydrogen Peroxide; Lysine; Macrophages; Maillard Reaction; Male; Mice; Mice, Inbred A; Oxidation-Reduction; Serum Albumin; Streptozocin; Structure-Activity Relationship | 2011 |
Elevated Nε-(carboxymethyl)lysine is associated with apoptosis of retinal pericytes in streptozotocin-induced diabetic rats.
Topics: Animals; Apoptosis; Caspase 3; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Fluorescent Antibody Technique, Indirect; Glycation End Products, Advanced; In Situ Nick-End Labeling; Lysine; NF-kappa B; Pericytes; Rats; Rats, Sprague-Dawley; Retinal Vessels | 2011 |
Temporal increases in urinary carboxymethyllysine correlate with albuminuria development in diabetes.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Animals; Biomarkers; Cytosol; Deoxyguanosine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Gene Expression; Glomerular Filtration Rate; Glycation End Products, Advanced; Kidney Cortex; Lysine; Male; Mitochondria; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA, Messenger; Streptozocin; Time Factors | 2011 |
Ω3-Polyunsaturated fatty acids prevent lipoperoxidation, modulate antioxidant enzymes, and reduce lipid content but do not alter glycogen metabolism in the livers of diabetic rats fed on a high fat thermolyzed diet.
Topics: Adiposity; Animals; Catalase; Diabetes Mellitus, Experimental; Diet, High-Fat; Fatty Acids, Omega-3; Glycation End Products, Advanced; Glycogen; Lipid Metabolism; Lipid Peroxidation; Liver; Lysine; Male; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2012 |
Advanced glycation end-product Nε-carboxymethyl-Lysine accelerates progression of atherosclerotic calcification in diabetes.
Topics: Alkaline Phosphatase; Animals; Apolipoproteins E; Apoptosis; Atherosclerosis; Blotting, Western; Bone Morphogenetic Protein 2; Cell Differentiation; Cell Line; Core Binding Factor Alpha 2 Subunit; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diet, High-Fat; Disease Progression; Glucose; Immunohistochemistry; Injections, Intravenous; Lipoproteins, LDL; Lysine; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteogenesis; Rats; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Staining and Labeling; Time Factors; Vascular Calcification | 2012 |
Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling.
Topics: Animals; Diabetes Mellitus, Experimental; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Lipid Metabolism; Liver; Lysine; Methylation; Mice; Mice, Knockout; Models, Biological; Muscle, Skeletal; Organ Specificity; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; Signal Transduction; Sirolimus; YY1 Transcription Factor | 2012 |
Reduction in embryonic malformations and alleviation of endoplasmic reticulum stress by nitric oxide synthase inhibition in diabetic embryopathy.
Topics: Animals; Apoptosis; Caspase 8; Diabetes Mellitus, Experimental; Endoplasmic Reticulum Stress; Female; Lysine; Mice; Mice, Inbred C57BL; Neural Tube; Neural Tube Defects; Nitric Oxide Synthase Type II; Pregnancy; Pregnancy in Diabetics | 2012 |
Advanced glycation end product Nε-carboxymethyllysine induces endothelial cell injury: the involvement of SHP-1-regulated VEGFR-2 dephosphorylation.
Topics: Animals; Aorta; Diabetes Mellitus, Experimental; Endothelium, Vascular; Gene Silencing; Glycation End Products, Advanced; Human Umbilical Vein Endothelial Cells; Humans; Lysine; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Reactive Oxygen Species; RNA, Small Interfering; Transfection; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
Renal protective effects of extracts from guava fruit (Psidium guajava L.) in diabetic mice.
Topics: Aldehyde Reductase; Animals; Anti-Inflammatory Agents; Antioxidants; Arginine; Blood Glucose; Blood Urea Nitrogen; Cytokines; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Response Relationship, Drug; Fructose; Fruit; Hypoglycemic Agents; Insulin; Kidney; Lysine; Male; Mice; Mice, Inbred BALB C; Phytotherapy; Plant Extracts; Psidium; Reactive Oxygen Species | 2012 |
The alternative crosstalk between RAGE and nitrative thioredoxin inactivation during diabetic myocardial ischemia-reperfusion injury.
Topics: Acetophenones; Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Free Radical Scavengers; Imines; Lysine; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Myocardial Reperfusion Injury; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide Synthase Type II; Organometallic Compounds; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA, Small Interfering; Salicylates; Superoxides; Thioredoxins; Tyrosine | 2012 |
Malondialdehyde and 4-hydroxynonenal adducts are not formed on cardiac ryanodine receptor (RyR2) and sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) in diabetes.
Topics: Aldehydes; Animals; Arginine; Calcium; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Echocardiography; Guanidines; Lysine; Male; Malondialdehyde; Myocytes, Cardiac; Norleucine; Protein Carbonylation; Pyridoxamine; Pyrroles; Rats; Rats, Sprague-Dawley; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Spin Labels | 2013 |
The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes.
Topics: Animals; Capillaries; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Extracellular Matrix; Female; Glycation End Products, Advanced; Laminin; Lysine; Pyridoxamine; Rats; Rats, Sprague-Dawley; Retina; Retinal Vessels; RNA, Messenger | 2002 |
Oxidative deamination of lysine residue in plasma protein of diabetic rats. Novel mechanism via the Maillard reaction.
Topics: 2-Aminoadipic Acid; Animals; Blood Proteins; Carbohydrate Metabolism; Chromatography, High Pressure Liquid; Copper; Diabetes Mellitus, Experimental; Hydrogen-Ion Concentration; Hydrolysis; Lysine; Maillard Reaction; Male; Models, Chemical; Oxidation-Reduction; Oxygen; Pyruvaldehyde; Rats; Rats, Wistar; Reactive Oxygen Species; Streptozocin; Temperature; Time Factors | 2002 |
Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine.
Topics: Animals; Cells, Cultured; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibronectins; Gene Expression; Glomerular Mesangium; Glycation End Products, Advanced; Guanidines; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Lysine; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Serum Albumin, Bovine | 2002 |
The amino-terminal domains of the ezrin, radixin, and moesin (ERM) proteins bind advanced glycation end products, an interaction that may play a role in the development of diabetic complications.
Topics: Animals; Binding Sites; Biosensing Techniques; Blood Proteins; Blotting, Western; Cattle; Chromatography, Affinity; Cloning, Molecular; Cytoskeletal Proteins; Detergents; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glycation End Products, Advanced; Humans; Kidney; Ligands; Lysine; Membrane Proteins; Microfilament Proteins; Phosphoproteins; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Rats; Recombinant Proteins; Serum Albumin; Time Factors; Tumor Cells, Cultured; Tyrosine | 2003 |
The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes.
Topics: Albuminuria; Animal Population Groups; Animals; Blood Pressure; Collagen; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fibrosis; Glycation End Products, Advanced; Immediate-Early Proteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kidney; Kinetics; Lysine; Models, Biological; Rats; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Solubility; Thiazoles; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrosine | 2003 |
Dietary G-rutin suppresses glycation in tissue proteins of streptozotocin-induced diabetic rats.
Topics: Animals; Blotting, Western; Diabetes Mellitus, Experimental; Diet; Glucose; Glycation End Products, Advanced; Lysine; Male; Rats; Rats, Wistar; Rutin; Streptozocin | 2003 |
Chemical modification of muscle protein in diabetes.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Lipid Peroxidation; Lysine; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Skin; Streptozocin | 2004 |
Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitus.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Antigens, CD; Autophagy; Diabetes Mellitus, Experimental; HSC70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Hypertrophy; Kidney Cortex; Lysine; Lysosomal Membrane Proteins; Lysosomes; Male; Molecular Chaperones; Phenylalanine; Proteins; Rats; Rats, Sprague-Dawley | 2004 |
Reduction of retinal albumin leakage by the antioxidant calcium dobesilate in streptozotocin-diabetic rats.
Topics: Albumins; Animals; Antioxidants; Blood-Retinal Barrier; Calcium Dobesilate; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Glycation End Products, Advanced; Hemostatics; Immunohistochemistry; Lysine; Male; Rats; Rats, Wistar; Retina; Vascular Endothelial Growth Factor A | 2004 |
Overproduction of N(epsilon)-(carboxymethyl)lysine-induced neovascularization in cultured choroidal explant of streptozotocin-diabetic rat.
Topics: Animals; Antibodies, Monoclonal; Choroid; Choroidal Neovascularization; Diabetes Mellitus, Experimental; Humans; Lysine; Male; Platelet-Derived Growth Factor; Rats; Rats, Wistar; Serum Albumin; Streptozocin; Time Factors; Tissue Culture Techniques; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2004 |
A new drug carrier, Nalpha-deoxycholyl-L: -lysyl-methylester, for enhancing insulin absorption in the intestine.
Topics: Animals; Blood Glucose; Chenodeoxycholic Acid; Diabetes Mellitus, Experimental; Drug Carriers; Humans; Hypoglycemic Agents; Insulin; Intestinal Absorption; Lysine; Male; Rats; Rats, Sprague-Dawley | 2005 |
Are food advanced glycation end products toxic in biological systems?
Topics: Animal Feed; Animals; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Glycosylation; Lysine; Maillard Reaction; Male; Portal System; Rats; Rats, Wistar; Soybean Proteins | 2005 |
Drug intervention can correct subnormal retinal oxygenation response in experimental diabetic retinopathy.
Topics: Animals; Blood Glucose; Carbon Dioxide; Celecoxib; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Inhibitors; Lysine; Magnetic Resonance Imaging; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Oxygen Consumption; Partial Pressure; Pyrazoles; Rats; Retina; Sulfonamides | 2005 |
HNE-dependent molecular damage in diabetic nephropathy and its possible prevention by N-acetyl-cysteine and oxerutin.
Topics: Acetylcysteine; Aldehydes; Animals; Apoptosis; Cell Division; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycation End Products, Advanced; Hydroxyethylrutoside; Immunohistochemistry; Kidney Glomerulus; Lipid Peroxidation; Lysine; Male; Rats; Rats, Wistar; Taurine | 2005 |
Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN/Kob rats.
Topics: Animals; Arginine; Blood Glucose; Bone Density; Collagen; Cross-Linking Reagents; Diabetes Mellitus, Experimental; Femur; Lysine; Male; Rats; Rats, Wistar; Stress, Mechanical; Vitamin B 6 | 2006 |
Pyridoxamine inhibits maillard reactions in diabetic rat lenses.
Topics: Aldehyde Reductase; Animals; Arginine; Chromatography, High Pressure Liquid; Diabetes Complications; Diabetes Mellitus, Experimental; Glucose; Glutathione; Glycation End Products, Advanced; Lactoylglutathione Lyase; Lens Diseases; Lens, Crystalline; Lysine; Maillard Reaction; Male; Organ Culture Techniques; Ornithine; Pyridoxamine; Pyrimidines; Pyruvaldehyde; Rats; Rats, Sprague-Dawley | 2006 |
Combination therapy with the advanced glycation end product cross-link breaker, alagebrium, and angiotensin converting enzyme inhibitors in diabetes: synergy or redundancy?
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cytosol; Diabetes Mellitus, Experimental; Drug Synergism; Drug Therapy, Combination; Enzyme Activation; Glycation End Products, Advanced; Kidney; Lysine; Male; Mitochondria; NF-kappa B; Oxidative Stress; Protein Kinase C; Ramipril; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Renin-Angiotensin System; Superoxide Dismutase; Thiazoles; Vascular Endothelial Growth Factor A | 2007 |
pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity.
Topics: 3T3-L1 Cells; Amino Acid Sequence; Amino Acids; Animals; Arginine; Binding, Competitive; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Dogs; Female; Humans; Hypoglycemic Agents; Insulin; Isoelectric Point; Lysine; Male; Mice; Molecular Sequence Data; Protein Binding; Radioimmunoassay; Receptor, IGF Type 1; Receptor, Insulin; Structure-Activity Relationship | 2007 |
Effects of selective iNOS inhibition on systemic hemodynamics and mortality rate on endotoxic shock in streptozotocin-induced diabetic rats.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hemodynamics; Lipopolysaccharides; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Random Allocation; Rats; Rats, Wistar; Shock, Septic; Tyrosine | 2007 |
Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway.
Topics: Acetophenones; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Glomerular Mesangium; Glycation End Products, Advanced; Lysine; Male; NADPH Oxidases; Protein Kinase C-alpha; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Superoxides | 2008 |
Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model.
Topics: Animals; Antimutagenic Agents; Arginine; Basic Helix-Loop-Helix Transcription Factors; Blood Pressure; Blotting, Western; Chromatography, High Pressure Liquid; Cobalt; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Progression; Gene Expression; Glycation End Products, Advanced; Hypertension; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immediate-Early Proteins; Insulin-Like Growth Factor Binding Proteins; Intercellular Signaling Peptides and Proteins; Kidney; Lysine; Male; NADPH Oxidases; Obesity; Oxidative Stress; Polymerase Chain Reaction; Rats; Rats, Inbred SHR; RNA, Messenger; Transforming Growth Factor beta | 2008 |
Immunochemical detection of Nepsilon-(carboxyethyl)lysine using a specific antibody.
Topics: Aldehydes; Animals; Antibodies, Monoclonal; Antibody Specificity; Antigen-Antibody Reactions; Cattle; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Kidney; Lysine; Male; Pyruvaldehyde; Rats; Rats, Wistar; Sensitivity and Specificity; Serum Albumin | 2008 |
Role of maltol in advanced glycation end products and free radicals: in-vitro and in-vivo studies.
Topics: Animals; Blood Glucose; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Glycated Serum Albumin; Glycation End Products, Advanced; Guanidines; Lysine; Male; Proteinuria; Pyrones; Rats; Rats, Wistar; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Serum Albumin; Streptozocin; Transcription Factor RelA | 2008 |
Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lipopolysaccharides; Lysine; Male; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitroprusside; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Streptozocin | 2008 |
Increased Nepsilon-(carboxymethyl)-lysine levels in cerebral blood vessels of diabetic patients and in a (streptozotocin-treated) rat model of diabetes mellitus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Brain; Cerebrovascular Circulation; Child; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Disease Models, Animal; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lysine; Male; Middle Aged; Rats; Rats, Wistar | 2008 |
The effect of alloxan diabetes on muscle and liver protein synthesis in the rat, measured by constant infusion of L-(C-14) lysine.
Topics: Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Liver; Lysine; Muscles; Protein Biosynthesis; Rats | 1967 |
The measurement of total lysine turnover in the rat by intravenous infusion of L-[U-14C]lysine.
Topics: Animals; Blood Proteins; Carbon Isotopes; Diabetes Mellitus, Experimental; Female; Injections, Intravenous; Kinetics; Lysine; Male; Rats; Sex Factors | 1967 |
Glucosylated collagen is antigenic.
Topics: Animals; Antibodies; Antibody Specificity; Collagen; Diabetes Mellitus, Experimental; Epitopes; Immunization; Lysine; Rats; Rats, Inbred Strains | 1983 |
Preparation and analysis of the products of non-enzymatic protein glycosylation and their relationship to cross-linking of proteins.
Topics: Animals; Carbon Radioisotopes; Chemical Phenomena; Chemistry; Diabetes Mellitus, Experimental; Drug Stability; Glycoproteins; Glycosides; Hexoses; Lysine; Oxidation-Reduction; Proteins; Rats; Structure-Activity Relationship | 1983 |
[Effect of (+)-catechin on protein and basal membrane collagen synthesis in isolated glomeruli of diabetic and nondiabetic rats].
Topics: Animals; Basement Membrane; Benzopyrans; Catechin; Collagen; Diabetes Mellitus, Experimental; Humans; Hydroxylysine; Kidney Glomerulus; Lysine; Male; Protein Biosynthesis; Rats | 1980 |
Influence of diabetes on basement membrane synthesis in isolated glomeruli.
Topics: Animals; Basement Membrane; Culture Techniques; Diabetes Mellitus, Experimental; Hydroxylation; Hydroxylysine; Kidney Glomerulus; Lysine; Male; Rats | 1980 |
[The effect of insulin on the metabolism of isolated rat glomeruli (author's transl)].
Topics: Animals; Diabetes Mellitus, Experimental; Glucose; In Vitro Techniques; Insulin; Kidney Glomerulus; Lysine; Male; Oxidation-Reduction; Proteins; Rats; Uridine | 1980 |
Identification of specific amino acids in diabetic glomerular basement membrane collagen subject to non-enzymatic glucosylation in vivo.
Topics: Amino Acids; Animals; Basement Membrane; Chemical Phenomena; Chemistry; Collagen; Diabetes Mellitus, Experimental; Glucose; Hydroxylysine; Kidney Glomerulus; Lysine; Male; Rats | 1981 |
Inhibition of increased synthesis of glomerular basement membrane collagen in diabetic rats in vivo.
Topics: Animals; Basement Membrane; Blood Glucose; Body Weight; Calcium Dobesilate; Catechin; Collagen; Creatinine; Diabetes Mellitus, Experimental; Hydroxylysine; Kidney Glomerulus; Lysine; Male; Rats; Rats, Inbred Strains | 1981 |
Characterization of N-glycosylated type I collagen in streptozotocin-induced diabetes.
Topics: Animals; Borohydrides; Chemical Phenomena; Chemistry; Collagen; Diabetes Mellitus, Experimental; Glycosides; Hexoses; Hydroxylysine; In Vitro Techniques; Lysine; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains; Tendons | 1981 |
Topology of CNS myelin proteolipid protein: evidence for the nonenzymatic glycosylation of extracytoplasmic domains in normal and diabetic animals.
Topics: Amino Acid Sequence; Animals; Binding Sites; Borohydrides; Brain; Cattle; Cytoplasm; Diabetes Mellitus, Experimental; Glycosylation; In Vitro Techniques; Lysine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Models, Molecular; Molecular Sequence Data; Molecular Structure; Myelin Proteins; Myelin Proteolipid Protein; Oxidation-Reduction; Pyridoxal Phosphate | 1994 |
Immunological detection of glycated proteins in normal and streptozotocin-induced diabetic rats using anti hexitol-lysine IgG.
Topics: Animals; Antibodies; Antibody Affinity; Antibody Specificity; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Glycoproteins; Immunoblotting; Lysine; Rats; Tissue Extracts | 1995 |
D-lysine and non-enzymatic glycation.
Topics: Animals; Blood Glucose; Blood Proteins; Diabetes Mellitus, Experimental; Glycosylation; Lysine; Rats | 1994 |
Glomerular filtration and tubular reabsorption of albumin in preproteinuric and proteinuric diabetic rats.
Topics: Animals; Blood Glucose; Blood Proteins; Blood Volume; Body Weight; Diabetes Mellitus, Experimental; Glomerular Filtration Rate; Hematocrit; Hyperglycemia; Insulin, Long-Acting; Kidney; Kidney Tubules, Proximal; Kinetics; Lysine; Male; Organ Size; Proteinuria; Rats; Rats, Wistar; Serum Albumin | 1993 |
D-lysine reduces the non-enzymatic glycation of proteins in experimental diabetes mellitus in rats.
Topics: Animals; Blood Glucose; Blood Proteins; Diabetes Mellitus, Experimental; Glycated Serum Proteins; Glycoproteins; Glycosylation; Lysine; Male; Rats; Rats, Sprague-Dawley; Reference Values; Stereoisomerism | 1993 |
Insulin stimulates cationic amino acid transport activity in the isolated perfused rat pancreas.
Topics: Amino Acids; Animals; Cell Membrane; Diabetes Mellitus, Experimental; Gastrointestinal Agents; Glucagon; Hypoglycemic Agents; In Vitro Techniques; Insulin; Kinetics; Lysine; Male; Oxygen Consumption; Pancreas; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1995 |
Evidence of a glycemic threshold for the formation of pentosidine in diabetic dog lens but not in collagen.
Topics: Animals; Arginine; Blood Glucose; Blood Proteins; Chromatography, High Pressure Liquid; Collagen; Diabetes Mellitus, Experimental; Dogs; Dura Mater; Female; Glycated Hemoglobin; Glycated Serum Proteins; Glycation End Products, Advanced; Glycoproteins; Glycosuria; Glycosylation; Lens, Crystalline; Lysine; Male; Reference Values | 1996 |
Acylation of human insulin with palmitic acid extends the time action of human insulin in diabetic dogs.
Topics: Acylation; Animals; Blood Glucose; Chromatography, Gel; Diabetes Mellitus, Experimental; Disease Models, Animal; Dogs; Fatty Acids, Nonesterified; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Lysine; Palmitic Acid; Protein Binding; Serum Albumin; Time Factors | 1997 |
Hyperlipidemia and tissue contents of N epsilon-(carboxymethyl)lysine in streptozotocin diabetes.
Topics: Animals; Antibodies, Monoclonal; Cholesterol; Creatinine; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Hyperlipidemias; Lipids; Lipoproteins; Lysine; Male; Rats; Rats, Wistar; Triglycerides | 1997 |
Glycoxidation in aortic collagen from STZ-induced diabetic rats and its relevance to vascular damage.
Topics: Aldehydes; Animals; Aorta; Collagen; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Glycosylation; Immunohistochemistry; Lipid Peroxidation; Lysine; Male; Malondialdehyde; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Streptozocin | 1998 |
Circulating advanced glycation peptides in streptozotocin-induced diabetic rats: evidence for preferential modification of IgG light chains.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamide Gel; Glycation End Products, Advanced; Guanidines; Immunoglobulin Light Chains; Lysine; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence | 1998 |
Specific detections of the early process of the glycation reaction by fructose and glucose in diabetic rat lens.
Topics: Animals; Crystallins; Diabetes Mellitus, Experimental; Fructose; Glucose; Glycosylation; Lens, Crystalline; Lysine; Platelet Activating Factor; Rats; Reference Values; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors | 1998 |
Beneficial effect of lysine and amino acids on cataractogenesis in experimental diabetes through possible antiglycation of lens proteins.
Topics: Amino Acids; Animals; Blood Glucose; Body Weight; Cataract; Crystallins; Diabetes Mellitus, Experimental; Female; Lysine; Male; Rats | 1998 |
Aminoguanidine inhibits albuminuria, but not the formation of advanced glycation end-products in skin collagen of diabetic rats.
Topics: Albuminuria; Animals; Arginine; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glycated Hemoglobin; Glycation End Products, Advanced; Guanidines; Kinetics; Lysine; Male; Metabolic Clearance Rate; Rats; Rats, Inbred Lew; Reference Values; Skin | 1999 |
Protein aging by carboxymethylation of lysines generates sites for divalent metal and redox active copper binding: relevance to diseases of glycoxidative stress.
Topics: Animals; Ascorbic Acid; Binding Sites; Biopolymers; Catalysis; Cations, Divalent; Collagen; Copper; Diabetes Mellitus, Experimental; Free Radicals; Glycation End Products, Advanced; Humans; Hydrogen Peroxide; Kidney Failure, Chronic; Lysine; Methylation; Oxidation-Reduction; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Serine | 1999 |
Evidence of a glycemic threshold for the development of cataracts in diabetic rats.
Topics: Animals; Blood Glucose; Cataract; Densitometry; Diabetes Mellitus, Experimental; Differential Threshold; Dose-Response Relationship, Drug; Fundus Oculi; Glycated Hemoglobin; Glycation End Products, Advanced; Lens, Crystalline; Lysine; Male; Rats; Rats, Sprague-Dawley; Streptozocin; Time Factors | 1999 |
Autoantibody against N(epsilon)-(carboxymethyl)lysine: an advanced glycation end product of the Maillard reaction.
Topics: Animals; Autoantibodies; Crystallins; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Epitopes; Glycation End Products, Advanced; Humans; Lysine; Maillard Reaction; Male; Rats; Rats, Wistar | 1999 |
Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney.
Topics: Animals; Cytosol; Diabetes Mellitus, Experimental; Glycosylation; Hydrazones; Kidney; Liver; Lysine; Organ Specificity; Oxidation-Reduction; Oxidative Stress; Proteins; Rats; Rats, Sprague-Dawley | 1999 |
Nitric oxide synthase isoforms and glomerular hyperfiltration in early diabetic nephropathy.
Topics: Animals; Blood Pressure Determination; Blotting, Northern; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glomerular Filtration Rate; Hemodynamics; Isoenzymes; Kidney Function Tests; Kidney Glomerulus; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Streptozocin | 2000 |
The effects of simultaneous hyperlipemia-hyperglycemia on the resistance arteries, myocardium and kidney glomeruli.
Topics: Acetylcholine; Animals; Arginine; Blood Glucose; Cholesterol; Cholesterol, Dietary; Collagen; Cricetinae; Diabetes Mellitus, Experimental; Erythrocytes; Glomerular Mesangium; Glycation End Products, Advanced; Hyperlipidemias; Hypertrophy, Left Ventricular; Lysine; Male; Mesenteric Arteries; Mesocricetus; Myocardium; Norepinephrine; Osmotic Fragility; Peptidyl-Dipeptidase A; Vascular Resistance | 2000 |
L-lysine reduces nonenzymatic glycation of glomerular basement membrane collagen and albuminuria in diabetic rats.
Topics: Albuminuria; Animals; Basement Membrane; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycated Hemoglobin; Glycosylation; Kidney Glomerulus; Lysine; Male; Rats; Rats, Wistar | 2001 |
Glycation decreases calmodulin binding to lens transmembrane protein, MIP.
Topics: Animals; Aquaporins; Calmodulin; Cattle; Cell Membrane; Diabetes Mellitus, Experimental; Eye Proteins; Glycosylation; Iodine Radioisotopes; Lens, Crystalline; Lysine; Membrane Glycoproteins; Mutagenesis, Site-Directed; Rats; Rats, Sprague-Dawley | 2001 |
Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin.
Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Dogs; Glycated Hemoglobin; Glycation End Products, Advanced; Glycosuria; Guanidines; Kidney; Lysine; Neural Conduction; Platelet Aggregation; Random Allocation; Retinal Vessels; Ulnar Nerve | 2001 |
Actin and annexins I and II are among the main endothelial plasmalemma-associated proteins forming early glucose adducts in experimental diabetes.
Topics: Actins; Amino Acid Sequence; Animals; Annexin A1; Annexin A2; Antibodies, Monoclonal; Blotting, Western; Cell Membrane; Diabetes Mellitus, Experimental; Electrophoresis, Gel, Two-Dimensional; Endothelium, Vascular; Glucose; Hydrogen-Ion Concentration; Lysine; Male; Molecular Sequence Data; Rats; Rats, Sprague-Dawley | 2001 |
N-phenacylthiazolium bromide decreases renal and increases urinary advanced glycation end products excretion without ameliorating diabetic nephropathy in C57BL/6 mice.
Topics: Animals; Arginine; Collagen; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Glomerular Mesangium; Glycation End Products, Advanced; Kidney; Kidney Glomerulus; Lysine; Mice; Mice, Inbred C57BL; Proteinuria; Thiazoles | 2001 |
Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Glycosylation; Lysine; Male; Neural Conduction; Oxidation-Reduction; Peripheral Nerves; Rats; Rats, Wistar; Reference Values; Thiamine; Time Factors | 2001 |
Effect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve.
Topics: Aldehyde Reductase; Animals; Arginine; Arterioles; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Guanidines; Imidazoles; Imidazolidines; Inositol; Lysine; Male; Neural Conduction; Rats; Rats, Sprague-Dawley; Retina; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Superoxides | 2002 |
Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal.
Topics: Animals; Arginine; Cattle; Chromatography, High Pressure Liquid; Crystallins; Diabetes Mellitus, Experimental; Dimerization; Erythrocytes; Glutathione; Glycation End Products, Advanced; Lactoylglutathione Lyase; Lysine; Magnetic Resonance Spectroscopy; Maillard Reaction; Models, Chemical; Oxidative Stress; Pyridoxamine; Pyruvaldehyde; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances | 2002 |
Role of nonenzymatic glycosylation in the development of the sequelae of diabetes mellitus.
Topics: Animals; Cataract; Cattle; Chemical Phenomena; Chemistry; Crystallins; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disulfides; Glucose; Glucosephosphates; Glycated Hemoglobin; Humans; In Vitro Techniques; Lens, Crystalline; Lysine; Mice; Oxidation-Reduction; Rats; Sulfhydryl Compounds | 1979 |
Diabetic cataract formation: potential role of glycosylation of lens crystallins.
Topics: Animals; Cataract; Crystallins; Diabetes Mellitus, Experimental; Glucose; Glucosephosphates; In Vitro Techniques; Lysine; Molecular Weight; Rats | 1978 |
Nonenzymatic glycosylation, sulfhydryl oxidation, and aggregation of lens proteins in experimental sugar cataracts.
Topics: Alloxan; Animals; Cataract; Centrifugation, Density Gradient; Chromatography, Gel; Crystallins; Diabetes Mellitus, Experimental; Female; Galactosemias; Lysine; Oxidation-Reduction; Rats; Sulfhydryl Compounds | 1979 |
Effects of the insulin-secreting action of lysine on some metabolic parameters of blood and of tissues in subdiabetic rats.
Topics: Animals; Blood Glucose; Blood Proteins; Creatinine; Diabetes Mellitus, Experimental; Glycogen; Insulin; Insulin Secretion; Liver Glycogen; Lysine; Male; Muscles; Rats | 1976 |
L-arginine reduces glomerular basement membrane collagen N epsilon-carboxymethyllysine in the diabetic db/db mouse.
Topics: Administration, Oral; Animals; Arginine; Basement Membrane; Collagen; Diabetes Mellitus, Experimental; Glycosylation; Kidney Glomerulus; Lysine; Mice; Mice, Mutant Strains | 1992 |
Glycation of rat sciatic nerve tubulin in experimental diabetes mellitus.
Topics: Animals; Axonal Transport; Brain; Diabetes Mellitus, Experimental; Female; Glycosylation; Lysine; Microtubule Proteins; Microtubules; Rats; Rats, Inbred Strains; Sciatic Nerve; Streptozocin; Tubulin | 1991 |
Determination of furosine in biomedical samples employing an improved hydrolysis and high-performance liquid chromatographic technique.
Topics: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Glycosylation; Hydrolysis; Liver; Lysine; Membrane Glycoproteins; Rats; Rats, Inbred Strains; Time Factors | 1991 |
Immunohistochemical localization of glycated protein in diabetic rat kidney.
Topics: Animals; Antibodies; Basement Membrane; Diabetes Mellitus, Experimental; Glycosylation; Immune Sera; Immunoenzyme Techniques; Kidney; Lysine; Male; Microvilli; Organ Specificity; Proteins; Rats | 1990 |
Accelerated onset of albuminuria in diabetic rats preimmunized with glucosylated rat serum albumin.
Topics: Albuminuria; Animals; Antibody Formation; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Response Relationship, Immunologic; Enzyme-Linked Immunosorbent Assay; Epitopes; Immunization; Lysine; Rats; Serum Albumin; Streptozocin | 1985 |
Regulation of gluconeogenesis in hepatocytes from fasted alloxan-diabetic rats.
Topics: Animals; Bucladesine; Carnitine; Diabetes Mellitus, Experimental; Dihydroxyacetone; Fasting; Gluconeogenesis; In Vitro Techniques; Liver; Lysine; Male; Norepinephrine; Oleic Acid; Oleic Acids; Rats; Rats, Inbred Strains | 1985 |
Regional amino acid transport into brain during diabetes: effect of plasma amino acids.
Topics: Amino Acids; Animals; Biological Transport; Blood Glucose; Blood-Brain Barrier; Brain; Diabetes Mellitus, Experimental; Ketone Bodies; Lysine; Male; Phenylalanine; Rats; Tissue Distribution | 1987 |
Accelerated glycation of the aorta in diabetic rats.
Topics: Animals; Aorta, Abdominal; Diabetes Mellitus, Experimental; Glycosylation; Lysine; Male; Rats; Rats, Inbred Strains | 1987 |
Specific radioimmunoassay of glucitol-lysine--application to lens proteins in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Crystallins; Diabetes Mellitus, Experimental; Lysine; Male; Radioimmunoassay; Rats; Rats, Inbred Strains; Sorbitol | 1988 |
In situ metabolism of 1,omega medium chain dicarboxylic acids in the liver of intact rats as detected by 13C and 1H NMR.
Topics: Adipates; Animals; Diabetes Mellitus, Experimental; Dicarboxylic Acids; Fasting; Kinetics; Liver; Lysine; Magnetic Resonance Spectroscopy; Male; Microbodies; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1988 |
Age-related and diabetes-associated glycation in tissue proteins.
Topics: Aging; Animals; Aorta; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Glycated Hemoglobin; Glycosylation; Lysine; Maillard Reaction; Male; Proteins; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence | 1988 |
Intestinal adaptation in diabetes: amino acid absorption.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport; Chromatography, Paper; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glycine; Intestinal Absorption; Intestinal Mucosa; Leucine; Lysine; Male; Organ Size; Proline; Rats; Serous Membrane; Streptozocin; Time Factors | 1974 |
Biochemistry of the glomerular basement membrane in diabetes.
Topics: Amino Acids; Animals; Basement Membrane; Carbohydrate Metabolism; Chromatography, Gel; Diabetes Mellitus; Diabetes Mellitus, Experimental; Electrophoresis, Disc; Electrophoresis, Polyacrylamide Gel; Glucosyltransferases; Glycoside Hydrolases; Humans; Hydroxylysine; Insulin; Kidney Glomerulus; Lysine; Polysaccharides | 1973 |
Studies on the induction and repression of enzymes in rat liver. VI. Some properties and the metabolic regulation of two isozymic forms of serine dehydratase.
Topics: Adrenal Glands; Adrenalectomy; Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Chromatography, DEAE-Cellulose; Cortisone; Crystallization; Diabetes Mellitus, Experimental; Electrophoresis, Disc; Enzyme Induction; Glucagon; Hydro-Lyases; Immune Sera; Immunodiffusion; Isoenzymes; L-Serine Dehydratase; Leucine; Liver; Lysine; Male; Molecular Weight; Phosphates; Proline; Pyridoxal Phosphate; Rats; Spectrophotometry; Tritium; Ultraviolet Rays | 1971 |
The effect of alloxan diabetes on skin collagen metabolism.
Topics: Animals; Carbon Isotopes; Collagen; Diabetes Mellitus, Experimental; Lysine; Male; Proline; Rats; Rats, Inbred Strains; Skin; Wound Healing | 1972 |
[Aminoacyl-t-RNA-synthetases of the rabbit liver in case of insulin insufficiency and their sensitivity to inactivation].
Topics: Amino Acids; Animals; Cattle; Diabetes Mellitus, Experimental; Leucine; Ligases; Liver; Lysine; Methionine; Rabbits; RNA, Transfer; Yeast, Dried | 1970 |
Studies on the biosynthesis of the hydroxylysine-linked disaccharide unit of basement membranes and collagens. 3. Tissue and subcellular distribution of glycosyltransferases and the effect of various conditions on the enzyme levels.
Topics: Acetates; Aging; Amino Alcohols; Animals; Animals, Newborn; Basement Membrane; Brain; Carbon Isotopes; Cartilage, Articular; Cell Fractionation; Chromatography, Gel; Chromatography, Paper; Collagen; Diabetes Mellitus, Experimental; Disaccharides; Female; Galactose; Glucosamine; Glucose; Glucosyltransferases; Kidney; Liver; Lysine; Male; Myocardium; Nucleoside Diphosphate Sugars; Organ Specificity; Pregnancy; Rats; Skin; Spleen; Thyroid Gland; Transferases; Uracil Nucleotides; Uterus | 1971 |
Insulin and the attachment of amino-acids to the liver transfer RNAs.
Topics: Amino Acids; Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Insulin; Leucine; Liver; Lysine; Methionine; Protein Binding; Rabbits; RNA, Transfer; Saccharomyces | 1969 |
Studies of the metabolic effects of acute insulin deficiency. I. Mechanism of impairment of hepatic fatty acid and protein synthesis.
Topics: Acetates; Animals; Diabetes Mellitus, Experimental; Enzymes; Fatty Acids; Guinea Pigs; In Vitro Techniques; Insulin; Insulin Antibodies; Ligases; Lipids; Liver; Lysine; Palmitic Acids; Protein Biosynthesis; Rats; Subcellular Fractions | 1966 |