lysine has been researched along with Acute Confusional Senile Dementia in 115 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.87) | 18.7374 |
| 1990's | 15 (13.04) | 18.2507 |
| 2000's | 29 (25.22) | 29.6817 |
| 2010's | 44 (38.26) | 24.3611 |
| 2020's | 26 (22.61) | 2.80 |
| Authors | Studies |
|---|---|
| Alfiler, L; Anastassiou, C; Arkhipov, A; Baker, K; Bakken, TE; Barkan, E; Barzo, P; Beller, A; Berg, J; Bernard, A; Berry, K; Bertagnolli, D; Bickley, K; Bomben, J; Braun, T; Brouner, K; Buchin, A; Budzillo, A; Casper, T; Chartrand, T; Chong, P; Cobbs, C; Crichton, K; D'Orazi, F; Dalley, R; de Frates, R; de Kock, CPJ; de Witt Hamer, PC; Dee, N; Desta, T; Ding, SL; Dotson, N; Egdorf, T; Ellenbogen, RG; Enstrom, R; Esposito, L; Farrell, C; Feng, D; Ferreira, M; Fong, O; Furdan, S; Galakhova, AA; Gamlin, C; Gary, A; Glandon, A; Goldy, J; Gorham, M; Goriounova, NA; Gouwens, NW; Gratiy, S; Graybuck, L; Gu, H; Gwinn, RP; Hadley, K; Hansen, N; Hawrylycz, MJ; Heistek, TS; Henry, AM; Heyer, DB; Hill, C; Hill, D; Hodge, RD; Hof, PR; Hupp, M; Idema, S; Jarsky, T; Jones, AR; Kalmbach, B; Kebede, S; Keene, CD; Keene, L; Kim, L; Kim, MH; Ko, AL; Koch, C; Kroll, M; Latimer, C; Lee, BR; Lee, C; Lee, SD; Lein, ES; Levi, BP; Link, KE; Mallory, M; Mann, R; Mansvelder, HD; Marshall, D; Maxwell, M; McGraw, M; McMillen, D; Melief, E; Mertens, EJ; Mezei, L; Mihut, N; Miller, JA; Mok, S; Molnar, G; Mukora, A; Murphy, GJ; Ng, L; Ngo, K; Nicovich, PR; Nyhus, J; Ojemann, JG; Olah, G; Oldre, A; Omstead, V; Ozsvar, A; Park, D; Patel, AP; Peng, H; Pham, T; Phillips, JW; Pom, CA; Potekhina, L; Rajanbabu, R; Ransford, S; Reid, D; Rimorin, C; Ruiz, A; Sandman, D; Segev, I; Silbergeld, DL; Smith, K; Sorensen, SA; Sulc, J; Sunkin, SM; Szafer, A; Szemenyei, V; Tamas, G; Tasic, B; Thomsen, ER; Tieu, M; Ting, JT; Torkelson, A; Trinh, J; Tung, H; Wakeman, W; Waleboer, F; Ward, K; Wilbers, R; Williams, G; Yao, Z; Yoon, JG; Yuste, R; Zeng, H | 1 |
| Gadhavi, J; Gupta, S; Jain, A; Shah, S; Sinha, T | 1 |
| Acosta, DM; Bracken, C; Eliezer, D; Mancinelli, C | 1 |
| Assfalg, M; Barracchia, CG; Capaldi, S; D'Onofrio, M; Munari, F; Parolini, F; Tira, R | 1 |
| Bhatt, N; Bhuyan, A; Gaikwad, S; Garcia, S; Jerez, C; Kayed, R; McAllen, S; Montalbano, M; Puangmalai, N; Sengupta, U; Sonawane, M; Zhao, Y | 1 |
| Amatori, S; Auber, LA; Cantatore, F; Casciaro, F; Fanelli, M; Giorgio, M; Perna, A; Persico, G; Rusin, M | 1 |
| Cheng, J; Gao, J; Guan, F; He, L; Li, Q; Liao, Y; Liu, X; Pan, RY; Sun, L; Xing, Q; Yan, Y; Yuan, Z; Zhang, J; Zhou, X | 1 |
| Ávila-López, PA; Bellver-Sanchis, A; Brea Floriani, JM; Companys-Alemany, J; Griñán-Ferré, C; Malik, R; Martínez Rodríguez, AL; Pallàs, M; Pérez, B; Singh Choudhary, B | 1 |
| Abelein, A; Bascuñana, P; Baumann, M; Brackhan, M; Brüning, T; Calza, G; Kumar, R; Lalowski, M; Lundgren, K; Pahnke, J; Soliymani, R | 1 |
| Bae, J; Cha, MY; Choi, MS; Ha, S; Hwang, D; Hyeon, SJ; Jeong, H; Kang, M; Kim, DK; Kim, H; Kim, JI; Kim, YS; Lee, SW; Mook-Jung, I; Ryu, H; Shin, D; Suh, K; Yu, SW | 1 |
| Iga, JI; Mawatari, K; Mori, T; Nakayama, T; Numata, S; Ohmori, T; Ozaki, T; Shimizu, H; Tachibana, A; Takahashi, A; Ueno, SI; Yoshino, Y | 1 |
| Perugini, V; Santin, M | 1 |
| Igarashi, K; Kashiwagi, K; Mizoi, M; Sakamoto, A; Terui, Y; Uemura, T; Waragai, M; Yoshida, M | 1 |
| Cho, K; Hong, M; Jang, H; Jeon, YN; Jung, M; Kim, DH; Kim, MI; Kim, MS; Kim, NY; Lee, KH; Lee, SJ; Mun, YS; Na, DL; Pack, CG; Park, J; Shim, YL; Song, HL; Song, JA; Yoon, SY | 1 |
| Chai, GS; Gong, J; Jia, DD; Ma, RK; Nie, YJ; Sun, HX; Wu, JJ; Xu, YL; Yu, HT; Zhai, XR; Zhang, YQ; Zhao, P; Zhu, J | 1 |
| Bell, BM; Giasson, BI; Xia, Y | 1 |
| Balty, C; Boyer, E; Hanseeuw, BJ; Herinckx, G; Huyghe, NDG; Johanns, M; Kienlen-Campard, P; Kyalu Ngoie Zola, N; Pyr Dit Ruys, S; Rider, MH; Vanparys, AAT; Vertommen, D | 1 |
| Guo, J; Liu, H; Shah, SJA; Villà-Freixa, J; Zhang, Q | 1 |
| Alonso, AP; Cocuron, JC; Cooper, GL; Hoffman, CN; Huseby, CJ; Kuret, J; Thomas, SN; Yang, AJ | 1 |
| Legleiter, J; Nyman, M; Pilkington, AW; Schupp, J; Smith, DM; Valentine, SJ | 1 |
| Choi, S; Fica-Contreras, SM; Hedges, JS; Henning, NJ; Shuster, SO | 1 |
| Fujii, M; Michiba, H; Muguruma, K; Ode, Y; Pradipta, AR; Tanaka, K; Terashima, K | 1 |
| Haroutunian, V; Li, Y; Niu, M; Peng, J; Wang, H; Wu, Z; Yu, K; Zhang, B | 1 |
| Anderson, ET; Bhawal, R; Chen, H; Cross, AC; Gibson, GE; Haroutunian, V; Sun, L; Xu, H; Zhang, S | 1 |
| Akbarian, S; Crowley, CA; Dracheva, S; Geschwind, DH; Hu, B; Kassim, B; Kozlenkov, A; Li, Y; Mah, W; Park, RB; Pochareddy, S; Sestan, N; Spiess, K; Won, H | 1 |
| Ang, SRX; Han, JLT; Pang, KKL; Sajikumar, S; Sharma, M | 1 |
| Bichmann, M; Ehrnhoefer, DE; Ercan-Herbst, E; Gasparini, L; Gomez Ramos, B; Haberkant, P; Hu, C; Jin, L; Neu, M; Prat Oriol, N; Ried, JS; Schlüter, A; Schöndorf, DC; Schwärzler, V; Tian, Y; Wang, X | 1 |
| Ambadipudi, S; Biernat, J; Mandelkow, E; Riedel, D; Zweckstetter, M | 1 |
| Bowe, GJK; Choi, S; Durfee, ND; Fica-Contreras, SM; Henning, NJ; Hill, SA; Sandwick, RK; Shuster, SO; Stillman, DR; Suralik, KM; Vrla, GD | 1 |
| Chang, HW; Chen, CH; Hsu, IU; Kao, SH; Lee, CK; Lee, HM; Lin, CY; Lin, YF; Sheu, JJ; Tsai, IS; Wang, ST; Yang, LY | 1 |
| Bhasne, K; Jain, N; Mukhopadhyay, S; Sebastian, S | 1 |
| Kumar, D; Kumar, P | 1 |
| Cao, Q; Chen, GJ; Cheng, J; Lin, L; Liu, A; Ma, K; Matas, E; Wang, W; Wang, X; Wang, ZJ; Wei, J; Yan, Z; Zhang, F; Zheng, Y | 1 |
| Allison, JR; Birch, NP; Brimble, MA; Brooks, AES; Chang, K; Collier, T; Hickey, A; Kaur, H; Ng, J | 1 |
| Fülöp, T; Haddad, M; Landri, S; Lepage, A; Perrotte, M; Ramassamy, C | 1 |
| Biernat, J; Cima-Omori, MS; Dormann, D; Grieshop, MP; Hutten, S; Mandelkow, E; Rezaei-Ghaleh, N; Söding, J; Ukmar-Godec, T; Zweckstetter, M | 1 |
| Borghi, R; Monacelli, F; Odetti, P; Pacini, D; Serrati, C; Traverso, N | 1 |
| Ding, X; Duan, P; Hu, G; Lin, YJ; Liu, J; Qiao, Y; Tu, P; Wu, HP; Xu, R | 1 |
| Akagi, K; Irie, K; Katayama, S; Masuda, Y; Murakami, K; Nakagawa, Y; Sato, M; Takegoshi, K; Uno, M | 1 |
| Derreumaux, P; Li, MS; Ngo, ST; Nguyen, PH; Viet, MH | 1 |
| Sugiyama, A; Sun, J | 1 |
| Ahmadzadeh, A | 1 |
| Amininasab, M; Becker, S; Giller, K; Kumar, S; Rezaei-Ghaleh, N; Schneider, A; Stündl, A; Walter, J; Zweckstetter, M | 1 |
| Adame, A; Campioni, S; Gage, FH; Gerez, J; Jensen, PH; Mante, M; Masliah, E; Nuber, S; Overk, CR; Patrick, C; Picotti, P; Riek, R; Rockenstein, E; Trejo-Morales, M; Ubhi, K; Winkler, J; Winner, B | 1 |
| Wang, Y; Yan, R; Yang, H; Zeng, Q; Zhang, Z; Zhu, D | 1 |
| Ferrer, I; Heinsen, H; Hong, I; Kang, T; Kim, JH; Kwon, KH; Lee, JY; Park, N; Park, NH; Park, YM; Ravid, R; Yoo, JS | 1 |
| Becker, A; Beutel, T; Friedrichs, D; Henneberg, N; Justus, D; Kaneko, H; Pitsch, J; Remy, S; Schoch, S; Šišková, Z; von der Kammer, H | 1 |
| Borghi, R; Cammarata, S; Monacelli, F; Nencioni, A; Odetti, P; Piccini, A; Tabaton, M | 1 |
| Akkaya, BG; Bauer, B; Hartz, AM; Linton, KJ; Ritchie, TK; Sullivan, JA; Zolnerciks, JK | 1 |
| Ehrlich, D; Humpel, C; Kniewallner, KM; Marksteiner, J; Plagg, B | 1 |
| Jia, J; Li, D; Li, H; Qin, W; Wang, Q; Wu, L | 1 |
| Coleman, PD; Delvaux, E; Grover, A; Mastroeni, D; Nolz, J; Oddo, S; Tan, Y | 1 |
| Burnouf, S; Dols, J; Gorsky, MK; Mandelkow, E; Partridge, L | 1 |
| Choi, H; Hwang, YJ; Jung, ES; Kim, A; Mook-Jung, I; Ryu, H; Song, H | 1 |
| Kato, R; Kioka, N; Kobayashi, A; Matsuo, M; Michikawa, M; Remaley, AT; Sano, O; Shimizu, Y; Tsujita, M; Ueda, K | 1 |
| Cohen, TJ; Constance, BH; Hwang, AW; James, M; Yuan, CX | 1 |
| Gonzalez, J; Ramirez, J; Schwans, JP | 1 |
| Dimitrov, M; Fraering, PC; Garcia Osuna, GM; Gerber, H; Wu, F | 1 |
| Sarge, KD; Zhang, YQ | 1 |
| Bajaj, N; Bedford, L; Cavey, JR; Layfield, R; Lowe, J; Mayer, RJ; Paine, S; Sheppard, PW; Thorpe, JR | 1 |
| Escobedo, JO; Lim, S; Samoei, GK; Sibrian-Vazquez, M; Strongin, RM | 1 |
| Chichelli, T; Munschauer, F; Ostrow, P; Sternberg, Z; Vaughan, M | 1 |
| Cohen, TJ; Guo, JL; Hurtado, DE; Kwong, LK; Lee, VM; Mills, IP; Trojanowski, JQ | 1 |
| Chen, YG; Hao, PP; Wang, JL; Wang, XL; Zhang, Y | 1 |
| Casapullo, A; Margarucci, L; Monti, MC; Riccio, R; Tosco, A | 1 |
| Davies, P; Funk, KE; Kuret, J; Liao, Z; Thomas, SN; Wan, Y; Yang, AJ | 1 |
| Barnham, KJ; Hatsuta, H; Irie, K; Kaneko, T; Kinoshita, N; Murakami, K; Murata, N; Murayama, S; Noda, Y; Shimizu, T; Shirasawa, T; Tahara, S | 1 |
| Deng, Y; Lu, H; Qing, H; Song, W; Wang, R; Ying, Z; Zhang, Y; Zhao, J | 1 |
| Bonvicini, C; Bucossi, S; Manfellotto, D; Mariani, S; Migliore, S; Polimanti, R; Rossini, PM; Salustri, C; Squitti, R; Ventriglia, M; Vernieri, F | 1 |
| Barré, P; Eliezer, D; Huster, D; Künze, G; Scheidt, HA; Thomas, L | 1 |
| Attar, A; Bitan, G; Frautschy, SA; Gale, GD; Grassi, C; Hayes, J; Jones, MR; Klärner, FG; Li Puma, DD; Lichti-Kaiser, K; Liu, T; Maiti, P; Riccardi, E; Ripoli, C; Schrader, T; Straudinger, JL; Tan, M; Tseng, CH; Xie, CW; Yang, F | 1 |
| Baguet, A; Beher, D; Genoud, S; Hussain, I; Losberger, C; Ousson, S; Permanne, B; Saric, A; Vilbois, F | 1 |
| Dei, R; Horie, K; Inagaki, T; Li, M; Miyata, T; Nakagomi, Y; Niwa, H; Sobue, G; Takeda, A; Washimi, Y; Watanabe, M; Yasuda, Y | 1 |
| Chamson, A; Denis, C; Ferron, C; Frey, J; Gonthier, R; Laurent, B; Meli, M; Parssegny, F; Perier, C; Reynaud, E | 1 |
| Dickerson, TJ; Janda, KD | 1 |
| Brune, D; Liu, R; Paul, S; Planque, S; Rangan, SK; Sierks, MR | 1 |
| Castellani, RJ; Ghanbari, HA; Ghanbari, K; Harris, PL; Jones, PK; Kubat, Z; Perry, G; Smith, MA; Wolozin, BL | 1 |
| Cruz-Sánchez, CZ; Cruz-Sánchez, FF; Gironès, X; Guimerà, A; Kalaria, R; Lafuente, JV; Makita, Z; Ortega, A; Sasaki, N | 1 |
| Devreese, B; Fésüs, L; Nemes, Z; Steinert, PM; Van Beeumen, J | 1 |
| Ahmed, N; Ahmed, U; Fleischer, G; Hager, K; Münch, G; Thornalley, PJ | 1 |
| Berciano, J; Combarros, O; Fernández-Viadero, C; Infante, J; Llorca, J; Peña, N | 1 |
| Ayala, V; Bellmunt, MJ; Dalfó, E; Ferrer, I; Pamplona, R; Portero-Otín, M; Prat, J | 1 |
| Biernat, J; Griesinger, C; Mandelkow, E; Mukrasch, MD; von Bergen, M; Zweckstetter, M | 1 |
| Amarnath, V; Andreasson, KI; Boutaud, O; Masterson, TS; Montine, TJ; Oates, JA; Zagol-Ikapitte, I | 1 |
| Castellani, RJ; Moreira, PI; Nunomura, A; Perry, G; Smith, MA; Zhu, X | 1 |
| Abdel-Meguid, SS; Babine, RE; Jin, L; Navaneetham, D; Pandey, P; Strickler, JE; Walsh, PN | 1 |
| Chen, J; Chen, LF; Gan, L; Kwon, H; Mucke, L; Mueller-Steiner, S; Yi, S; Zhou, Y | 1 |
| Doe, N; Kitamura, Y; Matsuyama, S; Mori, H; Saito, N; Tanaka, C; Taniguchi, T | 1 |
| Schmitt, HP | 1 |
| Cripps, D; Davies, P; Jeng, Y; Thomas, SN; Yang, AJ; Yang, F | 1 |
| DeKosky, ST; Feingold, E; Kamboh, MI; Minster, RL; Sundar, PD | 1 |
| Boeras, DI; Crespo, NC; Granic, A; Padmanabhan, J; Potter, H; Rojiani, AM | 1 |
| Azmani, A; Bronner, IF; Heutink, P; Kamphorst, W; Ravid, R; Rizzu, P; Severijnen, LA; van Swieten, JC; Willemsen, R | 1 |
| de Silva, R; Hardy, J; Hulette, C; Lashley, T; Lees, A; Luk, C; Malzer, E; Momeni, P; Pittman, A; Revesz, T; Vandrovcova, J | 1 |
| Gliemann, J; Jensen, PH; Petersen, TE; Rasmussen, LK; Sørensen, ES | 1 |
| Dudek, SM; Johnson, GV | 1 |
| Avila, J; Bonay, P; Colaço, C; Ledesma, MD | 1 |
| Ikura, K; Sasaki, R; Takahata, K | 1 |
| Miyata, S; Monnier, VM; Perry, G; Richey, PL; Sayre, LM; Smith, MA; Stern, D; Taneda, S; Yan, SD | 1 |
| Felsenstein, KM; Ingalls, KM; Ripellino, JA; Robakis, NK; Roberts, SB | 1 |
| Farías, GA; Maccioni, RB; Vial, C | 1 |
| Horie, K; Kurokawa, K; Maeda, K; Miyata, T; Sobue, G; Takeda, A; Yasuda, T; Yasuda, Y | 1 |
| Mochizuki, Y; Oishi, M; Takasu, T | 1 |
| Doyu, M; Goto, Y; Horie, K; Inagaki, T; Maeda, K; Miyata, T; Sobue, G; Takeda, A; Wakai, M; Watanabe, M; Yasuda, T; Yasuda, Y | 1 |
| Birlouez-Aragon, I; Riviere, S; Vellas, B | 1 |
| Appelt, DM; Balin, BJ; Loewy, AG | 1 |
| Uchida, K | 1 |
| Angelini, G; Garibaldi, S; Marinelli, L; Menini, S; Norese, R; Odetti, P; Perry, G; Siedlak, S; Smith, MA; Tabaton, M; Traverso, N; Valentini, S; Zaccheo, D | 1 |
| Dei, R; Goto, Y; Inagaki, T; Li, M; Miyata, T; Nakagomi, Y; Niwa, H; Sobue, G; Takeda, A; Wakai, M; Watanabe, M; Yamamoto, M; Yasuda, T; Yasuda, Y | 1 |
| Barbour, R; Maltese, WA; McConlogue, L; Sinha, S; Suomensaari, S; Tan, Y; Wilson, S | 1 |
| Bayer, TA; Beher, D; Beyreuther, K; Hambsch, B; Hesse, L; Multhaup, G; Scheuermann, S; Schmidt, C; Stumm, J | 1 |
| Atwood, CS; Castellani, RJ; Founds, H; Fujii, J; Harris, PL; Perry, G; Sayre, LM; Smith, MA; Taniguchi, N; Vitek, MP | 1 |
| Anderson, JP; Chen, Y; Kim, KS; Robakis, NK | 1 |
| Gibson, AM; McDermott, JR | 1 |
| Pollock, NJ; Wood, JG | 1 |
5 review(s) available for lysine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry.
Topics: Acrolein; Alzheimer Disease; Autoimmune Diseases; Brain Diseases; Humans; Lysine; Polyamines; Proteins | 2020 |
Immunochemical detection of lipid hydroperoxide- and aldehyde-modified proteins in diseases.
Topics: Aldehydes; Alzheimer Disease; Fatty Acids, Unsaturated; Humans; Lipid Peroxidation; Lipid Peroxides; Lysine; Oxidative Stress; Parkinson Disease; Protein Processing, Post-Translational | 2014 |
Meta-analysis of aldehyde dehydrogenase 2 gene polymorphism and Alzheimer's disease in East Asians.
Topics: Aged; Aged, 80 and over; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Alzheimer Disease; Apolipoprotein E4; Asia, Eastern; Confidence Intervals; Databases, Bibliographic; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutamic Acid; Humans; Lysine; Male; Odds Ratio; Polymorphism, Single Nucleotide | 2011 |
Oxidative stress and neurodegeneration.
Topics: Aging; Alzheimer Disease; Glycation End Products, Advanced; Humans; Lysine; Nerve Degeneration; Oxidative Stress | 2005 |
Current status of acrolein as a lipid peroxidation product.
Topics: Acrolein; Air Pollutants; Aldehydes; Alzheimer Disease; Arteriosclerosis; Cross-Linking Reagents; Fatty Acids, Unsaturated; Glyoxal; Humans; Lipid Peroxidation; Lipid Peroxides; Lysine; Malondialdehyde; Oxidative Stress | 1999 |
1 trial(s) available for lysine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Effect of the Tottori familial disease mutation (D7N) on the monomers and dimers of Aβ40 and Aβ42.
Topics: Alzheimer Disease; Amination; Amyloid beta-Peptides; Asparagine; Aspartic Acid; Humans; Hydrogen-Ion Concentration; Lysine; Molecular Dynamics Simulation; Multiprotein Complexes; Mutation; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Static Electricity; Substrate Specificity; Up-Regulation | 2013 |
109 other study(ies) available for lysine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Human neocortical expansion involves glutamatergic neuron diversification.
Topics: Alzheimer Disease; Animals; Cell Shape; Collagen; Electrophysiology; Extracellular Matrix Proteins; Female; Glutamic Acid; Humans; Lysine; Male; Mice; Neocortex; Neurons; Patch-Clamp Techniques; Transcriptome | 2021 |
Charge neutralization of lysine via carbamylation reveals hidden aggregation hot-spots in tau protein flanking regions.
Topics: Alzheimer Disease; Amyloid; Humans; Lysine; Peptides; Protein Carbamylation; tau Proteins | 2022 |
Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation.
Topics: Alzheimer Disease; Humans; Lysine; Microtubules; Neurofibrillary Tangles; Phosphorylation; Protein Processing, Post-Translational; tau Proteins; Tubulin | 2022 |
Ubiquitination of Alzheimer's-related tau protein affects liquid-liquid phase separation in a site- and cofactor-dependent manner.
Topics: Alzheimer Disease; Humans; Lysine; tau Proteins; Ubiquitin; Ubiquitination | 2022 |
Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer's disease.
Topics: Alzheimer Disease; Cells, Cultured; Humans; Lysine; Neurons; tau Proteins; Tauopathies; Ubiquitin; Ubiquitination | 2022 |
Histone H3 Lysine 4 and 27 Trimethylation Landscape of Human Alzheimer's Disease.
Topics: Alzheimer Disease; Epigenesis, Genetic; Female; Histones; Humans; Lysine; Male; Methylation; Neurodegenerative Diseases; Promoter Regions, Genetic | 2022 |
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Feedback, Physiological; Glucose; Histones; Lysine; Mice; Mice, Transgenic; Microglia | 2022 |
Structure-Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti-Alzheimer's Agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine | 2022 |
Isotope-labeled amyloid-β does not transmit to the brain in a prion-like manner after peripheral administration.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Humans; Isotopes; Lysine; Mammals; Mice; Mice, Transgenic; Prions; Proteomics | 2022 |
Aβ-induced mitochondrial dysfunction in neural progenitors controls KDM5A to influence neuronal differentiation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Differentiation; Lysine; Mice; Mitochondria; Neurons; Proteome; Proteomics; Retinoblastoma-Binding Protein 2 | 2022 |
Metabolomic alterations in the blood plasma of older adults with mild cognitive impairment and Alzheimer's disease (from the Nakayama Study).
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Betaine; Biomarkers; Cognitive Dysfunction; Humans; Lysine; Ornithine; Plasma; RNA, Messenger; Thymine | 2022 |
The Real-Time Validation of the Effectiveness of Third-Generation Hyperbranched Poly(ɛ-lysine) Dendrons-Modified KLVFF Sequences to Bind Amyloid-β
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Humans; Lysine; Peptide Fragments; Spectrum Analysis | 2022 |
Urinary Amino Acid-Conjugated Acrolein and Taurine as New Biomarkers for Detection of Dementia.
Topics: Acrolein; Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Humans; Lysine; Quality of Life | 2023 |
Monoclonal antibody Y01 prevents tauopathy progression induced by lysine 280-acetylated tau in cell and mouse models.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Brain; Disease Models, Animal; Lysine; Mice; Neurodegenerative Diseases; tau Proteins; Tauopathies | 2023 |
Danggui Buxue decoction ameliorates mitochondrial biogenesis and cognitive deficits through upregulating histone H4 lysine 12 acetylation in APP/PS1 mice.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cognition; Disease Models, Animal; Histones; Lysine; Mice; Mice, Transgenic; Neurodegenerative Diseases; Organelle Biogenesis; Protein Processing, Post-Translational | 2023 |
Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation.
Topics: Alzheimer Disease; Frontotemporal Dementia; Humans; Lysine; Microtubules; Pick Disease of the Brain; Prions; tau Proteins; Tauopathies | 2023 |
Specific post-translational modifications of soluble tau protein distinguishes Alzheimer's disease and primary tauopathies.
Topics: Alzheimer Disease; Brain; Corticobasal Degeneration; Humans; Lysine; Pick Disease of the Brain; Protein Isoforms; Protein Processing, Post-Translational; tau Proteins; Tauopathies | 2023 |
Identification of Aggregation Mechanism of Acetylated PHF6* and PHF6 Tau Peptides Based on Molecular Dynamics Simulations and Markov State Modeling.
Topics: Alzheimer Disease; Humans; Lysine; Molecular Dynamics Simulation; Neurofibrillary Tangles; Peptides; Repressor Proteins; tau Proteins | 2023 |
Quantification of Tau Protein Lysine Methylation in Aging and Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Humans; Lysine; Male; Metabolomics; Methylation; Middle Aged; Phosphorylation; Protein Processing, Post-Translational; Proteomics; Tandem Mass Spectrometry; tau Proteins | 2019 |
Acetylation of Aβ
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Peptides; Animals; Lipid Bilayers; Lysine; Mice; Peptide Fragments; Protein Aggregation, Pathological | 2020 |
Comparison of the reaction of methylglyoxal (MGO) with murine and human amyloid beta (Aβ): Insights into a mechanism of Alzheimer's disease (AD).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arginine; Humans; Lysine; Mice; Peptide Fragments; Pyruvaldehyde; Superoxides | 2020 |
Global Profiling of Lysine Accessibility to Evaluate Protein Structure Changes in Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Brain Chemistry; Chromatography, Liquid; Humans; Indicators and Reagents; Lysine; Mice; Middle Aged; Nerve Tissue Proteins; Peptides; Protein Binding; Protein Conformation; Protein Processing, Post-Translational; Proteome; Specific Pathogen-Free Organisms; Specimen Handling; Structure-Activity Relationship; Tandem Mass Spectrometry; tau Proteins; Temperature; Time Factors | 2021 |
The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease.
Topics: Acetylation; Aged; Aged, 80 and over; Alzheimer Disease; Brain Chemistry; Computational Biology; Female; Glial Fibrillary Acidic Protein; Humans; Ketoglutarate Dehydrogenase Complex; Lysine; Male; Metabolome; Mitochondrial Proteins; Protein Processing, Post-Translational; Pyruvate Dehydrogenase Complex; Subcellular Fractions; tau Proteins | 2021 |
Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders.
Topics: Acetylation; Alzheimer Disease; Bipolar Disorder; Chromatin; Chromatin Immunoprecipitation Sequencing; Enhancer Elements, Genetic; Epigenesis, Genetic; GABAergic Neurons; Gene Expression Regulation; Genome-Wide Association Study; Histones; Humans; Lysine; Neuroglia; Neurons; Promoter Regions, Genetic; Schizophrenia | 2021 |
Inhibition of lysine methyltransferase G9a/GLP reinstates long-term synaptic plasticity and synaptic tagging/capture by facilitating protein synthesis in the hippocampal CA1 area of APP/PS1 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; CA1 Region, Hippocampal; Histone-Lysine N-Methyltransferase; Lysine; Methyltransferases; Mice; Neuronal Plasticity; Synapses | 2021 |
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Mice; Mice, Transgenic; Protein Processing, Post-Translational; tau Proteins | 2021 |
Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.
Topics: Alternative Splicing; Alzheimer Disease; Amino Acid Sequence; Brain; Humans; Lysine; Magnetic Resonance Spectroscopy; Microscopy, Confocal; Microtubules; Phosphorylation; Protein Aggregation, Pathological; Protein Binding; Protein Isoforms; tau Proteins | 2017 |
Glycation of Lys-16 and Arg-5 in amyloid-β and the presence of Cu
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Arginine; Copper; Cytochromes c; Deoxyguanine Nucleotides; DNA Damage; Glycosylation; Guanosine Monophosphate; Lysine; Models, Molecular; Oxidation-Reduction; Oxidative Stress; Protein Conformation | 2017 |
Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141-147 in Taiwanese with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antibody Specificity; Apolipoprotein A-I; Autoantibodies; Autoimmunity; Biomarkers; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Glycation End Products, Advanced; Humans; Immunoglobulin M; Lysine; Male; Peptide Fragments; Protein Processing, Post-Translational; Psychiatric Status Rating Scales; ROC Curve; Taiwan; Up-Regulation | 2018 |
Synergistic Amyloid Switch Triggered by Early Heterotypic Oligomerization of Intrinsically Disordered α-Synuclein and Tau.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid; Humans; Lysine; Models, Molecular; Parkinson Disease; Protein Aggregates; Protein Conformation; Protein Folding; Spectrometry, Fluorescence; tau Proteins | 2018 |
An In-Silico Investigation of Key Lysine Residues and Their Selection for Clearing off Aβ and Holo-AβPP Through Ubiquitination.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Apolipoproteins E; Computer Simulation; Databases, Protein; Humans; Lysine; Neurodegenerative Diseases; Neurons; Static Electricity; tau Proteins; Ubiquitin; Ubiquitination | 2019 |
Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Chromosome Deletion; Cognition; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Hippocampus; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Memory Disorders; Methylation; Mice; Mice, Transgenic; Prefrontal Cortex; Synapses | 2019 |
Site-specific glycation of Aβ1-42 affects fibril formation and is neurotoxic.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Apoptosis; Cell Line, Tumor; Glycosylation; Humans; Lysine; Membrane Potential, Mitochondrial; Mitochondria; Peptide Fragments; Protein Aggregates; Protein Conformation, beta-Strand; Protein Stability; Singlet Oxygen | 2019 |
Circulating and Extracellular Vesicles Levels of N-(1-Carboxymethyl)-L-Lysine (CML) Differentiate Early to Moderate Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Biomarkers; Cell Line; Diagnosis, Differential; Disease Progression; Extracellular Vesicles; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Mental Status and Dementia Tests; Neurons | 2019 |
Lysine/RNA-interactions drive and regulate biomolecular condensation.
Topics: Acetylation; Alzheimer Disease; Cell Line; Cytoplasmic Granules; Humans; Lysine; RNA; tau Proteins | 2019 |
Pentosidine determination in CSF: a potential biomarker of Alzheimer's disease?
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lysine; Male; Middle Aged; Peptide Fragments | 2014 |
Rhein lysinate decreases the generation of β-amyloid in the brain tissues of Alzheimer's disease model mice by inhibiting inflammatory response and oxidative stress.
Topics: Aging; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anthraquinones; Brain; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Glutathione Peroxidase; Interleukin-6; Lysine; Male; Malondialdehyde; Mice; Oxidative Stress; Sirtuin 1; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2013 |
Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Catechols; Humans; Lysine; Norleucine; Peptide Fragments; Quercetin | 2013 |
Papaverine increases human serum albumin glycation.
Topics: Alzheimer Disease; Glucose; Glycosylation; Humans; Lysine; Papaverine; Protein Binding; Protein Structure, Secondary; Serum Albumin; Temperature | 2014 |
Turn plasticity distinguishes different modes of amyloid-β aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Lysine; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Phosphorylation; Protein Stability; Protein Structure, Secondary | 2014 |
Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.
Topics: alpha-Synuclein; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Gene Expression Regulation; Glutamic Acid; Humans; Lewy Body Disease; Lysine; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Synapses; Thy-1 Antigens | 2014 |
Efficient strategy for maintaining and enhancing the huperzine A production of Shiraia sp. Slf14 through inducer elicitation.
Topics: Alkaloids; Alzheimer Disease; Ascomycota; Cell Extracts; Endophytes; Fermentation; Huperzia; Lysine; Microbial Viability; Secondary Metabolism; Sesquiterpenes | 2014 |
Large-scale analysis of posttranslational modifications in the hippocampus of patients with Alzheimer's disease using pI shift and label-free quantification without enrichment.
Topics: Age Factors; Aged; Aged, 80 and over; Aldehyde Dehydrogenase; Alzheimer Disease; Apoferritins; Hippocampus; Humans; Hydrogen-Ion Concentration; Isoelectric Focusing; L-Aminoadipate-Semialdehyde Dehydrogenase; Lysine; Middle Aged; Neoplasm Proteins; Peptides; Phosphorylation; Protein Processing, Post-Translational; Tandem Mass Spectrometry; Trypsin; Ubiquitin | 2014 |
Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer's disease.
Topics: Action Potentials; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Computer Simulation; Dendrites; Disease Models, Animal; Electric Stimulation; Female; Hippocampus; Humans; In Vitro Techniques; Lysine; Male; Mice; Mice, Transgenic; Models, Neurological; Mutation; Nerve Degeneration; Neurons; Presenilin-1 | 2014 |
Amnestic mild cognitive impairment and conversion to Alzheimer's disease: insulin resistance and glycoxidation as early biomarker clusters.
Topics: Aged; Alzheimer Disease; Arginine; Blood Glucose; Case-Control Studies; Cognitive Dysfunction; Disease Progression; Female; Humans; Insulin; Insulin Resistance; Lysine; Male; Malondialdehyde; Neuropsychological Tests; Psychiatric Status Rating Scales; Statistics as Topic | 2015 |
The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Blood-Brain Barrier; Brain; Endosomal Sorting Complexes Required for Transport; HEK293 Cells; Humans; Lysine; Mice; Mice, Transgenic; Models, Molecular; Nedd4 Ubiquitin Protein Ligases; Protein Structure, Secondary; Protein Structure, Tertiary; Sf9 Cells; Ubiquitin-Protein Ligases | 2015 |
Increased Acetylation of Histone H4 at Lysine 12 (H4K12) in Monocytes of Transgenic Alzheimer's Mice and in Human Patients.
Topics: Acetylation; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Cell Death; Cognitive Dysfunction; Cytokines; Disease Models, Animal; Female; Flow Cytometry; Histones; Humans; Lysine; Male; Mice; Mice, Transgenic; Monocytes; Mutation; Presenilin-1; tau Proteins | 2015 |
A Novel AβPP M722K Mutation Affects Amyloid-β Secretion and Tau Phosphorylation and May Cause Early-Onset Familial Alzheimer's Disease in Chinese Individuals.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Asian People; Cell Line, Tumor; Exons; Female; Humans; Lysine; Male; Methionine; Mice; Middle Aged; Mutation; Neuroblastoma; Phosphorylation; tau Proteins | 2015 |
Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Epigenesis, Genetic; Female; Gene Expression; Histones; Humans; Lysine; Male; Methylation; Middle Aged; Transcription, Genetic; Transcriptional Activation | 2015 |
Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.
Topics: Acetylation; Alzheimer Disease; Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila; Female; Humans; Lysine; Neurotoxins; Protein Aggregation, Pathological; Protein Processing, Post-Translational; tau Proteins | 2016 |
p53-dependent SIRT6 expression protects Aβ42-induced DNA damage.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anthracenes; Brain; Cell Line; DNA Damage; Down-Regulation; HCT116 Cells; Histones; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lysine; Mice; Mice, Transgenic; Piperazines; Protein Kinase Inhibitors; Rats, Sprague-Dawley; Sirtuins; Tumor Suppressor Protein p53 | 2016 |
ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; ATP Binding Cassette Transporter, Subfamily G; ATP Binding Cassette Transporter, Subfamily G, Member 1; Caveolin 1; Cell Line, Tumor; Cell Membrane; Gene Silencing; HEK293 Cells; Humans; Lysine; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; RNA Interference | 2016 |
Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation.
Topics: Acetylation; Alzheimer Disease; Antibodies; Brain; Calpain; Catalysis; Humans; Lysine; Mass Spectrometry; Microtubules; Phosphorylation; Proline; Protein Binding; Protein Domains; Protein Isoforms; Protein Processing, Post-Translational; Proteolysis; Recombinant Proteins; tau Proteins; Tauopathies | 2016 |
Evaluating Fmoc-amino acids as selective inhibitors of butyrylcholinesterase.
Topics: Acetylcholinesterase; Alzheimer Disease; Amino Acids; Butyrylcholinesterase; Cholinesterase Inhibitors; Fluorenes; Humans; Leucine; Lysine; Protein Binding; Tryptophan | 2016 |
Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Brain; Cell-Free System; Copper; HEK293 Cells; Histidine; Humans; Inhibitory Concentration 50; Lipid Bilayers; Lysine; Membrane Glycoproteins; Mutation; Peptide Fragments; Plasmids; Presenilins; Protein Domains; Protein Multimerization; Recombinant Proteins; Zinc | 2017 |
Sumoylation of amyloid precursor protein negatively regulates Abeta aggregate levels.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Endoplasmic Reticulum; HeLa Cells; Humans; Lysine; Protein Processing, Post-Translational; Small Ubiquitin-Related Modifier Proteins; Transfection; Ubiquitin-Conjugating Enzymes | 2008 |
Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration.
Topics: Alzheimer Disease; Animals; Brain; Humans; Huntington Disease; Immunohistochemistry; Lewy Bodies; Lysine; Mice; Neurodegenerative Diseases; Neurons; Parkinson Disease; Polyubiquitin; Proteasome Endopeptidase Complex | 2009 |
Homocystamides promote free-radical and oxidative damage to proteins.
Topics: Alzheimer Disease; Cardiovascular Diseases; Congenital Abnormalities; Free Radicals; Homocysteine; Humans; Hydrogen Bonding; Kinetics; Lysine; Osteoporosis; Oxidative Stress; Protein Processing, Post-Translational; Renal Insufficiency; Serum Albumin | 2010 |
AGE-RAGE in multiple sclerosis brain.
Topics: Adult; Alzheimer Disease; Brain; Case-Control Studies; Female; Gene Expression Regulation; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Multiple Sclerosis; Pilot Projects; Receptor for Advanced Glycation End Products; Receptors, Immunologic | 2011 |
The acetylation of tau inhibits its function and promotes pathological tau aggregation.
Topics: Acetylation; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Brain; Female; HEK293 Cells; Humans; Immunohistochemistry; Lysine; Male; Mass Spectrometry; Membrane Proteins; Mice; Mice, Transgenic; Microtomy; Microtubules; Middle Aged; Neurons; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Recombinant Proteins; Transfection | 2011 |
New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component.
Topics: Aldehydes; Alzheimer Disease; Cyclopentane Monoterpenes; Lysine; Mass Spectrometry; Olive Oil; Peptide Fragments; Phenols; Plant Oils; Propylamines; Schiff Bases; tau Proteins | 2011 |
Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Female; Humans; Lysine; Male; Methylation; Middle Aged; Molecular Sequence Data; Neurofibrillary Tangles; Phosphorylation; Protein Processing, Post-Translational; Tandem Mass Spectrometry; tau Proteins; Ubiquitination | 2012 |
SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Enzyme Activation; Glycation End Products, Advanced; Humans; Inflammation; Lysine; Memory Disorders; Mice; Mice, Knockout; Neurons; Oxidation-Reduction; Protein Multimerization; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides | 2011 |
Lys(203) and Lys(382) are essential for the proteasomal degradation of BACE1.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Codon; DNA, Complementary; HEK293 Cells; Humans; Lysine; Mutagenesis, Site-Directed; Ubiquitination | 2012 |
Association of K832R and R952K SNPs of Wilson's disease gene with Alzheimer's disease.
Topics: Adenosine Triphosphatases; Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Cation Transport Proteins; Copper-Transporting ATPases; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Logistic Models; Lysine; Male; Middle Aged; Polymorphism, Single Nucleotide | 2012 |
Binding of the three-repeat domain of tau to phospholipid membranes induces an aggregated-like state of the protein.
Topics: Alzheimer Disease; Amino Acid Sequence; Benzothiazoles; Biophysics; Circular Dichroism; Humans; Lipid Bilayers; Lipids; Liposomes; Lysine; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Phosphatidylcholines; Phosphatidylserines; Phospholipids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Static Electricity; tau Proteins; Thiazoles; Unilamellar Liposomes | 2012 |
Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antiparasitic Agents; Blood-Testis Barrier; Brain; Cells, Cultured; Cytochrome P-450 Enzyme System; Dendritic Spines; Disease Models, Animal; Electric Stimulation; Exploratory Behavior; Long-Term Potentiation; Lysine; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Neurons; Protein Isoforms; Synaptic Transmission; tau Proteins | 2012 |
Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Binding Sites; Enzyme Activation; HEK293 Cells; Humans; Leucine; Lysine; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Protein Structure, Tertiary; Substrate Specificity | 2013 |
Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's disease.
Topics: Adolescent; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lipid Peroxidation; Lysine; Male; Malondialdehyde; Neuroglia; Neurons; Oxidative Stress | 2002 |
Serum pentosidine as an indicator of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Arginine; Biomarkers; Chromatography, High Pressure Liquid; Female; Humans; Lysine; Male; Predictive Value of Tests; Reference Values; Serum Albumin | 2002 |
Glycation of the amyloid beta-protein by a nicotine metabolite: a fortuitous chemical dynamic between smoking and Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Amyloid beta-Peptides; Glucose; Glycosylation; Humans; Lysine; Molecular Sequence Data; Neuroprotective Agents; Nicotine; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Peptide Fragments; Smoking; Solubility | 2003 |
Degradation of beta-amyloid by proteolytic antibody light chains.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Antibodies, Monoclonal; Aspartic Acid Endopeptidases; Carboxypeptidases; Catalysis; Chromogenic Compounds; Endopeptidases; Humans; Hydrolysis; Immunoglobulin Fragments; Immunoglobulin Light Chains; Kinetics; Lysine; Mass Spectrometry; Mice; Peptide Fragments; Substrate Specificity | 2003 |
Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients.
Topics: Aldehydes; Alzheimer Disease; Cell Line; Cells, Cultured; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Immunohistochemistry; Lipid Peroxidation; Lysine; Membrane Proteins; Neurons; Olfactory Mucosa; Oxidative Stress | 2004 |
N epsilon-carboxymethyllysine in brain aging, diabetes mellitus, and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Cytoplasm; Diabetes Mellitus; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; tau Proteins | 2004 |
Cross-linking of ubiquitin, HSP27, parkin, and alpha-synuclein by gamma-glutamyl-epsilon-lysine bonds in Alzheimer's neurofibrillary tangles.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Dipeptides; Enzyme-Linked Immunosorbent Assay; Female; Glutamine; Heat-Shock Proteins; Hippocampus; HSP27 Heat-Shock Proteins; Humans; Inclusion Bodies; Lysine; Macromolecular Substances; Male; Molecular Chaperones; Neoplasm Proteins; Nerve Tissue Proteins; Neurofibrillary Tangles; Neurofilament Proteins; Plaque, Amyloid; Proteasome Endopeptidase Complex; Solubility; Synucleins; tau Proteins; Ubiquitin; Ubiquitin-Protein Ligases | 2004 |
Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment.
Topics: Aged; Alzheimer Disease; Biomarkers; Cerebrospinal Fluid Proteins; Cognition Disorders; Female; Glycosylation; Humans; Lysine; Male; Neuropsychological Tests; Nitrates; Nitroso Compounds; Oxidation-Reduction; Reference Values; Tyrosine | 2005 |
Interaction between interleukin-6 and intercellular adhesion molecule-1 genes and Alzheimer's disease risk.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chi-Square Distribution; Confidence Intervals; Female; Genotype; Glutamic Acid; Humans; Intercellular Adhesion Molecule-1; Interleukin-6; Lysine; Male; Meta-Analysis as Topic; Middle Aged; Odds Ratio; Polymorphism, Genetic; Risk | 2005 |
Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blotting, Western; Brain; Carbon; Cerebral Cortex; Databases as Topic; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Fatty Acids; Fatty Acids, Unsaturated; Female; Glial Fibrillary Acidic Protein; Glycation End Products, Advanced; Glycolysis; Humans; Lipid Metabolism; Lipid Peroxidation; Lysine; Male; Malondialdehyde; NADH Dehydrogenase; Oxygen; Phenylhydrazines; Proteins; Silver Staining; Ubiquinone | 2005 |
Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Anions; Brain; Crystallography, X-Ray; Electrophoresis, Polyacrylamide Gel; Humans; Lysine; Magnetic Resonance Spectroscopy; Microtubules; Molecular Sequence Data; Mutation; Neurofibrillary Tangles; Polyelectrolytes; Polymers; Protein Binding; Protein Folding; Protein Isoforms; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Swine; tau Proteins; Temperature; Tubulin | 2005 |
Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Case-Control Studies; Hippocampus; Humans; Lactams; Lysine; Nerve Tissue Proteins; Prostaglandin H2; Prostaglandins E; Severity of Illness Index | 2005 |
Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2.
Topics: Alanine; Alzheimer Disease; Arginine; Binding Sites; Carrier Proteins; Catalytic Domain; Crystallography, X-Ray; Disulfides; DNA Mutational Analysis; Dose-Response Relationship, Drug; Factor XIa; Humans; Inhibitory Concentration 50; Kinetics; Lysine; Models, Molecular; Models, Statistical; Mutation; Partial Thromboplastin Time; Phenylalanine; Plasmids; Point Mutation; Proline; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Recombinant Proteins; Serine; Serine Proteinase Inhibitors; Structure-Activity Relationship; Thromboplastin; Time Factors; Vesicular Transport Proteins | 2005 |
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Bromodeoxyuridine; Cells, Cultured; Genes, Reporter; Genetic Vectors; Green Fluorescent Proteins; Humans; Immunohistochemistry; Lentivirus; Lysine; Microglia; Microscopy, Fluorescence; Models, Biological; Models, Genetic; Neurons; NF-kappa B; Rats; Rats, Sprague-Dawley; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sirtuin 1; Sirtuins; Stilbenes | 2005 |
Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation.
Topics: Alzheimer Disease; Animals; Asparagine; Avoidance Learning; Chromosomes, Human, Pair 17; Cognition Disorders; Disease Models, Animal; Hippocampus; Humans; Lysine; Maze Learning; Mice; Mice, Transgenic; Mutation, Missense; Nerve Tissue Proteins; Neurofibrillary Tangles; Phosphorylation; tau Proteins | 2005 |
epsilon-Glycation, APP and Abeta in ageing and Alzheimer disease: a hypothesis.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Glycation End Products, Advanced; Humans; Lysine; Models, Neurological | 2006 |
Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.
Topics: Algorithms; Alzheimer Disease; Amino Acid Sequence; Chromatography, Liquid; Humans; Immunoblotting; Immunoprecipitation; Lysine; Mass Spectrometry; Molecular Sequence Data; Nerve Degeneration; Neurofibrillary Tangles; Peptides; Phosphorylation; Proteasome Endopeptidase Complex; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine; Solvents; tau Proteins; Threonine; Trypsin; Ubiquitin | 2006 |
Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's disease.
Topics: Adaptor Proteins, Signal Transducing; Aged; Alzheimer Disease; Apolipoprotein E4; Arginine; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Autophagy-Related Proteins; Carrier Proteins; Cell Cycle Proteins; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Logistic Models; Lysine; Male; Polymorphism, Genetic; Sex Characteristics | 2007 |
Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy.
Topics: Alzheimer Disease; Aneuploidy; Animals; Cells, Cultured; Chromosome Segregation; Humans; Lysine; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurons; Platelet-Derived Growth Factor; Presenilin-1; Spindle Apparatus; Spleen; Transfection; Valine | 2008 |
The DeltaK280 mutation in MAP tau favors exon 10 skipping in vivo.
Topics: Alzheimer Disease; Blotting, Western; Brain; Dementia; Exons; Female; Humans; Immunohistochemistry; Lysine; Microscopy, Electron, Transmission; Middle Aged; Molecular Weight; Mutation; Neurons; Serine; tau Proteins; Trinucleotide Repeat Expansion | 2007 |
Clinical and pathological features of an Alzheimer's disease patient with the MAPT Delta K280 mutation.
Topics: Aged, 80 and over; Alzheimer Disease; Codon; Exons; Gene Deletion; Humans; Lysine; Male; Microtubule-Associated Proteins; Protein Structure, Tertiary; Repetitive Sequences, Amino Acid; tau Proteins | 2009 |
Identification of glutamine and lysine residues in Alzheimer amyloid beta A4 peptide responsible for transglutaminase-catalysed homopolymerization and cross-linking to alpha 2M receptor.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Binding Sites; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Extracellular Matrix Proteins; Glutamine; Low Density Lipoprotein Receptor-Related Protein-1; Lysine; Molecular Sequence Data; Polymers; Receptors, Immunologic; Structure-Activity Relationship; Transglutaminases | 1994 |
Transglutaminase facilitates the formation of polymers of the beta-amyloid peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Glycine; Humans; Lysine; Mutation; Transglutaminases | 1994 |
Analysis of microtubule-associated protein tau glycation in paired helical filaments.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Animals; Brain Chemistry; Cattle; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Lysine; Microtubules; Molecular Sequence Data; Neurofibrillary Tangles; Protein Binding; tau Proteins | 1994 |
Cross-linking of a synthetic partial-length (1-28) peptide of the Alzheimer beta/A4 amyloid protein by transglutaminase.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Glutamine; Humans; Lysine; Molecular Sequence Data; Peptide Fragments; Transglutaminases | 1993 |
Advanced Maillard reaction end products are associated with Alzheimer disease pathology.
Topics: Alzheimer Disease; Arginine; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Hippocampus; Humans; Immunoenzyme Techniques; Lysine; Maillard Reaction; Neurofibrillary Tangles; Norleucine; Pyrroles | 1994 |
Non-amyloidogenic cleavage of the beta-amyloid precursor protein by an integral membrane metalloendopeptidase.
Topics: Alkaline Phosphatase; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Cell Line; Cell Membrane; Detergents; Enzyme Stability; Glioma; Humans; Kinetics; Lysine; Metalloendopeptidases; Models, Biological; Protease Inhibitors; Protein Processing, Post-Translational; Substrate Specificity; Transfection; Tumor Cells, Cultured | 1994 |
Functional domains on chemically modified tau protein.
Topics: Acylation; Alzheimer Disease; Animals; Cattle; Humans; Lysine; Microscopy, Electron; Microtubules; Neurofibrillary Tangles; Peptide Fragments; Polymers; Protein Structure, Tertiary; tau Proteins; Tubulin | 1993 |
Immunohistochemical localization of advanced glycation end products, pentosidine, and carboxymethyllysine in lipofuscin pigments of Alzheimer's disease and aged neurons.
Topics: Adolescent; Aged; Aging; Alzheimer Disease; Arginine; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lipofuscin; Lysine; Nerve Degeneration; Nerve Tissue Proteins; Neurons | 1997 |
Correlations between P300 components and neurotransmitters in the cerebrospinal fluid.
Topics: 3-Methoxy-4-hydroxyphenylethanol; Aged; Aged, 80 and over; Alzheimer Disease; Dementia, Vascular; Event-Related Potentials, P300; Humans; Lysine; Middle Aged; Neurotransmitter Agents; Norepinephrine; Tyrosine | 1998 |
Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arginine; Astrocytes; Cytoplasmic Granules; Extracellular Space; Glycoconjugates; Hippocampus; Humans; Lysine; Microglia; Staining and Labeling | 1998 |
Plasma protein glycation in Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Blood Glucose; Blood Proteins; Diabetes Mellitus, Type 1; Female; Glycation End Products, Advanced; Glycosylation; Humans; Lysine; Male; Middle Aged | 1998 |
Analysis of transglutaminase-catalyzed isopeptide bonds in paired helical filaments and neurofibrillary tangles from Alzheimer's disease.
Topics: Alzheimer Disease; Bacillus cereus; Brain; Carbon-Nitrogen Lyases; Caseins; Catalysis; Cross-Linking Reagents; Humans; Lysine; Neurofibrillary Tangles; Transglutaminases | 1999 |
Lipoperoxidation is selectively involved in progressive supranuclear palsy.
Topics: Aged; Aldehydes; Alzheimer Disease; Arginine; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lipid Peroxides; Lysine; Mesencephalon; Middle Aged; Norleucine; Pyrroles; Reference Values; Supranuclear Palsy, Progressive; tau Proteins; Thiobarbituric Acid Reactive Substances | 2000 |
Neuronal and glial advanced glycation end product [Nepsilon-(carboxymethyl)lysine]] in Alzheimer's disease brains.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Neuroglia; Neurons | 2001 |
Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide.
Topics: Alzheimer Disease; Amino Acid Motifs; Amyloid beta-Protein Precursor; Endoplasmic Reticulum; Golgi Apparatus; Humans; Lysine; Peptide Fragments; Subcellular Fractions | 2001 |
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Binding Sites; Blotting, Western; Cell Membrane; Chromatography, Gel; Collagen; COS Cells; Cross-Linking Reagents; Cysteine; Dimerization; Disulfides; Humans; Immunoblotting; Lysine; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Signal Transduction; Transfection; Tumor Cells, Cultured | 2001 |
Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Free Radicals; Glycation End Products, Advanced; Glycosylation; Humans; Lysine; Middle Aged; Neurofibrillary Tangles | 2001 |
An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Humans; Immunoblotting; Kidney; Leucine; Lysine; Molecular Sequence Data; PC12 Cells; Rats; Transfection | 1992 |
The processing of Alzheimer A4/beta-amyloid protein precursor: identification of a human brain metallopeptidase which cleaves -Lys-Leu- in a model peptide.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Brain; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Kinetics; Leucine; Lysine; Metalloendopeptidases; Molecular Sequence Data; Peptides; Protein Processing, Post-Translational; Substrate Specificity | 1991 |
Differential sensitivity of the microtubule-associated protein, tau, in Alzheimer's disease tissue to formalin fixation.
Topics: Alzheimer Disease; Axons; Densitometry; Fixatives; Formaldehyde; Humans; Immunoassay; Immunohistochemistry; Lysine; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurofibrils; Periodic Acid; tau Proteins | 1988 |