lysergic acid diethylamide has been researched along with Depression, Endogenous in 21 studies
Lysergic Acid Diethylamide: Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is a potent hallucinogen, but the mechanisms of that effect are not well understood.
lysergic acid diethylamide : An ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two adolescents with a long history of abuse of lysergic acid diethylamide (LSD) and symptoms consistent with major depressive disorder, on initiation of antidepressant therapy with selective serotonin reuptake inhibitor agents, had the new onset or worsening of LSD flashback syndrome." | 3.69 | LSD flashback syndrome exacerbated by selective serotonin reuptake inhibitor antidepressants in adolescents. ( Domino, EF; Holmes, RD; Lee, A; Markel, H, 1994) |
| "To determine how differences in the type of psychedelic agent used and the number of dosing sessions administered affect subjects' depression and anxiety outcomes and adverse drug reactions (ADR)." | 2.82 | Assessing the effects of methodological differences on outcomes in the use of psychedelics in the treatment of anxiety and depressive disorders: A systematic review and meta-analysis. ( Leger, RF; Unterwald, EM, 2022) |
| " Although several pharmacological treatments are available, they are not effective for a significant proportion of patients and are associated with several adverse reactions." | 2.58 | Efficacy, tolerability, and safety of serotonergic psychedelics for the management of mood, anxiety, and substance-use disorders: a systematic review of systematic reviews. ( Alcázar-Córcoles, MÁ; Bouso, JC; Dos Santos, RG; Hallak, JEC, 2018) |
| " Furthermore, most currently available medications need several weeks to achieve therapeutic effects, and the long-term use of these drugs is often associated with significant unwanted side effects and resultant reductions in treatment compliance." | 1.62 | Hallucinogenic/psychedelic 5HT2A receptor agonists as rapid antidepressant therapeutics: Evidence and mechanisms of action. ( Baker, G; Dos Santos, RG; Dursun, S; Hallak, JE, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (33.33) | 18.7374 |
| 1990's | 6 (28.57) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Leger, RF | 1 |
| Unterwald, EM | 1 |
| Dos Santos, RG | 2 |
| Hallak, JE | 1 |
| Baker, G | 1 |
| Dursun, S | 1 |
| Nichols, DE | 1 |
| Bouso, JC | 1 |
| Alcázar-Córcoles, MÁ | 1 |
| Hallak, JEC | 1 |
| Kvam, TM | 1 |
| Stewart, LH | 1 |
| Andreassen, OA | 1 |
| Muttoni, S | 1 |
| Ardissino, M | 1 |
| John, C | 1 |
| KENNA, JC | 2 |
| SEDMAN, G | 2 |
| LISS, L | 1 |
| SOLZE, DA | 1 |
| FISCHER, R | 1 |
| Knudsen, K | 1 |
| SAVAGE, C | 1 |
| Snyder, SH | 1 |
| Peroutka, SJ | 1 |
| Sheline, YI | 1 |
| Black, KJ | 1 |
| Bardgett, ME | 1 |
| Csernansky, JG | 1 |
| Hrdina, PD | 2 |
| Bakish, D | 2 |
| Chudzik, J | 2 |
| Ravindran, A | 2 |
| Lapierre, YD | 1 |
| Markel, H | 1 |
| Lee, A | 1 |
| Holmes, RD | 1 |
| Domino, EF | 1 |
| Pandey, SC | 2 |
| Kim, SW | 1 |
| Davis, JM | 2 |
| Pandey, GN | 2 |
| Cavazzoni, P | 1 |
| Stain-Malmgren, R | 1 |
| Khoury, AE | 1 |
| Aberg-Wistedt, A | 1 |
| Tham, A | 1 |
| Niswender, CM | 1 |
| Herrick-Davis, K | 1 |
| Dilley, GE | 1 |
| Meltzer, HY | 2 |
| Overholser, JC | 1 |
| Stockmeier, CA | 1 |
| Emeson, RB | 1 |
| Sanders-Bush, E | 1 |
| Janicak, PG | 1 |
| Marks, RC | 1 |
| Arora, RC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Trial of Visual Healing®, a Nature-themed Virtual Immersive Experience, to Optimize Set and Setting in Psilocybin-assisted Therapy for Alcohol Use Disorder[NCT04410913] | Phase 2 | 20 participants (Actual) | Interventional | 2021-02-18 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for lysergic acid diethylamide and Depression, Endogenous
| Article | Year |
|---|---|
Assessing the effects of methodological differences on outcomes in the use of psychedelics in the treatment of anxiety and depressive disorders: A systematic review and meta-analysis.
Topics: Affect; Anxiety Disorders; Banisteriopsis; Depressive Disorder; Hallucinogens; Humans; Lysergic Acid | 2022 |
Dark Classics in Chemical Neuroscience: Lysergic Acid Diethylamide (LSD).
Topics: Anxiety Disorders; Depressive Disorder; Drug and Narcotic Control; Europe; Hallucinogens; History, 2 | 2018 |
Efficacy, tolerability, and safety of serotonergic psychedelics for the management of mood, anxiety, and substance-use disorders: a systematic review of systematic reviews.
Topics: Anxiety Disorders; Banisteriopsis; Depressive Disorder; Hallucinogens; Humans; Lysergic Acid Diethyl | 2018 |
Psychedelic drugs in the treatment of anxiety, depression and addiction.
Topics: Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Hallucinogens; Humans; Lysergic Acid Di | 2018 |
Classical psychedelics for the treatment of depression and anxiety: A systematic review.
Topics: Adult; Anxiety Disorders; Depressive Disorder; Female; Hallucinogens; Humans; Lysergic Acid Diethyla | 2019 |
Platelet serotonin-2 receptors in obsessive-compulsive disorder.
Topics: Adult; Binding Sites; Depressive Disorder; Female; Humans; Lysergic Acid Diethylamide; Male; Obsessi | 1993 |
4 trials available for lysergic acid diethylamide and Depression, Endogenous
| Article | Year |
|---|---|
Platelet binding characteristics distinguish placebo responders from nonresponders in depression.
Topics: Adult; Biomarkers; Blood Platelets; Depressive Disorder; Female; Humans; Iodine Radioisotopes; Lyser | 1995 |
Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors.
Topics: Adolescent; Adult; Biomarkers; Blood Platelets; Depressive Disorder; Female; Humans; Lysergic Acid D | 1995 |
Effects of selective serotonin reuptake inhibitors on platelet serotonin parameters in major depressive disorder.
Topics: Adult; Blood Platelets; Depressive Disorder; Double-Blind Method; Female; Fluoxetine; Humans; Lyserg | 1997 |
Serotonergic function in major depression and effect of sertraline and paroxetine treatment.
Topics: Administration, Oral; Adult; Depressive Disorder; Female; Humans; Lysergic Acid Diethylamide; Male; | 2001 |
11 other studies available for lysergic acid diethylamide and Depression, Endogenous
| Article | Year |
|---|---|
Hallucinogenic/psychedelic 5HT2A receptor agonists as rapid antidepressant therapeutics: Evidence and mechanisms of action.
Topics: Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Drug Evaluation, Preclinical; | 2021 |
THE SUBJECTIVE EXPERIENCE OF TIME DURING LYSERGIC ACID DIETHYLAMIDE (LSD-25) INTOXICATION.
Topics: Bipolar Disorder; Depression; Depressive Disorder; Humans; Hysteria; Lysergic Acid Diethylamide; Neu | 1964 |
THE HISTOMORPHOLOGY OF EXPERIMENTAL EXCITATION.
Topics: Acridines; Coloring Agents; Depression; Depressive Disorder; Hippocampus; Histology; Lysergic Acid D | 1964 |
THE USE OF LSD-25 AS A DIAGNOSTIC AID IN DOUBTFUL CASES OF SCHIZOPHRENIA.
Topics: Depression; Depressive Disorder; Diagnosis; Drug Therapy; Humans; Lysergic Acid Diethylamide; Person | 1965 |
HOMICIDE AFTER TREATMENT WITH LYSERGIC ACID DIETHYLAMIDE.
Topics: Antisocial Personality Disorder; Depression; Depressive Disorder; Drug Therapy; Homicide; Humans; Ly | 1964 |
Lysergic acid diethylamide; a clinical-psychological study.
Topics: Biomedical Research; Depression; Depressive Disorder; Ergot Alkaloids; Lysergic Acid Diethylamide; M | 1952 |
A possible role of serotonin receptors in antidepressant drug action.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder; Humans; Lysergic Acid Diethylamide; Rats | 1982 |
LSD flashback syndrome exacerbated by selective serotonin reuptake inhibitor antidepressants in adolescents.
Topics: 1-Naphthylamine; Adolescent; Antidepressive Agents; Depressive Disorder; Drug Interactions; Female; | 1994 |
RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy.
Topics: Adult; Amino Acid Sequence; Animals; Antipsychotic Agents; COS Cells; Depressive Disorder; Female; H | 2001 |
Platelet serotonin-2 receptor binding sites in depression and suicide.
Topics: Adult; Blood Platelets; Depressive Disorder; Female; Humans; Lysergic Acid Diethylamide; Male; Psych | 1990 |
Increased serotonin2 (5-HT2) receptor binding as measured by 3H-lysergic acid diethylamide (3H-LSD) in the blood platelets of depressed patients.
Topics: Adult; Blood Platelets; Cell Membrane; Depressive Disorder; Female; Humans; Imipramine; Lysergic Aci | 1989 |