lyoniside and Lymphoma--B-Cell

Four new phenylpropanoid esters of sucrose, lapathosides A (1), B (2), C (3), and D (4), were isolated from the aerial parts of Polygonum lapathifolium together with known esters, vanicoside B (5) and hydropiperoside (6). The structures of 1-4 were determined by spectral (1D and 2D NMR and MS) analysis. Lapathoside A (1) and vanicoside B (2) showed significant inhibitory effects on the Epstein-Barr virus early antigen activation by tumor-promoters.

Topics: Animals; Anticarcinogenic Agents; Antigens, Viral; Cinnamates; Disaccharides; Dose-Response Relationship, Drug; Epstein-Barr Virus Nuclear Antigens; Esters; Humans; Lymphoma, B-Cell; Magnetic Resonance Spectroscopy; Mass Spectrometry; Medicine, Chinese Traditional; Nitric Oxide Donors; Plants, Medicinal; Polygonum; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Sucrose; Tumor Cells, Cultured; Virus Activation