Page last updated: 2024-11-07

lynestrenol and Menopause

lynestrenol has been researched along with Menopause in 28 studies

Lynestrenol: A synthetic progestational hormone used often in mixtures with estrogens as an oral contraceptive (CONTRACEPTIVES, ORAL).

Menopause: The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.

Research Excerpts

ExcerptRelevanceReference
"Intratumoral activity of the enzyme 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) was measured in 55 patients with breast cancer (17 pre- and 38 post-menopausal) before and/or after 8 days of a progestin treatment (lynestrenol 10 mg/day)."3.67[Evaluation of 17-beta-hydroxysteroid dehydrogenase activity as a marker of the hormone dependence of breast cancers]. ( Allali, F; Debertrand, P; Diebold, N; Durand, JC; Fournier, S; Kuttenn, F; Martin, PM; Mauvais-Jarvis, P; Sterkers, N, 1985)
" The combination of ethinyl estradiol with megestrol acetate gave results comparable with those attained during pregnancy."3.65The influence of hormonal contraceptives on sex hormone binding globulin (SHBG) capacity. ( Rademaker, B; Schwarz, F; Thijssen, JH; van Kammen, E, 1975)
"Estriol is a weak estrogen with a claimed specific action on the epithelium in cervix uteri and vagina and with no or limited ability to induce endometrial proliferation."1.26Endometrial effect of oral estriol treatment in postmenopausal women. ( Englund, DE; Johansson, ED, 1980)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199025 (89.29)18.7374
1990's1 (3.57)18.2507
2000's2 (7.14)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
SAS, M1
KOVACS, L1
NEMETH, I1
SZONTAGH, FE1
SERBAN, AM1
CUPCEANCU, B1
KLEPSCH, I1
STROE, E1
STOLL, BA1
ANDREWS, JT1
MOTTERAM, R1
UPFILL, J1
SWYER, GI1
LITTLE, V1
EISALO, A2
JAERVINEN, PA1
LUUKKAINEN, T2
Sivin, I1
Mishell, DR1
Alvarez, F1
Brache, V1
Elomaa, K1
Lähteenmäki, P1
Massai, R1
Miranda, P1
Croxatto, H1
Dean, C1
Small, M1
Nash, H1
Jackanicz, TM1
Pietrzak, B1
Wielgos, M1
Kaminski, P1
Bobrowska, K1
Rosselin, G1
Dolais, J1
Holst, J4
von Schoultz, B4
Punnonen, R1
Liukko, P1
Cortes-Prieto, J1
Eydam, F1
Milojevic, S1
Trévoux, R1
Chryssikopoulos, E1
Franchi, F1
Luisi, M1
Kicovic, PM1
De Baene, L1
Van Bogaert, LJ1
De Muylder, E2
Thomas, K1
Hofer, PA1
Cajander, S1
Dequeker, J1
Englund, DE1
Johansson, ED1
Kugler, P2
Wrobel, KH2
Wallner, HJ2
Heinzmann, U2
van Kammen, E1
Thijssen, JH1
Rademaker, B1
Schwarz, F1
Viel, A1
Goriaux, JL1
Rouge, JC1
Crouet, H1
Héron, JF1
Bäckström, T2
Hammarbäck, S2
Fournier, S1
Allali, F1
Durand, JC1
Sterkers, N1
Debertrand, P1
Diebold, N1
Martin, PM1
Kuttenn, F1
Mauvais-Jarvis, P1
Lyrenäs, S1
Jayle, MF1
Chemama, R1
Ennuyer, A1
Bataini, P1
Adlercreutz, H1
Heino, A1
Penttilä, I1
Saukkonen, H1
Warnecke, G1
Györvári, W1
Balogh, J1
Schubert, L1
Giarola, P1
Gibelli, A1
Iurlaro, F1
Higier, J1
Grzeniewski, L1
Ludwig, E1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multicenter, Open-label Randomized Study on the Efficacy, Cycle Control and Safety of a Contraceptive Vaginal Ring Delivering a Daily Dose of Nestorone® and Estradiol (NES-E2 CVR).[NCT03432416]Phase 2300 participants (Anticipated)Interventional2018-02-12Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for lynestrenol and Menopause

ArticleYear
Contraceptive vaginal rings releasing Nestorone and ethinylestradiol: a 1-year dose-finding trial.
    Contraception, 2005, Volume: 71, Issue:2

    Topics: Adult; Contraception; Contraceptive Agents, Female; Contraceptive Devices, Female; Dose-Response Rel

2005
Two routes of hormonal replacement therapy in symptomatic menopausal women after kidney transplantation.
    Neuro endocrinology letters, 2006, Volume: 27, Issue:3

    Topics: Administration, Cutaneous; Administration, Oral; Adult; Drug Combinations; Drug Therapy, Combination

2006
[Percutaneous estrogen replacement therapy. An alternative for oral treatment].
    Duodecim; laaketieteellinen aikakauskirja, 1983, Volume: 99, Issue:20

    Topics: Estradiol; Estrone; Female; Humans; Lynestrenol; Menopause; Middle Aged; Skin Absorption

1983

Other Studies

25 other studies available for lynestrenol and Menopause

ArticleYear
[ON THE METHANISM OF THE OVULATION-INHIBITING EFFECT OF ORAL PROGESTAGENS].
    Endokrinologie, 1964, Volume: 46

    Topics: Amenorrhea; Biological Assay; Contraceptive Agents; Contraceptives, Oral; Female; Gonadotropins; Hum

1964
[CLINICAL RESULTS AFTER ADMINISTRATION OF LYNESTRENOL WITH METHOXY-ETHINYLESTRADIOL].
    Studii si cercetari de endocrinologie, 1964, Volume: 15

    Topics: Amenorrhea; Autonomic Nervous System Diseases; Drug Therapy; Ethinyl Estradiol; Female; Humans; Lyne

1964
ORAL CONTRACEPTIVES AND LIVER DAMAGE.
    British medical journal, 1965, Mar-13, Volume: 1, Issue:5436

    Topics: Biopsy; Chemical and Drug Induced Liver Injury; Contraceptive Agents; Contraceptives, Oral; Estradio

1965
ABSENCE OF HEPATIC IMPAIRMENT IN LONG-TERM ORAL-CONTRACEPTIVE USERS.
    British medical journal, 1965, May-29, Volume: 1, Issue:5447

    Topics: Chemical and Drug Induced Liver Injury; Contraceptive Agents; Contraceptives, Oral; Ethinyl Estradio

1965
LIVER-FUNCTION TESTS DURING INTAKE OF CONTRACEPTIVE TABLETS IN PRE-MENOPAUSAL WOMEN.
    British medical journal, 1965, May-29, Volume: 1, Issue:5447

    Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood; Climacter

1965
[Determination of the human follicle-stimulating hormone (H.F.S.H.) by the radio-immunological method. Preliminary results obtained in the normal and hypogonadal male; in the female during the menstrual cycle and after the menopause. Effect of various pit
    La Presse medicale, 1967, Oct-07, Volume: 75, Issue:41

    Topics: Adult; Aged; Chorionic Gonadotropin; Ethinyl Estradiol; Female; Follicle Stimulating Hormone; Humans

1967
Multicentre study of effects of Org OD 14 on endometrium, vaginal cytology and cervical mucus in post-menopausal and oophorectomized women.
    Maturitas, 1984, Volume: 5, Issue:4

    Topics: Adult; Biopsy; Castration; Cell Division; Cervix Uteri; Drug Evaluation; Endometrium; Estrogens; Fem

1984
Ovarian morphology during and after lynestrenol treatment around menopause.
    Contraception, 1982, Volume: 25, Issue:2

    Topics: Adult; Corpus Luteum; Female; Granulosa Cells; Humans; Lynestrenol; Menopause; Menstruation; Middle

1982
Percutaneous estrogen therapy--a semi-quantitative histologic study of the abdominal skin.
    Acta obstetricia et gynecologica Scandinavica, 1982, Volume: 61, Issue:6

    Topics: Abdomen; Aged; Cell Count; Estradiol; Female; Humans; Lynestrenol; Menopause; Middle Aged; Mitosis;

1982
Long-term progestogen treatment and bone remodelling in peri-menopausal women: a longitudinal study.
    Maturitas, 1982, Volume: 4, Issue:4

    Topics: Adult; Bone Development; Estrogens; Female; Humans; Longitudinal Studies; Lynestrenol; Menopause; Mi

1982
Endometrial effect of oral estriol treatment in postmenopausal women.
    Acta obstetricia et gynecologica Scandinavica, 1980, Volume: 59, Issue:5

    Topics: Administration, Oral; Aged; Endometrium; Estriol; Female; Humans; Lynestrenol; Menopause; Middle Age

1980
[Histochemical and histological investigations on the human fallopian tube under different hormonal influences. I. Demonstration of ATPase with special reference to reactive ciliated cells (author's transl)].
    Archiv fur Gynakologie, 1976, Dec-10, Volume: 221, Issue:4

    Topics: Adenosine Triphosphatases; Adult; Cilia; Estrogens; Fallopian Tubes; Female; Humans; Lynestrenol; Ma

1976
[Histochemical and histological investigations on the human Fallopian tube under different hormonal influences. II. Proliferative processes within endosalpingeal epithelium (author's transl)].
    Archiv fur Gynakologie, 1977, May-29, Volume: 222, Issue:3

    Topics: Adult; Contraceptives, Oral; Epithelial Cells; Estrogens; Fallopian Tubes; Female; Follicular Phase;

1977
The influence of hormonal contraceptives on sex hormone binding globulin (SHBG) capacity.
    Contraception, 1975, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Drug Combinations; Ethinyl Estradiol; Female; Gonadal Steroid Hormones; Humans; L

1975
[Is the progesterone test a generalizable method of screening for neoplastic and preneoplastic lesions of the endometrium?].
    Bulletin du cancer, 1990, Volume: 77, Issue:4

    Topics: Aged; Female; Humans; Lynestrenol; Mass Screening; Menopause; Metrorrhagia; Middle Aged; Precancerou

1990
Progestogen addition during oestrogen replacement therapy--effects on vasomotor symptoms and mood.
    Maturitas, 1989, Volume: 11, Issue:1

    Topics: Affect; Climacteric; Estradiol; Female; Humans; Lynestrenol; Menopause; Middle Aged; Vasomotor Syste

1989
[Evaluation of 17-beta-hydroxysteroid dehydrogenase activity as a marker of the hormone dependence of breast cancers].
    Pathologie-biologie, 1985, Volume: 33, Issue:6

    Topics: 17-Hydroxysteroid Dehydrogenases; Adult; Aged; Breast; Breast Neoplasms; Estradiol; Evaluation Studi

1985
Cyclical mood changes as in the premenstrual tension syndrome during sequential estrogen-progestagen postmenopausal replacement therapy.
    Acta obstetricia et gynecologica Scandinavica, 1985, Volume: 64, Issue:5

    Topics: Adult; Behavior; Drug Therapy, Combination; Estradiol; Female; Humans; Lynestrenol; Menopause; Middl

1985
[Value of medicamentous pituitary inhibition in the treatment of breast neoplasms].
    Journal de radiologie, d'electrologie, et de medecine nucleaire, 1967, Volume: 48, Issue:11

    Topics: Adult; Aged; Breast Neoplasms; Chlormadinone Acetate; Dexamethasone; Ethinyl Estradiol; Female; Huma

1967
Investigations on the effect of an oral contraceptive and its components on liver function, serum proteins, copper, coeruloplasmin and gamma-glutamyl peptidase in postmenopausal women.
    Scandinavian journal of gastroenterology, 1968, Volume: 3, Issue:3

    Topics: Acyltransferases; Aged; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Blood Proteins

1968
[Treatment of the pre-menopause syndrome with a normophasic sequential preparation].
    Medizinische Monatsschrift, 1973, Volume: 27, Issue:12

    Topics: Adult; Body Weight; Climacteric; Drug Combinations; Female; Humans; Libido; Lynestrenol; Menopause;

1973
[Treatment of uterine bleedings due to hyperplasia in menopause].
    Medizinische Monatsschrift, 1971, Volume: 25, Issue:11

    Topics: Adult; Female; Humans; Hyperplasia; Lynestrenol; Menopause; Middle Aged; Uterine Diseases; Uterine H

1971
[Estroprogestinic associations in the preclimacteric syndrome: blood coagulation problems].
    Giornale di gerontologia, 1969, Volume: 17, Issue:11

    Topics: Adult; Blood Coagulation Disorders; Endometriosis; Female; Humans; Lynestrenol; Menopause; Menstruat

1969
[Attempts of treatment of menopausal hemorrhage and functional hemorrhages of the preclimacteric period with oral gestagen].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1968, Jan-15, Volume: 21, Issue:2

    Topics: Adult; Estradiol; Female; Humans; Lynestrenol; Menopause; Metrorrhagia; Middle Aged; Uterine Hemorrh

1968
[On the endocrine substrate of diffuse female (androgenetic) alopecia].
    Archiv fur klinische und experimentelle Dermatologie, 1966, Volume: 227, Issue:1

    Topics: Adult; Aged; Alopecia; Androgens; Estradiol; Estriol; Estrone; Female; Gonadotropins; Humans; Lynest

1966