lynestrenol has been researched along with Hepatic Encephalopathy in 1 studies
Lynestrenol: A synthetic progestational hormone used often in mixtures with estrogens as an oral contraceptive (CONTRACEPTIVES, ORAL).
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The pathophysiology of this almost fatal drug reaction is described as a pharmacokinetic interaction: the inherent hepatotoxicity of prothionamide-the drug finally prescribed during convalescence-was significantly potentiated by the Cyt-P-450-inducing effect of the progestagen component of the hormonal contraceptive." | 1.27 | [Fulminant liver failure in tuberculostatic therapy. A contribution to clinical aspects and pharmacokinetics]. ( Bülau, P; Köster, O; Lelbach, WK; Musch, E; Stiens, R, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Musch, E | 1 |
| Lelbach, WK | 1 |
| Stiens, R | 1 |
| Bülau, P | 1 |
| Köster, O | 1 |
1 other study available for lynestrenol and Hepatic Encephalopathy
| Article | Year |
|---|---|
[Fulminant liver failure in tuberculostatic therapy. A contribution to clinical aspects and pharmacokinetics].
Topics: Adult; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Contraceptives, Oral, Combined | 1987 |