lymecycline and Urethritis

Topics: Anti-Bacterial Agents; Chlamydia Infections; Cost-Benefit Analysis; Drug Costs; Humans; Lymecycline; Male; Sweden; Tetracycline; Urethritis

The treatment of chlamydial urethritis in males depends on the susceptibility of Chlamydia trachomatis to different antimicrobial agents. Tetracyclines seem to be the drugs of choice; long-acting tetracyclines are recommended, as these are more convenient for the patient. Both lymecycline and doxycycline produce clinical and bacteriological cure in approximately 90% of cases, when used in adequate doses. Erythromycin is the alternative treatment in patients who should not be given tetracyclines. Trimethoprim/sulfamethoxazole is effective in patients with chlamydial urethritis, but it seems to be ineffective in those with Chlamydia-negative urethritis. The importance of treating sexual partners should not be overlooked.

Topics: Anti-Bacterial Agents; Chlamydia Infections; Chlamydia trachomatis; Doxycycline; Erythromycin; Genital Diseases, Male; Humans; Lymecycline; Male; Tetracyclines; Urethritis

Chlamydia trachomatis was isolated from the urethra in 71 of 275 men primarily attending the outpatient clinic of the Department of Urology because of symptoms of acute urethritis, and with more than four polymorphonuclear leukocytes in each of at least five fields of the swabbed urethral exudate (x1000). C. trachomatis was isolated from 34 of 48 men below 26 years of age, while only 37 of the 227 men aged 26 years or older harboured chlamydial infection. C. trachomatis was isolated from the prostatic secretion of 26 men with acute urethritis and more than 20 polymorphonuclear leukocytes in 10 or more random fields (x450) in the stripped prostatic fluid, suggesting a positive correlation between chlamydial infection and sub-acute silent prostatitis. Among 70 men with C. trachomatis isolated from the urethra, the organism had disappeared at re-examination within 10 days in 19 (27%). Such a disappearance was found in only one of 26 men (4%) in whom C. trachomatis had been isolated not only from the urethra but also from stripped prostatic fluid. Four weeks after two treatment cycles of lymecycline 300 mg twice daily for 7 days with an interval of 10 days, C. trachomatis was but isolated in any urethral specimen, nor from the expressed prostatic fluid.

Topics: Adolescent; Adult; Body Fluids; Chlamydia Infections; Chlamydia trachomatis; Humans; Lymecycline; Male; Middle Aged; Prostate; Prostatitis; Urethra; Urethritis

Topics: Humans; Lymecycline; Tetracyclines; Urethritis

A group of 213 men with non-gonococcal urethritis and their sexual partners were treated either with erythromycin stearate 500 mgx2 for 15 days or with lymecycline 300 mgx2 for 10 or 20 days. Chlamydia trachomatis was isolated from 40% of the men, from 26% of their female partners and from 56% of the partners of men with chlamydia-positive urethritis. One hundred and eighty-one men were available for evaluation of therapy. There were no significant differences between the treatment schedules. The cure rate was 86-90% in men with chlamydia-positive and 89-100% in men with chlamydia-negative urethritis. Four of the 17 chlamydia-positive females treated with erythromycin and 2 of the 20 chlamydia-positive females treated with lymecycline for 10 days still had chlamydia at re-examination.

Topics: Chlamydia Infections; Drug Evaluation; Erythromycin; Female; Humans; Lymecycline; Male; Tetracyclines; Time Factors; Urethritis

Men with non-gonococcal urethritis (NGU) were divided into two groups and treated with either lymecycline or tinidazole; anaerobic cultures were performed before and after treatment. Neither treatment affected the anaerobic flora. However, the men treated with lymecycline were relieved of symptoms and signs, while those treated with tinidazole were not. The anaerobic bacteria found are considered normal inhabitants of the urethral tract and without significance in the aetiology of NGU.

Topics: Adult; Anaerobiosis; Bacterial Infections; Humans; Lymecycline; Male; Tinidazole; Urethritis

One thousand and sixty patients with non-specific urethritis were treated with lymecycline (Tetralysal). An initial course of 600mg 12-hourly for one week was successful in 90.5% of cases, while 2% responded to a further course of 300mg 12-hourly for three weeks.

Topics: Humans; Lymecycline; Male; Tetracyclines; Urethritis

Topics: Humans; Lymecycline; Male; Tetracycline; Urethritis