lymecycline and Sinusitis

After evaluation of the clinical efficacy and the tolerance of lymecycline 2 x 300 mg/day in patients with subacute sinusitis, we may conclude that lymecycline can be considered a first choice antibioticum in the treatment of acute and subacute sinusitis (Tetralysal).

Topics: Adult; Drug Evaluation; Female; Humans; Lymecycline; Male; Maxillary Sinus; Sinusitis; Tetracyclines

A micro-method was developed for determination of the concentrations of antibiotics in the mucous membranes of the maxillary sinus in man. At different times after the administration of antibiotics (potassium phenoxymethylpenicillin, lymecycline and bacampicillin) the concentration was determined in serum and in pieces of maxillary sinus mucosa obtained at operation. It was found that the concentrations in the mucosa varied within wide ranges during the first 60 minutes after the operation but in samples taken at 90 minutes the fluctuations between the individuals were within the standard error of the method. Concentrations well above the MIC values for the majority of bacterias found in sinusitis were registered in the peaks. Six hours after the administration considerable amounts of active antibiotics were still detected in the maxillary sinus mucosa.

Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Chronic Disease; Humans; Lymecycline; Maxillary Sinus; Microbiological Techniques; Mucous Membrane; Penicillin V; Sinusitis

Topics: Adult; Aged; Female; Humans; Lymecycline; Male; Maxillary Sinus; Middle Aged; Sinusitis; Tetracyclines