lymecycline and Salpingitis

In a study at the University Hospital in Trondheim during 1983, the frequency of Chlamydia trachomatis among women terminating their pregnancies was 8.2%. Younger women were infected by C. trachomatis at a more frequent rate than older women (p less than 0.001). Treatment of chlamydia-positive women was initiated within the first two weeks after the abortion. However, among women readmitted to the hospital, chlamydia-positive women showed a higher frequency of salpingitis than chlamydia-negative women (p less than 0.08). Preabortion examination for C. trachomatis and treatment of chlamydia-positive women by practitioners before the abortion is carried out, may reduce the postabortal frequency of salpingitis.. A study was conducted at the University Hospital in Trondheim, Norway, in 1983 to investigate the routines for sampling of "C. trachomatis" and treatment of chlamydia-positive women in relation to abortion during the 1st trimester. 823 abortions were performed during the 1st trimester in 1983. The patients were examined the day prior to the operation and specimens for "C. trachomatis" and "N. gonorrhea" were collected from the cervix uteri. 769 women were included in the final analysis. The number of women infected with "C. trachomatis" at the time of abortion was 60 (8.2%). This did not include 37 cultures which were inconclusive due to nonspecific cytopathogenic effects. The highest frequencies were found in the younger age groups. After age standardization, nulliparous women (9.8%) had a higher infection rate than women (5.0%) with 1 or more previous pregnancies. The prevalence of "N. gonorrhea" was 0.6%. 2 women were positive for both "C. trachomatis" and "N. gonorrhea." Of 37 patients who were readmitted to the hospital, 6 were chlamydia-positive and 30 chlamydia-negative, representing 10% and 4.5%, respectively. 1 patient, who was readmitted, had inconclusive chlamydia culture. Postabortal salpingitis was confirmed at readmission among 5% of the chlamydia-positive women; 1.2% of the chlamydia-negative women were treated in the hospital for salpingitis.

Topics: Abortion, Induced; Adult; Cervix Uteri; Chlamydia Infections; Chlamydia trachomatis; Drug Therapy, Combination; Female; Humans; Lymecycline; Metronidazole; Norway; Postoperative Complications; Pregnancy; Salpingitis

A group of 782 patients with a diagnosis of acute salpingitis (a few of the patients because of other infection in the pelvis) were treated with the recommended oral dose of doxycycline (200 mg the first day and 100 mg once daily for at least the following 9-12 days) in combination with 1 g benzyl penicillin and 0.6 g procaine penicillin twice daily intramuscularly for 5-7 days. The plasma concentrations of doxycycline were determined on the third day of treatment before the next dose was given. In 26.5% of the patients the concentrations were below 1 microgram/ml plasma, considered as the minimum therapeutic level. The dose of doxycycline was increased to 200 mg a day in these patients and the plasma concentrations increased accordingly. In another group of 80 patients, 40 were treated with the standard doxycycline dose, and the other 40 patients with the standard lymecycline dose (300 mg twice a day). The plasma concentrations, determined before the dose on the third day, were below 1 microgram/ml in 35% of the patients treated with doxycycline, and in 5% of those treated with lymecycline. Since acute salpingitis in most cases is a serious complication to a lower genital tract infection, often a sexually transmitted disease caused by tetracycline-sensitive organisms, the importance of achieving and determining the therapeutic plasma concentrations of tetracyclines is stressed.

Topics: Acute Disease; Adolescent; Adult; Aged; Blood Bactericidal Activity; Doxycycline; Drug Therapy, Combination; Female; Humans; Lymecycline; Microbial Sensitivity Tests; Middle Aged; Penicillin G; Penicillin G Procaine; Salpingitis; Tetracyclines