lymecycline and Genital-Diseases--Female

To compare the clinical and microbiological efficacy of azithromycin in curing chlamydial infections in women with that of lymecycline, and with a view of the possibility of minimizing the problem of compliance by means of single-dose administration, 146 women with culture-positive Chlamydia trachomatis infections were randomly assigned to treatment with a 1 g bolus dose of azithromycin or a 10-day course of lymecycline 300 mg twice daily. Clinical and microbiological evaluations were performed and adverse effects monitored at check-ups after 15-35 and 40-65 days. Of the 146 patients enrolled in the study, 120 were evaluable. At the second check-up, C. trachomatis was found to have been eradicated in all patients in both treatment groups. Of the 51 patients who had clinical signs and symptoms of genital infection at enrolment, 96% (22/23) of those in the azithromycin group were considered cured (n = 18) or improved (n = 4), as compared with 100% (28/28) of those considered cured (n = 22) or improved (n = 6) in the lymecycline group. Adverse events related, or possibly related, to treatment were reported by 16 (21.6%) of the lymecycline group, but by only 6 (8.3%) of the azithromycin group. The 2 drugs were comparable with regard to microbiological and clinical efficacy in the treatment of genital chlamydial infection in women. The markedly lower rate of side-effects associated with azithromycin may be a feature conducive to patient compliance.

Topics: Adult; Anti-Bacterial Agents; Azithromycin; Chlamydia Infections; Chlamydia trachomatis; Double-Blind Method; Female; Genital Diseases, Female; Humans; Lymecycline; Recurrence; Safety; Treatment Outcome

Results of sensitivity to antibiotic in vitro and results of antibiotic treatment in vivo seem to recognize so far lymecycline as the tetracycline to prescribe in infections by mycoplasmas.

Topics: Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Lymecycline; Male; Microbial Sensitivity Tests; Mycoplasma pneumoniae; Tetracyclines; Ureaplasma; Urinary Tract Infections; Urogenital System

Topics: Adult; Aged; Female; Genital Diseases, Female; Humans; Lymecycline; Middle Aged; Urinary Tract Infections; Urologic Diseases