lychnopholide and Glioblastoma

Gliomas are responsible for more than 60% of all primary brain tumors. Glioblastoma multiforme (GBM), a grade IV tumor (WHO), is one of the most frequent and malignant gliomas. Despite two decades of advances in the discovery of new markers for GBM, the chemotherapy of choice falls to temozolomide after surgery and radiotherapy, which are not enough to increase the survival of patients to more than 15 months. It is urgent to discover new anti-glioma compounds. Many compounds derived from natural products have been used in the development of anti-tumor drugs. In this work, we have screened six low molecular weight sesquiterpene lactones, isolated from

Topics: Antineoplastic Agents; Asteraceae; Blood-Brain Barrier; Brain Neoplasms; Brazil; Bridged-Ring Compounds; Cell Line, Tumor; Cell Proliferation; Cell Survival; Furans; Glioblastoma; Glioma; Humans; Lactones; Plant Extracts; Sesquiterpenes; Sesterterpenes; Vernonia