ly3201 and Obesity

Estrogen, via estrogen receptor alpha (ERα), exerts several beneficial effects on metabolism and energy homeostasis by controlling size, enzymatic activity and hormonal content of adipose tissue. The actions of estrogen on sympathetic ganglia, which are key players in the browning process, are less well known. In the present study we show that ERβ influences browning of subcutaneous adipose tissue (SAT) via its actions both on sympathetic ganglia and on the SAT itself. A 3-day-treatment with a selective ERβ agonist, LY3201, induced browning of SAT in 1-year-old obese WT and ERα

Topics: Adipose Tissue, Brown; Adipose Tissue, White; Age Factors; Animals; Benzopyrans; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression; Male; Mice; Mice, Knockout; Mice, Obese; Models, Biological; Obesity; Sex Factors; Subcutaneous Fat, Abdominal; Sympathetic Nervous System