ly2784544 has been researched along with Adenocarcinoma* in 1 studies
1 other study(ies) available for ly2784544 and Adenocarcinoma
| Article | Year |
|---|---|
Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.
SIRT6 activation is thought to be a promising target for the treatment of many diseases, particularly cancer. Herein, we report the discovery of a series of new small-molecule SIRT6 activators. Structure-activity relationship analyses led to the identification of the most potent compound, 2-(1-benzofuran-2-yl)- Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enzyme Activators; Female; G2 Phase Cell Cycle Checkpoints; Humans; Mice, Inbred BALB C; Molecular Docking Simulation; Molecular Structure; Pancreatic Neoplasms; Protein Binding; Quinolines; Sirtuins; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2020 |