ly 353381 has been researched along with Breast Neoplasms in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 24 (72.73) | 29.6817 |
| 2010's | 9 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aparicio, A; Bonnefous, C; Brigham, D; Darimont, B; Douglas, K; Govek, S; Grillot, K; Hager, JH; Heyman, R; Joseph, JD; Julien, J; Kahraman, M; Kaufman, J; Lai, A; Lee, KJ; Lu, N; Moon, MJ; Nagasawa, J; Prudente, R; Qian, J; Rix, PJ; Sensintaffar, J; Shao, G; Smith, ND | 1 |
| Briarava, M; Mocellin, S; Nitti, D; Pilati, P | 1 |
| Alam, J; Bolognese, M; Broy, S; Feldman, R; Krege, JH; Lakshmanan, M; Meats, DL; Omizo, M; Utian, WH | 1 |
| Bolton, JL; Lu, M; Peng, KW; Qin, Z; Thatcher, GR; Wang, H; Wang, Z; Wijewickrama, GT | 1 |
| Silverman, SL | 1 |
| Amewou-Atisso, M; Christiansen, C; Cox, D; Cummings, SR; McClung, M; Miller, P; Mitlak, B; Powles, T; Reginster, JY; Stock, J; Zanchetta, J | 1 |
| Powles, T | 1 |
| Arun, B; Brown, PH; Castiglione, M; Cuzick, J; DeCensi, A; Dunn, B; Forbes, JF; Glaus, A; Howell, A; Vogel, V; von Minckwitz, G; Zwierzina, H | 1 |
| Agnusdei, D; Amewou-Atisso, M; Cox, DA; Cummings, SR; Diem, SJ; Dowsett, SA; Fabian, CJ; Muram, D; Neven, P; Powles, TJ; Wickerham, DL | 1 |
| Cuzick, J; Sestak, I | 1 |
| Calaf Alsina, J; Coronado Martín, PJ | 1 |
| Chan, S | 2 |
| Cox, DA; Hurn, PD; Littleton-Kearney, MT; Ostrowski, NL; Rossberg, MI | 1 |
| Booser, DJ; Buzdar, A; Hudis, C; Jones, SE; Melemed, AS; Munster, PN; O'Shaughnessy, JA; Peterson, P; Pippen, JE; Winer, E | 1 |
| Baselga, J; Bellet, M; Carrasco, E; Enas, N; Guillem-Porta, V; Kayitalire, L; Kerbrat, P; Krejcy, K; Kuta, M; Llombart-Cussac, A; Lluch, A; Namer, M; Petruzelka, L; Vodvarka, P | 1 |
| Licun, W; Tannock, IF | 1 |
| A'Hern, R; Detre, S; Dowsett, M; Johnston, SR; Riddler, S; Salter, J | 1 |
| Bartholomaeussen, M; Freddie, CT; Larsen, SS; Lykkesfeldt, AE | 1 |
| Christensen, GL; Freddie, CT; Lykkesfeldt, AE | 1 |
| Sporn, MB | 1 |
| Albain, KS; Anderson, J; Arneson, DW; Bacus, JW; Beenken, SW; Browne, D; Budd, GT; Burak, WE; Fabian, CJ; Fruehauf, JP; Ganz, PA; Grizzle, WE; Hyams, DM; Johnson, KA; Kimler, BF; Lagios, MD; Mayo, MS; O'Shaughnessy, JA; Sauter, ER; Tawfik, OW | 1 |
| Hede, K | 1 |
| Bolton, JL; Liu, H; Liu, J; Thatcher, GR; van Breemen, RB | 1 |
| Johansen, AM | 1 |
| Tannock, IF; Wu, L | 1 |
| Munster, PN | 1 |
| Bolton, JL; Dietz, BM; Dunlap, T; Kastrati, I; Lantvit, DD; Overk, CR; Qin, Z; Thatcher, GR; Yao, P; Yu, B | 1 |
| Buzdar, AU; Deshmane, V; Krishnamurthy, S; Melemed, AS; Peterson, P | 1 |
| Booser, D; Buzdar, A; Dhingra, K; Enas, N; Hudis, C; Major, M; Melemed, A; Münster, PN; Ni, L; Norton, L; Seidman, A; Theriault, R | 1 |
| Bentrem, D; Dardes, RC; De Los Reyes, A; Jordan, VC; Lee, ES; O'Regan, RM; Schafer, JM | 1 |
| Fabian, CJ; Kimler, BF | 1 |
| Gajdos, C; Jordan, VC | 1 |
11 review(s) available for ly 353381 and Breast Neoplasms
| Article | Year |
|---|---|
Breast Cancer Chemoprevention: A Network Meta-Analysis of Randomized Controlled Trials.
Topics: Adult; Aged; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Middle Aged; Norpregnenes; Piperidines; Postmenopause; Primary Prevention; Pyrrolidines; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes | 2016 |
New selective estrogen receptor modulators (SERMs) in development.
Topics: Bone Density Conservation Agents; Breast Neoplasms; Female; Humans; Indoles; Osteoporosis; Piperidines; Pyrrolidines; Risk Factors; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Thiophenes | 2010 |
Preventive therapy for breast cancer: a consensus statement.
Topics: Anastrozole; Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Consensus Development Conferences as Topic; Diphosphonates; Estrogen Receptor Modulators; Expert Testimony; Female; Fenretinide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Nitriles; Norpregnenes; Piperidines; Premenopause; Pyrrolidines; Raloxifene Hydrochloride; Retinoids; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Triazoles | 2011 |
[Third generation selective estrogen receptor modulators: benefits beyond bone. II, endometrial action].
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation, Preclinical; Endometrial Neoplasms; Endometrium; Estradiol; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Hot Flashes; Humans; Indoles; Menopause; Multicenter Studies as Topic; Organ Specificity; Osteoporosis, Postmenopausal; Piperidines; Pyrrolidines; Rats; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Thromboembolism | 2013 |
A review of selective estrogen receptor modulators in the treatment of breast and endometrial cancer.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Endometrial Neoplasms; Estradiol; Female; Fulvestrant; Humans; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes | 2002 |
Selective estrogen receptor modulators: tissue actions and potential for CNS protection.
Topics: Animals; Breast Neoplasms; Cardiovascular System; Central Nervous System; Cognition; Estrogen Antagonists; Estrogen Receptor Modulators; Female; Hormone Replacement Therapy; Humans; Hypothalamo-Hypophyseal System; Male; Neuroprotective Agents; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Receptors, Neurotransmitter; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus | 2002 |
Arzoxifene: a promising new selective estrogen receptor modulator for clinical chemoprevention of breast cancer.
Topics: Anticarcinogenic Agents; Breast Neoplasms; Female; Humans; Molecular Structure; Neoplasm Staging; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes | 2004 |
Breast cancer chemoprevention: a review of selective estrogen receptor modulators.
Topics: Breast Neoplasms; Female; Humans; Piperidines; Raloxifene Hydrochloride; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes | 2005 |
Arzoxifene: the development and clinical outcome of an ideal SERM.
Topics: Animals; Breast Neoplasms; Endometrial Neoplasms; Female; Humans; Piperidines; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Thiophenes; Treatment Outcome | 2006 |
Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention.
Topics: Aneuploidy; Angiogenesis Inhibitors; Anticarcinogenic Agents; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Carcinoma in Situ; Clinical Trials, Phase II as Topic; Cyclooxygenase Inhibitors; Disease Progression; Eflornithine; Endpoint Determination; Enzyme Inhibitors; Estrogens; Female; Fenretinide; Gonadotropin-Releasing Hormone; Humans; Hyperplasia; Isoflavones; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Phenotype; Piperidines; Polyamines; Precancerous Conditions; Protein-Tyrosine Kinases; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Uterine Neoplasms | 2001 |
Selective estrogen receptor modulators as a new therapeutic drug group: concept to reality in a decade.
Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cinnamates; Drug Design; Forecasting; Humans; Molecular Biology; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Stilbenes; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Toremifene; Treatment Outcome | 2002 |
8 trial(s) available for ly 353381 and Breast Neoplasms
| Article | Year |
|---|---|
Effects of arzoxifene on bone mineral density and endometrium in postmenopausal women with normal or low bone mass.
Topics: Aged; Algorithms; Antineoplastic Agents; Bone and Bones; Bone Density; Breast Neoplasms; Carcinoma; Endometrium; Female; Humans; Middle Aged; Organ Size; Piperidines; Placebos; Postmenopause; Thiophenes | 2009 |
Arzoxifene for prevention of fractures and invasive breast cancer in postmenopausal women.
Topics: Aged; Aged, 80 and over; Bone Resorption; Breast Neoplasms; Diphosphonates; Female; Fractures, Bone; Humans; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Placebos; Postmenopause; Selective Estrogen Receptor Modulators; Thiophenes | 2011 |
Breast cancer incidence in postmenopausal women with osteoporosis or low bone mass using arzoxifene.
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Double-Blind Method; Female; Fractures, Bone; Humans; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Postmenopause; Risk Factors; Thiophenes | 2012 |
Phase II, randomized, double-blind study of two dose levels of arzoxifene in patients with locally advanced or metastatic breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Resistance, Neoplasm; Endometrium; Estrogen Receptor Modulators; Female; Humans; Middle Aged; Patient Selection; Piperidines; Receptors, Estrogen; Survival Analysis; Tamoxifen; Thiophenes; Treatment Outcome | 2003 |
Randomized, double-blind, multicenter trial comparing two doses of arzoxifene (LY353381) in hormone-sensitive advanced or metastatic breast cancer patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Endometrium; Female; Humans; Middle Aged; Piperidines; Selective Estrogen Receptor Modulators; Thiophenes | 2003 |
Breast cancer chemoprevention phase I evaluation of biomarker modulation by arzoxifene, a third generation selective estrogen receptor modulator.
Topics: Anticarcinogenic Agents; Biopsy; Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Estrone; Female; Hormones; Humans; Middle Aged; Patient Selection; Piperidines; Postmenopause; Reoperation; Selective Estrogen Receptor Modulators; Thiophenes | 2004 |
Phase III double-blind trial of arzoxifene compared with tamoxifen for locally advanced or metastatic breast cancer.
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Disease Progression; Double-Blind Method; Female; Humans; Piperidines; Postmenopause; Receptors, Steroid; Survival Analysis; Tamoxifen; Thiophenes; Time Factors; Treatment Failure | 2007 |
Phase I study of a third-generation selective estrogen receptor modulator, LY353381.HCL, in metastatic breast cancer.
Topics: Actuarial Analysis; Adult; Aged; Breast Neoplasms; Dose-Response Relationship, Drug; Endometrium; Estrogen Antagonists; Female; Humans; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Piperidines; Thiophenes | 2001 |
14 other study(ies) available for ly 353381 and Breast Neoplasms
| Article | Year |
|---|---|
Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Dogs; Drug Discovery; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Heterografts; Humans; Mice; Proteolysis; Rats; Selective Estrogen Receptor Modulators; Small Molecule Libraries; Tamoxifen | 2015 |
Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Caspase 3; Caspase 7; Catechols; Cell Line, Tumor; DNA Damage; Female; Gene Deletion; Humans; Hydroquinones; Piperidines; Prodrugs; Protein Binding; Reactive Oxygen Species; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Thiophenes | 2009 |
Prevention of breast cancer by newer SERMs in the future.
Topics: Breast Neoplasms; Female; Humans; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Thiophenes | 2011 |
Preventive therapy for breast cancer.
Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Endometrial Neoplasms; Female; Humans; Meta-Analysis as Topic; Middle Aged; Piperidines; Preventive Medicine; Pyrrolidines; Raloxifene Hydrochloride; Receptor, ErbB-2; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes | 2012 |
Arzoxifene in breast cancer.
Topics: Breast Neoplasms; Double-Blind Method; Female; Humans; Piperidines; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Thiophenes | 2002 |
Selective estrogen receptor modulators as inhibitors of repopulation of human breast cancer cell lines after chemotherapy.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Methotrexate; Neoplasms, Hormone-Dependent; Piperidines; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2003 |
Comparison of the selective estrogen receptor modulator arzoxifene (LY353381) with tamoxifen on tumor growth and biomarker expression in an MCF-7 human breast cancer xenograft model.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; Female; Humans; Mice; Mice, Nude; Piperidines; Protein Biosynthesis; Proteins; Receptors, Estrogen; Receptors, Progesterone; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Trefoil Factor-1; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2003 |
The effect of the new SERM arzoxifene on growth and gene expression in MCF-7 breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cathepsin D; Cell Line, Tumor; Cell Proliferation; Estradiol; Estrogen Receptor alpha; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Piperidines; RNA, Messenger; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes | 2004 |
A new MCF-7 breast cancer cell line resistant to the arzoxifene metabolite desmethylarzoxifene.
Topics: Breast Neoplasms; Cathepsin D; Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor alpha; Fulvestrant; Histone Acetyltransferases; Humans; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Nuclear Receptor Coactivator 1; Piperidines; Proto-Oncogene Proteins c-bcl-2; Receptors, Progesterone; Repressor Proteins; RNA, Messenger; Tamoxifen; Thiophenes; Transcription Factors | 2004 |
Rexinoids may be ready for prime time in prevention, but challenges remain.
Topics: Animals; Anticarcinogenic Agents; Bexarotene; Breast Neoplasms; Clinical Trials as Topic; Disease Models, Animal; Female; Humans; Nicotinic Acids; Piperidines; Retinoid X Receptors; Tetrahydronaphthalenes; Thiophenes | 2004 |
Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.
Topics: Alkaline Phosphatase; Animals; Biotransformation; Breast Neoplasms; Cell Line, Tumor; DNA Damage; Estradiol; Female; Glutathione; Humans; Kinetics; Microsomes, Liver; Molecular Structure; Oligodeoxyribonucleotides; Piperidines; Quinones; Rats; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes | 2005 |
Effect of the selective estrogen receptor modulator arzoxifene on repopulation of hormone-responsive breast cancer xenografts between courses of chemotherapy.
Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Female; Humans; Immunohistochemistry; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Piperidines; Receptors, Estrogen; Thiophenes; Treatment Outcome; Xenograft Model Antitumor Assays | 2005 |
Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms.
Topics: Animals; Antioxidants; Breast Neoplasms; Carcinoma, Hepatocellular; Chemoprevention; Female; Humans; Liver; Liver Neoplasms; Luciferases; Mice; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Peroxides; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Thiophenes; Tumor Cells, Cultured | 2007 |
Analysis of cross-resistance of the selective estrogen receptor modulators arzoxifene (LY353381) and LY117018 in tamoxifen-stimulated breast cancer xenografts.
Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Estradiol; Female; Humans; Mice; Mice, Nude; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Time Factors; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |