Page last updated: 2024-09-05

ly 300164 and Seizures

ly 300164 has been researched along with Seizures in 15 studies

*Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder. [MeSH]

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (20.00)	18.2507
2000's	9 (60.00)	29.6817
2010's	3 (20.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Anderson, BA; Hansen, MM; Harkness, AR; Harn, NK; Leander, JD; Lodge, D	1
Barreca, ML; Chimirri, A; Constanti, A; De Luca, L; De Sarro, G; Ferreri, G; Gitto, R; Quartarone, S; Russo, E	1
Caruso, R; Chimirri, A; Citraro, R; De Luca, L; De Sarro, G; Gitto, R; Pagano, B; Russo, E	1
Inami, H; Kato, K; Ohno, K; Sakamoto, S; Shishikura, J; Yamashita, H; Yasunaga, T	1
Blecic, S; De Witte, O; Lefranc, F; Rynkowski, M	1
Chavda, V; Dhir, A	1
Aujla, PK; Fetell, MR; Jensen, FE	1
Barreca, ML; Caruso, R; Chimirri, A; De Sarro, G; Ferreri, G; Gitto, R; Orlando, V; Quartarone, S; Russo, E	1
Borowicz, KK; Czuczwar, SJ; Swiader, M; Wielosz, M	1
Barkoczy, J; Gigler, G; Gressens, P; Harsing, LG; Kapus, G; Kertesz, S; Levay, G; Medja, F; Spedding, M; Szenasi, G; Villa, P; Williamson, T	1
Agoston, M; Albert, M; Barkóczy, J; Benedek, A; Gacsályi, I; Gigler, G; Hársing, LG; Kapus, G; Kertész, S; Lévay, G; Markó, B; Matucz, E; Móricz, K; Simó, A; Szabó, G; Szénási, G; Vegh, M	1
Czuczwar, SJ; Gasior, M; Kleinrok, Z; Kuźniar, H; Swiader, M	1
Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J; Szadkowski, M	1
Borowicz, KK; Czuczwar, SJ; Kleinrok, Z	1
Gacsályi, I; Gigler, G; Gyertyán, I; Lévay, G; Szabados, T	1

Reviews

1 review(s) available for ly 300164 and Seizures

Article	Year
[Glutamate and malignant gliomas, from epilepsia to biological aggressiveness: therapeutic implications]. Bulletin du cancer, 2013, Volume: 100, Issue:9 Topics: Benzodiazepines; Brain Neoplasms; Cell Death; Cell Movement; Cell Proliferation; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glioma; Glutamic Acid; Humans; Memantine; Neoplasm Invasiveness; Neuroglia; Neurons; Receptors, AMPA; Receptors, Glutamate; Seizures; Sulfasalazine	2013

Article

Year

[Glutamate and malignant gliomas, from epilepsia to biological aggressiveness: therapeutic implications].

Bulletin du cancer, 2013, Volume: 100, Issue:9

Topics: Benzodiazepines; Brain Neoplasms; Cell Death; Cell Movement; Cell Proliferation; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glioma; Glutamic Acid; Humans; Memantine; Neoplasm Invasiveness; Neuroglia; Neurons; Receptors, AMPA; Receptors, Glutamate; Seizures; Sulfasalazine

2013

Other Studies

14 other study(ies) available for ly 300164 and Seizures

Article	Year
Synthesis and anticonvulsant activity of 3-aryl-5H-2,3-benzodiazephine AMPA antagonists. Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; Dose-Response Relationship, Drug; Electroshock; Mice; Seizures; Structure-Activity Relationship	1999
Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist. Journal of medicinal chemistry, 2003, Jan-02, Volume: 46, Issue:1 Topics: Acoustic Stimulation; Animals; Anticonvulsants; Excitatory Amino Acid Antagonists; Isoquinolines; Ligands; Mice; Mice, Inbred DBA; Receptors, AMPA; Seizures; Structure-Activity Relationship; Tetrahydroisoquinolines	2003
Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton. Journal of medicinal chemistry, 2006, Sep-07, Volume: 49, Issue:18 Topics: Acoustic Stimulation; Animals; Anticonvulsants; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Inbred DBA; Olfactory Pathways; Piperidines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Structure-Activity Relationship; Tetrahydroisoquinolines	2006
Synthesis, structure-activity relationships, and anticonvulsant activities of 2-amino-4H-pyrido[3,2-e][1,3]thiazin-4-one derivatives as orally active AMPA receptor antagonists. Bioorganic & medicinal chemistry, 2015, Apr-15, Volume: 23, Issue:8 Topics: Animals; Anticonvulsants; Antinematodal Agents; Cells, Cultured; Electroshock; Hippocampus; Kainic Acid; Mice; Neurons; Pyridines; Rats; Receptors, AMPA; Seizures; Structure-Activity Relationship; Thiazines	2015
Pre- and post-exposure talampanel (GYKI 53773) against kainic acid seizures in neonatal rats. Pharmacological reports : PR, 2016, Volume: 68, Issue:1 Topics: Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Dose-Response Relationship, Drug; Female; Kainic Acid; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, AMPA; Seizures	2016
Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model. Epilepsia, 2009, Volume: 50, Issue:4 Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Brain; Cell Death; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Hypoxia; Kainic Acid; Rats; Rats, Long-Evans; Receptors, AMPA; Seizures; Time Factors	2009
Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives. Farmaco (Societa chimica italiana : 1989), 2004, Volume: 59, Issue:1 Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Female; Male; Mice; Mice, Inbred DBA; Models, Molecular; Molecular Structure; Receptors, AMPA; Seizures; Structure-Activity Relationship; Tetrahydroisoquinolines	2004
Influence of the combined treatment of LY 300164 (an AMPA/kainate receptor antagonist) with adenosine receptor agonists on the electroconvulsive threshold in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2004, Volume: 14, Issue:5 Topics: Adenosine-5'-(N-ethylcarboxamide); Animals; Avoidance Learning; Behavior, Animal; Benzodiazepines; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Combinations; Drug Interactions; Electroshock; Male; Mice; Psychomotor Performance; Purinergic P1 Receptor Agonists; Receptors, AMPA; Retention, Psychology; Seizures; Sensory Thresholds	2004
The effects of AMPA receptor antagonists in models of stroke and neurodegeneration. European journal of pharmacology, 2005, Sep-05, Volume: 519, Issue:1-2 Topics: Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Brain; Brain Ischemia; Cell Survival; Chickens; Cortical Spreading Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Excitatory Amino Acid Antagonists; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred Strains; Motor Neurons; Nerve Degeneration; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Retina; Seizures; Stroke	2005
Neuroprotective and anticonvulsant effects of EGIS-8332, a non-competitive AMPA receptor antagonist, in a range of animal models. British journal of pharmacology, 2007, Volume: 152, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; Brain; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Gerbillinae; Male; Membrane Potentials; Mice; Mice, Inbred DBA; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Purkinje Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, AMPA; Seizures; Telencephalon; Time Factors	2007
LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the anticonvulsive activity of antiepileptic drugs. European journal of pharmacology, 1998, Oct-23, Volume: 359, Issue:2-3 Topics: Animals; Anticonvulsants; Avoidance Learning; Benzodiazepines; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Mice; Psychomotor Performance; Receptors, AMPA; Seizures; Sensory Thresholds	1998
Influence of LY 300164, an antagonist of AMPA/kainate receptors, on the anticonvulsant activity of clonazepam. European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3 Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Avoidance Learning; Benzodiazepines; Clonazepam; Drug Synergism; Electroshock; Excitatory Amino Acid Antagonists; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Species Specificity	1999
The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of diazepam. Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 361, Issue:6 Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Diazepam; Drug Interactions; Drug Synergism; Electroshock; Excitatory Amino Acid Antagonists; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Seizures	2000
Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain research bulletin, 2001, Volume: 55, Issue:3 Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain Ischemia; Dose-Response Relationship, Drug; Electroshock; Magnesium Chloride; Male; Mice; Mice, Inbred Strains; Neuroprotective Agents; Seizures; Survival Analysis; Time Factors	2001