ly-295427 and Hypercholesterolemia

ly-295427 has been researched along with Hypercholesterolemia* in 1 studies

Other Studies

1 other study(ies) available for ly-295427 and Hypercholesterolemia

ArticleYear
Effects of LY295427, a low-density lipoprotein (LDL) receptor up-regulator, on LDL receptor gene transcription and cholesterol metabolism in normal and hypercholesterolemic hamsters.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1

    The action of LY295427 [(3alpha,4alpha, 5alpha)-4-(2-propenylcholestan-3-ol)], a compound that derepresses low-density lipoprotein receptor (LDL-R) expression in a cell-based model, was examined in hamsters. It was found that the compound does not have an effect in normal chow-fed hamsters, in which LDL-R levels are not repressed, but exerts a marked hypocholesterolemic effect (>70% decrease) in cholesterol-coconut oil-fed hamsters, in which LDL-R is repressed. In this model, there is a dose-response for cholesterol lowering with an approximate ED50 value of 40 mg/kg/day and an inverse relationship between serum cholesterol and serum LY295427 levels. LDL-R mRNA is increased (2-fold) and liver cholesterol ester content is decreased (>90%). Unlike the 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitor lovastatin, the decreased serum cholesterol is confined to the non-high-density lipoprotein fraction. Furthermore, LY295427 does not affect cholesterol biosynthesis, and it does not have a significant effect on cholesterol absorption. These data suggest that LY295427 acts in the hypercholesterolemic hamster by derepressing LDL-R transcription, thereby enhancing cholesterol clearance from the blood. The results with LY295427 suggest that compounds that act to increase LDL-R may represent a novel approach in the pharmacotherapy for hypercholesterolemia.

    Topics: Acetates; Animals; Anticholesteremic Agents; Cholestanols; Cholesterol; Cholesterol, Dietary; Cholesterol, LDL; Coconut Oil; Cocos; Cricetinae; Dietary Fats; Homeostasis; Hypercholesterolemia; Intestinal Absorption; Liver; Lovastatin; Male; Mesocricetus; Plant Oils; Receptors, LDL; RNA, Messenger; Up-Regulation

1999