ly-295337 and Cryptococcosis

ly-295337 has been researched along with Cryptococcosis* in 1 studies

Other Studies

1 other study(ies) available for ly-295337 and Cryptococcosis

Article	Year
An alternative animal model for comparison of treatments for cryptococcal meningitis. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:2 Weanling outbred rats were infected with Cryptococcus neoformans by direct percranial puncture and inoculation into the cranium. A lethal infection ensued. Treatment with LY295337, a depsipeptide with antifungal activity, was effective in prolonging survival and reducing fungal counts in brain tissue. Weanling rats are an acceptable model for the study of central nervous system infection with C. neoformans. Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Colony-Forming Units Assay; Cryptococcosis; Disease Models, Animal; Meningitis, Cryptococcal; Peptides; Rats	1999

Article

Year

An alternative animal model for comparison of treatments for cryptococcal meningitis.

Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:2

Weanling outbred rats were infected with Cryptococcus neoformans by direct percranial puncture and inoculation into the cranium. A lethal infection ensued. Treatment with LY295337, a depsipeptide with antifungal activity, was effective in prolonging survival and reducing fungal counts in brain tissue. Weanling rats are an acceptable model for the study of central nervous system infection with C. neoformans.

Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Colony-Forming Units Assay; Cryptococcosis; Disease Models, Animal; Meningitis, Cryptococcal; Peptides; Rats

1999