ly 293558 has been researched along with Disease Models, Animal in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 8 (57.14) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
| Bohme, GA; Boireau, A; Bouquerel, J; Damour, D; Debono, MW; Genevois-Borella, A; Hardy, JC; Hubert, P; Jimonet, P; Manfré, F; Mignani, S; Nemecek, P; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
| Bell, MG; Bleakman, D; Bleisch, TJ; Castaño, AM; Clemens-Smith, A; del Prado, M; Dieckman, DK; Dominguez, E; Escribano, A; Filla, SA; Ho, KH; Hudziak, KJ; Johnson, KW; Katofiasc, MA; Martinez-Perez, JA; Mateo, A; Mathes, BM; Mattiuz, EL; Ogden, AM; Ornstein, PL; Phebus, LA; Stack, DR; Stratford, RE; Winter, MA | 1 |
| Alt, A; Arnold, BM; Bell, MG; Bleakman, D; Bleisch, TJ; Buckmaster, JL; Castano, AM; Del Prado, M; Dominguez, E; Escribano, A; Filla, SA; Ho, KH; Hudziak, KJ; Iyengar, S; Jones, CK; Martinez-Perez, JA; Mateo, A; Mathes, BM; Mattiuz, EL; Ogden, AM; Ornstein, PL; Shannon, HE; Simmons, RM; Stack, DR; Stratford, RE; Winter, MA; Wu, Z | 1 |
| Alt, A; Arnold, BM; Bell, MG; Bleakman, D; Bleisch, TJ; Castaño, AM; Clawson, DK; Del Prado, M; Dominguez, E; Escribano, AM; Filla, SA; Ho, KH; Hudziak, KJ; Iyengar, S; Jones, CK; Martinez-Perez, JA; Mateo, A; Mathes, BM; Mattiuz, EL; Ogden, AM; Ornstein, PL; Shannon, HE; Simmons, RM; Stack, DR; Stratford, RE; Winter, MA; Wu, Z | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Apland, JP; Aroniadou-Anderjaska, V; Braga, MFM; Figueiredo, TH; Pidoplichko, VI; Rossetti, K | 1 |
| Apland, JP; Aroniadou-Anderjaska, V; Braga, MFM; De Araujo Furtado, M; Figueiredo, TH | 1 |
| Almeida-Suhett, CP; Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Prager, EM | 1 |
| Bonastre, M; Hirsch, EC; Marin, C; Périer, C; Tolosa, E | 1 |
| Brennan, TJ; Lee, HJ; Pogatzki-Zahn, EM | 1 |
| Huang, M; LeBlanc, MH; Li, XQ; Patel, DM; Smith, EE | 1 |
| Kundrotiené, J; Liljequist, S; Wägner, A | 1 |
| de Groat, WC; Yoshiyama, M | 1 |
14 other study(ies) available for ly 293558 and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]inden.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Brain; Cell Membrane; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Agonists; Heterocyclic Compounds, 4 or More Rings; Imidazoles; Inhibitory Concentration 50; Male; Mice; Mice, Inbred DBA; Oocytes; Protein Binding; Pyrazines; Rats; Receptors, AMPA; Seizures; Structure-Activity Relationship; Time Factors; Xenopus | 2000 |
Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Combinatorial Chemistry Techniques; Disease Models, Animal; Excitatory Amino Acid Antagonists; Imidazoles; Inhibitory Concentration 50; Male; Mice; Oocytes; Pyrazinamide; Pyrazines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship | 2001 |
Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.
Topics: Acute Disease; Administration, Oral; Animals; Biological Availability; Calcium; Carboxylic Acids; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Esters; Excitatory Amino Acid Antagonists; Humans; Isoquinolines; Migraine Disorders; Prodrugs; Radioligand Assay; Rats; Rats, Wistar; Receptors, Kainic Acid | 2002 |
Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Analgesics; Animals; Biological Availability; Cell Line; Disease Models, Animal; Humans; Hyperalgesia; Pain; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Spinal Cord | 2005 |
GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.
Topics: Administration, Oral; Amino Acid Sequence; Animals; Disease Models, Animal; Isoquinolines; Male; Molecular Sequence Data; Pain; Prodrugs; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Structure-Activity Relationship; Tetrazoles | 2013 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population.
Topics: Animals; Anticonvulsants; Anxiety; Basolateral Nuclear Complex; Behavior, Animal; Child; Cyclopentanes; Diazepam; Disease Models, Animal; Drug Interactions; Humans; Isoquinolines; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Soman; Status Epilepticus; Tetrazoles | 2018 |
Full Protection Against Soman-Induced Seizures and Brain Damage by LY293558 and Caramiphen Combination Treatment in Adult Rats.
Topics: Animals; Anticonvulsants; Body Weight; Brain Injuries; Brain Waves; Cholinesterase Inhibitors; Cyclopentanes; Disease Models, Animal; Drug Therapy, Combination; Electroencephalography; Fluoresceins; Fourier Analysis; Isoquinolines; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures; Soman; Tetrazoles; Time Factors | 2018 |
A rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonists.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Disease Models, Animal; Hippocampus; Isoquinolines; Male; Nerve Degeneration; Oximes; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Seizures; Soman; Status Epilepticus; Tetrazoles | 2015 |
AMPA receptor antagonist LY293558 reverses preproenkephalin mRNA overexpression in the striatum of 6-OHDA-lesioned-rats treated with L-dopa.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Enkephalins; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Isoquinolines; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Oxidopamine; Parkinsonian Disorders; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tetrazoles | 2002 |
The effect of the AMPA/kainate receptor antagonist LY293558 in a rat model of postoperative pain.
Topics: Afferent Pathways; Analgesics; Animals; Carboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Injections, Subcutaneous; Isoquinolines; Male; Nociceptors; Pain Measurement; Pain Threshold; Pain, Postoperative; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles; Treatment Outcome | 2006 |
AMPA antagonist LY293558 does not affect the severity of hypoxic-ischemic injury in newborn pigs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Blood Pressure; Body Temperature; Brain; Brain Ischemia; Carbon Dioxide; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Heart Rate; Hydrogen-Ion Concentration; Hypnotics and Sedatives; Hypoxia, Brain; Isoquinolines; Oxygen; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Swine; Tetrazoles; Time Factors | 1995 |
Extradural compression of sensorimotor cortex: a useful model for studies on ischemic brain damage and neuroprotection.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Dura Mater; Excitatory Amino Acid Antagonists; Hypothermia, Induced; Isoquinolines; Male; Motor Activity; Motor Cortex; Neuroprotective Agents; Postural Balance; Pressure; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Recovery of Function; Somatosensory Cortex; Tetrazoles | 2002 |
Effect of bilateral hypogastric nerve transection on voiding dysfunction in rats with spinal cord injury.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Drug Therapy, Combination; Female; Isoquinolines; Muscle Contraction; Neuroprotective Agents; Peripheral Nerves; Rats; Receptors, AMPA; Spinal Cord Injuries; Sympathectomy; Tetrazoles; Treatment Outcome; Urination; Urination Disorders; Urine | 2002 |