Page last updated: 2024-09-03

ly 293558 and Ache

ly 293558 has been researched along with Ache in 5 studies

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	2 (40.00)	29.6817
2010's	2 (40.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Alt, A; Arnold, BM; Bell, MG; Bleakman, D; Bleisch, TJ; Buckmaster, JL; Castano, AM; Del Prado, M; Dominguez, E; Escribano, A; Filla, SA; Ho, KH; Hudziak, KJ; Iyengar, S; Jones, CK; Martinez-Perez, JA; Mateo, A; Mathes, BM; Mattiuz, EL; Ogden, AM; Ornstein, PL; Shannon, HE; Simmons, RM; Stack, DR; Stratford, RE; Winter, MA; Wu, Z	1
Alt, A; Arnold, BM; Bell, MG; Bleakman, D; Bleisch, TJ; Castaño, AM; Clawson, DK; Del Prado, M; Dominguez, E; Escribano, AM; Filla, SA; Ho, KH; Hudziak, KJ; Iyengar, S; Jones, CK; Martinez-Perez, JA; Mateo, A; Mathes, BM; Mattiuz, EL; Ogden, AM; Ornstein, PL; Shannon, HE; Simmons, RM; Stack, DR; Stratford, RE; Winter, MA; Wu, Z	1
Lam, V; Schettler, J; Wallace, MS	1
Caruso, R; Chappell, AS; Gracely, RH; Hostetter, MP; Lee, G; Max, MB; Sang, CN; Schoepp, DD; Whitcup, S	1
Gilron, I	1

Reviews

1 review(s) available for ly 293558 and Ache

Article	Year
LY-293558. Eli Lilly & Co. Current opinion in investigational drugs (London, England : 2000), 2001, Volume: 2, Issue:9 Topics: Animals; Cerebrovascular Disorders; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Contraindications; Excitatory Amino Acid Antagonists; Humans; Isoquinolines; Pain; Receptors, AMPA; Structure-Activity Relationship; Tetrazoles	2001

Trials

2 trial(s) available for ly 293558 and Ache

Article	Year
NGX426, an oral AMPA-kainate antagonist, is effective in human capsaicin-induced pain and hyperalgesia. Pain medicine (Malden, Mass.), 2012, Volume: 13, Issue:12 Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Isoquinolines; Male; Pain; Pain Measurement; Prodrugs; Receptors, AMPA; Receptors, Kainic Acid; Sensory System Agents; Tetrazoles; Young Adult	2012
AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans. Anesthesiology, 1998, Volume: 89, Issue:5 Topics: Adult; Analgesics, Non-Narcotic; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia; Isoquinolines; Male; Middle Aged; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Receptors, AMPA; Receptors, Kainic Acid; Skin; Tetrazoles	1998

Article

Year

NGX426, an oral AMPA-kainate antagonist, is effective in human capsaicin-induced pain and hyperalgesia.

Pain medicine (Malden, Mass.), 2012, Volume: 13, Issue:12

Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Humans; Hyperalgesia; Isoquinolines; Male; Pain; Pain Measurement; Prodrugs; Receptors, AMPA; Receptors, Kainic Acid; Sensory System Agents; Tetrazoles; Young Adult

2012

AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans.

Anesthesiology, 1998, Volume: 89, Issue:5

Topics: Adult; Analgesics, Non-Narcotic; Capsaicin; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia; Isoquinolines; Male; Middle Aged; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Receptors, AMPA; Receptors, Kainic Acid; Skin; Tetrazoles

1998

Other Studies

2 other study(ies) available for ly 293558 and Ache

Article	Year
Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain. Journal of medicinal chemistry, 2005, Jun-30, Volume: 48, Issue:13 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Analgesics; Animals; Biological Availability; Cell Line; Disease Models, Animal; Humans; Hyperalgesia; Pain; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Spinal Cord	2005
GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy. Bioorganic & medicinal chemistry letters, 2013, Dec-01, Volume: 23, Issue:23 Topics: Administration, Oral; Amino Acid Sequence; Animals; Disease Models, Animal; Isoquinolines; Male; Molecular Sequence Data; Pain; Prodrugs; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Structure-Activity Relationship; Tetrazoles	2013

Article

Year

Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.

Journal of medicinal chemistry, 2005, Jun-30, Volume: 48, Issue:13

Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Analgesics; Animals; Biological Availability; Cell Line; Disease Models, Animal; Humans; Hyperalgesia; Pain; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Spinal Cord

2005

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.

Bioorganic & medicinal chemistry letters, 2013, Dec-01, Volume: 23, Issue:23

Topics: Administration, Oral; Amino Acid Sequence; Animals; Disease Models, Animal; Isoquinolines; Male; Molecular Sequence Data; Pain; Prodrugs; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Structure-Activity Relationship; Tetrazoles

2013