ly-233053 and Brain-Ischemia

ly-233053 has been researched along with Brain-Ischemia* in 1 studies

Other Studies

1 other study(ies) available for ly-233053 and Brain-Ischemia

Article	Year
Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia. Journal of neurosurgery, 1992, Volume: 76, Issue:1 Antagonists of excitatory amino acids appear to serve a neuroprotective role during ischemic conditions in a variety of in vivo and in vitro models. The usefulness of such agents in the clinical setting, however, may be limited by poor central nervous system (CNS) entry and intolerable side effects. The authors report high efficacy in reducing neurological damage and relatively limited side effects of LY233053, a novel competitive glutamate antagonist, in two models of experimental CNS ischemia in the rabbit. Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Ischemia; N-Methylaspartate; Pipecolic Acids; Rabbits; Spinal Cord; Tetrazoles	1992

Article

Year

Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia.

Journal of neurosurgery, 1992, Volume: 76, Issue:1

Antagonists of excitatory amino acids appear to serve a neuroprotective role during ischemic conditions in a variety of in vivo and in vitro models. The usefulness of such agents in the clinical setting, however, may be limited by poor central nervous system (CNS) entry and intolerable side effects. The authors report high efficacy in reducing neurological damage and relatively limited side effects of LY233053, a novel competitive glutamate antagonist, in two models of experimental CNS ischemia in the rabbit.

Topics: Animals; Brain Ischemia; Dose-Response Relationship, Drug; Ischemia; N-Methylaspartate; Pipecolic Acids; Rabbits; Spinal Cord; Tetrazoles

1992