ly-2157299 has been researched along with Melanoma* in 1 studies
1 other study(ies) available for ly-2157299 and Melanoma
| Article | Year |
|---|---|
Stromal Fibroblasts Mediate Anti-PD-1 Resistance via MMP-9 and Dictate TGFβ Inhibitor Sequencing in Melanoma.
Although anti-PD-1 therapy has improved clinical outcomes for select patients with advanced cancer, many patients exhibit either primary or adaptive resistance to checkpoint inhibitor immunotherapy. The role of the tumor stroma in the development of these mechanisms of resistance to checkpoint inhibitors remains unclear. We demonstrated that pharmacologic inhibition of the TGFβ signaling pathway synergistically enhanced the efficacy of anti-CTLA-4 immunotherapy but failed to augment anti-PD-1/PD-L1 responses in an autochthonous model of BRAF Topics: Animals; B7-H1 Antigen; CTLA-4 Antigen; Drug Resistance, Neoplasm; Female; Fibroblasts; Immunotherapy; Male; Matrix Metalloproteinase 9; Melanoma; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Proto-Oncogene Proteins B-raf; Pyrazoles; Quinolines; Transforming Growth Factor beta; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2018 |