ly-2157299 has been researched along with Diabetes-Mellitus* in 1 studies
1 other study(ies) available for ly-2157299 and Diabetes-Mellitus
Article | Year |
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Discovery of a drug candidate for GLIS3-associated diabetes.
GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes, reflecting a key function for this gene in pancreatic β-cell biology. Previous attempts to recapitulate disease-relevant phenotypes in GLIS3 Topics: Animals; Cell Differentiation; Cell Line; Diabetes Mellitus; DNA-Binding Proteins; Drug Discovery; Gene Expression Profiling; Human Embryonic Stem Cells; Humans; Hypoglycemic Agents; Insulin Secretion; Insulin-Secreting Cells; Male; Mice, SCID; Mutation; Pyrazoles; Quinolines; Repressor Proteins; Trans-Activators; Transcription Factors; Transplantation, Heterologous | 2018 |