ly 171883 and Edema
ly 171883 has been researched along with Edema in 5 studies
LY 171883: structure in first source; leukotriene receptor antagonist
tomelukast : A member of the class of acetophenones that is 1-phenylethanone substituted at position 2 by a hydroxy group, a propyl group at position 3 and a 4-(1H-tetrazol-5-yl)butoxy group at position 4. A leukotriene antagonist, it exhibits anti-asthmatic activity.
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since the non-steroidal anti-inflammatory agents, indomethacin and aspirin, were inactive, cyclooxygenase products are not involved in the anaphylactic reaction in boosted or unboosted mice." | 3.69 | Involvement of leukotrienes in allergic inflammation in mice. ( Cordeiro, RS; Vargaftig, BB; Zuany-Amorim, C, 1994) |
| " The edematogenic reaction appeared 5 min after the intraplantar injection of ovalbumin, peaked at 30 min after the antigenic challenge, and decreased thereafter." | 3.68 | Effect of PAF-acether antagonists on active anaphylactic mouse paw edema. ( Amorim, CZ; Cordeiro, RS; Henriques, MG; Vargaftig, BB; Weg, VB, 1991) |
Research
Studies (5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Musser, JH | 2 |
| Kreft, AF | 2 |
| Bender, RH | 2 |
| Kubrak, DM | 2 |
| Grimes, D | 1 |
| Carlson, RP | 2 |
| Hand, JM | 2 |
| Chang, J | 2 |
| Tabuchi, Y | 1 |
| Kawarabayashi, K | 1 |
| Komada, T | 1 |
| Furuhama, K | 1 |
| Zuany-Amorim, C | 1 |
| Cordeiro, RS | 2 |
| Vargaftig, BB | 2 |
| Amorim, CZ | 1 |
| Henriques, MG | 1 |
| Weg, VB | 1 |
Other Studies
5 other studies available for ly 171883 and Edema
| Article | Year |
|---|---|
N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.
Topics: Animals; Azoles; Benzamides; Biological Assay; Bronchial Spasm; Carrageenan; Chemical Phenomena; Che | 1990 |
N-[(arylmethoxy)phenyl] and N-[(arylmethoxy)naphthyl] sulfonamides: potent orally active leukotriene D4 antagonists of novel structure.
Topics: Acetophenones; Animals; Bronchi; Chemical Phenomena; Chemistry; Constriction, Pathologic; Cyclooxyge | 1989 |
Protective effect of DS-4574 on gastric mucosal injury induced by acidified ethanol in rats.
Topics: Acetophenones; Animals; Autacoids; Cell Degranulation; Edema; Ethanol; Gastric Mucosa; Hydrogen-Ion | 1993 |
Involvement of leukotrienes in allergic inflammation in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; A | 1994 |
Effect of PAF-acether antagonists on active anaphylactic mouse paw edema.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; A | 1991 |