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ly 171883 and Edema

ly 171883 has been researched along with Edema in 5 studies

LY 171883: structure in first source; leukotriene receptor antagonist
tomelukast : A member of the class of acetophenones that is 1-phenylethanone substituted at position 2 by a hydroxy group, a propyl group at position 3 and a 4-(1H-tetrazol-5-yl)butoxy group at position 4. A leukotriene antagonist, it exhibits anti-asthmatic activity.

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
" Since the non-steroidal anti-inflammatory agents, indomethacin and aspirin, were inactive, cyclooxygenase products are not involved in the anaphylactic reaction in boosted or unboosted mice."3.69Involvement of leukotrienes in allergic inflammation in mice. ( Cordeiro, RS; Vargaftig, BB; Zuany-Amorim, C, 1994)
" The edematogenic reaction appeared 5 min after the intraplantar injection of ovalbumin, peaked at 30 min after the antigenic challenge, and decreased thereafter."3.68Effect of PAF-acether antagonists on active anaphylactic mouse paw edema. ( Amorim, CZ; Cordeiro, RS; Henriques, MG; Vargaftig, BB; Weg, VB, 1991)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Musser, JH2
Kreft, AF2
Bender, RH2
Kubrak, DM2
Grimes, D1
Carlson, RP2
Hand, JM2
Chang, J2
Tabuchi, Y1
Kawarabayashi, K1
Komada, T1
Furuhama, K1
Zuany-Amorim, C1
Cordeiro, RS2
Vargaftig, BB2
Amorim, CZ1
Henriques, MG1
Weg, VB1

Other Studies

5 other studies available for ly 171883 and Edema

ArticleYear
N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: Animals; Azoles; Benzamides; Biological Assay; Bronchial Spasm; Carrageenan; Chemical Phenomena; Che

1990
N-[(arylmethoxy)phenyl] and N-[(arylmethoxy)naphthyl] sulfonamides: potent orally active leukotriene D4 antagonists of novel structure.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:6

    Topics: Acetophenones; Animals; Bronchi; Chemical Phenomena; Chemistry; Constriction, Pathologic; Cyclooxyge

1989
Protective effect of DS-4574 on gastric mucosal injury induced by acidified ethanol in rats.
    European journal of pharmacology, 1993, Nov-30, Volume: 250, Issue:1

    Topics: Acetophenones; Animals; Autacoids; Cell Degranulation; Edema; Ethanol; Gastric Mucosa; Hydrogen-Ion

1993
Involvement of leukotrienes in allergic inflammation in mice.
    European journal of pharmacology, 1994, May-23, Volume: 257, Issue:3

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; A

1994
Effect of PAF-acether antagonists on active anaphylactic mouse paw edema.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; A

1991