ly 171883 has been researched along with Bronchospasm in 5 studies
LY 171883: structure in first source; leukotriene receptor antagonist
tomelukast : A member of the class of acetophenones that is 1-phenylethanone substituted at position 2 by a hydroxy group, a propyl group at position 3 and a 4-(1H-tetrazol-5-yl)butoxy group at position 4. A leukotriene antagonist, it exhibits anti-asthmatic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two series of phenylephrine derivatives were prepared and tested as inhibitors of leukotriene D4 (LTD4) induced and ovalbumin-induced bronchospasm in the guinea pig." | 3.67 | Phenylephrine derivatives as leukotriene D4 antagonists. ( Bender, RH; Chang, J; Hand, JM; Kreft, AF; Kubrak, DM; Lefer, AM; Lewis, AJ; Musser, JH; Nielsen, ST, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Musser, JH | 2 |
| Kreft, AF | 2 |
| Bender, RH | 2 |
| Kubrak, DM | 2 |
| Grimes, D | 1 |
| Carlson, RP | 1 |
| Hand, JM | 2 |
| Chang, J | 2 |
| Nielsen, ST | 1 |
| Lefer, AM | 1 |
| Lewis, AJ | 1 |
| Tsunoda, H | 1 |
| Katayama, S | 1 |
| Sakuma, Y | 1 |
| Tanaka, S | 1 |
| Tsukidate, K | 1 |
| Abe, S | 1 |
| Yamatsu, I | 1 |
| Katayama, K | 1 |
| Israel, E | 1 |
| Juniper, EF | 1 |
| Callaghan, JT | 1 |
| Mathur, PN | 1 |
| Morris, MM | 1 |
| Dowell, AR | 1 |
| Enas, GG | 1 |
| Hargreave, FE | 1 |
| Drazen, JM | 1 |
| O'Byrne, PM | 1 |
1 review available for ly 171883 and Bronchospasm
| Article | Year |
|---|---|
Leukotrienes, airway hyperresponsiveness, and asthma.
Topics: Acetophenones; Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Dogs; Human | 1988 |
1 trial available for ly 171883 and Bronchospasm
| Article | Year |
|---|---|
Effect of a leukotriene antagonist, LY171883, on cold air-induced bronchoconstriction in asthmatics.
Topics: Acetophenones; Asthma; Body Temperature Regulation; Bronchial Spasm; Cold Temperature; Dose-Response | 1989 |
3 other studies available for ly 171883 and Bronchospasm
| Article | Year |
|---|---|
N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.
Topics: Animals; Azoles; Benzamides; Biological Assay; Bronchial Spasm; Carrageenan; Chemical Phenomena; Che | 1990 |
Phenylephrine derivatives as leukotriene D4 antagonists.
Topics: Animals; Bronchial Spasm; Cats; Coronary Circulation; Gastric Mucosa; Guinea Pigs; In Vitro Techniqu | 1987 |
Effect of a novel 5-lipoxygenase inhibitor, E6080 on bronchospasm, airway cellular infiltration and leukotriene production in guinea pigs.
Topics: Acetophenones; Animals; Autacoids; Benzoquinones; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Eos | 1991 |