ly 171883 has been researched along with Asthma in 8 studies
LY 171883: structure in first source; leukotriene receptor antagonist
tomelukast : A member of the class of acetophenones that is 1-phenylethanone substituted at position 2 by a hydroxy group, a propyl group at position 3 and a 4-(1H-tetrazol-5-yl)butoxy group at position 4. A leukotriene antagonist, it exhibits anti-asthmatic activity.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Musser, JH | 1 |
| Kreft, AF | 1 |
| Santais, MC | 1 |
| Callens, E | 1 |
| Djebbar, R | 1 |
| Ruff, F | 1 |
| Cheng, JB | 1 |
| Cloud, ML | 2 |
| Enas, GC | 1 |
| Kemp, J | 1 |
| Platts-Mills, T | 1 |
| Altman, LC | 1 |
| Townley, R | 1 |
| Tinkelman, D | 1 |
| King, T | 1 |
| Middleton, E | 1 |
| Sheffer, AL | 1 |
| Israel, E | 1 |
| Juniper, EF | 1 |
| Callaghan, JT | 1 |
| Mathur, PN | 1 |
| Morris, MM | 1 |
| Dowell, AR | 1 |
| Enas, GG | 1 |
| Hargreave, FE | 1 |
| Drazen, JM | 1 |
| Barnes, N | 1 |
| Evans, J | 1 |
| Zakrzewski, J | 1 |
| Piper, P | 1 |
| Costello, J | 1 |
| O'Byrne, PM | 1 |
| Fleisch, JH | 1 |
| Marshall, WS | 1 |
6 reviews available for ly 171883 and Asthma
| Article | Year |
|---|---|
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.
Topics: Animals; Arachidonate 5-Lipoxygenase; Asthma; Eosinophils; Humans; Inflammation; Leukotriene Antagon | 1992 |
[Potential importance of antileukotrienes in the treatment of asthma and other inflammatory diseases: apropos of a new pharmacological class].
Topics: Acetophenones; Adult; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthr | 1998 |
Early efficacy data with a newer generation of LTD4 antagonists in antiasthma trials: early promise for a single mediator antagonist.
Topics: Acetophenones; Animals; Asthma; Bronchodilator Agents; Humans; Indoles; Phenylcarbamates; Propionate | 1992 |
Studies of leukotriene antagonists and synthesis inhibitors in man.
Topics: Acetophenones; Asthma; Chromones; Epoprostenol; Humans; Hydroxyquinolines; Keto Acids; Leukotriene B | 1988 |
Leukotrienes, airway hyperresponsiveness, and asthma.
Topics: Acetophenones; Allergens; Animals; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Dogs; Human | 1988 |
A brief review of preclinical and clinical studies with LY171883 and some comments on newer cysteinyl leukotriene receptor antagonists.
Topics: Acetophenones; Animals; Asthma; Azoles; Bronchi; Chromones; Dicarboxylic Acids; Drug Evaluation; Dru | 1988 |
2 trials available for ly 171883 and Asthma
| Article | Year |
|---|---|
A specific LTD4/LTE4-receptor antagonist improves pulmonary function in patients with mild, chronic asthma.
Topics: Acetophenones; Adolescent; Adult; Asthma; Chemical Phenomena; Chemistry; Chronic Disease; Female; Fo | 1989 |
Effect of a leukotriene antagonist, LY171883, on cold air-induced bronchoconstriction in asthmatics.
Topics: Acetophenones; Asthma; Body Temperature Regulation; Bronchial Spasm; Cold Temperature; Dose-Response | 1989 |