ly 171883 has been researched along with Acute Liver Injury, Drug-Induced in 4 studies
LY 171883: structure in first source; leukotriene receptor antagonist
tomelukast : A member of the class of acetophenones that is 1-phenylethanone substituted at position 2 by a hydroxy group, a propyl group at position 3 and a 4-(1H-tetrazol-5-yl)butoxy group at position 4. A leukotriene antagonist, it exhibits anti-asthmatic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Survival was not adversely affected by treatment, however, body weight of males and females in the high dose group was significantly lower than that of controls." | 1.28 | Effects of chronic treatment with the leukotriene D4-antagonist compound LY171883 on B6C3F1 mice. ( Bendele, AM; Eacho, PI; Foxworthy, PS; Hoover, DM; van Lier, RB, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Bendele, AM | 1 |
| Hoover, DM | 1 |
| van Lier, RB | 1 |
| Foxworthy, PS | 1 |
| Eacho, PI | 1 |
| Shimazawa, T | 2 |
| Nagai, H | 2 |
| Koda, A | 2 |
| Kasahara, M | 2 |
| Yakuo, I | 1 |
| Aoki, M | 1 |
4 other studies available for ly 171883 and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Effects of chronic treatment with the leukotriene D4-antagonist compound LY171883 on B6C3F1 mice.
Topics: Acetophenones; Animals; Autacoids; Body Weight; Carcinogens; Chemical and Drug Induced Liver Injury; | 1990 |
The effects of thromboxane A2 inhibitors (OKY-046 and ONO-3708) and leukotriene inhibitors (AA-861 and LY-171883) on CCl4-induced chronic liver injury in mice.
Topics: Acetophenones; Acrylates; Animals; Azoles; Benzoquinones; Carbon Tetrachloride Poisoning; Chemical a | 1990 |
Role of peptide-leukotrienes in liver injury in mice.
Topics: Acetophenones; Animals; Autacoids; Benzoquinones; Carbon Tetrachloride; Chemical and Drug Induced Li | 1989 |