ly-146032 has been researched along with Anthrax* in 1 studies
1 other study(ies) available for ly-146032 and Anthrax
Article | Year |
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Efficacy of Daptomycin against Bacillus anthracis in a murine model of anthrax spore inhalation.
Daptomycin demonstrated in vitro (MIC(90), 4 μg/ml) and in vivo activities against Bacillus anthracis. Twice-daily treatment with a dose of 50 mg/kg of body weight was begun 24 h after challenge and continued for 14 or 21 days; results were compared to those for controls treated with phosphate-buffered saline or ciprofloxacin. Day 43 survival rates were 6/10 mice for the 14-day and 9/10 mice for the 21-day treatment groups, compared to survival with ciprofloxacin: 8/10 and 9/10 mice, respectively. Culture results from tissues removed at the termination of the experiment were negative. Topics: Animals; Anthrax; Anti-Bacterial Agents; Bacillus anthracis; Ciprofloxacin; Daptomycin; Female; Mice; Mice, Inbred BALB C; Spores, Bacterial | 2010 |