ly 117018 has been researched along with Breast Neoplasms in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (50.00) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blaszczak, LC; Crowell, TA; Goettel, ME; Jones, CD; Mabry, TE; Ruenitz, PC; Srivatsan, V; Suarez, T | 1 |
| Balaguer, P; Bonnet, S; Cavaillès, V; Duong, V; Escande, A; Margueron, R; Vignon, F | 1 |
| Levine, L | 1 |
| Body, JJ; Journé, F; Laurent, G; Leclercq, G; Nonclercq, D | 1 |
| Aknin, C; Chalbos, D; Freiss, G; Galtier, F; Maudelonde, T; Puech, C; Vignon, F | 1 |
| Clarke, R; Dai, P; Lou, MA; Lu, JF; Nazarov, V; Wong, LJ | 1 |
| Jordan, VC | 1 |
| Green, LR; Newboult, E; Valcaccia, B; Wakeling, AE | 1 |
| Huff, KK; Lippman, ME; Scholl, SM | 1 |
| Berthois, Y; Crastes de Paulet, A; Dussert, C; Martin, PM; Pons, M | 1 |
| Bentrem, D; Dardes, RC; De Los Reyes, A; Jordan, VC; Lee, ES; O'Regan, RM; Schafer, JM | 1 |
| Koga, M; Sutherland, RL | 2 |
| Hagino, Y; Kohno, K; Kuwano, M; Mizoguchi, H; Uchiumi, T | 1 |
| Katzenellenbogen, BS; Keith, D; Read, LD; Slamon, DJ | 1 |
| Braunsberg, H; Coldham, NG; Patel, K | 1 |
| Davidson, NE; Gelmann, EP; Kasid, A; Lippman, ME | 1 |
| Hölzel, F; May, FE; Westley, BR | 1 |
| Dickson, RB; Katz, D; Lippman, ME; Shima, TB; Thompson, EW; Wakeling, AE | 1 |
| Cheville, A; Freter, CE; Gelmann, EP; Lippman, ME; Zinn, S | 1 |
| May, FE; Westley, BR | 1 |
| Bronzert, DA; Davidson, N; Lippman, M | 1 |
| Bronzert, DA; Greene, GL; Lippman, ME | 1 |
| Gelmann, EP; Kasid, A; Lippman, ME; Lowy, DR; Papageorge, AG | 1 |
2 review(s) available for ly 117018 and Breast Neoplasms
| Article | Year |
|---|---|
Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: problems and potential for future clinical applications.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Half-Life; Humans; Mammary Neoplasms, Experimental; Models, Biological; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen; Thiophenes | 1983 |
Estrogen and antiestrogen resistance in human breast cancer cell lines.
Topics: Breast Neoplasms; Cell Division; Cell Line; Diethylstilbestrol; Drug Resistance; Estradiol; Estrogen Antagonists; Estrogens; Female; Glycoproteins; Humans; Molecular Weight; Pyrrolidines; Tamoxifen; Thiophenes; Time Factors | 1986 |
22 other study(ies) available for ly 117018 and Breast Neoplasms
| Article | Year |
|---|---|
Antiestrogens. 3. Estrogen receptor affinities and antiproliferative effects in MCF-7 cells of phenolic analogues of trioxifene, [3,4-dihydro-2-(4- methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)ethoxy]- phenyl]methanone.
Topics: Antineoplastic Agents; Binding, Competitive; Breast Neoplasms; Calmodulin; Cell Division; Estradiol; Estrogen Antagonists; Humans; Molecular Structure; Phenols; Pyrrolidines; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured | 1992 |
Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens.
Topics: Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; Fulvestrant; Genes, Reporter; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Pyrrolidines; Raloxifene Hydrochloride; Response Elements; Tamoxifen; Thiophenes; Transcription, Genetic; Tumor Cells, Cultured | 2004 |
Tamoxifen and the Rafoxifene analog LY117018: their effects on arachidonic acid release from cells in culture and on prostaglandin I2 production by rat liver cells.
Topics: Animals; Antineoplastic Agents, Hormonal; Arachidonic Acid; Breast Neoplasms; Colonic Neoplasms; Cyclooxygenase 2; Epoprostenol; Estrogen Antagonists; Humans; Isoenzymes; Liver; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrrolidines; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 2004 |
Ligand-independent and agonist-mediated degradation of estrogen receptor-alpha in breast carcinoma cells: evidence for distinct degradative pathways.
Topics: Breast Neoplasms; Cycloheximide; Enzyme Inhibitors; Estrogen Antagonists; Estrogen Receptor alpha; Female; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Immunoenzyme Techniques; Lactones; Leupeptins; Ligands; Macrolides; Molecular Chaperones; Proteasome Inhibitors; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Pyrrolidines; Signal Transduction; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 2004 |
Anti-growth factor activities of benzothiophenes in human breast cancer cells.
Topics: Breast Neoplasms; Cell Proliferation; Estrogen Antagonists; Humans; Insulin-Like Growth Factor I; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes; Transcription Factor AP-1; Transcription, Genetic | 2005 |
AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines.
Topics: Acetyltransferases; Alleles; Breast Neoplasms; Cell Line, Tumor; Cloning, Molecular; Drug Resistance, Neoplasm; Estradiol; Fulvestrant; Histone Acetyltransferases; Humans; Nuclear Receptor Coactivator 3; Oncogene Proteins; Peptides; Polymerase Chain Reaction; Pyrrolidines; Raloxifene Hydrochloride; Reverse Transcriptase Polymerase Chain Reaction; Selective Estrogen Receptor Modulators; Sequence Analysis, DNA; Tamoxifen; Thiophenes; Trans-Activators | 2006 |
Non-steroidal antioestrogens--receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line; Estrogen Antagonists; Female; Humans; Mammary Neoplasms, Experimental; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Uterus | 1984 |
Antiestrogenic effects of LY 117018 in MCF-7 cells.
Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; DNA Replication; Estradiol; Estrogen Antagonists; Female; Humans; Kinetics; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Thiophenes | 1983 |
Agonist-antagonist activity of anti-estrogens in the human breast cancer cell line MCF-7: an hypothesis for the interaction with a site distinct from the estrogen binding site.
Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Fractionation; Centrifugation, Density Gradient; Cytosol; Estradiol; Estrogen Antagonists; Humans; Pyrrolidines; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 1994 |
Analysis of cross-resistance of the selective estrogen receptor modulators arzoxifene (LY353381) and LY117018 in tamoxifen-stimulated breast cancer xenografts.
Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Estradiol; Female; Humans; Mice; Mice, Nude; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Time Factors; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Retinoic acid acts synergistically with 1,25-dihydroxyvitamin D3 or antioestrogen to inhibit T-47D human breast cancer cell proliferation.
Topics: Breast Neoplasms; Calcitriol; Cell Division; Cell Line; Clomiphene; Drug Synergism; Estradiol; Estrogen Antagonists; Female; Humans; Kinetics; Pyrrolidines; Receptors, Calcitriol; Receptors, Estradiol; Receptors, Steroid; Tamoxifen; Thiophenes; Tretinoin | 1991 |
Counteraction of estradiol-induced activation of tissue-type plasminogen activator in a human breast cancer cell line by an anti-estrogen, LY117018.
Topics: Breast Neoplasms; Cell Division; Cell Line; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Estradiol; Estrogen Antagonists; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Pyrrolidines; Receptors, Estrogen; RNA; Tamoxifen; Thiophenes; Tissue Plasminogen Activator | 1991 |
Hormonal modulation of HER-2/neu protooncogene messenger ribonucleic acid and p185 protein expression in human breast cancer cell lines.
Topics: Breast Neoplasms; Estrogen Antagonists; Estrogens; Humans; Mifepristone; Neoplasms, Hormone-Dependent; Progestins; Prognosis; Promegestone; Proto-Oncogene Proteins; Pyrrolidines; Receptor, ErbB-2; RNA, Messenger; RNA, Neoplasm; Thiophenes; Tumor Cells, Cultured | 1990 |
Hormone and cytotoxic drug responsiveness of cultured human breast cancer cells resistant to specific hormones.
Topics: Breast Neoplasms; Cell Division; Dexamethasone; Drug Resistance; Estradiol; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Methotrexate; Pyrrolidines; Tamoxifen; Thiophenes; Tumor Cells, Cultured; Vincristine | 1990 |
Transcriptional control of thymidine kinase gene expression by estrogen and antiestrogens in MCF-7 human breast cancer cells.
Topics: Amanitins; Breast Neoplasms; Cell Cycle; Cell Line; DNA; Estradiol; Estrogen Antagonists; Estrogens; Gene Expression Regulation; Humans; Methylation; Pyrrolidines; RNA; RNA, Messenger; Tamoxifen; Thiophenes; Thymidine; Thymidine Kinase; Time Factors | 1986 |
Effects of oestrogen and the antioestrogens, tamoxifen and LY117018, on four oestrogen-regulated RNAs in the EFM-19 breast cancer cell line.
Topics: Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Gene Expression Regulation; Humans; Nucleic Acid Hybridization; Pyrrolidines; Receptors, Estrogen; RNA; RNA, Messenger; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 1989 |
ICI 164,384, a pure antagonist of estrogen-stimulated MCF-7 cell proliferation and invasiveness.
Topics: Basement Membrane; Binding, Competitive; Breast Neoplasms; Cell Cycle; Estradiol; Estrogen Antagonists; Humans; Neoplasm Invasiveness; Polyunsaturated Alkamides; Pyrrolidines; Receptors, Estrogen; Stimulation, Chemical; Tamoxifen; Thiophenes; Tumor Cells, Cultured | 1989 |
Alterations in phosphoinositide metabolism associated with 17 beta-estradiol and growth factor treatment of MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Estradiol; Female; Growth Substances; Humans; Phosphatidylinositols; Pyrrolidines; Thiophenes; Tumor Cells, Cultured | 1988 |
Oestrogen regulates oestrogen receptor mRNA levels in an oestrogen-responsive human breast cancer cell line.
Topics: Breast Neoplasms; Cell Line; Estradiol; Female; Humans; Pyrrolidines; Receptors, Estrogen; RNA, Messenger; Thiophenes | 1988 |
Epidermal growth factor partially reverses the inhibitory effects of antiestrogens on T 47D human breast cancer cell growth.
Topics: Breast Neoplasms; Cell Division; Cell Line; Clomiphene; Epidermal Growth Factor; Estrogen Antagonists; Humans; Pyrrolidines; Tamoxifen; Thiophenes | 1987 |
Selection and characterization of a breast cancer cell line resistant to the antiestrogen LY 117018.
Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; Drug Resistance; Estradiol; Female; Humans; Molecular Weight; Phenotype; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Thiophenes | 1985 |
Transfection of v-rasH DNA into MCF-7 human breast cancer cells bypasses dependence on estrogen for tumorigenicity.
Topics: Animals; Breast Neoplasms; Cell Line; Cell Transformation, Neoplastic; DNA, Neoplasm; Estrogens; Female; Humans; Mice; Mice, Nude; Neoplasms, Experimental; Oncogenes; Pyrrolidines; Repetitive Sequences, Nucleic Acid; Thiophenes; Transfection | 1985 |