lutetium-lu-177-dotatate has been researched along with Kidney-Neoplasms* in 3 studies
1 trial(s) available for lutetium-lu-177-dotatate and Kidney-Neoplasms
Article | Year |
---|---|
Long-term follow-up of renal function after peptide receptor radiation therapy with (90)Y-DOTA(0),Tyr(3)-octreotide and (177)Lu-DOTA(0), Tyr(3)-octreotate.
The kidneys are critical organs in peptide receptor radiation therapy (PRRT). Renal function loss may become apparent many years after PRRT. We analyzed the time course of decline in creatinine clearance (CLR) in patients during a follow-up of at least 18 mo after the start of PRRT with (90)Y-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA),Tyr(3)-octreotide ((90)Y-DOTATOC) or (177)Lu-DOTA(0),Tyr(3)-octreotate ((177)Lu-DOTATATE).. Twenty-eight patients with metastasized neuroendocrine tumors received 1-5 cycles of (90)Y-DOTATOC, leading to renal radiation doses of 5.9-26.9 Gy per cycle and a total of 18.3-38.7 Gy. Median follow-up was 2.9 y (range, 1.5-5.4 y), with a median of 16 measurements (range, 5-53) per patient. Thirty-seven patients with metastasized neuroendocrine tumors received 3-7 cycles of (177)Lu-DOTATATE, leading to renal radiation doses of 1.8-7.8 Gy per cycle and a total of 7.3-26.7 Gy. Median follow-up was 2.4 y (range, 1.7-4.0 y), with a median of 10 (range, 6-27) measurements per patient. All renal dose estimates were calculated with the MIRDOSE3 model. All patients were infused with renoprotective amino acids during the administration of the radioactive peptides. The time trend of CLR was determined by fitting a monoexponential function through the data of individual patients, yielding the decline in CLR in terms of percentage change per year.. The median decline in CLR was 7.3% per y in patients treated with (90)Y-DOTATOC and 3.8% per y in patients treated with (177)Lu-DOTATATE (P = 0.06). The time trend of decline in CLR was sustained during the follow-up period. Eleven patients had a >15% per y decline in CLR. Cumulative renal radiation dose, per-cycle renal radiation dose, age, hypertension, and diabetes are probable contributing factors to the rate of decline in CLR after PRRT.. This study showed that the time course of CLR after PRRT was compatible with the pattern of sustained CLR loss in progressive chronic kidney disease. Topics: Adult; Aged; Female; Follow-Up Studies; Humans; Kidney; Kidney Function Tests; Kidney Neoplasms; Longitudinal Studies; Male; Middle Aged; Necrosis; Neuroendocrine Tumors; Octreotide; Organometallic Compounds; Radiation Injuries; Radiopharmaceuticals; Receptors, Peptide; Recovery of Function; Treatment Outcome | 2005 |
2 other study(ies) available for lutetium-lu-177-dotatate and Kidney-Neoplasms
Article | Year |
---|---|
Personalized kidney dosimetry in
Topics: Adult; Coordination Complexes; Humans; Kidney Neoplasms; Neuroendocrine Tumors; Octreotide; Patient-Specific Modeling; Radiopharmaceuticals; Radiotherapy Planning, Computer-Assisted; Single Photon Emission Computed Tomography Computed Tomography; Software | 2019 |
Accuracy of kidney dosimetry performed using simplified time activity curve modelling methods: a
Topics: Female; Humans; Kidney Neoplasms; Male; Neuroendocrine Tumors; Octreotide; Organometallic Compounds; Radiometry; Radiopharmaceuticals; Radiotherapy Planning, Computer-Assisted; Single Photon Emission Computed Tomography Computed Tomography | 2019 |