luteolin and Stomach-Neoplasms

luteolin has been researched along with Stomach-Neoplasms* in 3 studies

Other Studies

3 other study(ies) available for luteolin and Stomach-Neoplasms

ArticleYear
Eudesmane-type sesquiterpenoid and guaianolides from Kandelia candel in a screening program for compounds to overcome TRAIL resistance.
    Journal of natural products, 2012, Aug-24, Volume: 75, Issue:8

    In a screening program for natural products that can overcome TRAIL resistance, a new eudesmane-type sesquiterpenoid (1), three new guaianolides, mehirugins A-C (2-4), and two known guaianolides (5 and 6) were isolated from a MeOH extract of Kandelia candel leaves. Compounds 1 and 3-6 in combination with TRAIL showed cytotoxic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma cells.

    Topics: Bangladesh; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Leaves; Receptors, TNF-Related Apoptosis-Inducing Ligand; Rhizophoraceae; Sesquiterpenes, Eudesmane; Stomach Neoplasms

2012
Cardenolide glycosides of Thevetia peruviana and triterpenoid saponins of Sapindus emarginatus as TRAIL resistance-overcoming compounds.
    Journal of natural products, 2009, Volume: 72, Issue:8

    A screening study for TRAIL resistance-overcoming activity was carried out, and activity-guided fractionations of Thevetia peruviana and Sapindus emarginatus led to the isolation of four cardenolide glycosides (1-4) and four triterpenoid saponins (5-8), respectively. In particular, cardenolide glycosides (1 and 2) from T. peruviana were shown to have a significant reversal effect on TRAIL resistance in human gastric adenocarcinoma cells, and real-time PCR showed that thevefolin (2) enhanced mRNA expression of death receptor 4 (DR4) and DR5. In addition, 1H and 13C NMR characterizations are shown for thevefolin (2) for the first time.

    Topics: Base Sequence; Cardenolides; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Receptors, TNF-Related Apoptosis-Inducing Ligand; Sapindus; Saponins; Stomach Neoplasms; Thailand; Thevetia; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured

2009
Tyrosine derivatives isolated from Streptomyces sp. IFM 10937 in a screening program for TRAIL-resistance-overcoming activity.
    Journal of natural products, 2008, Volume: 71, Issue:11

    Exploration of actinomycetes for isolation of natural products for abrogating TRAIL resistance led to the isolation of two new tyrosine derivatives (1 and 2) along with novobiocin (3). The structures of 1 and 2 were determined by spectroscopic methods, while the absolute configuration was determined by analyzing CD spectra and by a modified Marfey's method. Compounds 1 (150 μM) and 3 (37.5 and 75 μM) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma cells.

    Topics: Cell Line, Tumor; Circular Dichroism; Humans; Molecular Structure; Receptors, TNF-Related Apoptosis-Inducing Ligand; Stomach Neoplasms; Streptomyces; Tyrosine

2008
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