lupane has been researched along with Edema* in 2 studies
2 other study(ies) available for lupane and Edema
| Article | Year |
|---|---|
Lupane-type conjugates with aminoacids, 1,3,4- oxadiazole and 1,2,5-oxadiazole-2-oxide derivatives: Synthesis, anti-inflammatory activity and in silico evaluation of target affinity.
With the purpose to improve anti-inflammatory activity, the impact of introduction of 1,2,5- and 1,3,4-oxadiazole fragments to betulonic acid core as well as hybrids tethered with short ω-amino acids has been studied. The anti-inflammatory activity of synthesized compounds was tested in vivo using models of inflammation induced by concanavalin A and histamine. The majority of new compounds demonstrated higher anti-inflammatory activity compared with starting betulonic acid. To confirm the molecular targets of new derivatives in NRf2 and NFκB pathways the docking at Kelch and BTB active sites of Keap1 as well as IKK was done. The novelty of the present work is the development of new class of low toxic anti-inflammatory substances consisting of amino acid-linked betulonic acid - oxadiazole conjugates. These compounds can be considered as prospective chemopreventive agents. Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Computer Simulation; Concanavalin A; Disease Models, Animal; Edema; Female; Fibroblasts; Histamine; Inflammation; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Molecular Conformation; Molecular Docking Simulation; NF-E2-Related Factor 2; NF-kappa B; Oxadiazoles; Triterpenes | 2019 |
Lupane triterpenes with a δ-lactone at ring E, from Lippia mexicana.
Three new lupane-type triterpenes, lippiolide (1), lippiolidolic acid (2), and lippiolic acid (3), were isolated from aerial parts of Lippia mexicana. Compounds 1 and 2 exhibited a δ-lactone at ring E. The known cycloartane triterpene 5 was also isolated. The structures of these compounds were established on the basis of spectroscopic data and chemical reactions, and the structure of compound 1 was confirmed by X-ray diffraction analysis. Anti-inflammatory activity of compounds 1, 3, and 5 was evaluated in the TPA-induced ear mouse edema model. Lupanes 1 and 3 were more active than cycloartane 5. Topics: Animals; Anti-Inflammatory Agents; Crystallography, X-Ray; Disease Models, Animal; Edema; Lactones; Lippia; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism; Triterpenes | 2010 |