lu-208075 and Heart-Arrest

Pulmonary arterial hypertension (PAH) is characterized by elevations in the pulmonary arterial pressure and the vascular resistance in pulmonary placenta. One of the kinds of the pulmonary hypertension is the idiopathic arterial pulmonary hypertension, which etiology is not known. Below we present the case of 51 year old woman with idiopathic arterial pulmonary hypertension. Due to worsening shortness of breath occurring at night and heart palpitations, the noninvasive and invasive diagnostics were conducted. The diagnostics have shown a dilatation of the right atrium and ventricle, widening of the pulmonary vessels with the pressure in the pulmonary artery 108 mmHg, and moderate regurgitation of tricuspid valve and pulmonary artery. In spite of the treatment, increasing right sided heart failure was the cause of patient's further hospitalization. After the introduction of Ambrisentan therapy, her condition has improved. She waited for a lung transplant. The last exacerbation of ascites was probably a result of the cessation of the use of the above mentioned drug. Then there was a sudden cardiac arrest and, despite of the treatment the patient has died.

Topics: Echocardiography; Electrocardiography; Familial Primary Pulmonary Hypertension; Fatal Outcome; Female; Heart Arrest; Humans; Hypertension, Pulmonary; Middle Aged; Patient Compliance; Phenylpropionates; Pyridazines