Compounds > lu 135252
Page last updated: 2024-09-05

lu 135252 and Cardiac Failure

lu 135252 has been researched along with Cardiac Failure in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (11.54)18.2507
2000's23 (88.46)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Epstein, BJ1
Dietz, R; Langenickel, T; Lüscher, T; Monti, J; Notter, T; Pagel, I; Philipp, S; Ruschitzka, F; Willenbrock, R1
Boujedaini, H; Henry, JP; Mulder, P; Münter, K; Renet, S; Richard, V; Thuillez, C1
Bauersachs, J; Ertl, G; Fraccarollo, D; Schäfer, A1
Goldenthal, MJ; Marín-García, J; Moe, GW1
Dietz, R; Enseleit, F; Hürlimann, D; Lüscher, TF; Mitrovic, V; Noll, G; Notter, T; Pacher, R; Philipp, S; Rousson, V; Ruschitzka, F; Schulze, MR; Willenbrock, R1
Lüscher, TF; Spieker, LE1
Piuhola, J; Ruskoaho, H; Szokodi, I1
Austin, PC; Lapointe, N; Lee, DS; Nguyen, QT; Ohlsson, A; Rouleau, JL; Stewart, DJ; Tu, JV1
Boerrigter, G; Burnett, JC; Cataliotti, A; Chen, HH; Jougasaki, M; Lisy, O; Schirger, JA1
Berger, R; Bergler-Klein, J; Bojic, A; Pacher, R; Stanek, B1
Miyauchi, T1
Backs, J; Bresch, E; Haass, M; Kristen, AV; Lutz, M1
Daemen, MJ; Dorenkamp, M; Reinecke, A; Simon, R; Unger, T; Xia, QG1
Albernaz, A; Huntington, K; Moe, G; Monge, JC; Picard, P; Stewart, DJ1
Bouchart, F; Derumeaux, G; Mulder, P; Münter, K; Richard, V; Thuillez, C1
Albernaz, A; Kirchengast, M; Moe, GW; Naik, GO; Stewart, DJ1
Kiowski, W; Lüscher, TF; Mitrovic, V; Muntwyler, J; Noll, G; Pacher, R; Schalcher, C; Schulze, MR; Spieker, LE1
Bauersachs, J; Ertl, G; Fraccarollo, D; Galuppo, P; Widder, J1
Cernacek, P; Dupuis, J; Lucas, M; Thorin, E1
Bauersachs, J; Braun, C; Ertl, G; Fraccarollo, D; Kirchengast, M; Rohmeiss, P; Schilling, L; Widder, J1
Berger, R; Frey, B; Heher, S; Hülsmann, M; Neunteufl, T; Pacher, R; Stanek, B1
Lüscher, TF; Noll, G; Ruschitzka, FT; Spieker, LE1
Dupuis, J; Jasmin, JF; Lucas, M1
Cheng, TO1
Bauersachs, J; Ertl, G; Fraccarollo, D; Galuppo, P; Kellner, M1

Reviews

4 review(s) available for lu 135252 and Cardiac Failure

ArticleYear
Will endothelin receptor antagonists have a role in heart failure?
    The Medical clinics of North America, 2003, Volume: 87, Issue:2

    Topics: Animals; Bosentan; Cardiovascular Agents; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelins; Heart Failure; Humans; Isoxazoles; Oligopeptides; Peptides, Cyclic; Phenylpropionates; Piperidines; Pyridines; Pyrimidines; Sulfonamides; Tetrazoles; Thiophenes; Treatment Outcome

2003
Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure.
    Journal of cardiac failure, 2003, Volume: 9, Issue:5

    Topics: Animals; Atrasentan; Cardiotonic Agents; Endothelin Receptor Antagonists; Heart Failure; Peptides, Cyclic; Phenylpropionates; Pyrimidines; Pyrrolidines; Rats; Risk; Survival Rate

2003
[Endothelin and heart failure].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 9

    Topics: Animals; Biomarkers; Clinical Trials as Topic; Drug Design; Endothelin Receptor Antagonists; Endothelin-1; Gene Expression; Heart Failure; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Pathologic; Peptides, Cyclic; Phenylpropionates; Pyrimidines; Transcription Factors; Vasoconstriction; Ventricular Remodeling

2004
Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future?
    Journal of the American College of Cardiology, 2001, Volume: 37, Issue:6

    Topics: Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Forecasting; Heart Failure; Hemodynamics; Humans; Infusions, Intravenous; Myocardial Contraction; Peptides, Cyclic; Phenylpropionates; Predictive Value of Tests; Prognosis; Pyrimidines; Sulfonamides; Time Factors; Vascular Resistance; Vasoconstriction; Ventricular Function, Left

2001

Trials

4 trial(s) available for lu 135252 and Cardiac Failure

ArticleYear
Treatment with darusentan over 21 days improved cGMP generation in patients with chronic heart failure.
    Clinical science (London, England : 1979), 2002, Volume: 103 Suppl 48

    Topics: Atrial Natriuretic Factor; Cardiac Output; Cyclic GMP; Double-Blind Method; Drug Administration Schedule; Endothelin Receptor Antagonists; Heart Failure; Humans; Middle Aged; Natriuretic Peptide, Brain; Phenylpropionates; Pyrimidines; Receptor, Endothelin A; Vasodilator Agents

2002
Hemodynamic and neurohumoral effects of selective endothelin A (ET(A)) receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade Trial (HEAT).
    Circulation, 2002, Nov-19, Volume: 106, Issue:21

    Topics: Blood Pressure; Catecholamines; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Eruptions; Endothelin Receptor Antagonists; Europe; Female; Follow-Up Studies; Headache; Heart Failure; Heart Function Tests; Hemodynamics; Humans; Hypotension; Male; Middle Aged; Phenylpropionates; Pulmonary Wedge Pressure; Pyrimidines; Receptor, Endothelin A; Shock, Cardiogenic; Treatment Outcome; Vascular Resistance; Ventricular Fibrillation

2002
Neurohumoral and hemodynamic effects of the selective endothelin antagonist darusentan in advanced chronic heart failure.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2004, Volume: 23, Issue:1

    Topics: Atrial Natriuretic Factor; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Endothelin A Receptor Antagonists; Endothelin-1; Female; Heart Failure; Heart Function Tests; Hemodynamics; Humans; Liver Function Tests; Male; Middle Aged; Natriuretic Peptide, Brain; Phenylpropionates; Pyrimidines

2004
Effects of endothelin a receptor blockade on endothelial function in patients with chronic heart failure.
    Circulation, 2001, Feb-20, Volume: 103, Issue:7

    Topics: Blood Flow Velocity; Brachial Artery; Chronic Disease; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Endothelium, Vascular; Female; Heart Failure; Heart Function Tests; Humans; Linear Models; Male; Middle Aged; Nitroglycerin; Phenylpropionates; Protein Precursors; Pyrimidines; Receptor, Endothelin A; Treatment Outcome; Vasodilation

2001

Other Studies

18 other study(ies) available for lu 135252 and Cardiac Failure

ArticleYear
Efficacy and safety of darusentan: a novel endothelin receptor antagonist.
    The Annals of pharmacotherapy, 2008, Volume: 42, Issue:7

    Topics: Antihypertensive Agents; Endothelin A Receptor Antagonists; Heart Failure; Humans; Hypertension; Phenylpropionates; Pyrimidines; Substrate Specificity

2008
Long-term survival and hemodynamics after endothelin-a receptor antagonism and angiotensin-converting enzyme inhibition in rats with chronic heart failure: monotherapy versus combination therapy.
    Circulation, 2002, Aug-27, Volume: 106, Issue:9

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Chronic Disease; Coronary Vessels; Disease Models, Animal; Drug Therapy, Combination; Echocardiography; Endothelin Receptor Antagonists; Heart Failure; Hemodynamics; Ligation; Male; Myocardium; Peptidyl-Dipeptidase A; Phenylpropionates; Pyrimidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptors, Endothelin; Stroke Volume; Survival Rate; Ventricular Function, Left; Ventricular Remodeling; Wakefulness

2002
Angiotensin-converting enzyme inhibition and endothelin antagonism for endothelial dysfunction in heart failure: mono-or combination therapy.
    Journal of cardiovascular pharmacology, 2002, Volume: 40, Issue:4

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelium, Vascular; Heart Failure; In Vitro Techniques; Indoles; Male; Peptidyl-Dipeptidase A; Phenylpropionates; Pyrimidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptors, Endothelin; Vasodilation

2002
Selective endothelin receptor blockade reverses mitochondrial dysfunction in canine heart failure.
    Journal of cardiac failure, 2002, Volume: 8, Issue:5

    Topics: Adenosine Triphosphatases; Animals; Cardiac Pacing, Artificial; Carrier Proteins; Citrate (si)-Synthase; Citric Acid Cycle; Disease Models, Animal; Dogs; Endothelin Receptor Antagonists; Heart Failure; Hemodynamics; Membrane Proteins; Mitochondria, Heart; Mitochondrial Proton-Translocating ATPases; Models, Cardiovascular; Multienzyme Complexes; Muscle, Skeletal; Oxidative Phosphorylation; Oxidative Stress; Phenylpropionates; Pyrimidines; Treatment Outcome

2002
Endothelin receptor blockade and exacerbation of heart failure.
    Circulation, 2003, Jun-10, Volume: 107, Issue:22

    Topics: Animals; Bosentan; Chronic Disease; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelins; Heart; Heart Failure; Humans; Myocardial Contraction; Phenylpropionates; Pyrimidines; Rats; Receptor, Endothelin A; Sulfonamides; Vascular Resistance; Water-Electrolyte Balance

2003
Endothelin A receptor antagonism in experimental congestive heart failure results in augmentation of the renin-angiotensin system and sustained sodium retention.
    Circulation, 2004, Jan-20, Volume: 109, Issue:2

    Topics: Animals; Disease Progression; Dogs; Endothelin A Receptor Antagonists; Endothelin-1; Heart Failure; Hemodynamics; Kidney; Male; Phenylpropionates; Pyrimidines; Renin; Renin-Angiotensin System; Sodium

2004
Endothelin-1 inhibits the neuronal norepinephrine transporter in hearts of male rats.
    Cardiovascular research, 2005, Aug-01, Volume: 67, Issue:2

    Topics: Animals; Biological Transport; Carrier Proteins; Endothelin-1; Heart Failure; Male; Mazindol; Myocardial Contraction; Myocardium; Neurons; Norepinephrine; Perfusion; Phenylpropionates; Pyrimidines; Rats; Rats, Wistar

2005
Effects of endothelin ETA receptor blocker LU 135252 on cardiac remodeling and survival in a hypertensive rat model of chronic heart failure.
    Acta pharmacologica Sinica, 2006, Volume: 27, Issue:11

    Topics: Animals; Blood Pressure; Endothelin A Receptor Antagonists; Heart Failure; Heart Rate; Hypertension; Male; Myocardium; Organ Size; Phenylpropionates; Pyrimidines; Rats; Rats, Inbred SHR; Ventricular Remodeling

2006
Increased cardiac and pulmonary endothelin-1 mRNA expression in canine pacing-induced heart failure.
    Journal of cardiovascular pharmacology, 1998, Volume: 31 Suppl 1

    Topics: Animals; Cardiac Pacing, Artificial; Dogs; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Gene Expression; Heart Failure; Humans; Lung; Male; Myocardium; Phenylpropionates; Protein Precursors; Pyrimidines; Receptor, Endothelin A; Ribonucleases; RNA, Messenger

1998
Selective ETA receptor blockade prevents left ventricular remodeling and deterioration of cardiac function in experimental heart failure.
    Cardiovascular research, 1998, Volume: 39, Issue:3

    Topics: Animals; Blood Pressure; Cardiac Output; Collagen; Coronary Vessels; Dose-Response Relationship, Drug; Echocardiography; Endothelin Receptor Antagonists; Endothelin-1; Heart Failure; Heart Rate; Hemodynamics; Ligation; Male; Myocardium; Organ Size; Phenylpropionates; Pyrimidines; Rats; Rats, Wistar; Receptor, Endothelin A; Vasoconstrictor Agents; Ventricular Remodeling; Viper Venoms

1998
Beneficial effects of long-term selective endothelin type A receptor blockade in canine experimental heart failure.
    Cardiovascular research, 1998, Volume: 39, Issue:3

    Topics: Administration, Oral; Animals; Atrial Natriuretic Factor; Blood Pressure; Cardiac Output; Cardiac Pacing, Artificial; Dogs; Echocardiography; Endothelin Receptor Antagonists; Endothelin-1; Heart Failure; Male; Norepinephrine; Phenylpropionates; Pyrimidines; Random Allocation; Receptor, Endothelin A; Vascular Resistance; Ventricular Remodeling

1998
Acute hemodynamic and neurohumoral effects of selective ET(A) receptor blockade in patients with congestive heart failure. ET 003 Investigators.
    Journal of the American College of Cardiology, 2000, Volume: 35, Issue:7

    Topics: Catecholamines; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Phenylpropionates; Pyrimidines

2000
Endothelin-receptor blockade improves endothelial vasomotor dysfunction in heart failure.
    Cardiovascular research, 2000, Volume: 47, Issue:1

    Topics: Acetylcholine; Analysis of Variance; Animals; Aorta; Bosentan; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Heart Failure; In Vitro Techniques; Male; Myocardial Infarction; Nitroprusside; Oxygen; Phenylpropionates; Pyrimidines; Rats; Rats, Wistar; Renin; Sulfonamides; Superoxide Dismutase; Vasoconstrictor Agents; Vasodilator Agents

2000
Role of ET(A) receptors in the regulation of vascular reactivity in rats with congestive heart failure.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:2

    Topics: Animals; Cerebral Arteries; Electrocardiography; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Heart Failure; Hemodynamics; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Myocardial Infarction; Nitroarginine; Nitroprusside; Phenylpropionates; Pyrimidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptors, Endothelin; Vasoconstrictor Agents; Vasodilation; Viper Venoms

2000
Improvement of renal dysfunction in rats with chronic heart failure after myocardial infarction by treatment with the endothelin A receptor antagonist, LU 135252.
    Journal of hypertension, 2000, Volume: 18, Issue:10

    Topics: Animals; Chronic Disease; Endothelin Receptor Antagonists; Endothelins; Heart Failure; Kidney; Male; Myocardial Infarction; Phenylpropionates; Pyrimidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptors, Endothelin; Renal Artery; Vasodilation

2000
Effect of ET(A) receptor antagonist on pulmonary hypertension and vascular reactivity in rats with congestive heart failure.
    Pulmonary pharmacology & therapeutics, 2001, Volume: 14, Issue:4

    Topics: Animals; Disease Models, Animal; Heart Failure; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Male; Myocardial Infarction; Phenylpropionates; Pyrimidines; Rats; Rats, Wistar; Receptors, Endothelin; Vasoconstriction; Vasodilation

2001
Endothelin receptor blockade in congestive heart failure.
    Circulation, 2001, Oct-30, Volume: 104, Issue:18

    Topics: Acute Disease; Antihypertensive Agents; Bosentan; Chronic Disease; Clinical Trials as Topic; Endothelin Receptor Antagonists; Endothelin-1; Exercise Tolerance; Heart Failure; Hemodynamics; Humans; Phenylpropionates; Pyridines; Pyrimidines; Sulfonamides; Tetrazoles; Treatment Outcome; Vasodilator Agents

2001
Cardioprotection by long-term ET(A) receptor blockade and ACE inhibition in rats with congestive heart failure: mono- versus combination therapy.
    Cardiovascular research, 2002, Volume: 54, Issue:1

    Topics: Actins; Angiotensin-Converting Enzyme Inhibitors; Animals; Atrial Natriuretic Factor; Collagen; Drug Therapy, Combination; Endothelin Receptor Antagonists; Endothelin-1; Gene Expression; Heart Failure; Heart Ventricles; Hemodynamics; Indoles; Male; Matrix Metalloproteinase 2; Models, Animal; Myosin Heavy Chains; Norepinephrine; Phenylpropionates; Pyrimidines; Rats; Rats, Wistar; Renin; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta

2002