loxoprofen has been researched along with Stomach Ulcer in 11 studies
loxoprofen: RN given refers to parent cpd without isomeric designation; structure in first source
loxoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously reported that 2-fluoroloxoprofen has lower gastric ulcerogenic activity than loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID) without selectivity for COX-2." | 3.78 | Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity. ( Asano, T; Ishihara, T; Miyata, K; Mizushima, T; Okamoto, Y; Otsuka, M; Suemasu, S; Tanaka, K; Yamakawa, N, 2012) |
| " We investigated the effect of such a combination therapy, using the Ephedra herb, which is a common ingredient of Kakkon-to and Mao-to, and Loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID), on fever induced in an experimental model of mice under strong stress." | 3.71 | The combination therapy of Ephedra herb and Loxoprofen caused gastric lesions in mice. ( Aikawa, Y; Cho, S; Cyong, JC; Hong, T; Jin, GB; Miura, M; Yasuno, F; Yoshino, G, 2002) |
| " The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac." | 3.68 | NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993) |
| " Overall, the pharmacokinetic characteristics of F-LOX, including the formation of metabolites in vivo and in vitro, were comparable to those of LOX." | 1.39 | Comparison of pharmacokinetics between loxoprofen and its derivative with lower ulcerogenic activity, fluoro-loxoprofen. ( Maruyama, T; Mizushima, T; Ohtsuka, M; Okamoto, Y; Suemasu, S; Tahara, K; Tanaka, K; Watanabe, H; Yamakawa, N, 2013) |
| ") occurring after the start of rabeprazole treatment were handled as adverse events." | 1.35 | Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan. ( Mizokami, Y, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamakawa, N | 2 |
| Suemasu, S | 2 |
| Okamoto, Y | 2 |
| Tanaka, K | 2 |
| Ishihara, T | 1 |
| Asano, T | 1 |
| Miyata, K | 2 |
| Otsuka, M | 1 |
| Mizushima, T | 2 |
| Abe, K | 1 |
| Yamamoto, T | 1 |
| Kita, H | 1 |
| Kuyama, Y | 1 |
| Kanbayashi, Y | 1 |
| Konishi, H | 1 |
| Mizokami, Y | 1 |
| Watanabe, H | 1 |
| Tahara, K | 1 |
| Ohtsuka, M | 1 |
| Maruyama, T | 1 |
| Nagai, N | 1 |
| Takeda, A | 1 |
| Itanami, Y | 1 |
| Ito, Y | 1 |
| Cho, S | 1 |
| Hong, T | 1 |
| Jin, GB | 1 |
| Yoshino, G | 1 |
| Miura, M | 1 |
| Aikawa, Y | 1 |
| Yasuno, F | 1 |
| Cyong, JC | 1 |
| Noguchi, M | 1 |
| Kimoto, A | 1 |
| Kobayashi, S | 1 |
| Yoshino, T | 1 |
| Sasamata, M | 1 |
| Chi, YM | 1 |
| Nakamura, M | 1 |
| Zhao, XY | 1 |
| Yoshizawa, T | 1 |
| Yan, WM | 1 |
| Hashimoto, F | 1 |
| Kinjo, J | 1 |
| Nohara, T | 1 |
| Sakurada, S | 1 |
| Arakawa, T | 1 |
| Fukuda, T | 1 |
| Nakagawa, K | 1 |
| Higuchi, K | 1 |
| Watanabe, T | 1 |
| Tominaga, K | 1 |
| Kobayashi, K | 1 |
| Futaki, N | 1 |
| Yoshikawa, K | 1 |
| Hamasaka, Y | 1 |
| Arai, I | 1 |
| Higuchi, S | 1 |
| Iizuka, H | 1 |
| Otomo, S | 1 |
11 other studies available for loxoprofen and Stomach Ulcer
| Article | Year |
|---|---|
Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; | 2012 |
Video of the month: Hemostasis for spurting bleeding from a gastric ulcer using argon plasma coagulation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Argon Plasma Coagulation; Humans; Low Back Pain; Male; Midd | 2015 |
Predictive Factors for NSAIDs-related Gastrointestinal Toxicity: Can COX-2 Selective Inhibtor Prevent it?.
Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antineoplast | 2015 |
Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclo | 2009 |
Comparison of pharmacokinetics between loxoprofen and its derivative with lower ulcerogenic activity, fluoro-loxoprofen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Male; Phenylpropionates; Prodrugs; Rats; Stomach U | 2013 |
Co-administration of water containing magnesium ion prevents loxoprofen-induced lesions in gastric mucosa of adjuvant-induced arthritis rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Experimental; Drug T | 2012 |
The combination therapy of Ephedra herb and Loxoprofen caused gastric lesions in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Body Weight; Ephedra; | 2002 |
Effect of celecoxib, a cyclooxygenase-2 inhibitor, on the pathophysiology of adjuvant arthritis in rat.
Topics: Animals; Arthritis, Experimental; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy | 2005 |
Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclobutanes; Diclofenac; Female; Formaldehyde; In | 2006 |
Ulcerogenicity and effect on inhibition of prostaglandin generation of indometacin farnesil, a prodrug of indomethacin, in rat gastric mucosa: comparison with indomethacin or loxoprofen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Epoprostenol; Gastric Mucosa; Indome | 1995 |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 1993 |