Page last updated: 2024-10-30

loxoprofen and Spasm

loxoprofen has been researched along with Spasm in 1 studies

loxoprofen: RN given refers to parent cpd without isomeric designation; structure in first source
loxoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration.

Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.

Research Excerpts

ExcerptRelevanceReference
"Non-steroidal anti-inflammatory drugs (NSAIDs) are an effective and common treatment for chronic pain disorders, but long-term use is associated with risk of potentially life-threatening gastrointestinal adverse events (AEs)."2.78Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs. ( Kinoshita, Y; Miwa, H; Sugano, K; Takeuchi, T, 2013)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sugano, K1
Kinoshita, Y1
Miwa, H1
Takeuchi, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Long Term Study to Investigate the Efficacy and Safety Study of D961H (Esomeprazole) (20 mg Once Daily) for the Prevention of Gastric and/or Duodenal Ulcers Associated With Daily Nonsteroidal Anti-inflammatory Drug (NSAID) Use[NCT00595517]Phase 3395 participants (Actual)Interventional2007-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants Without Gastric and/or Duodenal Ulcer Throughout the Treatment Period

(NCT00595517)
Timeframe: up to 52 weeks

InterventionParticipants (Number)
Esomeprazole 20mg125

Number of Participants Without Gastric and/or Duodenal Ulcer up to 12 Weeks After Treatment

(NCT00595517)
Timeframe: up to 12 weeks after treatment

Interventionparticipants (Number)
Esomeprazole 20mg127

Number of Participants Without Gastric and/or Duodenal Ulcer up to 24 Weeks After Treatment

(NCT00595517)
Timeframe: up to 24 weeks after treatment

Interventionparticipants (Number)
Esomeprazole 20mg126

Number of Participants Without Gastric and/or Duodenal Ulcer up to 4 Weeks After Treatment

(NCT00595517)
Timeframe: up to 4 weeks after treatment

InterventionParticipants (Number)
Esomeprazole 20mg130

Trials

1 trial available for loxoprofen and Spasm

ArticleYear
Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs.
    BMC gastroenterology, 2013, Mar-26, Volume: 13

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Esomeprazole; Fema

2013