loxoprofen has been researched along with Osteoarthritis of Knee in 5 studies
loxoprofen: RN given refers to parent cpd without isomeric designation; structure in first source
loxoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with chronic pain, oral analgesics are essential treatment options to manage pain appropriately, improve activities of daily living abilities and achieve a higher quality of life (QOL)." | 7.30 | Protocol for the RETHINK study: a randomised, double-blind, parallel-group, non-inferiority clinical trial comparing acetaminophen and NSAIDs for treatment of chronic pain in elderly patients with osteoarthritis of the hip and knee. ( Aono, H; Endo, M; Hara, T; Kawahara, S; Kawano, T; Mawatari, T; Miyaji, T; Miyake, M; Nakashima, Y; Sakamoto, S; Sato, T; Shimokawa, M; Takano, T; Tokunaga, M; Zenda, S, 2023) |
| "In patients with chronic pain, oral analgesics are essential treatment options to manage pain appropriately, improve activities of daily living abilities and achieve a higher quality of life (QOL)." | 3.30 | Protocol for the RETHINK study: a randomised, double-blind, parallel-group, non-inferiority clinical trial comparing acetaminophen and NSAIDs for treatment of chronic pain in elderly patients with osteoarthritis of the hip and knee. ( Aono, H; Endo, M; Hara, T; Kawahara, S; Kawano, T; Mawatari, T; Miyaji, T; Miyake, M; Nakashima, Y; Sakamoto, S; Sato, T; Shimokawa, M; Takano, T; Tokunaga, M; Zenda, S, 2023) |
| " There were four secondary outcomes, including the extent of pain relief, the change trends of VAS scores, joint function scores measured by the Western Ontario and McMaster University Osteoarthritis Index (WOMAC), and adverse events." | 3.30 | Efficacy and safety of flurbiprofen cataplasms versus loxoprofen sodium cataplasms in knee osteoarthritis: a randomized controlled trial. ( Cheng, Y; Guan, Z; Jia, J; Kan, J; Li, D; Liu, J; Wang, Z; Wu, Z; Xue, T; Yuan, P; Zhai, S; Zhang, G; Zhang, H; Zhang, K, 2023) |
| " A lower incidence of adverse events was observed in LX-P group; however, the difference was not statistically significant." | 2.82 | Efficacy and safety of loxoprofen hydrogel patch versus loxoprofen tablet in patients with knee osteoarthritis: a randomized controlled non-inferiority trial. ( Bao, CD; Chen, ZW; Hu, SX; Li, YJ; Li, ZG; Mu, R; Shao, ZW; Wang, GC; Xiao, WG; Zhang, W; Zhang, ZY; Zhao, DB; Zheng, Y, 2016) |
| "To observe the clinical efficacy of silver needle heat conduction therapy combined with loxoprofen sodium patch in the treatment of knee osteoarthritis (KOA)." | 1.62 | [Therapeutic effect and mechanism of silver needle heat conduction therapy combined with loxoprofen sodium patch in patients with knee osteoarthritis]. ( Han, J; Ling, DY; Wang, ZY; Wu, CX; Zhang, ZW, 2021) |
| "To explore the efficacy of glucosamine sulfate (GS) combined with loxoprofen sodium (LS) in rats with knee osteoarthritis (KOA) and its effect on chondrocytes." | 1.62 | The inhibiting effect of glucosamine sulfate combined with loxoprofen sodium on chondrocyte apoptosis in rats with knee osteoarthritis. ( Luo, M; Luo, W; Wang, Q; Xu, F, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 4 (80.00) | 2.80 |
| Authors | Studies |
|---|---|
| Endo, M | 1 |
| Kawahara, S | 1 |
| Sato, T | 1 |
| Tokunaga, M | 1 |
| Hara, T | 1 |
| Mawatari, T | 1 |
| Kawano, T | 1 |
| Zenda, S | 1 |
| Miyaji, T | 1 |
| Shimokawa, M | 1 |
| Sakamoto, S | 1 |
| Takano, T | 1 |
| Miyake, M | 1 |
| Aono, H | 1 |
| Nakashima, Y | 1 |
| Li, D | 1 |
| Cheng, Y | 1 |
| Yuan, P | 1 |
| Wu, Z | 1 |
| Liu, J | 1 |
| Kan, J | 1 |
| Zhang, K | 1 |
| Wang, Z | 1 |
| Zhang, H | 1 |
| Zhang, G | 1 |
| Xue, T | 1 |
| Jia, J | 1 |
| Zhai, S | 1 |
| Guan, Z | 1 |
| Zhang, ZW | 1 |
| Ling, DY | 1 |
| Han, J | 1 |
| Wu, CX | 1 |
| Wang, ZY | 1 |
| Luo, M | 1 |
| Xu, F | 1 |
| Wang, Q | 1 |
| Luo, W | 1 |
| Mu, R | 1 |
| Bao, CD | 1 |
| Chen, ZW | 1 |
| Zheng, Y | 1 |
| Wang, GC | 1 |
| Zhao, DB | 1 |
| Hu, SX | 1 |
| Li, YJ | 1 |
| Shao, ZW | 1 |
| Zhang, ZY | 1 |
| Xiao, WG | 1 |
| Zhang, W | 1 |
| Li, ZG | 1 |
3 trials available for loxoprofen and Osteoarthritis of Knee
2 other studies available for loxoprofen and Osteoarthritis of Knee
| Article | Year |
|---|---|
[Therapeutic effect and mechanism of silver needle heat conduction therapy combined with loxoprofen sodium patch in patients with knee osteoarthritis].
Topics: Hot Temperature; Humans; Osteoarthritis, Knee; Phenylpropionates; Silver; Sodium; Treatment Outcome | 2021 |
The inhibiting effect of glucosamine sulfate combined with loxoprofen sodium on chondrocyte apoptosis in rats with knee osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cells, Cultured; Chondrocytes; Drug The | 2021 |