loxoprofen has been researched along with Inflammation in 11 studies
loxoprofen: RN given refers to parent cpd without isomeric designation; structure in first source
loxoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lornoxicam exhibits strong analgesic but weak antipyretic effects in rats with paw inflammation." | 7.75 | The importance of brain PGE2 inhibition versus paw PGE2 inhibition as a mechanism for the separation of analgesic and antipyretic effects of lornoxicam in rats with paw inflammation. ( Arai, I; Futaki, N; Harada, M; Hashimoto, Y; Honma, Y; Hoshi, K; Nakaike, S; Sugimoto, M, 2009) |
| "Metastasis is a major contributor of death in cancer patients, and there is an urgent need for effective treatments of metastatic malignancies." | 5.62 | Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response. ( Chen, Y; Cui, J; Han, J; Li, L; Li, Z; Liu, M; Liu, Z; Wang, Q; Wang, Z; Zhang, N, 2021) |
| "Celecoxib was administered at the rate of 3 mg/kg per day, loxoprofen at 3 mg/kg per day, and SC-58560 at 10 mg/kg per day." | 5.35 | Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats. ( Kimoto, A; Miyata, K; Noguchi, M; Sasamata, M, 2008) |
| "Lornoxicam exhibits strong analgesic but weak antipyretic effects in rats with paw inflammation." | 3.75 | The importance of brain PGE2 inhibition versus paw PGE2 inhibition as a mechanism for the separation of analgesic and antipyretic effects of lornoxicam in rats with paw inflammation. ( Arai, I; Futaki, N; Harada, M; Hashimoto, Y; Honma, Y; Hoshi, K; Nakaike, S; Sugimoto, M, 2009) |
| "Pain threshold increased after treatment, and was significantly increased in the loxoprofen-Na group compared with the control group (p < 0." | 3.74 | Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model. ( Kikuchi, S; Konno, S; Sekiguchi, M; Shirasaka, M, 2008) |
| "The effect of loxoprofen-Na, a novel non-steroidal anti-inflammatory drug with a prodrug property, on prostaglandin (PG) levels in the inflammatory tissue was investigated with a carrageenin-induced pleurisy model in rats." | 3.68 | Inhibition of prostaglandin production in the inflammatory tissue by loxoprofen-Na, an anti-inflammatory prodrug. ( Asami, M; Iizuka, Y; Kojima, T; Matsuda, K; Sugimoto, M, 1991) |
| "Metastasis is a major contributor of death in cancer patients, and there is an urgent need for effective treatments of metastatic malignancies." | 1.62 | Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response. ( Chen, Y; Cui, J; Han, J; Li, L; Li, Z; Liu, M; Liu, Z; Wang, Q; Wang, Z; Zhang, N, 2021) |
| "Celecoxib was administered at the rate of 3 mg/kg per day, loxoprofen at 3 mg/kg per day, and SC-58560 at 10 mg/kg per day." | 1.35 | Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats. ( Kimoto, A; Miyata, K; Noguchi, M; Sasamata, M, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Terada, A | 1 |
| Naruto, S | 1 |
| Wachi, K | 1 |
| Tanaka, S | 1 |
| Iizuka, Y | 2 |
| Misaka, E | 1 |
| Li, Z | 1 |
| Wang, Q | 1 |
| Li, L | 1 |
| Chen, Y | 1 |
| Cui, J | 1 |
| Liu, M | 1 |
| Zhang, N | 1 |
| Liu, Z | 1 |
| Han, J | 1 |
| Wang, Z | 1 |
| Zhang, D | 1 |
| Bian, Q | 1 |
| Li, J | 1 |
| Huang, Q | 1 |
| Gao, J | 1 |
| Greig, SL | 1 |
| Garnock-Jones, KP | 1 |
| Nakajima, A | 1 |
| Sato, H | 1 |
| Oda, S | 1 |
| Yokoi, T | 1 |
| Noguchi, M | 1 |
| Kimoto, A | 1 |
| Sasamata, M | 1 |
| Miyata, K | 1 |
| Futaki, N | 1 |
| Harada, M | 1 |
| Sugimoto, M | 2 |
| Hashimoto, Y | 1 |
| Honma, Y | 1 |
| Arai, I | 1 |
| Nakaike, S | 1 |
| Hoshi, K | 1 |
| Chi, YM | 1 |
| Nakamura, M | 1 |
| Zhao, XY | 1 |
| Yoshizawa, T | 1 |
| Yan, WM | 1 |
| Hashimoto, F | 1 |
| Kinjo, J | 1 |
| Nohara, T | 1 |
| Sakurada, S | 1 |
| Ikeda, M | 1 |
| Kawatani, M | 1 |
| Maruyama, T | 1 |
| Ishihama, H | 1 |
| Sekiguchi, M | 1 |
| Shirasaka, M | 1 |
| Konno, S | 1 |
| Kikuchi, S | 1 |
| Kojima, T | 1 |
| Asami, M | 1 |
| Matsuda, K | 1 |
1 review available for loxoprofen and Inflammation
| Article | Year |
|---|---|
Loxoprofen: A Review in Pain and Inflammation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Inflammation; Pain; Phenylpropionates; Randomized C | 2016 |
10 other studies available for loxoprofen and Inflammation
| Article | Year |
|---|---|
Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds.
Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Female; Fever; Ibuprofen; Indomethacin; Inflamma | 1984 |
Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response.
Topics: Animals; Cell Line, Tumor; Coordination Complexes; DNA Damage; Drug Screening Assays, Antitumor; Hum | 2021 |
Enhancing effect of fumaric acid on transdermal penetration of loxoprofen sodium.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Mo | 2020 |
Fluoroquinolones and propionic acid derivatives induce inflammatory responses in vitro.
Topics: Allopurinol; Cell Line; Fluoroquinolones; Gene Expression Regulation; Humans; Inflammation; Levoflox | 2018 |
Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Bone Diseases; Celecoxib; | 2008 |
The importance of brain PGE2 inhibition versus paw PGE2 inhibition as a mechanism for the separation of analgesic and antipyretic effects of lornoxicam in rats with paw inflammation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cel | 2009 |
Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclobutanes; Diclofenac; Female; Formaldehyde; In | 2006 |
Prostaglandin facilitates afferent nerve activity via EP1 receptors during urinary bladder inflammation in rats.
Topics: Acetic Acid; Afferent Pathways; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bridged Bicyclo Co | 2006 |
Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.
Topics: Acute Disease; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Contusions | 2008 |
Inhibition of prostaglandin production in the inflammatory tissue by loxoprofen-Na, an anti-inflammatory prodrug.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cells, | 1991 |