Page last updated: 2024-10-30

loxoprofen and Gastric Ulcer

loxoprofen has been researched along with Gastric Ulcer in 11 studies

loxoprofen: RN given refers to parent cpd without isomeric designation; structure in first source
loxoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration.

Research Excerpts

ExcerptRelevanceReference
"We previously reported that 2-fluoroloxoprofen has lower gastric ulcerogenic activity than loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID) without selectivity for COX-2."3.78Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity. ( Asano, T; Ishihara, T; Miyata, K; Mizushima, T; Okamoto, Y; Otsuka, M; Suemasu, S; Tanaka, K; Yamakawa, N, 2012)
" We investigated the effect of such a combination therapy, using the Ephedra herb, which is a common ingredient of Kakkon-to and Mao-to, and Loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID), on fever induced in an experimental model of mice under strong stress."3.71The combination therapy of Ephedra herb and Loxoprofen caused gastric lesions in mice. ( Aikawa, Y; Cho, S; Cyong, JC; Hong, T; Jin, GB; Miura, M; Yasuno, F; Yoshino, G, 2002)
" The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac."3.68NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993)
" Overall, the pharmacokinetic characteristics of F-LOX, including the formation of metabolites in vivo and in vitro, were comparable to those of LOX."1.39Comparison of pharmacokinetics between loxoprofen and its derivative with lower ulcerogenic activity, fluoro-loxoprofen. ( Maruyama, T; Mizushima, T; Ohtsuka, M; Okamoto, Y; Suemasu, S; Tahara, K; Tanaka, K; Watanabe, H; Yamakawa, N, 2013)
") occurring after the start of rabeprazole treatment were handled as adverse events."1.35Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan. ( Mizokami, Y, 2009)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (18.18)18.2507
2000's4 (36.36)29.6817
2010's5 (45.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yamakawa, N2
Suemasu, S2
Okamoto, Y2
Tanaka, K2
Ishihara, T1
Asano, T1
Miyata, K2
Otsuka, M1
Mizushima, T2
Abe, K1
Yamamoto, T1
Kita, H1
Kuyama, Y1
Kanbayashi, Y1
Konishi, H1
Mizokami, Y1
Watanabe, H1
Tahara, K1
Ohtsuka, M1
Maruyama, T1
Nagai, N1
Takeda, A1
Itanami, Y1
Ito, Y1
Cho, S1
Hong, T1
Jin, GB1
Yoshino, G1
Miura, M1
Aikawa, Y1
Yasuno, F1
Cyong, JC1
Noguchi, M1
Kimoto, A1
Kobayashi, S1
Yoshino, T1
Sasamata, M1
Chi, YM1
Nakamura, M1
Zhao, XY1
Yoshizawa, T1
Yan, WM1
Hashimoto, F1
Kinjo, J1
Nohara, T1
Sakurada, S1
Arakawa, T1
Fukuda, T1
Nakagawa, K1
Higuchi, K1
Watanabe, T1
Tominaga, K1
Kobayashi, K1
Futaki, N1
Yoshikawa, K1
Hamasaka, Y1
Arai, I1
Higuchi, S1
Iizuka, H1
Otomo, S1

Other Studies

11 other studies available for loxoprofen and Gastric Ulcer

ArticleYear
Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity.
    Journal of medicinal chemistry, 2012, Jun-14, Volume: 55, Issue:11

    Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1;

2012
Video of the month: Hemostasis for spurting bleeding from a gastric ulcer using argon plasma coagulation.
    The American journal of gastroenterology, 2015, Volume: 110, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Argon Plasma Coagulation; Humans; Low Back Pain; Male; Midd

2015
Predictive Factors for NSAIDs-related Gastrointestinal Toxicity: Can COX-2 Selective Inhibtor Prevent it?.
    Hepato-gastroenterology, 2015, Volume: 62, Issue:140

    Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antineoplast

2015
Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan.
    World journal of gastroenterology, 2009, Oct-28, Volume: 15, Issue:40

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclo

2009
Comparison of pharmacokinetics between loxoprofen and its derivative with lower ulcerogenic activity, fluoro-loxoprofen.
    Drug metabolism and pharmacokinetics, 2013, Volume: 28, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Male; Phenylpropionates; Prodrugs; Rats; Stomach U

2013
Co-administration of water containing magnesium ion prevents loxoprofen-induced lesions in gastric mucosa of adjuvant-induced arthritis rat.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Experimental; Drug T

2012
The combination therapy of Ephedra herb and Loxoprofen caused gastric lesions in mice.
    The American journal of Chinese medicine, 2002, Volume: 30, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; Body Weight; Ephedra;

2002
Effect of celecoxib, a cyclooxygenase-2 inhibitor, on the pathophysiology of adjuvant arthritis in rat.
    European journal of pharmacology, 2005, Apr-25, Volume: 513, Issue:3

    Topics: Animals; Arthritis, Experimental; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy

2005
Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclobutanes; Diclofenac; Female; Formaldehyde; In

2006
Ulcerogenicity and effect on inhibition of prostaglandin generation of indometacin farnesil, a prodrug of indomethacin, in rat gastric mucosa: comparison with indomethacin or loxoprofen.
    Drugs under experimental and clinical research, 1995, Volume: 21, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Epoprostenol; Gastric Mucosa; Indome

1995
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
    General pharmacology, 1993, Volume: 24, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena

1993