loxoprofen has been researched along with Adenocarcinoma in 2 studies
loxoprofen: RN given refers to parent cpd without isomeric designation; structure in first source
loxoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The disease appeared during low-dose oral methotrexate (MTX) therapy for rheumatoid arthritis." | 7.74 | Massive myelinolytic leukoencephalopathy in a patient medicated with low-dose oral methotrexate for rheumatoid arthritis: an autopsy report. ( Harigaya, Y; Igeta, Y; Itoh, H; Nakazato, Y; Sasaki, N; Yokoo, H, 2007) |
| " We recently showed that NSAIDs such as indomethacin and celecoxib have direct cytotoxicity (ability to induce necrosis and apoptosis in gastric mucosal cells) due to their membrane permeabilizing activities, which is involved in NSAID-induced gastric lesions." | 3.76 | Low direct cytotoxicity of loxoprofen on gastric mucosal cells. ( Arai, Y; Ishihara, T; Kimoto, A; Mizushima, T; Okamoto, Y; Otsuka, M; Suemasu, S; Tanaka, K; Yamakawa, N; Yokomizo, K, 2010) |
| " The disease appeared during low-dose oral methotrexate (MTX) therapy for rheumatoid arthritis." | 3.74 | Massive myelinolytic leukoencephalopathy in a patient medicated with low-dose oral methotrexate for rheumatoid arthritis: an autopsy report. ( Harigaya, Y; Igeta, Y; Itoh, H; Nakazato, Y; Sasaki, N; Yokoo, H, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamakawa, N | 1 |
| Suemasu, S | 1 |
| Kimoto, A | 1 |
| Arai, Y | 1 |
| Ishihara, T | 1 |
| Yokomizo, K | 1 |
| Okamoto, Y | 1 |
| Otsuka, M | 1 |
| Tanaka, K | 1 |
| Mizushima, T | 1 |
| Yokoo, H | 1 |
| Nakazato, Y | 1 |
| Harigaya, Y | 1 |
| Sasaki, N | 1 |
| Igeta, Y | 1 |
| Itoh, H | 1 |
2 other studies available for loxoprofen and Adenocarcinoma
| Article | Year |
|---|---|
Low direct cytotoxicity of loxoprofen on gastric mucosal cells.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; | 2010 |
Massive myelinolytic leukoencephalopathy in a patient medicated with low-dose oral methotrexate for rheumatoid arthritis: an autopsy report.
Topics: Adenocarcinoma; Administration, Oral; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non- | 2007 |