Page last updated: 2024-10-30
loxoprofen and Ache
loxoprofen has been researched along with Ache in 9 studies
loxoprofen: RN given refers to parent cpd without isomeric designation; structure in first source
loxoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " To estimate the effects of Shakuyaku-kanzo-to, the constituent herbal medicines Shakuyaku and Kanzo, and loxoprofen sodium as a non-steroidal anti-inflammatory drug on paclitaxel-induced pain, mechanical allodynia and hyperalgesia of the hind paw were assessed." | 7.75 | Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice. ( Aono, Y; Arai, T; Hidaka, T; Ieki, M; Kuraishi, Y; Nagira, K; Nakamura, T; Saito, S; Shima, T, 2009) |
| " However, oral nonsteroidal anti-inflammatory drugs cause several adverse events, with topical formulations arising as an important alternative." | 6.90 | Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, noninferiority trial. ( Daher, MT; Fujiki, EN; Kraychete, DC; Lopes, DG; Nakamoto, A; Netto, NA; Tardini, R, 2019) |
| " To estimate the effects of Shakuyaku-kanzo-to, the constituent herbal medicines Shakuyaku and Kanzo, and loxoprofen sodium as a non-steroidal anti-inflammatory drug on paclitaxel-induced pain, mechanical allodynia and hyperalgesia of the hind paw were assessed." | 3.75 | Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice. ( Aono, Y; Arai, T; Hidaka, T; Ieki, M; Kuraishi, Y; Nagira, K; Nakamura, T; Saito, S; Shima, T, 2009) |
| "Pain threshold increased after treatment, and was significantly increased in the loxoprofen-Na group compared with the control group (p < 0." | 3.74 | Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model. ( Kikuchi, S; Konno, S; Sekiguchi, M; Shirasaka, M, 2008) |
| " The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac." | 3.68 | NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993) |
| " There were four secondary outcomes, including the extent of pain relief, the change trends of VAS scores, joint function scores measured by the Western Ontario and McMaster University Osteoarthritis Index (WOMAC), and adverse events." | 3.30 | Efficacy and safety of flurbiprofen cataplasms versus loxoprofen sodium cataplasms in knee osteoarthritis: a randomized controlled trial. ( Cheng, Y; Guan, Z; Jia, J; Kan, J; Li, D; Liu, J; Wang, Z; Wu, Z; Xue, T; Yuan, P; Zhai, S; Zhang, G; Zhang, H; Zhang, K, 2023) |
| " However, oral nonsteroidal anti-inflammatory drugs cause several adverse events, with topical formulations arising as an important alternative." | 2.90 | Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, noninferiority trial. ( Daher, MT; Fujiki, EN; Kraychete, DC; Lopes, DG; Nakamoto, A; Netto, NA; Tardini, R, 2019) |
| "A detection kit for influenza virus A and B antigens was used to determine the presence of influenza virus infection." | 2.76 | Antipyretic and analgesic effects of zaltoprofen for the treatment of acute upper respiratory tract infection: verification of a noninferiority hypothesis using loxoprofen sodium. ( Azuma, A; Kudoh, S; Nagatake, T; Nakashima, M, 2011) |
| "Knee pain was assessed by weight distribution on the hind paw, and cartilage damage and MMP production in the joints were evaluated 18 days after surgery." | 1.36 | High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis. ( Hashizume, M; Koike, N; Mihara, M; Suzuki, M; Yoshida, H, 2010) |
Research
Studies (9)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Li, D | 1 |
| Cheng, Y | 1 |
| Yuan, P | 1 |
| Wu, Z | 1 |
| Liu, J | 1 |
| Kan, J | 1 |
| Zhang, K | 1 |
| Wang, Z | 1 |
| Zhang, H | 1 |
| Zhang, G | 1 |
| Xue, T | 1 |
| Jia, J | 1 |
| Zhai, S | 1 |
| Guan, Z | 1 |
| Fujiki, EN | 1 |
| Netto, NA | 1 |
| Kraychete, DC | 1 |
| Daher, MT | 1 |
| Tardini, R | 1 |
| Nakamoto, A | 1 |
| Lopes, DG | 1 |
| Greig, SL | 1 |
| Garnock-Jones, KP | 1 |
| Hashizume, M | 1 |
| Koike, N | 1 |
| Yoshida, H | 1 |
| Suzuki, M | 1 |
| Mihara, M | 1 |
| Azuma, A | 1 |
| Kudoh, S | 1 |
| Nakashima, M | 1 |
| Nagatake, T | 1 |
| Noguchi, M | 1 |
| Kimoto, A | 1 |
| Kobayashi, S | 1 |
| Yoshino, T | 1 |
| Miyata, K | 1 |
| Sasamata, M | 1 |
| Sekiguchi, M | 1 |
| Shirasaka, M | 1 |
| Konno, S | 1 |
| Kikuchi, S | 1 |
| Hidaka, T | 1 |
| Shima, T | 1 |
| Nagira, K | 1 |
| Ieki, M | 1 |
| Nakamura, T | 1 |
| Aono, Y | 1 |
| Kuraishi, Y | 1 |
| Arai, T | 1 |
| Saito, S | 1 |
| Futaki, N | 1 |
| Yoshikawa, K | 1 |
| Hamasaka, Y | 1 |
| Arai, I | 1 |
| Higuchi, S | 1 |
| Iizuka, H | 1 |
| Otomo, S | 1 |
Reviews
1 review available for loxoprofen and Ache
| Article | Year |
|---|---|
Loxoprofen: A Review in Pain and Inflammation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Inflammation; Pain; Phenylpropionates; Randomized C | 2016 |
Trials
3 trials available for loxoprofen and Ache
| Article | Year |
|---|---|
Efficacy and safety of flurbiprofen cataplasms versus loxoprofen sodium cataplasms in knee osteoarthritis: a randomized controlled trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Flurbiprofen; Humans; Mi | 2023 |
Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, noninferiority trial.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Brazil; Double-Blind Method; Extre | 2019 |
Antipyretic and analgesic effects of zaltoprofen for the treatment of acute upper respiratory tract infection: verification of a noninferiority hypothesis using loxoprofen sodium.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Benzopyrans; Bod | 2011 |
Other Studies
5 other studies available for loxoprofen and Ache
| Article | Year |
|---|---|
High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis.
Topics: Adjuvants, Immunologic; Analgesics; Animals; Animals, Inbred Strains; Anti-Inflammatory Agents, Non- | 2010 |
Effect of celecoxib, a cyclooxygenase-2 inhibitor, on the pathophysiology of adjuvant arthritis in rat.
Topics: Animals; Arthritis, Experimental; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy | 2005 |
Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.
Topics: Acute Disease; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Contusions | 2008 |
Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Behavior, Anima | 2009 |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 1993 |