Page last updated: 2024-10-30

loxoprofen and Ache

loxoprofen has been researched along with Ache in 9 studies

loxoprofen: RN given refers to parent cpd without isomeric designation; structure in first source
loxoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration.

Research Excerpts

ExcerptRelevanceReference
" To estimate the effects of Shakuyaku-kanzo-to, the constituent herbal medicines Shakuyaku and Kanzo, and loxoprofen sodium as a non-steroidal anti-inflammatory drug on paclitaxel-induced pain, mechanical allodynia and hyperalgesia of the hind paw were assessed."7.75Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice. ( Aono, Y; Arai, T; Hidaka, T; Ieki, M; Kuraishi, Y; Nagira, K; Nakamura, T; Saito, S; Shima, T, 2009)
" However, oral nonsteroidal anti-inflammatory drugs cause several adverse events, with topical formulations arising as an important alternative."6.90Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, noninferiority trial. ( Daher, MT; Fujiki, EN; Kraychete, DC; Lopes, DG; Nakamoto, A; Netto, NA; Tardini, R, 2019)
" To estimate the effects of Shakuyaku-kanzo-to, the constituent herbal medicines Shakuyaku and Kanzo, and loxoprofen sodium as a non-steroidal anti-inflammatory drug on paclitaxel-induced pain, mechanical allodynia and hyperalgesia of the hind paw were assessed."3.75Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice. ( Aono, Y; Arai, T; Hidaka, T; Ieki, M; Kuraishi, Y; Nagira, K; Nakamura, T; Saito, S; Shima, T, 2009)
"Pain threshold increased after treatment, and was significantly increased in the loxoprofen-Na group compared with the control group (p < 0."3.74Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model. ( Kikuchi, S; Konno, S; Sekiguchi, M; Shirasaka, M, 2008)
" The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac."3.68NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993)
" There were four secondary outcomes, including the extent of pain relief, the change trends of VAS scores, joint function scores measured by the Western Ontario and McMaster University Osteoarthritis Index (WOMAC), and adverse events."3.30Efficacy and safety of flurbiprofen cataplasms versus loxoprofen sodium cataplasms in knee osteoarthritis: a randomized controlled trial. ( Cheng, Y; Guan, Z; Jia, J; Kan, J; Li, D; Liu, J; Wang, Z; Wu, Z; Xue, T; Yuan, P; Zhai, S; Zhang, G; Zhang, H; Zhang, K, 2023)
" However, oral nonsteroidal anti-inflammatory drugs cause several adverse events, with topical formulations arising as an important alternative."2.90Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, noninferiority trial. ( Daher, MT; Fujiki, EN; Kraychete, DC; Lopes, DG; Nakamoto, A; Netto, NA; Tardini, R, 2019)
"A detection kit for influenza virus A and B antigens was used to determine the presence of influenza virus infection."2.76Antipyretic and analgesic effects of zaltoprofen for the treatment of acute upper respiratory tract infection: verification of a noninferiority hypothesis using loxoprofen sodium. ( Azuma, A; Kudoh, S; Nagatake, T; Nakashima, M, 2011)
"Knee pain was assessed by weight distribution on the hind paw, and cartilage damage and MMP production in the joints were evaluated 18 days after surgery."1.36High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis. ( Hashizume, M; Koike, N; Mihara, M; Suzuki, M; Yoshida, H, 2010)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's3 (33.33)29.6817
2010's4 (44.44)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Li, D1
Cheng, Y1
Yuan, P1
Wu, Z1
Liu, J1
Kan, J1
Zhang, K1
Wang, Z1
Zhang, H1
Zhang, G1
Xue, T1
Jia, J1
Zhai, S1
Guan, Z1
Fujiki, EN1
Netto, NA1
Kraychete, DC1
Daher, MT1
Tardini, R1
Nakamoto, A1
Lopes, DG1
Greig, SL1
Garnock-Jones, KP1
Hashizume, M1
Koike, N1
Yoshida, H1
Suzuki, M1
Mihara, M1
Azuma, A1
Kudoh, S1
Nakashima, M1
Nagatake, T1
Noguchi, M1
Kimoto, A1
Kobayashi, S1
Yoshino, T1
Miyata, K1
Sasamata, M1
Sekiguchi, M1
Shirasaka, M1
Konno, S1
Kikuchi, S1
Hidaka, T1
Shima, T1
Nagira, K1
Ieki, M1
Nakamura, T1
Aono, Y1
Kuraishi, Y1
Arai, T1
Saito, S1
Futaki, N1
Yoshikawa, K1
Hamasaka, Y1
Arai, I1
Higuchi, S1
Iizuka, H1
Otomo, S1

Reviews

1 review available for loxoprofen and Ache

ArticleYear
Loxoprofen: A Review in Pain and Inflammation.
    Clinical drug investigation, 2016, Volume: 36, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Inflammation; Pain; Phenylpropionates; Randomized C

2016

Trials

3 trials available for loxoprofen and Ache

ArticleYear
Efficacy and safety of flurbiprofen cataplasms versus loxoprofen sodium cataplasms in knee osteoarthritis: a randomized controlled trial.
    Chinese medical journal, 2023, Sep-20, Volume: 136, Issue:18

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Flurbiprofen; Humans; Mi

2023
Efficacy and safety of loxoprofen sodium topical patch for the treatment of pain in patients with minor acute traumatic limb injuries in Brazil: a randomized, double-blind, noninferiority trial.
    Pain, 2019, Volume: 160, Issue:7

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Brazil; Double-Blind Method; Extre

2019
Antipyretic and analgesic effects of zaltoprofen for the treatment of acute upper respiratory tract infection: verification of a noninferiority hypothesis using loxoprofen sodium.
    Pharmacology, 2011, Volume: 87, Issue:3-4

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Benzopyrans; Bod

2011

Other Studies

5 other studies available for loxoprofen and Ache

ArticleYear
High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis.
    Modern rheumatology, 2010, Volume: 20, Issue:5

    Topics: Adjuvants, Immunologic; Analgesics; Animals; Animals, Inbred Strains; Anti-Inflammatory Agents, Non-

2010
Effect of celecoxib, a cyclooxygenase-2 inhibitor, on the pathophysiology of adjuvant arthritis in rat.
    European journal of pharmacology, 2005, Apr-25, Volume: 513, Issue:3

    Topics: Animals; Arthritis, Experimental; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy

2005
Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.
    BMC musculoskeletal disorders, 2008, Jan-31, Volume: 9

    Topics: Acute Disease; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Contusions

2008
Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice.
    European journal of pain (London, England), 2009, Volume: 13, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Behavior, Anima

2009
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
    General pharmacology, 1993, Volume: 24, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena

1993